Click here to switch to the map view.

The map label for this gene is mdaB [H]

Identifier: 188527521

GI number: 188527521

Start: 712766

End: 713350

Strand: Direct

Name: mdaB [H]

Synonym: HPSH_03715

Alternate gene names: 188527521

Gene position: 712766-713350 (Clockwise)

Preceding gene: 188527515

Following gene: 188527526

Centisome position: 44.31

GC content: 44.27

Gene sequence:

>585_bases
ATGAAAAAAGTACTCATCATTAATGGGGCTAAAGCGTTCGGGAGCTCTGGGGGGAAACTCAATGAAACCTTGAGCAATCA
TGCAAAAAAGACTCTAGAATCTTTGGGGCTAGAAGTGGATACTACAATCGTGGATAAGGGCTATAATCATAGTCAAGAAG
TGGAAAAGATCGTTAGCGCTGATGCGACGATTTGGCAGATGCCTGGCTGGTGGATGGGAGAGCCTTGGATTGTGAAAAAA
TACATTGATGAAGTCTTTAGCGCAGGGCATGGGAAGCTTTGGGCTAGCGATGGCAGAAGCTCGCAAAACCCCACTAAAAA
CTACGGGAAAGGGGGCTTGATGCAAGGCAAAAAATACATGTTGAGCTTGACCTGGAACGCTCCTATTGAAGCCTTTAGTG
ATCCTAATGAATTTTTTGAAGGAGTGGGTGTGGATGTTGTGTATTTGCATTTGCATAAAGCGTTCCAGTTTTTAGGGCTT
TCAGCGTTGCCCACTTTTATTTGCAACGATGTAATGAAAAACCCCCAAGTAGAGCAGTATCTTAACTCTCTCACCACGCA
TTTGCACCAAGCTTTTGGCAAGTGA

Upstream 100 bases:

>100_bases
CTTAACATAATAAAAATAATACAATCGCAATTTAATCGCTTTTTAAAAATACCCTTTTGAGGTATAATCGCAATTTATAA
TTATCAAAAAAAGGAACAAA

Downstream 100 bases:

>100_bases
TTTTAAAATAAGGGTTTTTAACCCCCCATTTCTTTGGGGGGCTTGTTTATTCCACAATAAAATCTCTAGGATTGAGATCA
CAGCCTAAGATAAGATCCCT

Product: modulator of drug activity

Products: NADP; a reduced quinone; reduced acceptor [C]

Alternate protein names: NA

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MKKVLIINGAKAFGSSGGKLNETLSNHAKKTLESLGLEVDTTIVDKGYNHSQEVEKIVSADATIWQMPGWWMGEPWIVKK
YIDEVFSAGHGKLWASDGRSSQNPTKNYGKGGLMQGKKYMLSLTWNAPIEAFSDPNEFFEGVGVDVVYLHLHKAFQFLGL
SALPTFICNDVMKNPQVEQYLNSLTTHLHQAFGK

Sequences:

>Translated_194_residues
MKKVLIINGAKAFGSSGGKLNETLSNHAKKTLESLGLEVDTTIVDKGYNHSQEVEKIVSADATIWQMPGWWMGEPWIVKK
YIDEVFSAGHGKLWASDGRSSQNPTKNYGKGGLMQGKKYMLSLTWNAPIEAFSDPNEFFEGVGVDVVYLHLHKAFQFLGL
SALPTFICNDVMKNPQVEQYLNSLTTHLHQAFGK
>Mature_194_residues
MKKVLIINGAKAFGSSGGKLNETLSNHAKKTLESLGLEVDTTIVDKGYNHSQEVEKIVSADATIWQMPGWWMGEPWIVKK
YIDEVFSAGHGKLWASDGRSSQNPTKNYGKGGLMQGKKYMLSLTWNAPIEAFSDPNEFFEGVGVDVVYLHLHKAFQFLGL
SALPTFICNDVMKNPQVEQYLNSLTTHLHQAFGK

Specific function: Unknown

COG id: COG2249

COG function: function code R; Putative NADPH-quinone reductase (modulator of drug activity B)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli madB and S.pombe SPAC5H10.05c [H]

Homologues:

Organism=Escherichia coli, GI1789406, Length=193, Percent_Identity=58.5492227979275, Blast_Score=240, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003680 [H]

Pfam domain/function: PF02525 Flavodoxin_2 [H]

EC number: NA

Molecular weight: Translated: 21565; Mature: 21565

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLIINGAKAFGSSGGKLNETLSNHAKKTLESLGLEVDTTIVDKGYNHSQEVEKIVSA
CCEEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCHHHHHHHHHC
DATIWQMPGWWMGEPWIVKKYIDEVFSAGHGKLWASDGRSSQNPTKNYGKGGLMQGKKYM
CCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEEE
LSLTWNAPIEAFSDPNEFFEGVGVDVVYLHLHKAFQFLGLSALPTFICNDVMKNPQVEQY
EEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LNSLTTHLHQAFGK
HHHHHHHHHHHHCC
>Mature Secondary Structure
MKKVLIINGAKAFGSSGGKLNETLSNHAKKTLESLGLEVDTTIVDKGYNHSQEVEKIVSA
CCEEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCHHHHHHHHHC
DATIWQMPGWWMGEPWIVKKYIDEVFSAGHGKLWASDGRSSQNPTKNYGKGGLMQGKKYM
CCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEEE
LSLTWNAPIEAFSDPNEFFEGVGVDVVYLHLHKAFQFLGLSALPTFICNDVMKNPQVEQY
EEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LNSLTTHLHQAFGK
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH; a quinone; Acceptor; NADPH [C]

Specific reaction: NADPH + a quinone = NADP + a reduced quinone Acceptor + NADPH = reduced acceptor + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]