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The map label for this gene is ribA

Identifier: 188527354

GI number: 188527354

Start: 537530

End: 538108

Strand: Direct

Name: ribA

Synonym: HPSH_02805

Alternate gene names: 188527354

Gene position: 537530-538108 (Clockwise)

Preceding gene: 188527353

Following gene: 188527355

Centisome position: 33.42

GC content: 40.76

Gene sequence:

>579_bases
TTGAAACGATTAGAAGTTTCTAACCAAGCCAAATTACCCACTCAATTTGGGGAGTTTTGTATCCAGTGTTTTAGAGAAAA
GGGTTCTAACGGCTCTAAAGAACATTTAGTGGTTTTCACCCCTAATTTTTCTCAAAACCCCTTAGTGCGTTTGCATTCAG
AATGCTTGACCGGCGACGCTCTAGGCTCTCAAAAATGCGATTGCGGGGGGGCGTTGCAAATAGCGTTAGAAAGGATTTCT
AAAGAAGGGGGGCTAGTGATTTATTTGCGCCAAGAAGGGCGTGGGATAGGGCTGTTTAATAAAGTCAATGCCTACGCTTT
GCAAGATAAGGGCTATGATACTATTCAAGCCAATGAAATGATAGGGTTTAAAGACGATGAAAGGGATTATAGTATTGCGG
GTGAAATTTTAGAATATTACGGCATTAAAAAAATGCGCTTACTCACAAACAACCCTAAAAAAATCGCCGCTTTAGAAAAA
TACGCTGAGGTAACAAGAGAGAGCCTGATCGTGTGCGCTAATGAACACAATCAAGGGTATTTGGAAGTCAAAAAGCTCAA
AATGGGGCATTTATTGTGA

Upstream 100 bases:

>100_bases
GCGATTTTAAAAACATTTTTATCGGCACAAATTATAAAGAGTTTTGATAGAATACCTTTTTTTAAAAGATGCGTTTTAAA
AACTAATTTTAGGAGTATCC

Downstream 100 bases:

>100_bases
AAACCATGAGCGCTTTAAAGAGGTTTTAAAATACTAAAATCATGCTTTTAAAAATTTAATATAAGGGTAAATGATGGTAG
AAGTGCGATTTTTTGGACCC

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MKRLEVSNQAKLPTQFGEFCIQCFREKGSNGSKEHLVVFTPNFSQNPLVRLHSECLTGDALGSQKCDCGGALQIALERIS
KEGGLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANEMIGFKDDERDYSIAGEILEYYGIKKMRLLTNNPKKIAALEK
YAEVTRESLIVCANEHNQGYLEVKKLKMGHLL

Sequences:

>Translated_192_residues
MKRLEVSNQAKLPTQFGEFCIQCFREKGSNGSKEHLVVFTPNFSQNPLVRLHSECLTGDALGSQKCDCGGALQIALERIS
KEGGLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANEMIGFKDDERDYSIAGEILEYYGIKKMRLLTNNPKKIAALEK
YAEVTRESLIVCANEHNQGYLEVKKLKMGHLL
>Mature_192_residues
MKRLEVSNQAKLPTQFGEFCIQCFREKGSNGSKEHLVVFTPNFSQNPLVRLHSECLTGDALGSQKCDCGGALQIALERIS
KEGGLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANEMIGFKDDERDYSIAGEILEYYGIKKMRLLTNNPKKIAALEK
YAEVTRESLIVCANEHNQGYLEVKKLKMGHLL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=187, Percent_Identity=48.6631016042781, Blast_Score=175, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319438, Length=177, Percent_Identity=41.2429378531073, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 21566; Mature: 21566

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLEVSNQAKLPTQFGEFCIQCFREKGSNGSKEHLVVFTPNFSQNPLVRLHSECLTGDA
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCC
LGSQKCDCGGALQIALERISKEGGLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANEM
CCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEECEEECCCEEEECCCCCCEEECCCE
IGFKDDERDYSIAGEILEYYGIKKMRLLTNNPKKIAALEKYAEVTRESLIVCANEHNQGY
ECCCCCCCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHEEEEEECCCCCCE
LEVKKLKMGHLL
EEEEEECCCCCC
>Mature Secondary Structure
MKRLEVSNQAKLPTQFGEFCIQCFREKGSNGSKEHLVVFTPNFSQNPLVRLHSECLTGDA
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCC
LGSQKCDCGGALQIALERISKEGGLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANEM
CCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEECEEECCCEEEECCCCCCEEECCCE
IGFKDDERDYSIAGEILEYYGIKKMRLLTNNPKKIAALEKYAEVTRESLIVCANEHNQGY
ECCCCCCCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHEEEEEECCCCCCE
LEVKKLKMGHLL
EEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA