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The map label for this gene is ppiD [H]

Identifier: 188527796

GI number: 188527796

Start: 1020469

End: 1022022

Strand: Direct

Name: ppiD [H]

Synonym: HPSH_05160

Alternate gene names: 188527796

Gene position: 1020469-1022022 (Clockwise)

Preceding gene: 188527794

Following gene: 188527797

Centisome position: 63.44

GC content: 36.55

Gene sequence:

>1554_bases
TTGGTTAAAATAGGGTTATTTGATTTTACTATAAGGTTGTTTAAACCTGAATTTCACATTTTTGATTTTTTAAAAGGGAT
TAGAGTTCTTATGATTGAATGGATGCAAAATCATAGAAAGTATTTAGTGGTTACAATATGGATAAGCACGATCGCTTTTA
TTGCCGCCGGGATGATAGGCTGGGGGCAATACAGCTTTTCTTTAGATAGCGATAGCGCTGCCAAAGTGGGACAGATTAAG
ATTTCTCAAGAAGAATTAGCCCAAGAATACCGCCGCCTTAAAGACGCATACGCTGAGTCTATCCCCAATTTTAAAGAACT
CACTGAAGATCAAATCAAAGCCATGCATTTAGAAAAAAGCGCTTTAGATTCACTCATCAATCAAGCCTTATTAAGAAATC
TCGCTTTAGATTTAGGGCTTGGCGCTACAAAGCAAGAAGTGGCGAAAGAGATCCGAAAAACAAGCGTTTTTCAAAAAGAT
GGCGTTTTTGATGAAGAATTGTATAAAAATATCTTAAAGCAAAGCCATTACCGCCCTAAGCATTTTGAAGAAAGCGTTGA
AAGGCTTTTAATCCTTCAAAAAATCAGCGCTCTATTCCCCAAAACCACTACTCCTTTGGAGCAATCCAGTTTATCGCTTT
GGGCAAAATTGCAAGACAAATTAGACATTCTTATCCTAAACCCCAATGATGTTAAGATTTCTCTTAATGAAGAAGAGATG
AAAAAATATTACGAGTCCCATAAAAAGGATTTTAAAAAGCCCACAAGCTTTAAAACACGCTCTTTATATTTTGACGCTAG
TTTGGAAAAACCTGATTTGAAAGAGCTGGAGGAATACTACCATAAAAACAAGGTGTCTTATTTGGACAAAGAGGGGAAAT
TACAGGATTTTAAAAGCGTTCAAGAGCAAGTCAAGCATGATTTAAGCATGCAAAAAGTGAATGAAAAAGCCTTAAGGAGT
TATATCGCTTTAAAAAAAGCGAACGCGCAAAACTACACCACGCAAGATTTTGAAGAAAACAACTCCCCCTATACTGCTGA
AATCACGCAAAAGCTCGCCGCTCTCAAGCCCCTTGAAATCCTAAAACCAGAGCCTTTTAAAGATGGTTTTATTGTGGTGC
AGCTCGTCTCTCAAACCAAAGACGAATTGCAGAATTTTAATGAAGCTAAAAGCGCTCTTAAAACCCGCTTGACTCAAGAA
AAAACCCTTATGGCGTTACAAACTTTAGCTAAAGAAAAACTTAAGGATTTTAAAGGCAAAAGCATGGGCTATGTAAGCCC
TAATTTTGGAGGCACTATTAATGAGCTTAACCAAGAAGAAAGCGCTAAGTTTATCAACGCCCTTTTTAACCGCCAGGAAA
AAAAGGGGTTTATCGCTATTAATAATAAAATGGTGCTCTATCAAATCACAGAGCAAAATTTCAACCACTCATTTAGCGCA
GAAGAAAGCCAGTATATGCAGCGTTTAGTCAATAACACTAAAACGGATTTTTTTGATAAAGCGTTGATAGAAGAATTGAA
AAAACGCTATAAGATAGTCAAATACATTCAATAA

Upstream 100 bases:

>100_bases
GCGAGCAAGGGTGCCAGAGATACTCCAAATCCAAAGCGGCTAAATTTTCTTGAAAATTCATGTTAAAAACTCTCTATAAT
AAGGATAATTTTAATAACCT

Downstream 100 bases:

>100_bases
TGTAAGGGGAAATCATGGAACATAAAGAAATCGTTATAGGGGTTGATATAGGCTCTAGAAAGATTTGCGCGATAGTGGCT
GAATTTAAAGAAGGGATTTT

Product: conserved hypothetical secreted protein

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MVKIGLFDFTIRLFKPEFHIFDFLKGIRVLMIEWMQNHRKYLVVTIWISTIAFIAAGMIGWGQYSFSLDSDSAAKVGQIK
ISQEELAQEYRRLKDAYAESIPNFKELTEDQIKAMHLEKSALDSLINQALLRNLALDLGLGATKQEVAKEIRKTSVFQKD
GVFDEELYKNILKQSHYRPKHFEESVERLLILQKISALFPKTTTPLEQSSLSLWAKLQDKLDILILNPNDVKISLNEEEM
KKYYESHKKDFKKPTSFKTRSLYFDASLEKPDLKELEEYYHKNKVSYLDKEGKLQDFKSVQEQVKHDLSMQKVNEKALRS
YIALKKANAQNYTTQDFEENNSPYTAEITQKLAALKPLEILKPEPFKDGFIVVQLVSQTKDELQNFNEAKSALKTRLTQE
KTLMALQTLAKEKLKDFKGKSMGYVSPNFGGTINELNQEESAKFINALFNRQEKKGFIAINNKMVLYQITEQNFNHSFSA
EESQYMQRLVNNTKTDFFDKALIEELKKRYKIVKYIQ

Sequences:

>Translated_517_residues
MVKIGLFDFTIRLFKPEFHIFDFLKGIRVLMIEWMQNHRKYLVVTIWISTIAFIAAGMIGWGQYSFSLDSDSAAKVGQIK
ISQEELAQEYRRLKDAYAESIPNFKELTEDQIKAMHLEKSALDSLINQALLRNLALDLGLGATKQEVAKEIRKTSVFQKD
GVFDEELYKNILKQSHYRPKHFEESVERLLILQKISALFPKTTTPLEQSSLSLWAKLQDKLDILILNPNDVKISLNEEEM
KKYYESHKKDFKKPTSFKTRSLYFDASLEKPDLKELEEYYHKNKVSYLDKEGKLQDFKSVQEQVKHDLSMQKVNEKALRS
YIALKKANAQNYTTQDFEENNSPYTAEITQKLAALKPLEILKPEPFKDGFIVVQLVSQTKDELQNFNEAKSALKTRLTQE
KTLMALQTLAKEKLKDFKGKSMGYVSPNFGGTINELNQEESAKFINALFNRQEKKGFIAINNKMVLYQITEQNFNHSFSA
EESQYMQRLVNNTKTDFFDKALIEELKKRYKIVKYIQ
>Mature_517_residues
MVKIGLFDFTIRLFKPEFHIFDFLKGIRVLMIEWMQNHRKYLVVTIWISTIAFIAAGMIGWGQYSFSLDSDSAAKVGQIK
ISQEELAQEYRRLKDAYAESIPNFKELTEDQIKAMHLEKSALDSLINQALLRNLALDLGLGATKQEVAKEIRKTSVFQKD
GVFDEELYKNILKQSHYRPKHFEESVERLLILQKISALFPKTTTPLEQSSLSLWAKLQDKLDILILNPNDVKISLNEEEM
KKYYESHKKDFKKPTSFKTRSLYFDASLEKPDLKELEEYYHKNKVSYLDKEGKLQDFKSVQEQVKHDLSMQKVNEKALRS
YIALKKANAQNYTTQDFEENNSPYTAEITQKLAALKPLEILKPEPFKDGFIVVQLVSQTKDELQNFNEAKSALKTRLTQE
KTLMALQTLAKEKLKDFKGKSMGYVSPNFGGTINELNQEESAKFINALFNRQEKKGFIAINNKMVLYQITEQNFNHSFSA
EESQYMQRLVNNTKTDFFDKALIEELKKRYKIVKYIQ

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein; Periplasmic side (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=263, Percent_Identity=24.3346007604563, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 60177; Mature: 60177

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKIGLFDFTIRLFKPEFHIFDFLKGIRVLMIEWMQNHRKYLVVTIWISTIAFIAAGMIG
CEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHC
WGQYSFSLDSDSAAKVGQIKISQEELAQEYRRLKDAYAESIPNFKELTEDQIKAMHLEKS
CCCEEEECCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ALDSLINQALLRNLALDLGLGATKQEVAKEIRKTSVFQKDGVFDEELYKNILKQSHYRPK
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCH
HFEESVERLLILQKISALFPKTTTPLEQSSLSLWAKLQDKLDILILNPNDVKISLNEEEM
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCEEEEECHHHH
KKYYESHKKDFKKPTSFKTRSLYFDASLEKPDLKELEEYYHKNKVSYLDKEGKLQDFKSV
HHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCHHHHCCCCCCHHHHHHH
QEQVKHDLSMQKVNEKALRSYIALKKANAQNYTTQDFEENNSPYTAEITQKLAALKPLEI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCHHHHHHHHHHCCCHHH
LKPEPFKDGFIVVQLVSQTKDELQNFNEAKSALKTRLTQEKTLMALQTLAKEKLKDFKGK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SMGYVSPNFGGTINELNQEESAKFINALFNRQEKKGFIAINNKMVLYQITEQNFNHSFSA
CCCCCCCCCCCCHHHCCHHHHHHHHHHHHCHHHCCCEEEECCEEEEEEEECCCCCCCCCC
EESQYMQRLVNNTKTDFFDKALIEELKKRYKIVKYIQ
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVKIGLFDFTIRLFKPEFHIFDFLKGIRVLMIEWMQNHRKYLVVTIWISTIAFIAAGMIG
CEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHC
WGQYSFSLDSDSAAKVGQIKISQEELAQEYRRLKDAYAESIPNFKELTEDQIKAMHLEKS
CCCEEEECCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ALDSLINQALLRNLALDLGLGATKQEVAKEIRKTSVFQKDGVFDEELYKNILKQSHYRPK
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCH
HFEESVERLLILQKISALFPKTTTPLEQSSLSLWAKLQDKLDILILNPNDVKISLNEEEM
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCEEEEECHHHH
KKYYESHKKDFKKPTSFKTRSLYFDASLEKPDLKELEEYYHKNKVSYLDKEGKLQDFKSV
HHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCHHHHCCCCCCHHHHHHH
QEQVKHDLSMQKVNEKALRSYIALKKANAQNYTTQDFEENNSPYTAEITQKLAALKPLEI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCHHHHHHHHHHCCCHHH
LKPEPFKDGFIVVQLVSQTKDELQNFNEAKSALKTRLTQEKTLMALQTLAKEKLKDFKGK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SMGYVSPNFGGTINELNQEESAKFINALFNRQEKKGFIAINNKMVLYQITEQNFNHSFSA
CCCCCCCCCCCCHHHCCHHHHHHHHHHHHCHHHCCCEEEECCEEEEEEEECCCCCCCCCC
EESQYMQRLVNNTKTDFFDKALIEELKKRYKIVKYIQ
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]