| Definition | Helicobacter pylori Shi470, complete genome. |
|---|---|
| Accession | NC_010698 |
| Length | 1,608,548 |
Click here to switch to the map view.
The map label for this gene is mrcA [H]
Identifier: 188527554
GI number: 188527554
Start: 758859
End: 760838
Strand: Direct
Name: mrcA [H]
Synonym: HPSH_03880
Alternate gene names: 188527554
Gene position: 758859-760838 (Clockwise)
Preceding gene: 188527553
Following gene: 188527556
Centisome position: 47.18
GC content: 40.35
Gene sequence:
>1980_bases ATGCTAAAAAAAATTTTTTATGGTTTTATCGTTTTATTTTTGATTATCGTAGGGTTGTTAGCCATTCTTATCGCTCAAGT TTGGGTAACTACAGATAAGGATATTGCTAAAATTAAAGATTATCGCCCGGGCGTCGCTTCACAGATTTTAGACAGAAAAG GGCGTTTGATCGCTAATATCTATGATAAGGAATTCCGTTTTTATGCGCGTTTTGAAGAAATCCCCCCACGATTTATTGAA AGCCTTTTAGCGGTAGAAGACACCCTCTTTTTTGAGCATGGGGGGATCAATTTAGACGCTATCATGCGCGCTATGATTAA AAACGCTAAAAGCGGTCGTTACACCGAGGGGGGTAGCACCCTAACCCAACAACTCGTTAAAAACATGGTGCTCACACGAG AAAAAACCCTAACCAGAAAACTCAAAGAAGCTATCATTTCCATACGCATTGAAAAAGTCTTAAGCAAAGAAGAAATTTTA GAGCGCTATTTGAACCAAACTTTTTTTGGGCATGGGTATTATGGCGTCAAAACCGCAAGTTTAGGGTATTTTAAAAAACC CCTTGACAAACTCACGCTTAAAGAAATCACCATGTTAGTCGCCTTGCCTAGGGCTCCGAGTTTTTATGACCCTACCAAAA ATTTAGAATTTTCACTCTCTAGGGCTAATGATATTTTAAGGCGGTTGTATTCTTTAGGTTGGATTTCTTCTAACGAGCTC AAATCCGCTCTCAATGAAGTGCCAATTGTCTATAACCAAACTTCCACGCAAAATATCGCTCCCTATGTCGTGGATGAAGT GTTGAAACAATTGGATCAATTAGACGGGTTAAAAACTCAAGGCTATACCATAAAGCTCACGATAGATTTGGATTACCAAC GCTTAGCGTTAGAGTCCTTGCGTTTTGGGCATCAAAAAATCTTAGAAAAAATCGCTAAAGAAAAGCCAAAAACTAACGCA TCTAATGAAGATGAAGACAACTTGAACGCTAGCATGATAGTTACAGACACAAGCACCGGTAAGATTTTAGCTTTAGTGGG GGGGATTGATTATAAAAAAAGCGCTTTCAATCGCGCCACGCAAGCCAAACGGCAATTTGGGAGTGCGATAAAGCCTTTTG TGTATCAAATCGCTTTTGATAATGGCTATTCCACGACTTCTAAAATCCCTGATACCGCGCGAAACTTTGAAAATGGCAAT TATAGTAAAAACAGCGAACAAAACCACGCATGGCACCCTAGCAATTATTCTCGCAAGTTTTTAGGGCTTGTAACCTTGCA AGAAGCCTTGAGCCATTCGTTAAATCTAGCCACGATCAATTTAAGCGATCAGCTTGGCTTTGAAAAAATTTATCAATCTT TAAGCGATATGGGGTTTAAAAACCTCCCTAAAGACTTGTCTATTGTGTTAGGGAGTTTTGCTATCTCACCGATTGAAGCG GCTGAAAAGTATTCTTTATTTTCTAATTACGGCACCATGCTCAAACCCATGCTCATTGAAAGCATCACTAACCAACAAAA CGATGTCAAAACTTTCACGCCCATTGAAACCAAAAAGATCACCTCTAAAGAACAGGCTTTTTTAACCCTTTCAGTGCTGA TGAATGCGGTAGAAAATGGCACAGGGAGTTTGGCTCGCATTAAAGGTTTAGAAATTGCCGGTAAAACCGGGACTTCCAAT AATAATGTGGATGCCTGGTTCATTGGCTTTACCCCCACCTTACAAAGCGTGATTTGGTTTGGGAGAGACGACAACACGCC TATTGGCAAAGGAGCGACAGGAGGCGTTGTGAGCGCACCTGTGTATTCGTATTTCATGCGTAATATTTTAGCGATTGAAC CTTCTTTAAAAAGAAAGTTTGATGTCCCCAAAGGCTTGCGTAAAGAAATCGTGGATGAAATCCCCTACTATTCAACCCCT AATTCCATCACCCCCACCCCCAAAAAAACCGACGATAGCGAAGAACCCTTATTGTTCTAA
Upstream 100 bases:
>100_bases GCATCTCTTTATCCCTCAAAAACAGCTTACAAGACACTAAAGAGCTTGCGAACACCCTTTTAAATTATTCTAAAATACAA TCTTCTTTTAAGAGTGATTA
Downstream 100 bases:
>100_bases GCCTACATGGCTATAGGGACTTTAACATCTCCGTAATTGATAGAATCTTTAAAGATTTCTTCCACTTTAGAAATAAGAAT ACTCACCGCTTGATTGTCTA
Product: penicillin-binding protein 1A (PBP-1A)
Products: NA
Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 659; Mature: 659
Protein sequence:
>659_residues MLKKIFYGFIVLFLIIVGLLAILIAQVWVTTDKDIAKIKDYRPGVASQILDRKGRLIANIYDKEFRFYARFEEIPPRFIE SLLAVEDTLFFEHGGINLDAIMRAMIKNAKSGRYTEGGSTLTQQLVKNMVLTREKTLTRKLKEAIISIRIEKVLSKEEIL ERYLNQTFFGHGYYGVKTASLGYFKKPLDKLTLKEITMLVALPRAPSFYDPTKNLEFSLSRANDILRRLYSLGWISSNEL KSALNEVPIVYNQTSTQNIAPYVVDEVLKQLDQLDGLKTQGYTIKLTIDLDYQRLALESLRFGHQKILEKIAKEKPKTNA SNEDEDNLNASMIVTDTSTGKILALVGGIDYKKSAFNRATQAKRQFGSAIKPFVYQIAFDNGYSTTSKIPDTARNFENGN YSKNSEQNHAWHPSNYSRKFLGLVTLQEALSHSLNLATINLSDQLGFEKIYQSLSDMGFKNLPKDLSIVLGSFAISPIEA AEKYSLFSNYGTMLKPMLIESITNQQNDVKTFTPIETKKITSKEQAFLTLSVLMNAVENGTGSLARIKGLEIAGKTGTSN NNVDAWFIGFTPTLQSVIWFGRDDNTPIGKGATGGVVSAPVYSYFMRNILAIEPSLKRKFDVPKGLRKEIVDEIPYYSTP NSITPTPKKTDDSEEPLLF
Sequences:
>Translated_659_residues MLKKIFYGFIVLFLIIVGLLAILIAQVWVTTDKDIAKIKDYRPGVASQILDRKGRLIANIYDKEFRFYARFEEIPPRFIE SLLAVEDTLFFEHGGINLDAIMRAMIKNAKSGRYTEGGSTLTQQLVKNMVLTREKTLTRKLKEAIISIRIEKVLSKEEIL ERYLNQTFFGHGYYGVKTASLGYFKKPLDKLTLKEITMLVALPRAPSFYDPTKNLEFSLSRANDILRRLYSLGWISSNEL KSALNEVPIVYNQTSTQNIAPYVVDEVLKQLDQLDGLKTQGYTIKLTIDLDYQRLALESLRFGHQKILEKIAKEKPKTNA SNEDEDNLNASMIVTDTSTGKILALVGGIDYKKSAFNRATQAKRQFGSAIKPFVYQIAFDNGYSTTSKIPDTARNFENGN YSKNSEQNHAWHPSNYSRKFLGLVTLQEALSHSLNLATINLSDQLGFEKIYQSLSDMGFKNLPKDLSIVLGSFAISPIEA AEKYSLFSNYGTMLKPMLIESITNQQNDVKTFTPIETKKITSKEQAFLTLSVLMNAVENGTGSLARIKGLEIAGKTGTSN NNVDAWFIGFTPTLQSVIWFGRDDNTPIGKGATGGVVSAPVYSYFMRNILAIEPSLKRKFDVPKGLRKEIVDEIPYYSTP NSITPTPKKTDDSEEPLLF >Mature_659_residues MLKKIFYGFIVLFLIIVGLLAILIAQVWVTTDKDIAKIKDYRPGVASQILDRKGRLIANIYDKEFRFYARFEEIPPRFIE SLLAVEDTLFFEHGGINLDAIMRAMIKNAKSGRYTEGGSTLTQQLVKNMVLTREKTLTRKLKEAIISIRIEKVLSKEEIL ERYLNQTFFGHGYYGVKTASLGYFKKPLDKLTLKEITMLVALPRAPSFYDPTKNLEFSLSRANDILRRLYSLGWISSNEL KSALNEVPIVYNQTSTQNIAPYVVDEVLKQLDQLDGLKTQGYTIKLTIDLDYQRLALESLRFGHQKILEKIAKEKPKTNA SNEDEDNLNASMIVTDTSTGKILALVGGIDYKKSAFNRATQAKRQFGSAIKPFVYQIAFDNGYSTTSKIPDTARNFENGN YSKNSEQNHAWHPSNYSRKFLGLVTLQEALSHSLNLATINLSDQLGFEKIYQSLSDMGFKNLPKDLSIVLGSFAISPIEA AEKYSLFSNYGTMLKPMLIESITNQQNDVKTFTPIETKKITSKEQAFLTLSVLMNAVENGTGSLARIKGLEIAGKTGTSN NNVDAWFIGFTPTLQSVIWFGRDDNTPIGKGATGGVVSAPVYSYFMRNILAIEPSLKRKFDVPKGLRKEIVDEIPYYSTP NSITPTPKKTDDSEEPLLF
Specific function: Cell Wall Formation. Synthesis Of Cross-Linked Peptidoglycan From The Lipid Intermediates. The Enzyme Has A Penicillin-Insensitive Transglycosylase N-Terminal Domain (Formation Of Linear Glycan Strands) And A Penicillin-Sensitive Transpeptidase C-Terminal
COG id: COG0744
COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1786343, Length=575, Percent_Identity=30.9565217391304, Blast_Score=243, Evalue=3e-65, Organism=Escherichia coli, GI1788867, Length=593, Percent_Identity=28.6677908937605, Blast_Score=188, Evalue=9e-49, Organism=Escherichia coli, GI87082258, Length=271, Percent_Identity=35.7933579335793, Blast_Score=177, Evalue=2e-45, Organism=Escherichia coli, GI1789601, Length=184, Percent_Identity=34.2391304347826, Blast_Score=102, Evalue=5e-23,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.1.129; 3.4.-.- [C]
Molecular weight: Translated: 74113; Mature: 74113
Theoretical pI: Translated: 9.66; Mature: 9.66
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 1.7 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 1.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLKKIFYGFIVLFLIIVGLLAILIAQVWVTTDKDIAKIKDYRPGVASQILDRKGRLIANI CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHCCCEEEEH YDKEFRFYARFEEIPPRFIESLLAVEDTLFFEHGGINLDAIMRAMIKNAKSGRYTEGGST HHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCCCCCCHH LTQQLVKNMVLTREKTLTRKLKEAIISIRIEKVLSKEEILERYLNQTFFGHGYYGVKTAS HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCEEECC LGYFKKPLDKLTLKEITMLVALPRAPSFYDPTKNLEFSLSRANDILRRLYSLGWISSNEL CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHH KSALNEVPIVYNQTSTQNIAPYVVDEVLKQLDQLDGLKTQGYTIKLTIDLDYQRLALESL HHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHH RFGHQKILEKIAKEKPKTNASNEDEDNLNASMIVTDTSTGKILALVGGIDYKKSAFNRAT HCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHH QAKRQFGSAIKPFVYQIAFDNGYSTTSKIPDTARNFENGNYSKNSEQNHAWHPSNYSRKF HHHHHHCCHHCCCEEEEEECCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH LGLVTLQEALSHSLNLATINLSDQLGFEKIYQSLSDMGFKNLPKDLSIVLGSFAISPIEA HHHHHHHHHHHCCCEEEEEECHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHH AEKYSLFSNYGTMLKPMLIESITNQQNDVKTFTPIETKKITSKEQAFLTLSVLMNAVENG HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHCCCHHHHHHHHHHHHHHHHCC TGSLARIKGLEIAGKTGTSNNNVDAWFIGFTPTLQSVIWFGRDDNTPIGKGATGGVVSAP CCCEEEEECEEEECCCCCCCCCCEEEEEECCHHHHHHEEECCCCCCCCCCCCCCCCHHHH VYSYFMRNILAIEPSLKRKFDVPKGLRKEIVDEIPYYSTPNSITPTPKKTDDSEEPLLF HHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC >Mature Secondary Structure MLKKIFYGFIVLFLIIVGLLAILIAQVWVTTDKDIAKIKDYRPGVASQILDRKGRLIANI CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHCCCEEEEH YDKEFRFYARFEEIPPRFIESLLAVEDTLFFEHGGINLDAIMRAMIKNAKSGRYTEGGST HHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCCCCCCHH LTQQLVKNMVLTREKTLTRKLKEAIISIRIEKVLSKEEILERYLNQTFFGHGYYGVKTAS HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCEEECC LGYFKKPLDKLTLKEITMLVALPRAPSFYDPTKNLEFSLSRANDILRRLYSLGWISSNEL CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHH KSALNEVPIVYNQTSTQNIAPYVVDEVLKQLDQLDGLKTQGYTIKLTIDLDYQRLALESL HHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHH RFGHQKILEKIAKEKPKTNASNEDEDNLNASMIVTDTSTGKILALVGGIDYKKSAFNRAT HCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHH QAKRQFGSAIKPFVYQIAFDNGYSTTSKIPDTARNFENGNYSKNSEQNHAWHPSNYSRKF HHHHHHCCHHCCCEEEEEECCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH LGLVTLQEALSHSLNLATINLSDQLGFEKIYQSLSDMGFKNLPKDLSIVLGSFAISPIEA HHHHHHHHHHHCCCEEEEEECHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHH AEKYSLFSNYGTMLKPMLIESITNQQNDVKTFTPIETKKITSKEQAFLTLSVLMNAVENG HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHCCCHHHHHHHHHHHHHHHHCC TGSLARIKGLEIAGKTGTSNNNVDAWFIGFTPTLQSVIWFGRDDNTPIGKGATGGVVSAP CCCEEEEECEEEECCCCCCCCCCEEEEEECCHHHHHHEEECCCCCCCCCCCCCCCCHHHH VYSYFMRNILAIEPSLKRKFDVPKGLRKEIVDEIPYYSTPNSITPTPKKTDDSEEPLLF HHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 9537320 [H]