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The map label for this gene is yugH [H]

Identifier: 187934957

GI number: 187934957

Start: 2588136

End: 2589275

Strand: Reverse

Name: yugH [H]

Synonym: CLL_A2495

Alternate gene names: 187934957

Gene position: 2589275-2588136 (Counterclockwise)

Preceding gene: 187935425

Following gene: 187932806

Centisome position: 68.13

GC content: 28.16

Gene sequence:

>1140_bases
ATGAATAATAGAGTAGAAAAAATACAAATTTCAGGAATAAGAAGATTTTACGAAAAAGTTCAAAAAGTTGAAGGGGCCAT
ATCTCTAACAATAGGGCAACCAGATTTTAACGTTCCAATTGATATAAAGAAGGCAATGATAGCTGCAATAGAACAAGATA
AAACCACTTACACTTCTAATTCTGGTATTGAATCTTTAAGATCGGAAATTAGCAAGTATTTAAAGAATTTTAATATTAAT
TATAATAAGGATGAAATATGTATAACGGTTGGTGGTAGTGAAGGCTTATATTCAGTATTATCTGCAATCCTTAATGAAGG
GGATAAAGTATTAATACCCTCTCCTGCATATCCAGCTTATGAAAGTATATCTAATATAATAGGGGCAGATGTAATAAATT
ATTCATTAAACGATGATTTTACATTAAATATAGATGAGGTTAGAAAAAAAATAAAAGCGAAAAAAGTTAAATATTTATTG
ATTTCTTTTCCGTCTAATCCAACTGGTGCGATATTATCTGAAAAAAATAAGAGTGAGTTAATAAAACTTATAAAAGAAAA
TGATATTACTGTAATAACTGATGAAATGTATTCAGCCATAATATTTGATGAATATAATTCTGTTGCTCAAGATGATGAAA
TACTAGATAAAGTTATATACGTAAGTGGATTTTCAAAAATATTTTCAATGACTGGACTTAGAATAGGATATGTTGCATGT
AAAAGTAAGTTTATGAAAGAAATAATGAAAGTACATCAATATGCTGTTTCTTGTGCTCCGTCTATAGTACAATGGGGTGC
TTTAGAAGGATTAAAAAAATCACTTGATGATGTTGAAGTTATGAAAAAATCTTTTAAATTGAGAAAGGAGTATTGCATTA
AGAGGTTGAAGGATATGGGGATAGAAGTAGTTGATCCTAAAGGTGCTTTTTATATATTCCCTTCTATTAAAAAGTTTAAT
ATGACATCAGAAGAATTTTGTACTCGACTTTTAAATGAAGAAAAATTAGCTTGTGTTCCAGGAGATGCTTTTGGAACTTT
AGGTGAAGGGTATATGAGAATATCTTATTGTTATAGTGAAGAAGTTTTATGCGAGGCTTTTAATAGATTGGAGAAATTTA
TTAAAAAAATTGCTAAATAA

Upstream 100 bases:

>100_bases
GTTGAACATATTATATTAATAATTAAAGCAATATATTATAATTACAATATTTTGATAAGCAATAATACAAATATATTTTA
AATAAAAAGGAAGATTAATT

Downstream 100 bases:

>100_bases
TTTAAAATTTAAATAACAATAAGGTTTTTATGTATATAAAATAAATTACTTAAAGAAACACTTTATTATAGGTTAAACAA
GTATTTATAGTTGTTTAAAA

Product: aminotransferase A

Products: N-succinyl-2-L-amino-6-oxoheptanedioate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MNNRVEKIQISGIRRFYEKVQKVEGAISLTIGQPDFNVPIDIKKAMIAAIEQDKTTYTSNSGIESLRSEISKYLKNFNIN
YNKDEICITVGGSEGLYSVLSAILNEGDKVLIPSPAYPAYESISNIIGADVINYSLNDDFTLNIDEVRKKIKAKKVKYLL
ISFPSNPTGAILSEKNKSELIKLIKENDITVITDEMYSAIIFDEYNSVAQDDEILDKVIYVSGFSKIFSMTGLRIGYVAC
KSKFMKEIMKVHQYAVSCAPSIVQWGALEGLKKSLDDVEVMKKSFKLRKEYCIKRLKDMGIEVVDPKGAFYIFPSIKKFN
MTSEEFCTRLLNEEKLACVPGDAFGTLGEGYMRISYCYSEEVLCEAFNRLEKFIKKIAK

Sequences:

>Translated_379_residues
MNNRVEKIQISGIRRFYEKVQKVEGAISLTIGQPDFNVPIDIKKAMIAAIEQDKTTYTSNSGIESLRSEISKYLKNFNIN
YNKDEICITVGGSEGLYSVLSAILNEGDKVLIPSPAYPAYESISNIIGADVINYSLNDDFTLNIDEVRKKIKAKKVKYLL
ISFPSNPTGAILSEKNKSELIKLIKENDITVITDEMYSAIIFDEYNSVAQDDEILDKVIYVSGFSKIFSMTGLRIGYVAC
KSKFMKEIMKVHQYAVSCAPSIVQWGALEGLKKSLDDVEVMKKSFKLRKEYCIKRLKDMGIEVVDPKGAFYIFPSIKKFN
MTSEEFCTRLLNEEKLACVPGDAFGTLGEGYMRISYCYSEEVLCEAFNRLEKFIKKIAK
>Mature_379_residues
MNNRVEKIQISGIRRFYEKVQKVEGAISLTIGQPDFNVPIDIKKAMIAAIEQDKTTYTSNSGIESLRSEISKYLKNFNIN
YNKDEICITVGGSEGLYSVLSAILNEGDKVLIPSPAYPAYESISNIIGADVINYSLNDDFTLNIDEVRKKIKAKKVKYLL
ISFPSNPTGAILSEKNKSELIKLIKENDITVITDEMYSAIIFDEYNSVAQDDEILDKVIYVSGFSKIFSMTGLRIGYVAC
KSKFMKEIMKVHQYAVSCAPSIVQWGALEGLKKSLDDVEVMKKSFKLRKEYCIKRLKDMGIEVVDPKGAFYIFPSIKKFN
MTSEEFCTRLLNEEKLACVPGDAFGTLGEGYMRISYCYSEEVLCEAFNRLEKFIKKIAK

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=333, Percent_Identity=22.8228228228228, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI169881279, Length=333, Percent_Identity=22.8228228228228, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI4507369, Length=372, Percent_Identity=24.4623655913978, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI56713254, Length=363, Percent_Identity=23.6914600550964, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI56713256, Length=376, Percent_Identity=23.6702127659574, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI19263340, Length=371, Percent_Identity=23.7196765498652, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI215599424, Length=342, Percent_Identity=24.2690058479532, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI7705897, Length=410, Percent_Identity=25.1219512195122, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI33469970, Length=410, Percent_Identity=25.1219512195122, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI169881281, Length=244, Percent_Identity=22.5409836065574, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI187936925, Length=367, Percent_Identity=22.6158038147139, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI14211921, Length=367, Percent_Identity=22.6158038147139, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI149944424, Length=304, Percent_Identity=22.3684210526316, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1788722, Length=371, Percent_Identity=28.3018867924528, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1786816, Length=357, Percent_Identity=23.5294117647059, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1788627, Length=360, Percent_Identity=25.5555555555556, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1787710, Length=347, Percent_Identity=23.0547550432277, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790797, Length=239, Percent_Identity=23.4309623430962, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=398, Percent_Identity=24.3718592964824, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71994472, Length=398, Percent_Identity=24.3718592964824, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17567663, Length=367, Percent_Identity=22.6158038147139, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17567369, Length=365, Percent_Identity=24.6575342465753, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71981209, Length=372, Percent_Identity=21.505376344086, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71981215, Length=161, Percent_Identity=26.7080745341615, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322401, Length=379, Percent_Identity=23.7467018469657, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320317, Length=352, Percent_Identity=24.4318181818182, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323118, Length=368, Percent_Identity=25.8152173913043, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI18859735, Length=372, Percent_Identity=25, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28573069, Length=393, Percent_Identity=23.9185750636132, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24646114, Length=393, Percent_Identity=23.9185750636132, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28573067, Length=393, Percent_Identity=23.9185750636132, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28573065, Length=393, Percent_Identity=23.9185750636132, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45551451, Length=367, Percent_Identity=27.5204359673025, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24641770, Length=367, Percent_Identity=27.5204359673025, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24641760, Length=367, Percent_Identity=27.5204359673025, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24641768, Length=367, Percent_Identity=27.5204359673025, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24641766, Length=367, Percent_Identity=27.5204359673025, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24641764, Length=367, Percent_Identity=27.5204359673025, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356535, Length=346, Percent_Identity=24.5664739884393, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.17

Molecular weight: Translated: 42826; Mature: 42826

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNRVEKIQISGIRRFYEKVQKVEGAISLTIGQPDFNVPIDIKKAMIAAIEQDKTTYTSN
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCC
SGIESLRSEISKYLKNFNINYNKDEICITVGGSEGLYSVLSAILNEGDKVLIPSPAYPAY
CCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCHH
ESISNIIGADVINYSLNDDFTLNIDEVRKKIKAKKVKYLLISFPSNPTGAILSEKNKSEL
HHHHHHHHHHHEEEECCCCEEEEHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCHHHH
IKLIKENDITVITDEMYSAIIFDEYNSVAQDDEILDKVIYVSGFSKIFSMTGLRIGYVAC
HHHHHCCCCEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
KSKFMKEIMKVHQYAVSCAPSIVQWGALEGLKKSLDDVEVMKKSFKLRKEYCIKRLKDMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IEVVDPKGAFYIFPSIKKFNMTSEEFCTRLLNEEKLACVPGDAFGTLGEGYMRISYCYSE
CEEECCCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEECCCCHHHCCCCCEEEEEEEHHH
EVLCEAFNRLEKFIKKIAK
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNNRVEKIQISGIRRFYEKVQKVEGAISLTIGQPDFNVPIDIKKAMIAAIEQDKTTYTSN
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCC
SGIESLRSEISKYLKNFNINYNKDEICITVGGSEGLYSVLSAILNEGDKVLIPSPAYPAY
CCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCHH
ESISNIIGADVINYSLNDDFTLNIDEVRKKIKAKKVKYLLISFPSNPTGAILSEKNKSEL
HHHHHHHHHHHEEEECCCCEEEEHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCHHHH
IKLIKENDITVITDEMYSAIIFDEYNSVAQDDEILDKVIYVSGFSKIFSMTGLRIGYVAC
HHHHHCCCCEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
KSKFMKEIMKVHQYAVSCAPSIVQWGALEGLKKSLDDVEVMKKSFKLRKEYCIKRLKDMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IEVVDPKGAFYIFPSIKKFNMTSEEFCTRLLNEEKLACVPGDAFGTLGEGYMRISYCYSE
CEEECCCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEECCCCHHHCCCCCEEEEEEEHHH
EVLCEAFNRLEKFIKKIAK
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-succinyl-L-2,6-diaminoheptanedioate; 2-oxoglutarate

Specific reaction: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2-L-amino-6-oxoheptanedioate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377 [H]