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The map label for this gene is sppA [C]

Identifier: 188528198

GI number: 188528198

Start: 1425895

End: 1426773

Strand: Reverse

Name: sppA [C]

Synonym: HPSH_07310

Alternate gene names: 188528198

Gene position: 1426773-1425895 (Counterclockwise)

Preceding gene: 188528200

Following gene: 188528197

Centisome position: 88.7

GC content: 41.3

Gene sequence:

>879_bases
ATGTGGAGTCTCATTCAAAAAATCTTTAAGGCTTTGATAATCGCACCTTTAGATTTTATCACGAAGTATTTCAAATCGTT
TGTGCTGTTATTGATTGTATTAGTCTTTTTTAGCGCTAAAGAAAGCGCGCCAAGCGCCCCGCCCAATCTCGCTAAACTCT
ATTTAAATGGGGCGATTTTTAGCGCAGAGGATTTTGACAAAGAAGTGGATAAAATCTTAAAAACCCCTAGCATTAAGGGC
GTTTTGCTTTTGATTGACTCTCCTGGTGGGGCGGTGTCAGCGAGCGTGGAATTGAGCGAAAAAATCGCTGATTTGAAGCA
AAAAATGCCCGTTTTAGCGTATGCTAGGGGGGTTATGGCGAGCGGGAGTTATTATGCGGGCATGCAAGCGAGCGAAGTTT
ATGCCTCTAAAGCGAGTTTGATCGGATCGATTGGGGTGATTTTTTCGGGCGCGAATGTGGAAAATTTGCTCAATAAAGTC
GGCGTAGCCACTCAAGGCGTGCATGCGGGCGAATATAAAGAAATAGGCACTTTCACCAGAGCATGGAAACCCAACGAAAA
AGAATTTTTGCAAAATTTAGTCAATGAGCAATACCAAATGTTTGTGAATGATGTCGCAAAAGCTAGGAAATTAGATGCTA
AGGATTATAAGGATTTTGCTGAAGGGAAGGTTTTTAGCGCTCAAAACGCTTTGAAATTAAAACTCATTGACAAAATCAGC
ACGATCAAGCAAGCGCAAAATCGCTTAATGGAATTGAGTAAGGTTAAAAAAGCTTATTGGCTAGAAAAAAGCCCCATGGA
GCGCTTCATTGAAAAAGCCACGCAATCAGCGACAAATATCATCACGCAAGCGTTTGGCTATCAATTATTAATGAGATGA

Upstream 100 bases:

>100_bases
TCTGATCTTAGGGCAAAATTTACACGCCATGATTTAATCCTTAAAACATTTGAAGTATAATACACTCTTATGGTCAAATT
TTTAAGTCTAGGAAAACCGC

Downstream 100 bases:

>100_bases
ACATGTTAGAATTTATTTTAAAAATTCAAGCTAGAGACTCTAAAGGCTTGGTGAGCGCGATTAGCACCACTATTGCTAAC
AAGGGCTATAATATTGTCAA

Product: protease IV (PspA)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MWSLIQKIFKALIIAPLDFITKYFKSFVLLLIVLVFFSAKESAPSAPPNLAKLYLNGAIFSAEDFDKEVDKILKTPSIKG
VLLLIDSPGGAVSASVELSEKIADLKQKMPVLAYARGVMASGSYYAGMQASEVYASKASLIGSIGVIFSGANVENLLNKV
GVATQGVHAGEYKEIGTFTRAWKPNEKEFLQNLVNEQYQMFVNDVAKARKLDAKDYKDFAEGKVFSAQNALKLKLIDKIS
TIKQAQNRLMELSKVKKAYWLEKSPMERFIEKATQSATNIITQAFGYQLLMR

Sequences:

>Translated_292_residues
MWSLIQKIFKALIIAPLDFITKYFKSFVLLLIVLVFFSAKESAPSAPPNLAKLYLNGAIFSAEDFDKEVDKILKTPSIKG
VLLLIDSPGGAVSASVELSEKIADLKQKMPVLAYARGVMASGSYYAGMQASEVYASKASLIGSIGVIFSGANVENLLNKV
GVATQGVHAGEYKEIGTFTRAWKPNEKEFLQNLVNEQYQMFVNDVAKARKLDAKDYKDFAEGKVFSAQNALKLKLIDKIS
TIKQAQNRLMELSKVKKAYWLEKSPMERFIEKATQSATNIITQAFGYQLLMR
>Mature_292_residues
MWSLIQKIFKALIIAPLDFITKYFKSFVLLLIVLVFFSAKESAPSAPPNLAKLYLNGAIFSAEDFDKEVDKILKTPSIKG
VLLLIDSPGGAVSASVELSEKIADLKQKMPVLAYARGVMASGSYYAGMQASEVYASKASLIGSIGVIFSGANVENLLNKV
GVATQGVHAGEYKEIGTFTRAWKPNEKEFLQNLVNEQYQMFVNDVAKARKLDAKDYKDFAEGKVFSAQNALKLKLIDKIS
TIKQAQNRLMELSKVKKAYWLEKSPMERFIEKATQSATNIITQAFGYQLLMR

Specific function: Digestion Of The Cleaved Signal Peptides. This Activity Is Necessary To Maintain Proper Secretion Of Mature Proteins Across The Membrane. [C]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=237, Percent_Identity=29.535864978903, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787527, Length=247, Percent_Identity=25.1012145748988, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 32360; Mature: 32360

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWSLIQKIFKALIIAPLDFITKYFKSFVLLLIVLVFFSAKESAPSAPPNLAKLYLNGAIF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEE
SAEDFDKEVDKILKTPSIKGVLLLIDSPGGAVSASVELSEKIADLKQKMPVLAYARGVMA
CHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHCCHHHHHHHHHC
SGSYYAGMQASEVYASKASLIGSIGVIFSGANVENLLNKVGVATQGVHAGEYKEIGTFTR
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHCCCCCCCHHHHHHHHH
AWKPNEKEFLQNLVNEQYQMFVNDVAKARKLDAKDYKDFAEGKVFSAQNALKLKLIDKIS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEECCCCHHHHHHHHHHH
TIKQAQNRLMELSKVKKAYWLEKSPMERFIEKATQSATNIITQAFGYQLLMR
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MWSLIQKIFKALIIAPLDFITKYFKSFVLLLIVLVFFSAKESAPSAPPNLAKLYLNGAIF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEE
SAEDFDKEVDKILKTPSIKGVLLLIDSPGGAVSASVELSEKIADLKQKMPVLAYARGVMA
CHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHCCHHHHHHHHHC
SGSYYAGMQASEVYASKASLIGSIGVIFSGANVENLLNKVGVATQGVHAGEYKEIGTFTR
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHCCCCCCCHHHHHHHHH
AWKPNEKEFLQNLVNEQYQMFVNDVAKARKLDAKDYKDFAEGKVFSAQNALKLKLIDKIS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEECCCCHHHHHHHHHHH
TIKQAQNRLMELSKVKKAYWLEKSPMERFIEKATQSATNIITQAFGYQLLMR
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]