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The map label for this gene is bhuA [H]

Identifier: 188527741

GI number: 188527741

Start: 952775

End: 955216

Strand: Reverse

Name: bhuA [H]

Synonym: HPSH_04830

Alternate gene names: 188527741

Gene position: 955216-952775 (Counterclockwise)

Preceding gene: 188527742

Following gene: 188527740

Centisome position: 59.38

GC content: 42.1

Gene sequence:

>2442_bases
ATGAATGACAAGCGTTTTAGGAAATATTGTAGTTTTTCTCTTTTTTTGTCCTTATTAGGAATGTTTGAATTGGAGGCTAA
AGAAGAAGAAAAAGAAGAAAGAAAGACAGAAAGAAAAAAGGATAAAAAAAAGAACGCCCAACACACTCTAGGCAAAGTTA
CCACTCAAGCGGCTAAAATCTTTAATTACAACAACCAGACAACCATTTCAAGTAAAGAATTAGAAAGAAGGCAAGCCAAC
CAAATCAGCGACATGTTTAGAAGAAACCCTAATATCAATGTGGGCGGTGGCGCGGTTATAGCGCAAAAAATTTATGTGCG
CGGTATTGAAGACAGATTGGCTAGGGTTACGGTGGATGGTGTAGCTCAAATGGGCGCAAGCTATGGGCATCAAGGCAATA
CGATTATTGACCCTGGAATGCTCAAAAGCGTGGTGGTTACTAAGGGGGCGGCTCAAGCGAGCGCGGGGCCTATGGCTTTG
ATTGGCGCGATTAGAATGGAGACTAGAAGCGCGAGCGATTTTATCCCTAAAGGTAAAAACTACGCCATGAGTGGGGCTGC
CACTTTTTTAACTAACTTTGGGGATCGAGAAACCGTGATGGGTGCTTATCGTAACAATCATTTTGATATTCTTTTATATT
ACACGCATCAAAATATTTTCTATTATCGTGATGGGGATAATGCCACAAAAGATCTTTTTAGACCTAAAGCGGATAATAAA
GTTACAGGAAGTCCTAGCGAACAAAACAATGTGATGGCTAAGATCAATGGCTATTTGAGCGAAAGGGATACCTTAACGCT
CAGTTATAACATGACCAGAGATAACGCTAATCGCCCCTTAAGAGCGAATTTTACAGGCACTTTTTTACCCTATTCTTGCG
GTGATTTTAACGCTTTCCCTAACGAGAAAAACCCTAGCGATTGCTTGTTTGAAAATGACGCTAGTTTGTTTAAAACTTAT
AGCGTCAATTTAGTACATAATGTGAGTTTGAACTATGAAAGAGAAGGGGGGAGTCGTTTTGGTGATCCTAAATTAAAAAT
CAATGGTTATACAAGCATTAGGAATGTCCAAATTGATCCGCTTTTTAGGCCTAACGATATAGCGGCTATCATTCCTTTCA
CCCCAAACCCAGAACTTGGCGAAGAAAATGAATGCGTGGCGCAAGGGGGTATTTATGACGCTACTAAACAAACTTGCTCC
ATCACTTTTAAAAGCCTTGGAGGAGGTTCTGTGGTGGCTAATAAAAATTTATTCATCATCAATTCCGGGTTTAATGCGAA
TGTGATCCACACCATAGACCATAAGAATGACAATCTTTTTGAATACGGGTTGAATTACCAAAACTTAACCACTTTTGATA
AAGCGATCCCTAATAGCGAATTAGTCAAACCCGGCGATGCCCCTGATGCATGCTTAAGGGTTAGAGGCCCTAATGATCCC
AACATGAACGGGCGATGCCAAAGGAATGGCGCTAGCGCGAATGTGGTTGGGGTGTATGCGCAAGCGAATTACACCTTGCA
CCCCATGGTAACTTTAGGGGCAGGGACTCGTTATGATGTCTATACTTTAGTGGATAAAGATTGGCAGTTGCACATAACTC
AAGGGTTTAGCCCTAGCGCGGCTTTAAATGTCTCGCCTTTAGAAAATTTGAATTTCAGGCTTTCTTACGCGTATGTAACC
AGAGGCCCTATGCCTGGAGGTTTGGTGTGGATGCGTCAAGATAATTTGCGCTATAACCGCAATTTAAAGCCAGAGATCGG
GCAAAATGTGGAATTTAACACCGAATACAGCAGTAAGTATTTTGATTTCAGGGCCGCAGGTTTTGTCCAACTGATTTCTA
ATTACATCAACCAATTTTCTTCAACGCTTTTTGTAACCAACTTGCCCGCACAAGATATTATTTATGTGCCTGGTTATGAA
GTTTCAGGGACGGCTAAATACAAGGGCTTTTCTTTAGGCTTGAGCGTGGCGCGATCATGGCCTTCTTTAAAAGGGCGCTT
GATCGCTGATGTGTATGAATTGGCTGCCACAACAGGCAATGTGTTTATTTTAACGGCAAGCTATAAAATCCCACGCACCG
GCCTTAGCATCACTTGGCTTTCACGCTTTGTTACGGATTTGAGTTATTGCTCTTATAGCCCCTATCGCAACGGCCCTACG
GATATTGACAGACGGCCTAGCAATTGCCCCAAAACGCCCGGGATTTTTCATGTGCATAAGCCCGGTTATGGGGTGAGCAG
TTTTTTTGTAACCTACAAACCCACCTATAAGAAGCTTGAAGGCTTGAGTTTGAATGCGGTGTTTAACAATGTTTTTAACC
AACAATATATTGATCAAGCAAGCCCGGTGATGAGCCCTGATGAACCCAATCAAGACAAATACGCAAGGGGCATGGCAGAG
CCTGGCTTTAACGCAAGGTTTGAAATTTCTTATAAGTTTTAA

Upstream 100 bases:

>100_bases
TCAAAAATGGCTAGCTCTTTTAAGGTGGTTGTAATATTTTTTTGACTACAATAACACCTTTATTTTTTTAAGAAAAATTA
TTATAAGTAGGATTTTAAGA

Downstream 100 bases:

>100_bases
TAATGGAGCTAAAAATGAGGGTTTCATGGGTAGCGAGTTTAATCAAAAATAAAACATTCTTTAGAAGTAACAAATATATG
ATTTTAATCTTTTCATTTTA

Product: iron-regulated outer membrane protein

Products: NA

Alternate protein names: Brucella heme uptake protein A [H]

Number of amino acids: Translated: 813; Mature: 813

Protein sequence:

>813_residues
MNDKRFRKYCSFSLFLSLLGMFELEAKEEEKEERKTERKKDKKKNAQHTLGKVTTQAAKIFNYNNQTTISSKELERRQAN
QISDMFRRNPNINVGGGAVIAQKIYVRGIEDRLARVTVDGVAQMGASYGHQGNTIIDPGMLKSVVVTKGAAQASAGPMAL
IGAIRMETRSASDFIPKGKNYAMSGAATFLTNFGDRETVMGAYRNNHFDILLYYTHQNIFYYRDGDNATKDLFRPKADNK
VTGSPSEQNNVMAKINGYLSERDTLTLSYNMTRDNANRPLRANFTGTFLPYSCGDFNAFPNEKNPSDCLFENDASLFKTY
SVNLVHNVSLNYEREGGSRFGDPKLKINGYTSIRNVQIDPLFRPNDIAAIIPFTPNPELGEENECVAQGGIYDATKQTCS
ITFKSLGGGSVVANKNLFIINSGFNANVIHTIDHKNDNLFEYGLNYQNLTTFDKAIPNSELVKPGDAPDACLRVRGPNDP
NMNGRCQRNGASANVVGVYAQANYTLHPMVTLGAGTRYDVYTLVDKDWQLHITQGFSPSAALNVSPLENLNFRLSYAYVT
RGPMPGGLVWMRQDNLRYNRNLKPEIGQNVEFNTEYSSKYFDFRAAGFVQLISNYINQFSSTLFVTNLPAQDIIYVPGYE
VSGTAKYKGFSLGLSVARSWPSLKGRLIADVYELAATTGNVFILTASYKIPRTGLSITWLSRFVTDLSYCSYSPYRNGPT
DIDRRPSNCPKTPGIFHVHKPGYGVSSFFVTYKPTYKKLEGLSLNAVFNNVFNQQYIDQASPVMSPDEPNQDKYARGMAE
PGFNARFEISYKF

Sequences:

>Translated_813_residues
MNDKRFRKYCSFSLFLSLLGMFELEAKEEEKEERKTERKKDKKKNAQHTLGKVTTQAAKIFNYNNQTTISSKELERRQAN
QISDMFRRNPNINVGGGAVIAQKIYVRGIEDRLARVTVDGVAQMGASYGHQGNTIIDPGMLKSVVVTKGAAQASAGPMAL
IGAIRMETRSASDFIPKGKNYAMSGAATFLTNFGDRETVMGAYRNNHFDILLYYTHQNIFYYRDGDNATKDLFRPKADNK
VTGSPSEQNNVMAKINGYLSERDTLTLSYNMTRDNANRPLRANFTGTFLPYSCGDFNAFPNEKNPSDCLFENDASLFKTY
SVNLVHNVSLNYEREGGSRFGDPKLKINGYTSIRNVQIDPLFRPNDIAAIIPFTPNPELGEENECVAQGGIYDATKQTCS
ITFKSLGGGSVVANKNLFIINSGFNANVIHTIDHKNDNLFEYGLNYQNLTTFDKAIPNSELVKPGDAPDACLRVRGPNDP
NMNGRCQRNGASANVVGVYAQANYTLHPMVTLGAGTRYDVYTLVDKDWQLHITQGFSPSAALNVSPLENLNFRLSYAYVT
RGPMPGGLVWMRQDNLRYNRNLKPEIGQNVEFNTEYSSKYFDFRAAGFVQLISNYINQFSSTLFVTNLPAQDIIYVPGYE
VSGTAKYKGFSLGLSVARSWPSLKGRLIADVYELAATTGNVFILTASYKIPRTGLSITWLSRFVTDLSYCSYSPYRNGPT
DIDRRPSNCPKTPGIFHVHKPGYGVSSFFVTYKPTYKKLEGLSLNAVFNNVFNQQYIDQASPVMSPDEPNQDKYARGMAE
PGFNARFEISYKF
>Mature_813_residues
MNDKRFRKYCSFSLFLSLLGMFELEAKEEEKEERKTERKKDKKKNAQHTLGKVTTQAAKIFNYNNQTTISSKELERRQAN
QISDMFRRNPNINVGGGAVIAQKIYVRGIEDRLARVTVDGVAQMGASYGHQGNTIIDPGMLKSVVVTKGAAQASAGPMAL
IGAIRMETRSASDFIPKGKNYAMSGAATFLTNFGDRETVMGAYRNNHFDILLYYTHQNIFYYRDGDNATKDLFRPKADNK
VTGSPSEQNNVMAKINGYLSERDTLTLSYNMTRDNANRPLRANFTGTFLPYSCGDFNAFPNEKNPSDCLFENDASLFKTY
SVNLVHNVSLNYEREGGSRFGDPKLKINGYTSIRNVQIDPLFRPNDIAAIIPFTPNPELGEENECVAQGGIYDATKQTCS
ITFKSLGGGSVVANKNLFIINSGFNANVIHTIDHKNDNLFEYGLNYQNLTTFDKAIPNSELVKPGDAPDACLRVRGPNDP
NMNGRCQRNGASANVVGVYAQANYTLHPMVTLGAGTRYDVYTLVDKDWQLHITQGFSPSAALNVSPLENLNFRLSYAYVT
RGPMPGGLVWMRQDNLRYNRNLKPEIGQNVEFNTEYSSKYFDFRAAGFVQLISNYINQFSSTLFVTNLPAQDIIYVPGYE
VSGTAKYKGFSLGLSVARSWPSLKGRLIADVYELAATTGNVFILTASYKIPRTGLSITWLSRFVTDLSYCSYSPYRNGPT
DIDRRPSNCPKTPGIFHVHKPGYGVSSFFVTYKPTYKKLEGLSLNAVFNNVFNQQYIDQASPVMSPDEPNQDKYARGMAE
PGFNARFEISYKF

Specific function: Heme transporter playing an important role in stationary-phase iron acquisition and required for maintenance of chronic infection in mice [H]

COG id: COG1629

COG function: function code P; Outer membrane receptor proteins, mostly Fe transport

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 90865; Mature: 90865

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKRFRKYCSFSLFLSLLGMFELEAKEEEKEERKTERKKDKKKNAQHTLGKVTTQAAKI
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNYNNQTTISSKELERRQANQISDMFRRNPNINVGGGAVIAQKIYVRGIEDRLARVTVDG
EECCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEHHHHHHCHHHHHHEEEHHH
VAQMGASYGHQGNTIIDPGMLKSVVVTKGAAQASAGPMALIGAIRMETRSASDFIPKGKN
HHHHHHHCCCCCCEEECCHHHHHHHEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCC
YAMSGAATFLTNFGDRETVMGAYRNNHFDILLYYTHQNIFYYRDGDNATKDLFRPKADNK
EECCCHHHHHHCCCCCHHEEHHCCCCCEEEEEEEEECEEEEEECCCCCHHHHCCCCCCCC
VTGSPSEQNNVMAKINGYLSERDTLTLSYNMTRDNANRPLRANFTGTFLPYSCGDFNAFP
CCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCEEECCCEEECCCCCCCCCCCC
NEKNPSDCLFENDASLFKTYSVNLVHNVSLNYEREGGSRFGDPKLKINGYTSIRNVQIDP
CCCCCCCCEECCCCCEEEEEEEEEEEEEEEEEECCCCCCCCCCEEEEECCCEEEEEEECC
LFRPNDIAAIIPFTPNPELGEENECVAQGGIYDATKQTCSITFKSLGGGSVVANKNLFII
CCCCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEECCCCEEEECCCEEEE
NSGFNANVIHTIDHKNDNLFEYGLNYQNLTTFDKAIPNSELVKPGDAPDACLRVRGPNDP
ECCCCCCEEEEEECCCCCEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEECCCCC
NMNGRCQRNGASANVVGVYAQANYTLHPMVTLGAGTRYDVYTLVDKDWQLHITQGFSPSA
CCCCEEECCCCCCEEEEEEEECCEEEEEEEEECCCCCEEEEEEECCCEEEEEECCCCCCC
ALNVSPLENLNFRLSYAYVTRGPMPGGLVWMRQDNLRYNRNLKPEIGQNVEFNTEYSSKY
EEECCCCCCCCEEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCE
FDFRAAGFVQLISNYINQFSSTLFVTNLPAQDIIYVPGYEVSGTAKYKGFSLGLSVARSW
EEHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEECCEEECCCEEECCEEHHHHHHHCC
PSLKGRLIADVYELAATTGNVFILTASYKIPRTGLSITWLSRFVTDLSYCSYSPYRNGPT
CCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DIDRRPSNCPKTPGIFHVHKPGYGVSSFFVTYKPTYKKLEGLSLNAVFNNVFNQQYIDQA
CCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHC
SPVMSPDEPNQDKYARGMAEPGFNARFEISYKF
CCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MNDKRFRKYCSFSLFLSLLGMFELEAKEEEKEERKTERKKDKKKNAQHTLGKVTTQAAKI
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNYNNQTTISSKELERRQANQISDMFRRNPNINVGGGAVIAQKIYVRGIEDRLARVTVDG
EECCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEHHHHHHCHHHHHHEEEHHH
VAQMGASYGHQGNTIIDPGMLKSVVVTKGAAQASAGPMALIGAIRMETRSASDFIPKGKN
HHHHHHHCCCCCCEEECCHHHHHHHEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCC
YAMSGAATFLTNFGDRETVMGAYRNNHFDILLYYTHQNIFYYRDGDNATKDLFRPKADNK
EECCCHHHHHHCCCCCHHEEHHCCCCCEEEEEEEEECEEEEEECCCCCHHHHCCCCCCCC
VTGSPSEQNNVMAKINGYLSERDTLTLSYNMTRDNANRPLRANFTGTFLPYSCGDFNAFP
CCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCEEECCCEEECCCCCCCCCCCC
NEKNPSDCLFENDASLFKTYSVNLVHNVSLNYEREGGSRFGDPKLKINGYTSIRNVQIDP
CCCCCCCCEECCCCCEEEEEEEEEEEEEEEEEECCCCCCCCCCEEEEECCCEEEEEEECC
LFRPNDIAAIIPFTPNPELGEENECVAQGGIYDATKQTCSITFKSLGGGSVVANKNLFII
CCCCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEECCCCEEEECCCEEEE
NSGFNANVIHTIDHKNDNLFEYGLNYQNLTTFDKAIPNSELVKPGDAPDACLRVRGPNDP
ECCCCCCEEEEEECCCCCEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEECCCCC
NMNGRCQRNGASANVVGVYAQANYTLHPMVTLGAGTRYDVYTLVDKDWQLHITQGFSPSA
CCCCEEECCCCCCEEEEEEEECCEEEEEEEEECCCCCEEEEEEECCCEEEEEECCCCCCC
ALNVSPLENLNFRLSYAYVTRGPMPGGLVWMRQDNLRYNRNLKPEIGQNVEFNTEYSSKY
EEECCCCCCCCEEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCE
FDFRAAGFVQLISNYINQFSSTLFVTNLPAQDIIYVPGYEVSGTAKYKGFSLGLSVARSW
EEHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEECCEEECCCEEECCEEHHHHHHHCC
PSLKGRLIADVYELAATTGNVFILTASYKIPRTGLSITWLSRFVTDLSYCSYSPYRNGPT
CCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DIDRRPSNCPKTPGIFHVHKPGYGVSSFFVTYKPTYKKLEGLSLNAVFNNVFNQQYIDQA
CCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHC
SPVMSPDEPNQDKYARGMAEPGFNARFEISYKF
CCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA