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The map label for this gene is yeiA [H]

Identifier: 187935649

GI number: 187935649

Start: 2389291

End: 2390529

Strand: Reverse

Name: yeiA [H]

Synonym: CLL_A2317

Alternate gene names: 187935649

Gene position: 2390529-2389291 (Counterclockwise)

Preceding gene: 187933662

Following gene: 187935606

Centisome position: 62.9

GC content: 31.88

Gene sequence:

>1239_bases
ATGAGTATTATCAAAGACTTATCAATAGAATTTTGTGGAGTAAAATGTGAAAATCCATTTTTCTTATCATCATCACCAGT
AGGAAATTGCTATGAAATGTGTGCTAAAGCGTTTGAAGCTGGTTGGGGTGGAGTAATGTTTAAAACTATAGGTTTCTTTA
TGCCTAACGAAGTTTCTCCACGTTTTGATAGTTTAAGAAAAGAAGCAACTTCATTTGTTGGTTTTAAAAATATGGAACAA
ATATCAGATCACCCATTACAACAAAATTTAGATGATTTAAGAAGATTAAAAGAAAATTATCCTACTAAAATTGTAGTAGC
ATCAATAATGGGAGAAAATGAAAAAGAATGGGAAGACCTAGCAAAGCTTGTAACAGAAGCTGGTGCTGACATGATAGAAT
GTAATTTCTCATGTCCTCAAATGACAAGTCATGAAATGGGTTCAGACGTTGGTCAAAATCCAGAACTTGTTAAGAAATAT
TGTGAAGCAACTAGAAGAGGTACTAATTTACCAATACTAGCTAAAATGACTCCTAACATAGGGGATATGTCAGTACCAGC
TATTGCATCTATGGAAGGTGGAGCAACAGGACTTGCAACAATAAATACTATAAAAAGCATAACTGGTATTGATATAAATT
CAATGACAGCAAAGCCAGTAGTTAATGCTAAGTCATCTGTTTCAGGTTATTCAGGAAAGGCTGTAAAACCAATAGCTTTA
AGATTTATTTATGAACTTGCTAAGAATGAAAAATTAAAAGGTGTTCCTATAAGTGGGATTGGTGGAATAGAAACATGGGA
AGATGCTTTAGAATTTATATTATTAGGTTCAAGTAATCTTCAAGTTACTACTTCAGTAATGCAATATGGATATAGAGTAG
TAGAAGATATGATAAGTGGATTATCTCACTTCATGGATGAAAATGGATTTGAAAAGTTAGAAGATATGGTTGGAATAGCT
ATTAAAAATATTATTCCAGCTGAAGATTTAGATAGAGAATATATAGTTTATCCAAAAGTTGATGAAGAAAAATGTTTAGG
CTGTGGTAGATGTTACATTTCATGTTATGATGGTGCTCATCAAGCTATAAAATGGAATGCTGAAGAAAGAAAGCCGGAAG
TAAATAAAGATAGATGTGTTGGATGTCATTTATGTGCACTTGTATGTCCAGTTACAGCTATAGGCAAAGGTGAAATAAAA
TTCAAAAATAATGGAAAAGAAAGAGAAATAATTCTATAA

Upstream 100 bases:

>100_bases
TAGTTGAAGGTGATAAAACAGTTGTTTATGCACTTAAATTAGGAAAAGAAGCAGCAGAGAAAGTAGATCAATATTTAAAC
GAGAAAGAAGGTGCTAGATA

Downstream 100 bases:

>100_bases
ATTTCTTAATTATTCATTTATAATAATAGCTGTGTTAAAAATCCTTAAGATTAAACACAGCTATTTTTATAATTAAGTTG
TGTTTTAAATATGTGTTTAC

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSIIKDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKAFEAGWGGVMFKTIGFFMPNEVSPRFDSLRKEATSFVGFKNMEQ
ISDHPLQQNLDDLRRLKENYPTKIVVASIMGENEKEWEDLAKLVTEAGADMIECNFSCPQMTSHEMGSDVGQNPELVKKY
CEATRRGTNLPILAKMTPNIGDMSVPAIASMEGGATGLATINTIKSITGIDINSMTAKPVVNAKSSVSGYSGKAVKPIAL
RFIYELAKNEKLKGVPISGIGGIETWEDALEFILLGSSNLQVTTSVMQYGYRVVEDMISGLSHFMDENGFEKLEDMVGIA
IKNIIPAEDLDREYIVYPKVDEEKCLGCGRCYISCYDGAHQAIKWNAEERKPEVNKDRCVGCHLCALVCPVTAIGKGEIK
FKNNGKEREIIL

Sequences:

>Translated_412_residues
MSIIKDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKAFEAGWGGVMFKTIGFFMPNEVSPRFDSLRKEATSFVGFKNMEQ
ISDHPLQQNLDDLRRLKENYPTKIVVASIMGENEKEWEDLAKLVTEAGADMIECNFSCPQMTSHEMGSDVGQNPELVKKY
CEATRRGTNLPILAKMTPNIGDMSVPAIASMEGGATGLATINTIKSITGIDINSMTAKPVVNAKSSVSGYSGKAVKPIAL
RFIYELAKNEKLKGVPISGIGGIETWEDALEFILLGSSNLQVTTSVMQYGYRVVEDMISGLSHFMDENGFEKLEDMVGIA
IKNIIPAEDLDREYIVYPKVDEEKCLGCGRCYISCYDGAHQAIKWNAEERKPEVNKDRCVGCHLCALVCPVTAIGKGEIK
FKNNGKEREIIL
>Mature_411_residues
SIIKDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKAFEAGWGGVMFKTIGFFMPNEVSPRFDSLRKEATSFVGFKNMEQI
SDHPLQQNLDDLRRLKENYPTKIVVASIMGENEKEWEDLAKLVTEAGADMIECNFSCPQMTSHEMGSDVGQNPELVKKYC
EATRRGTNLPILAKMTPNIGDMSVPAIASMEGGATGLATINTIKSITGIDINSMTAKPVVNAKSSVSGYSGKAVKPIALR
FIYELAKNEKLKGVPISGIGGIETWEDALEFILLGSSNLQVTTSVMQYGYRVVEDMISGLSHFMDENGFEKLEDMVGIAI
KNIIPAEDLDREYIVYPKVDEEKCLGCGRCYISCYDGAHQAIKWNAEERKPEVNKDRCVGCHLCALVCPVTAIGKGEIKF
KNNGKEREIIL

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=322, Percent_Identity=35.4037267080745, Blast_Score=192, Evalue=4e-49,
Organism=Escherichia coli, GI87082059, Length=410, Percent_Identity=68.0487804878049, Blast_Score=613, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI71984108, Length=325, Percent_Identity=38.4615384615385, Blast_Score=208, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6322633, Length=228, Percent_Identity=27.1929824561404, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640763, Length=310, Percent_Identity=39.0322580645161, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI18858217, Length=310, Percent_Identity=39.0322580645161, Blast_Score=202, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 45408; Mature: 45277

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIIKDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKAFEAGWGGVMFKTIGFFMPNEVSP
CCCHHHCCEEEECEEECCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCH
RFDSLRKEATSFVGFKNMEQISDHPLQQNLDDLRRLKENYPTKIVVASIMGENEKEWEDL
HHHHHHHHHHHHHCCCCHHHHHCCCHHCCHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHH
AKLVTEAGADMIECNFSCPQMTSHEMGSDVGQNPELVKKYCEATRRGTNLPILAKMTPNI
HHHHHHCCCCEEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCC
GDMSVPAIASMEGGATGLATINTIKSITGIDINSMTAKPVVNAKSSVSGYSGKAVKPIAL
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
RFIYELAKNEKLKGVPISGIGGIETWEDALEFILLGSSNLQVTTSVMQYGYRVVEDMISG
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHEEEECCCCCEEHHHHHHHHHHHHHHHHHH
LSHFMDENGFEKLEDMVGIAIKNIIPAEDLDREYIVYPKVDEEKCLGCGRCYISCYDGAH
HHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHCCCCCEEEEEECCCC
QAIKWNAEERKPEVNKDRCVGCHLCALVCPVTAIGKGEIKFKNNGKEREIIL
HHEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
SIIKDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKAFEAGWGGVMFKTIGFFMPNEVSP
CCHHHCCEEEECEEECCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCH
RFDSLRKEATSFVGFKNMEQISDHPLQQNLDDLRRLKENYPTKIVVASIMGENEKEWEDL
HHHHHHHHHHHHHCCCCHHHHHCCCHHCCHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHH
AKLVTEAGADMIECNFSCPQMTSHEMGSDVGQNPELVKKYCEATRRGTNLPILAKMTPNI
HHHHHHCCCCEEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCC
GDMSVPAIASMEGGATGLATINTIKSITGIDINSMTAKPVVNAKSSVSGYSGKAVKPIAL
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
RFIYELAKNEKLKGVPISGIGGIETWEDALEFILLGSSNLQVTTSVMQYGYRVVEDMISG
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHEEEECCCCCEEHHHHHHHHHHHHHHHHHH
LSHFMDENGFEKLEDMVGIAIKNIIPAEDLDREYIVYPKVDEEKCLGCGRCYISCYDGAH
HHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHCCCCCEEEEEECCCC
QAIKWNAEERKPEVNKDRCVGCHLCALVCPVTAIGKGEIKFKNNGKEREIIL
HHEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]