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The map label for this gene is sdaA [H]

Identifier: 188526935

GI number: 188526935

Start: 127248

End: 128615

Strand: Reverse

Name: sdaA [H]

Synonym: HPSH_00660

Alternate gene names: 188526935

Gene position: 128615-127248 (Counterclockwise)

Preceding gene: 188526936

Following gene: 188526924

Centisome position: 8.0

GC content: 42.91

Gene sequence:

>1368_bases
ATGGCTAGTTTTTCTATTTTATCCATTTTTAAAATCGGCGTGGGGCCTAGCTCTTCACACACTATAGGGCCTATGAAAGC
TGGAGCGAGATTTTGCGGGTTGTTAAAAGGTGTTTTAGAGCAGGTTATGCGCGTTCAAATCACCTTGCATGGCTCATTAG
CTTTAACCGGTAAAGGGCATTTGAGCGATGAGGCGGTTTTAATTGGCTTGCATGGCATTTACGCTAACGAATTGGAGGTA
ACAACCAAAAAAGCCTTATTGCATGAAGCGCTTGAAAACAAGGTTTTAAAACTCGCTAACCAGCATTGCATCCATTTTGA
TTATTCTAAAGATTTGATTTTTGACAATAAACCTTTAGCCAGACACCAAAACGCTCTCATTCTAAAAGCTTTTAACTCTA
AAAATGAGGTTTTAAAAGAAGAAACTTACTATTCTGTCGGTGGAGGGTTTGTCTATACTGAAAAAGAATTAGACAACTTG
TCTGAAGAGGGCGGGAATGAAAGTGTTGCCTATGATTTTTCAAGCGCTAAGGAATTGCTAGAATTATGCCAAAAACACCA
AAAAAACATCGCTGAAATCGTGCGTTTGAGAGAAGACGCTCTCAAAAACCGCCCTGATGCAATGATGGCTAAAATTTATC
ATGCGATGCTTGAGTGTTATGATAATGGGGCTAATTCTAAAGAAAAGTATCTGCCCGGTTCTTTGAGAGTAACACGATTG
GCCCCAAGCATTAAAACGCGTTTAGAAAAACACCCCACAAGCGGGAAAGATCCCTTAGCGTTGATTGATTACATTTCGCT
TTACGCTCGCGCCATTGCTGAAGAAAACGCTAGCGGAGGAAAGGTGGTAACCGCTCCCACTAATGGAGCGTGCGCGGTGG
TGCCAAGCGTGCTTTTATACGCTAAAAACCATTTGTTTGAAAATTTATCGCAAAAAGCCATCAATGATTTTTTACTCACC
AGTGCAGCGATTGGCTATCTTTACAAAAAAAACGCTTCCTTGAGCGGTGCAGAAGCGGGGTGTCAGGCTGAAATTGGCGT
GGCAAGCTCTATGGCTGCGGGGGGGTTAGCCTGTTTGTGCCAAGCGACCACGCAACAGGTTTTAATCGCTAGTGAAATCG
CTATGGAACACCATTTAGGATTGACATGCGATCCGGTGGGGGGCTTGGTGCAAATCCCTTGCATTGAACGCAATGTTTTA
GGAGCGATCAAAGCGATCAGCGCTTCTAAACTGGCTTTAGAAGATGAATACAAGCCTAAAGTGAGCCTGGATGAAGTGAT
CGCTACGATGTATGCGACCGGAAAAGACATGAATGAAGAATACAAAGAGACTTCGTTAGGGGGATTAGCCAAAACCTTAA
AATGCTAA

Upstream 100 bases:

>100_bases
GCATTTCTAGTCTGAAGCGTTTTAGAAACCTTAAAGTGGATATTTTTGTGTTTGTTTTTGGGAGCTTGACGGCTTTGAGC
GTGTTTTTAGGACTATTTTA

Downstream 100 bases:

>100_bases
AGGATAAATCCAAACTTTAGGGGTTTTAAGTTCCTAAAAAAAGGCTTTGTTTTATCAAATGCGAACAAGCTTTTCCAACT
TTAATATCCTTCAAAAATTT

Product: L-serine deaminase

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MASFSILSIFKIGVGPSSSHTIGPMKAGARFCGLLKGVLEQVMRVQITLHGSLALTGKGHLSDEAVLIGLHGIYANELEV
TTKKALLHEALENKVLKLANQHCIHFDYSKDLIFDNKPLARHQNALILKAFNSKNEVLKEETYYSVGGGFVYTEKELDNL
SEEGGNESVAYDFSSAKELLELCQKHQKNIAEIVRLREDALKNRPDAMMAKIYHAMLECYDNGANSKEKYLPGSLRVTRL
APSIKTRLEKHPTSGKDPLALIDYISLYARAIAEENASGGKVVTAPTNGACAVVPSVLLYAKNHLFENLSQKAINDFLLT
SAAIGYLYKKNASLSGAEAGCQAEIGVASSMAAGGLACLCQATTQQVLIASEIAMEHHLGLTCDPVGGLVQIPCIERNVL
GAIKAISASKLALEDEYKPKVSLDEVIATMYATGKDMNEEYKETSLGGLAKTLKC

Sequences:

>Translated_455_residues
MASFSILSIFKIGVGPSSSHTIGPMKAGARFCGLLKGVLEQVMRVQITLHGSLALTGKGHLSDEAVLIGLHGIYANELEV
TTKKALLHEALENKVLKLANQHCIHFDYSKDLIFDNKPLARHQNALILKAFNSKNEVLKEETYYSVGGGFVYTEKELDNL
SEEGGNESVAYDFSSAKELLELCQKHQKNIAEIVRLREDALKNRPDAMMAKIYHAMLECYDNGANSKEKYLPGSLRVTRL
APSIKTRLEKHPTSGKDPLALIDYISLYARAIAEENASGGKVVTAPTNGACAVVPSVLLYAKNHLFENLSQKAINDFLLT
SAAIGYLYKKNASLSGAEAGCQAEIGVASSMAAGGLACLCQATTQQVLIASEIAMEHHLGLTCDPVGGLVQIPCIERNVL
GAIKAISASKLALEDEYKPKVSLDEVIATMYATGKDMNEEYKETSLGGLAKTLKC
>Mature_454_residues
ASFSILSIFKIGVGPSSSHTIGPMKAGARFCGLLKGVLEQVMRVQITLHGSLALTGKGHLSDEAVLIGLHGIYANELEVT
TKKALLHEALENKVLKLANQHCIHFDYSKDLIFDNKPLARHQNALILKAFNSKNEVLKEETYYSVGGGFVYTEKELDNLS
EEGGNESVAYDFSSAKELLELCQKHQKNIAEIVRLREDALKNRPDAMMAKIYHAMLECYDNGANSKEKYLPGSLRVTRLA
PSIKTRLEKHPTSGKDPLALIDYISLYARAIAEENASGGKVVTAPTNGACAVVPSVLLYAKNHLFENLSQKAINDFLLTS
AAIGYLYKKNASLSGAEAGCQAEIGVASSMAAGGLACLCQATTQQVLIASEIAMEHHLGLTCDPVGGLVQIPCIERNVLG
AIKAISASKLALEDEYKPKVSLDEVIATMYATGKDMNEEYKETSLGGLAKTLKC

Specific function: Deaminates Also Threonine, Particularly When It Is Present In High Concentration. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=458, Percent_Identity=45.8515283842795, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI48994925, Length=457, Percent_Identity=46.1706783369803, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1789161, Length=458, Percent_Identity=44.5414847161572, Blast_Score=383, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 49149; Mature: 49018

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASFSILSIFKIGVGPSSSHTIGPMKAGARFCGLLKGVLEQVMRVQITLHGSLALTGKGH
CCCCCEEHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECEEEEECCCC
LSDEAVLIGLHGIYANELEVTTKKALLHEALENKVLKLANQHCIHFDYSKDLIFDNKPLA
CCCCEEEEEEECEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEECCCCCH
RHQNALILKAFNSKNEVLKEETYYSVGGGFVYTEKELDNLSEEGGNESVAYDFSSAKELL
HCCCEEEEEEECCCHHHHHHHCEEECCCCEEEEHHHHHHHHHCCCCCCEEEEHHHHHHHH
ELCQKHQKNIAEIVRLREDALKNRPDAMMAKIYHAMLECYDNGANSKEKYLPGSLRVTRL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHCCCCCEEEEEE
APSIKTRLEKHPTSGKDPLALIDYISLYARAIAEENASGGKVVTAPTNGACAVVPSVLLY
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHH
AKNHLFENLSQKAINDFLLTSAAIGYLYKKNASLSGAEAGCQAEIGVASSMAAGGLACLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCHHHHHHCCHHHHH
QATTQQVLIASEIAMEHHLGLTCDPVGGLVQIPCIERNVLGAIKAISASKLALEDEYKPK
HHHHHHHHHHHHHHHHHCCCCEECCCCCEEECCCCCHHHHHHHHHHHHHHHEECCCCCCC
VSLDEVIATMYATGKDMNEEYKETSLGGLAKTLKC
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASFSILSIFKIGVGPSSSHTIGPMKAGARFCGLLKGVLEQVMRVQITLHGSLALTGKGH
CCCCEEHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECEEEEECCCC
LSDEAVLIGLHGIYANELEVTTKKALLHEALENKVLKLANQHCIHFDYSKDLIFDNKPLA
CCCCEEEEEEECEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEECCCCCH
RHQNALILKAFNSKNEVLKEETYYSVGGGFVYTEKELDNLSEEGGNESVAYDFSSAKELL
HCCCEEEEEEECCCHHHHHHHCEEECCCCEEEEHHHHHHHHHCCCCCCEEEEHHHHHHHH
ELCQKHQKNIAEIVRLREDALKNRPDAMMAKIYHAMLECYDNGANSKEKYLPGSLRVTRL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHCCCCCEEEEEE
APSIKTRLEKHPTSGKDPLALIDYISLYARAIAEENASGGKVVTAPTNGACAVVPSVLLY
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHH
AKNHLFENLSQKAINDFLLTSAAIGYLYKKNASLSGAEAGCQAEIGVASSMAAGGLACLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCHHHHHHCCHHHHH
QATTQQVLIASEIAMEHHLGLTCDPVGGLVQIPCIERNVLGAIKAISASKLALEDEYKPK
HHHHHHHHHHHHHHHHHCCCCEECCCCCEEECCCCCHHHHHHHHHHHHHHHEECCCCCCC
VSLDEVIATMYATGKDMNEEYKETSLGGLAKTLKC
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]