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The map label for this gene is lpxK

Identifier: 188527134

GI number: 188527134

Start: 326494

End: 327432

Strand: Reverse

Name: lpxK

Synonym: HPSH_01705

Alternate gene names: 188527134

Gene position: 327432-326494 (Counterclockwise)

Preceding gene: 188527135

Following gene: 188527129

Centisome position: 20.36

GC content: 38.13

Gene sequence:

>939_bases
ATGAAAAGCGATAAACCCTTTTTAGAACGCTATTTTTATGACCCCACTCTTTTGCAAAAGGGGTTGATTTTTGCACTCTA
TCCTTTTTCTTTGATCTATCAAGGCATCGCCACCCTTAAACGAAAAACCGCCAAAAAGCATGATTTTAAAATCCCCCTTA
TCAGCGTAGGCAATTTGATCGCTGGGGGAAGCGGTAAAACGCCCTTTATTTTAGAAACCGCTCCAAGATACCAAGAAGTG
GCGGTTATTTCTAGGGGGTACCAACGAGATTCTAAAGGTTTAGTGGTGGTGAGCGTTAAAGGAAACATTTTAGTTTCCCA
ACAAACAGCGGGCGATGAAGCCTATCTTTTAGCCTTGAATTTAAAACAAGCGAGCGTGATTGTGAGCGAAAAAAGAGAGC
TAGGCGTTTTAAAAGCCCTTGAATTAGGATCAAAGATCGTGTTTTTGGACGATGGTTTTAGGTTTAATTTCAACCAATTC
AATTTGCTTTTAAAGCCTAAAGTCCCCCCCTACTACCCCTTTTGTTTGCCTAGCGGGTTGTATAGAGAAAGCATCAAAAG
CTATAAAGAAGCCCATTTAGTCGTTACAGAAGATAAGGACTATAAAAGAATCACCTCTATTTCCCACCCCACCAAACGCA
TGCTTTTAGTAACGGCTATCGCTAATCCTAGCAGGCTTGATGCGTTTTTACCTAAAGAAGTGGTTAAAAAATTGTATTTT
AGAGATCATGCCCCTTTTGATTTGAAACTTTTAGAAAAAGAGTTTTATCAAAATAACGCCACTTCCTTATTGGTTACTTC
AAAAGATCTCGTCAAATTACAAGATTGCAACTTGCCCTTAAGCGTATTGGATTTAAAGCTAGAAATTTGCCCTAAAATTT
TAGAACAGATCGATCGTTATATCCTTTCTTATCCTTGTAATACAAAAGAACATCTATAA

Upstream 100 bases:

>100_bases
TAGGCTATGATGAAATTTTAGTGAAAAACATCATAAGCCGTATCCAAAAAAACGCTTTCAAATTAGAATTACCCACCATC
GCCAAACGATTTAACCCTAA

Downstream 100 bases:

>100_bases
ATTCCTTTTCTTTAGAAACAAAGCCTTTCAAACGCCCCTCTAACTCATAATGGTTTTTTTCATAAAAAGCGATCGCTTTG
AAATTGTTCTCCATCACTTC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKSDKPFLERYFYDPTLLQKGLIFALYPFSLIYQGIATLKRKTAKKHDFKIPLISVGNLIAGGSGKTPFILETAPRYQEV
AVISRGYQRDSKGLVVVSVKGNILVSQQTAGDEAYLLALNLKQASVIVSEKRELGVLKALELGSKIVFLDDGFRFNFNQF
NLLLKPKVPPYYPFCLPSGLYRESIKSYKEAHLVVTEDKDYKRITSISHPTKRMLLVTAIANPSRLDAFLPKEVVKKLYF
RDHAPFDLKLLEKEFYQNNATSLLVTSKDLVKLQDCNLPLSVLDLKLEICPKILEQIDRYILSYPCNTKEHL

Sequences:

>Translated_312_residues
MKSDKPFLERYFYDPTLLQKGLIFALYPFSLIYQGIATLKRKTAKKHDFKIPLISVGNLIAGGSGKTPFILETAPRYQEV
AVISRGYQRDSKGLVVVSVKGNILVSQQTAGDEAYLLALNLKQASVIVSEKRELGVLKALELGSKIVFLDDGFRFNFNQF
NLLLKPKVPPYYPFCLPSGLYRESIKSYKEAHLVVTEDKDYKRITSISHPTKRMLLVTAIANPSRLDAFLPKEVVKKLYF
RDHAPFDLKLLEKEFYQNNATSLLVTSKDLVKLQDCNLPLSVLDLKLEICPKILEQIDRYILSYPCNTKEHL
>Mature_312_residues
MKSDKPFLERYFYDPTLLQKGLIFALYPFSLIYQGIATLKRKTAKKHDFKIPLISVGNLIAGGSGKTPFILETAPRYQEV
AVISRGYQRDSKGLVVVSVKGNILVSQQTAGDEAYLLALNLKQASVIVSEKRELGVLKALELGSKIVFLDDGFRFNFNQF
NLLLKPKVPPYYPFCLPSGLYRESIKSYKEAHLVVTEDKDYKRITSISHPTKRMLLVTAIANPSRLDAFLPKEVVKKLYF
RDHAPFDLKLLEKEFYQNNATSLLVTSKDLVKLQDCNLPLSVLDLKLEICPKILEQIDRYILSYPCNTKEHL

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 35497; Mature: 35497

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDKPFLERYFYDPTLLQKGLIFALYPFSLIYQGIATLKRKTAKKHDFKIPLISVGNLI
CCCCCCHHHHHCCCHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEE
AGGSGKTPFILETAPRYQEVAVISRGYQRDSKGLVVVSVKGNILVSQQTAGDEAYLLALN
ECCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCEEEEEECCCEEEEECCCCCCEEEEEEE
LKQASVIVSEKRELGVLKALELGSKIVFLDDGFRFNFNQFNLLLKPKVPPYYPFCLPSGL
CCHHHEEEHHHHHHHHHHHHHCCCEEEEEECCCEECCCEEEEEECCCCCCCCCCCCCCHH
YRESIKSYKEAHLVVTEDKDYKRITSISHPTKRMLLVTAIANPSRLDAFLPKEVVKKLYF
HHHHHHHHHHEEEEEECCCCHHHHHHCCCCCCEEEEEEEECCCHHHHHHCHHHHHHHHHH
RDHAPFDLKLLEKEFYQNNATSLLVTSKDLVKLQDCNLPLSVLDLKLEICPKILEQIDRY
CCCCCCHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ILSYPCNTKEHL
HHCCCCCCCCCC
>Mature Secondary Structure
MKSDKPFLERYFYDPTLLQKGLIFALYPFSLIYQGIATLKRKTAKKHDFKIPLISVGNLI
CCCCCCHHHHHCCCHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEE
AGGSGKTPFILETAPRYQEVAVISRGYQRDSKGLVVVSVKGNILVSQQTAGDEAYLLALN
ECCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCEEEEEECCCEEEEECCCCCCEEEEEEE
LKQASVIVSEKRELGVLKALELGSKIVFLDDGFRFNFNQFNLLLKPKVPPYYPFCLPSGL
CCHHHEEEHHHHHHHHHHHHHCCCEEEEEECCCEECCCEEEEEECCCCCCCCCCCCCCHH
YRESIKSYKEAHLVVTEDKDYKRITSISHPTKRMLLVTAIANPSRLDAFLPKEVVKKLYF
HHHHHHHHHHEEEEEECCCCHHHHHHCCCCCCEEEEEEEECCCHHHHHHCHHHHHHHHHH
RDHAPFDLKLLEKEFYQNNATSLLVTSKDLVKLQDCNLPLSVLDLKLEICPKILEQIDRY
CCCCCCHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ILSYPCNTKEHL
HHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA