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The map label for this gene is folD [H]

Identifier: 187935746

GI number: 187935746

Start: 2496703

End: 2497551

Strand: Reverse

Name: folD [H]

Synonym: CLL_A2405

Alternate gene names: 187935746

Gene position: 2497551-2496703 (Counterclockwise)

Preceding gene: 187935150

Following gene: 187934773

Centisome position: 65.72

GC content: 28.03

Gene sequence:

>849_bases
ATGGGGCAAATTATAAATGGAAAAGAAGTAGCATTAAAGATAAAAGAAGAAATAAAGACCTTTGTTGAAGAAAGAAAAAA
AAATAAACTGAGGATTCCAAAGATTGCATCTATATTAGTTGGCAATGATGGAGGATCAATTTATTATATGTCAAGTCAAG
AAAAGGTAGCTAATTCTTTAGGGGTAGATTTTTTAAAGATTATATTAGAAGAGAATGTTACTGATGACGATGTTATAAAT
GAAATTCATAAGTTAAATGATGATGTTAATGTTCAAGGTATAATGCTTCAATTACCATTACCTAAGCATTTAAATGAAAA
AAAGATAATAAAAGAAATATCTGTTAAAAAGGATATAGATTGTCTTACATTTGAAAGTCAAGGTAAATTATATATGGGGG
AAAAGGGATTTTTACCATGTACACCTAATTCAGTTATAACTTTAATTAAGAGTCTTAAGATTGATATAACTGGTAAGGAA
GTAGTTGTTCTTGGAAGAAGTAATATAGTAGGAAAGCCAGTAGCACAACTTTTATTAAATGAAAATGCAACAGTTACTAT
ATGTCATTCTAAAACAAAAGATTTAAAAGAAGTATGTAGTAAAGCAGACATATTAGTTGTAGCAATTGGTAAACCTAAGT
TTATAGATGAAGAATACATAAAAGAAAATGCAATAGTTATTGATGTTGGTACTTCATCTTTTGAAGGTAAAATAACAGGC
GATGTTAATTTTGATAAGGTAATAGATAAAGCTTCTTTCGTAACACCAGTACCAGGTGGAGTTGGAGCTTTAACTACTAC
TCTTTTAATAAAAAATTCATGTGAGGCTTTAAAGGAATATGAAGATTAA

Upstream 100 bases:

>100_bases
GAAATAACAAAGAAATATTCAGATGAAAAAAGTGTTTCATTTGTAAATGGAGTTTTAGATAACATTTTAAAAAAATAAAT
TATAAGGGGCGAAAATAAAA

Downstream 100 bases:

>100_bases
AACTTTAACTGTTTCAGATCTAACAAACTATATAAAAAAAGTAATTGATAATGACTTTATTTTAAATAATCTCTCTGTAA
AAGGGGAGATTTCTAATTTA

Product: bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MGQIINGKEVALKIKEEIKTFVEERKKNKLRIPKIASILVGNDGGSIYYMSSQEKVANSLGVDFLKIILEENVTDDDVIN
EIHKLNDDVNVQGIMLQLPLPKHLNEKKIIKEISVKKDIDCLTFESQGKLYMGEKGFLPCTPNSVITLIKSLKIDITGKE
VVVLGRSNIVGKPVAQLLLNENATVTICHSKTKDLKEVCSKADILVVAIGKPKFIDEEYIKENAIVIDVGTSSFEGKITG
DVNFDKVIDKASFVTPVPGGVGALTTTLLIKNSCEALKEYED

Sequences:

>Translated_282_residues
MGQIINGKEVALKIKEEIKTFVEERKKNKLRIPKIASILVGNDGGSIYYMSSQEKVANSLGVDFLKIILEENVTDDDVIN
EIHKLNDDVNVQGIMLQLPLPKHLNEKKIIKEISVKKDIDCLTFESQGKLYMGEKGFLPCTPNSVITLIKSLKIDITGKE
VVVLGRSNIVGKPVAQLLLNENATVTICHSKTKDLKEVCSKADILVVAIGKPKFIDEEYIKENAIVIDVGTSSFEGKITG
DVNFDKVIDKASFVTPVPGGVGALTTTLLIKNSCEALKEYED
>Mature_281_residues
GQIINGKEVALKIKEEIKTFVEERKKNKLRIPKIASILVGNDGGSIYYMSSQEKVANSLGVDFLKIILEENVTDDDVINE
IHKLNDDVNVQGIMLQLPLPKHLNEKKIIKEISVKKDIDCLTFESQGKLYMGEKGFLPCTPNSVITLIKSLKIDITGKEV
VVLGRSNIVGKPVAQLLLNENATVTICHSKTKDLKEVCSKADILVVAIGKPKFIDEEYIKENAIVIDVGTSSFEGKITGD
VNFDKVIDKASFVTPVPGGVGALTTTLLIKNSCEALKEYED

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate [H]

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=291, Percent_Identity=40.2061855670103, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI222418558, Length=292, Percent_Identity=38.013698630137, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI94721354, Length=292, Percent_Identity=37.6712328767123, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI36796743, Length=225, Percent_Identity=24.8888888888889, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1786741, Length=282, Percent_Identity=39.3617021276596, Blast_Score=214, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17568735, Length=291, Percent_Identity=40.2061855670103, Blast_Score=190, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6319558, Length=287, Percent_Identity=38.3275261324042, Blast_Score=202, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6321643, Length=298, Percent_Identity=38.255033557047, Blast_Score=194, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6322933, Length=327, Percent_Identity=25.9938837920489, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI62472483, Length=290, Percent_Identity=37.2413793103448, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI45551871, Length=290, Percent_Identity=37.2413793103448, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24645718, Length=290, Percent_Identity=37.2413793103448, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17137370, Length=290, Percent_Identity=37.2413793103448, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17136818, Length=299, Percent_Identity=34.7826086956522, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17136816, Length=299, Percent_Identity=34.7826086956522, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020631 [H]

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C [H]

EC number: =1.5.1.5; =3.5.4.9 [H]

Molecular weight: Translated: 31001; Mature: 30869

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQIINGKEVALKIKEEIKTFVEERKKNKLRIPKIASILVGNDGGSIYYMSSQEKVANSL
CCCCCCCHHHEEEEHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEECCHHHHHHHH
GVDFLKIILEENVTDDDVINEIHKLNDDVNVQGIMLQLPLPKHLNEKKIIKEISVKKDID
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCE
CLTFESQGKLYMGEKGFLPCTPNSVITLIKSLKIDITGKEVVVLGRSNIVGKPVAQLLLN
EEEECCCCCEEECCCCCCCCCCHHHHHHHHHHEEEECCCEEEEEECCCCCCHHHHHHHHC
ENATVTICHSKTKDLKEVCSKADILVVAIGKPKFIDEEYIKENAIVIDVGTSSFEGKITG
CCCEEEEEECCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHCCCEEEEECCCCCCCEEEC
DVNFDKVIDKASFVTPVPGGVGALTTTLLIKNSCEALKEYED
CCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GQIINGKEVALKIKEEIKTFVEERKKNKLRIPKIASILVGNDGGSIYYMSSQEKVANSL
CCCCCCHHHEEEEHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEECCHHHHHHHH
GVDFLKIILEENVTDDDVINEIHKLNDDVNVQGIMLQLPLPKHLNEKKIIKEISVKKDID
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCE
CLTFESQGKLYMGEKGFLPCTPNSVITLIKSLKIDITGKEVVVLGRSNIVGKPVAQLLLN
EEEECCCCCEEECCCCCCCCCCHHHHHHHHHHEEEECCCEEEEEECCCCCCHHHHHHHHC
ENATVTICHSKTKDLKEVCSKADILVVAIGKPKFIDEEYIKENAIVIDVGTSSFEGKITG
CCCEEEEEECCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHCCCEEEEECCCCCCCEEEC
DVNFDKVIDKASFVTPVPGGVGALTTTLLIKNSCEALKEYED
CCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA