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The map label for this gene is hemH

Identifier: 188527859

GI number: 188527859

Start: 1093463

End: 1094470

Strand: Reverse

Name: hemH

Synonym: HPSH_05535

Alternate gene names: 188527859

Gene position: 1094470-1093463 (Counterclockwise)

Preceding gene: 188527862

Following gene: 188527858

Centisome position: 68.04

GC content: 37.6

Gene sequence:

>1008_bases
ATGAATTTAATCAATGAAAAGCTTAATAATTTAGAAAATAACGCTACAAAATCCCCTAAAGAAGCGGTCATTCTTTTGAA
TATGGGAGGGCCTAACAGCCTTTATGAAGTGGGGGTGTTTTTAAAAAACATGTTTGATGACCCCTTTATCCTTACCATTA
AAAATAATTTTATGCGTAAAATGGTGGGTAAAATGATCGTCAATAGCCGCATAGAAAAATCCAAAAAAATCTATGAAAAA
TTGGGAGGCAAATCCCCTTTAACGCCTATCACATTCGCCCTTACAGAGCGTTTGAATAAATTAGATCCTTCTCGCTTTTA
CACTTATGCGATGCGCTATACCCCCCCTTATGCGTCTATGGTCTTGCAAGATTTAGCCTTAAAAGAGGTAGAAAGCCTGG
TGTTTTTTTCCATGTATCCGCAATATTCTAGCACCACCACCCTTTCTAGTTTCAATGACGCTTTTAACGCCCTAAAAGCT
TTAGAAACTTTCCGCCCTAAAGTGCGGGTAATAGAGCGTTTTTATGCCAGTAAAAAGCTTAATGAAATCATTTTAAACAC
GATTTTAAGCACCCTAAACAACCGCAAAAGCCAGGATTTTGTCTTAATTTTTTCCGTCCATGGCTTACCTAAAAGCGTTA
TTGATGCCGGCGATACTTACCAGCAAGAATGCGAACACCATGTGAATTTGTTAAAAGAGTTGGTGCAACAAAAAAATATT
TCTTTTAAAGAAGTCTTACTCTCTTACCAATCCAAGCTAGGGCCTATGAAATGGCTAGAGCCAAGCACTGAAGAATTGAT
AGAAAAGCACCGCAAATCTCATATTATCATCTATCCTTTGGCTTTCACGATTGATAATTCTGAAACGCTCTATGAACTAG
ACATGCAATACCGCTTGATGGCAGAGCGCTTGGCGGTTAAAGAATATTTGGTTTGCCCGTGCTTAAACGATTCCATAGAG
TTTGCAAAATTTATCATTGAATTAGTGAATAACCTTAAAAGTGAGTGA

Upstream 100 bases:

>100_bases
AGAAGAATCTTGTGTATTTAATGCTTGCAAACTCATCTCTAACATTAACTTCTTTCTAACGATTTGTTTTTTATTAATCG
TTTTATTTTAGCATGCACCA

Downstream 100 bases:

>100_bases
AATTTGCATAAAAAGCGATTATTATAGTAAAATACCAATCTTTCAAATCTATTAAAAAATAAAGGTTATTACATGTTTTC
ACTTTCTTATGTTTCCAAGA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MNLINEKLNNLENNATKSPKEAVILLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNFMRKMVGKMIVNSRIEKSKKIYEK
LGGKSPLTPITFALTERLNKLDPSRFYTYAMRYTPPYASMVLQDLALKEVESLVFFSMYPQYSSTTTLSSFNDAFNALKA
LETFRPKVRVIERFYASKKLNEIILNTILSTLNNRKSQDFVLIFSVHGLPKSVIDAGDTYQQECEHHVNLLKELVQQKNI
SFKEVLLSYQSKLGPMKWLEPSTEELIEKHRKSHIIIYPLAFTIDNSETLYELDMQYRLMAERLAVKEYLVCPCLNDSIE
FAKFIIELVNNLKSE

Sequences:

>Translated_335_residues
MNLINEKLNNLENNATKSPKEAVILLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNFMRKMVGKMIVNSRIEKSKKIYEK
LGGKSPLTPITFALTERLNKLDPSRFYTYAMRYTPPYASMVLQDLALKEVESLVFFSMYPQYSSTTTLSSFNDAFNALKA
LETFRPKVRVIERFYASKKLNEIILNTILSTLNNRKSQDFVLIFSVHGLPKSVIDAGDTYQQECEHHVNLLKELVQQKNI
SFKEVLLSYQSKLGPMKWLEPSTEELIEKHRKSHIIIYPLAFTIDNSETLYELDMQYRLMAERLAVKEYLVCPCLNDSIE
FAKFIIELVNNLKSE
>Mature_335_residues
MNLINEKLNNLENNATKSPKEAVILLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNFMRKMVGKMIVNSRIEKSKKIYEK
LGGKSPLTPITFALTERLNKLDPSRFYTYAMRYTPPYASMVLQDLALKEVESLVFFSMYPQYSSTTTLSSFNDAFNALKA
LETFRPKVRVIERFYASKKLNEIILNTILSTLNNRKSQDFVLIFSVHGLPKSVIDAGDTYQQECEHHVNLLKELVQQKNI
SFKEVLLSYQSKLGPMKWLEPSTEELIEKHRKSHIIIYPLAFTIDNSETLYELDMQYRLMAERLAVKEYLVCPCLNDSIE
FAKFIIELVNNLKSE

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=334, Percent_Identity=32.3353293413174, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI60499025, Length=334, Percent_Identity=32.3353293413174, Blast_Score=146, Evalue=2e-35,
Organism=Escherichia coli, GI1786681, Length=317, Percent_Identity=23.9747634069401, Blast_Score=96, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324750, Length=341, Percent_Identity=30.2052785923754, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17864156, Length=343, Percent_Identity=28.5714285714286, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24651774, Length=271, Percent_Identity=28.0442804428044, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45552018, Length=177, Percent_Identity=29.9435028248588, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 38720; Mature: 38720

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLINEKLNNLENNATKSPKEAVILLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNFMRK
CCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECHHHHHH
MVGKMIVNSRIEKSKKIYEKLGGKSPLTPITFALTERLNKLDPSRFYTYAMRYTPPYASM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHEEEEEEECCCHHHH
VLQDLALKEVESLVFFSMYPQYSSTTTLSSFNDAFNALKALETFRPKVRVIERFYASKKL
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
NEIILNTILSTLNNRKSQDFVLIFSVHGLPKSVIDAGDTYQQECEHHVNLLKELVQQKNI
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
SFKEVLLSYQSKLGPMKWLEPSTEELIEKHRKSHIIIYPLAFTIDNSETLYELDMQYRLM
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHH
AERLAVKEYLVCPCLNDSIEFAKFIIELVNNLKSE
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLINEKLNNLENNATKSPKEAVILLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNFMRK
CCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECHHHHHH
MVGKMIVNSRIEKSKKIYEKLGGKSPLTPITFALTERLNKLDPSRFYTYAMRYTPPYASM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHEEEEEEECCCHHHH
VLQDLALKEVESLVFFSMYPQYSSTTTLSSFNDAFNALKALETFRPKVRVIERFYASKKL
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
NEIILNTILSTLNNRKSQDFVLIFSVHGLPKSVIDAGDTYQQECEHHVNLLKELVQQKNI
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
SFKEVLLSYQSKLGPMKWLEPSTEELIEKHRKSHIIIYPLAFTIDNSETLYELDMQYRLM
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHH
AERLAVKEYLVCPCLNDSIEFAKFIIELVNNLKSE
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA