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The map label for this gene is cadA [H]

Identifier: 188527365

GI number: 188527365

Start: 545788

End: 547848

Strand: Direct

Name: cadA [H]

Synonym: HPSH_02860

Alternate gene names: 188527365

Gene position: 545788-547848 (Clockwise)

Preceding gene: 188527364

Following gene: 188527366

Centisome position: 33.93

GC content: 42.99

Gene sequence:

>2061_bases
ATGCAAGAATACCACATTCATAATTTGGATTGCCCTGATTGCGCGTCTAAATTAGAAAGGGATTTAAACAAACTAGATTG
TGTGAAAAAAGCTCAAATCAATTTCAGCACCAGTAAGTTGTTTTTGGATACGAGCGATTTTGAAAAAGTTAAGGCTTTCA
TCAAGCAAAATGAACCGCATTTGAGCCTGTCTTTTAAAGAGGCTGCAGAAAAGCCCTTGAGTTTTACGCCACTCATTATT
ACGATCCTTGTCTTTTTGGGCGCGATTTTAATCTTACACCTAAACCCTAGCCCCTTTATTGAAAAGGCTATGTTTTTCGT
GTTGGCTATAGTGTATCTAGTGAGCGGTAAAGATGTGATTTTAGGGGCGTTTCGTGGGCTTAGAAAAGGGCAATTTTTTG
ATGAAAACGCTTTGATGCTCATTGCGACTATTGCGGCTTTTTGCGTGGGGGCTTATGAAGAGAGCGTGTCTATTATGGTG
TTTTATTCAGCGGGCGAATTTTTGCAAAAACTCGCTATCTCTCGCTCTAAAAAATCCCTTAAGGCTTTAGTGGATGTCGC
TCCTAATTTGGCTTATTTGAAAAAGGGCGATGCGCTAGTGAGCGTTGCGCCTGAAGATTTAAGAGTCAATGACATTGTGG
TGGTGAAAGTCGGCGAAAAAGTGCCTGTGGATGGCGTGGTGATTAAGGGCGAAAGTTTGCTAGATGAAAGGGCGTTGAGC
GGGGAGTCTATGCCTGTTAATGTCAGCGAACGCTCTAAAGTTTTAGGGGGGAGCTTGAATTTAAAAGCGGTCCTTGAAAT
TAAAGTAGAAAAAATGTATAAAGATTCTTCCATCGCTAAAGTGGTGGATTTAGTCCAACAAGCCACGAATGAAAAGAGCG
AAACTGAGAAATTCATCACTAAATTTTCACGCTACTACACCCCAAGCGTTTTATTCATTGCGCTAATGATTGCTATATTA
CCGCCCTTGTTTTCTATGGGGAGCTTTGATGAGTGGATTTATAGGGGGCTTGTGGCTTTAATGGTGAGCTGTCCTTGCGC
GTTAGTGATTTCTGTGCCTTTAGGGTATTTTGGGGGCGTGGGAGCGGCGAGCAGAAAGGGCATTTTAATGAAAGGCGTGC
ATGTTTTAGAGGTGCTTACCCAAGCTAAAAGCATCGCCTTTGATAAAACCGGCACTTTGACTAAAGGCGTTTTTAAAGTG
ATAGATATTGTGCCGCAAAATGGGCATTCTAAAGAAGAAGTTTTGCATTATGCTTCTTGTTCGCAGCTTTTATCCACGCA
CCCGATCGCTTTATCCATTCAAAAAGCATGCGAAGAAATGTTAAAGGACGATAAGCACCAGCATGACATTAAAAATTACG
AAGAAGTGAGCGGAATGGGGGTTAAAGCGCAATGCGATACGGATTTAATCATCGCAGGGAATGAAAAAATGCTAGAACAA
TTCAATATCGCGCACAGCCCTTCCCCAGAAAACGGCACGATCGTGCATGTGGCTTTCAATCAAACTTATGTGGGCTATAT
CGTCATTAGCGATGAGATTAAAGATGACGCCATAGAGTGCTTAAGGGATTTAAAAGCGCAAGGGATAGAGAATTTTTGCA
TTTTGAGCGGGGACAGAAAAAGCGCGACTGAGAGCATCGCCCAAACTTTAGGCTGTGAATATTATGCGAGCTTGTTGCCT
GAAGAAAAAACGAGCGTGTTTAAAACTTTTAAAGAACGCTATAAAGCCCCGGCGATTTTTGTAGGCGATGGCATCAATGA
CGCTCCGACTCTAGCGAGTGCTGATGTGGGGATTGGCATGGGGAAAGGCTCAGAATTGAGCAAGCAAAGCGCAGACATTG
TGATCACTAATGACTCCTTAAGCTCTTTAGTGAAAGTTTTAGCGATCGCTAAAAAAACTAAAAGCATTATTTGGCAAAAT
ATCTTGTTCGCTTTGGGGATTAAAGCCGTTTTTATCGTGCTAGGGCTTATGGGGGTAGCGAGCTTGTGGGAAGCGGTCTT
TGGCGATGTGGGGGTTACGCTTTTAGCCTTAGCCAACTCCATGCGCGCGATGAGGGCTTAA

Upstream 100 bases:

>100_bases
TGCGGATTTAAACGCTTGCGAGAATATAGAAAAATCTCACATGCTTAAAGCGCTGAGTTTTAGAAAGATTTCTTAAAAGG
ATTTTTATAAGGGAGAGAAA

Downstream 100 bases:

>100_bases
TGATCTTATTATCAGCCATTTAGAAGGGGGGCAAAATGCATAAAATAGAGCGCTTACTCCAAACTTTAGTGCCTAAGGGG
GTGGAGTTTAAAACGCTTGA

Product: cadmium-transporting ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MQEYHIHNLDCPDCASKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEAAEKPLSFTPLII
TILVFLGAILILHLNPSPFIEKAMFFVLAIVYLVSGKDVILGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIMV
FYSAGEFLQKLAISRSKKSLKALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVIKGESLLDERALS
GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAIL
PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV
IDIVPQNGHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCDTDLIIAGNEKMLEQ
FNIAHSPSPENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRKSATESIAQTLGCEYYASLLP
EEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLSSLVKVLAIAKKTKSIIWQN
ILFALGIKAVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA

Sequences:

>Translated_686_residues
MQEYHIHNLDCPDCASKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEAAEKPLSFTPLII
TILVFLGAILILHLNPSPFIEKAMFFVLAIVYLVSGKDVILGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIMV
FYSAGEFLQKLAISRSKKSLKALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVIKGESLLDERALS
GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAIL
PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV
IDIVPQNGHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCDTDLIIAGNEKMLEQ
FNIAHSPSPENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRKSATESIAQTLGCEYYASLLP
EEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLSSLVKVLAIAKKTKSIIWQN
ILFALGIKAVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA
>Mature_686_residues
MQEYHIHNLDCPDCASKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEAAEKPLSFTPLII
TILVFLGAILILHLNPSPFIEKAMFFVLAIVYLVSGKDVILGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIMV
FYSAGEFLQKLAISRSKKSLKALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVIKGESLLDERALS
GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAIL
PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV
IDIVPQNGHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCDTDLIIAGNEKMLEQ
FNIAHSPSPENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRKSATESIAQTLGCEYYASLLP
EEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLSSLVKVLAIAKKTKSIIWQN
ILFALGIKAVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=798, Percent_Identity=25.187969924812, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI115529486, Length=706, Percent_Identity=26.2039660056657, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI55743073, Length=518, Percent_Identity=27.2200772200772, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1789879, Length=690, Percent_Identity=33.9130434782609, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1786691, Length=505, Percent_Identity=28.7128712871287, Blast_Score=209, Evalue=7e-55,
Organism=Escherichia coli, GI1786914, Length=513, Percent_Identity=25.1461988304094, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17556548, Length=582, Percent_Identity=28.1786941580756, Blast_Score=180, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6320475, Length=540, Percent_Identity=27.5925925925926, Blast_Score=208, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6319772, Length=602, Percent_Identity=25.9136212624585, Blast_Score=176, Evalue=8e-45,
Organism=Drosophila melanogaster, GI221329854, Length=524, Percent_Identity=24.0458015267176, Blast_Score=119, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 74841; Mature: 74841

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEYHIHNLDCPDCASKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCC
LSLSFKEAAEKPLSFTPLIITILVFLGAILILHLNPSPFIEKAMFFVLAIVYLVSGKDVI
EEEEHHHHHCCCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCHHH
LGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIMVFYSAGEFLQKLAISRSKKSL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHH
KALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVIKGESLLDERALS
HHHHHHCCCHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCEEECCHHHHHHHHCC
GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFIT
CCCCCCCHHHHHHHHCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHH
KFSRYYTPSVLFIALMIAILPPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGV
HHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCC
GAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKVIDIVPQNGHSKEEVLHYASC
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCDTDLIIAGNEKMLEQ
HHHHHCCCHHEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCEEEECCHHHHHH
FNIAHSPSPENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRK
HCCCCCCCCCCCEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCH
SATESIAQTLGCEYYASLLPEEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGM
HHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
GKGSELSKQSADIVITNDSLSSLVKVLAIAKKTKSIIWQNILFALGIKAVFIVLGLMGVA
CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLWEAVFGDVGVTLLALANSMRAMRA
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQEYHIHNLDCPDCASKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCC
LSLSFKEAAEKPLSFTPLIITILVFLGAILILHLNPSPFIEKAMFFVLAIVYLVSGKDVI
EEEEHHHHHCCCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCHHH
LGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIMVFYSAGEFLQKLAISRSKKSL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHH
KALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVIKGESLLDERALS
HHHHHHCCCHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCEEECCHHHHHHHHCC
GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFIT
CCCCCCCHHHHHHHHCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHH
KFSRYYTPSVLFIALMIAILPPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGV
HHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCC
GAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKVIDIVPQNGHSKEEVLHYASC
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCDTDLIIAGNEKMLEQ
HHHHHCCCHHEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCEEEECCHHHHHH
FNIAHSPSPENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRK
HCCCCCCCCCCCEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCH
SATESIAQTLGCEYYASLLPEEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGM
HHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
GKGSELSKQSADIVITNDSLSSLVKVLAIAKKTKSIIWQNILFALGIKAVFIVLGLMGVA
CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLWEAVFGDVGVTLLALANSMRAMRA
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]