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The map label for this gene is ilvB [H]

Identifier: 187934917

GI number: 187934917

Start: 2412353

End: 2414155

Strand: Reverse

Name: ilvB [H]

Synonym: CLL_A2334

Alternate gene names: 187934917

Gene position: 2414155-2412353 (Counterclockwise)

Preceding gene: 187933918

Following gene: 187935443

Centisome position: 63.52

GC content: 31.06

Gene sequence:

>1803_bases
ATGATTAAATTATCAGACTATGTATTTAAATTTATAGAAGAAAAAATGGTTAAACATGCATTTCTTTTGCCAGGTGGTGG
AGCAATGCATTTAATTGATTCAATAGGAAAATCTAAAATAGAATATATATGTTGTGGACATGAACAAGCAGCAGCAATTG
CAGCTGAAAGTTATGGACAACATACAAATAATATTGGTGTAGTATTAGTTACATCAGGACCAGGTGCTACTAATGCAATT
ACTGGGGTTACAGCTGGTTGGATTGATTCAACTCCTATGCTTGTAATATCTGGACAAGCAAAACGTTCTGATTTGGTTGG
TAAAACTGGTGTTAGGCAAATGGGTTCGCAAGAGGTTCAAATAATTGAAATGATAAAACCTATTACAAAATATGCAGTGC
AAGTATTAGAACCGATGAAAATCAAATATTATTTGGAAAAGGCATATTGTGAAGCAACAACTGGAAGAATGGGACCAGTA
TGGTTGGATATTCCTGTTGATGTTCAAGCTGCTATGATTGATGAAGAAAAGCTTGAAGGGTATTATGACAAAAGTTCTAG
TGAATATAAATTGGATATTTCTAAAGAAATAGGAGAAACCTTAGAATTATTAAAAAATTCTAAGAAACCATTGATACTAG
CTGGTAATGGAATTAAGCTTGCAAGAGCAGAAAATAATTTTTATCAGCTTATTAATAAATTACAGATACCGGTATTAACT
ACTTGGAAAGCAATAGATATGTTAGATGAAAAGGATCCATTATATGCAGGACATCCTGGAATAATGGGAGATAGAGGAGC
TAACTTTATTCTTCAAAGCAGTGATTTATTACTTATTCTAGGAAGCAGGCTTGATACTAGTATTACAGCTTTTAATCATA
AAAACTTTGGAAAAAGTGCACAAAAAGTTATGGTTGATATTGATAAAAATGAAATTAATAAAATGCAAATGAATATAGAT
GTTAAGGTGGTTTGTAATGTTAAATATTTTATTGATGTATTAAATGAAAATAGCAGTGAGTTAATTAATAATTTAAGTAA
TAAGGAAATAAAGGAAAAAGAAAAGTGGCTATCTTATAGCAGGGATATAAGAGCTAAATATCCTTTAGTTACAAAAGAAC
ATAACGAGGTTAAAGATTATGTTAGTGCATACTGCTTTATTGATGAATTATGTAAACAATTAAATTGCGATGATATTATA
GTTCCAGAAAGTTCAGGTGGAGCGGGAGAAATTACATATCAAGCATTTAAGATAAAAAAAGGTCAAAAAATGAAAAATGC
AGCAGGTCTTGGATCAATGGGATTCGGGTTACCTTATTCTATAGGCGCATGTCTTGCAAATGATAGAAGAAGAACCATAT
TAATAAATGGTGATGGGGCATTTCAATTAAATATTCAAGAATTAGAGACTTTAAAAAGATTACAATTACCAATAAAAATA
TTTATATGGAATAACAATGGTTATGCAAGCATAAGGGCTATGCAGAGAAATACATTTAATGGATATTATGTAGCAAGTGA
TGAAGGAAGTGGCTTAACAATGCCTAGTATAAGCAAAATTGCAAGTGCCTATGGAATTAAAACATTTAGGGTTAAGAATA
ATGATGAGATGAAGTATATTTTACCGCAAGTATTAGAATCAGAAGGAACAGTATTGTGCGAATTGATGGTCTTACCAGAA
GAAACAGTATCTCCTAGAATTAAATCTATTAAATTAGAGGATGGAAATATGATTTCTAAGCCTTTAGAGGACATGTGGCC
GTTTATGGATGAGGCGGAAATTAAATGTAATTTGAAAATTTGA

Upstream 100 bases:

>100_bases
AGAAAATCTTTGATTGCCATGGGAATATTAGGGAATTTTTGTGAAATAAATCATGGTAAGTTTAAATATTTTATCCAAAA
GTGAGAAGAAAGGAAAATGT

Downstream 100 bases:

>100_bases
TAAATATATAAGGAGAATTTATGGAAAAAGAGAAAATAATAAATAATTTGCTAAAAAAATTTATAGGCTCTAAATTGATT
ATTCTTTTTGGAGCTGGAAG

Product: thiamine pyrophosphate enzyme TPP binding domain protein

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS; Vegetative protein 105; VEG105 [H]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MIKLSDYVFKFIEEKMVKHAFLLPGGGAMHLIDSIGKSKIEYICCGHEQAAAIAAESYGQHTNNIGVVLVTSGPGATNAI
TGVTAGWIDSTPMLVISGQAKRSDLVGKTGVRQMGSQEVQIIEMIKPITKYAVQVLEPMKIKYYLEKAYCEATTGRMGPV
WLDIPVDVQAAMIDEEKLEGYYDKSSSEYKLDISKEIGETLELLKNSKKPLILAGNGIKLARAENNFYQLINKLQIPVLT
TWKAIDMLDEKDPLYAGHPGIMGDRGANFILQSSDLLLILGSRLDTSITAFNHKNFGKSAQKVMVDIDKNEINKMQMNID
VKVVCNVKYFIDVLNENSSELINNLSNKEIKEKEKWLSYSRDIRAKYPLVTKEHNEVKDYVSAYCFIDELCKQLNCDDII
VPESSGGAGEITYQAFKIKKGQKMKNAAGLGSMGFGLPYSIGACLANDRRRTILINGDGAFQLNIQELETLKRLQLPIKI
FIWNNNGYASIRAMQRNTFNGYYVASDEGSGLTMPSISKIASAYGIKTFRVKNNDEMKYILPQVLESEGTVLCELMVLPE
ETVSPRIKSIKLEDGNMISKPLEDMWPFMDEAEIKCNLKI

Sequences:

>Translated_600_residues
MIKLSDYVFKFIEEKMVKHAFLLPGGGAMHLIDSIGKSKIEYICCGHEQAAAIAAESYGQHTNNIGVVLVTSGPGATNAI
TGVTAGWIDSTPMLVISGQAKRSDLVGKTGVRQMGSQEVQIIEMIKPITKYAVQVLEPMKIKYYLEKAYCEATTGRMGPV
WLDIPVDVQAAMIDEEKLEGYYDKSSSEYKLDISKEIGETLELLKNSKKPLILAGNGIKLARAENNFYQLINKLQIPVLT
TWKAIDMLDEKDPLYAGHPGIMGDRGANFILQSSDLLLILGSRLDTSITAFNHKNFGKSAQKVMVDIDKNEINKMQMNID
VKVVCNVKYFIDVLNENSSELINNLSNKEIKEKEKWLSYSRDIRAKYPLVTKEHNEVKDYVSAYCFIDELCKQLNCDDII
VPESSGGAGEITYQAFKIKKGQKMKNAAGLGSMGFGLPYSIGACLANDRRRTILINGDGAFQLNIQELETLKRLQLPIKI
FIWNNNGYASIRAMQRNTFNGYYVASDEGSGLTMPSISKIASAYGIKTFRVKNNDEMKYILPQVLESEGTVLCELMVLPE
ETVSPRIKSIKLEDGNMISKPLEDMWPFMDEAEIKCNLKI
>Mature_600_residues
MIKLSDYVFKFIEEKMVKHAFLLPGGGAMHLIDSIGKSKIEYICCGHEQAAAIAAESYGQHTNNIGVVLVTSGPGATNAI
TGVTAGWIDSTPMLVISGQAKRSDLVGKTGVRQMGSQEVQIIEMIKPITKYAVQVLEPMKIKYYLEKAYCEATTGRMGPV
WLDIPVDVQAAMIDEEKLEGYYDKSSSEYKLDISKEIGETLELLKNSKKPLILAGNGIKLARAENNFYQLINKLQIPVLT
TWKAIDMLDEKDPLYAGHPGIMGDRGANFILQSSDLLLILGSRLDTSITAFNHKNFGKSAQKVMVDIDKNEINKMQMNID
VKVVCNVKYFIDVLNENSSELINNLSNKEIKEKEKWLSYSRDIRAKYPLVTKEHNEVKDYVSAYCFIDELCKQLNCDDII
VPESSGGAGEITYQAFKIKKGQKMKNAAGLGSMGFGLPYSIGACLANDRRRTILINGDGAFQLNIQELETLKRLQLPIKI
FIWNNNGYASIRAMQRNTFNGYYVASDEGSGLTMPSISKIASAYGIKTFRVKNNDEMKYILPQVLESEGTVLCELMVLPE
ETVSPRIKSIKLEDGNMISKPLEDMWPFMDEAEIKCNLKI

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=545, Percent_Identity=24.4036697247706, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI21361361, Length=564, Percent_Identity=22.1631205673759, Blast_Score=113, Evalue=5e-25,
Organism=Escherichia coli, GI1790104, Length=566, Percent_Identity=28.9752650176678, Blast_Score=238, Evalue=9e-64,
Organism=Escherichia coli, GI87081685, Length=594, Percent_Identity=27.2727272727273, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1786717, Length=547, Percent_Identity=27.2394881170018, Blast_Score=165, Evalue=9e-42,
Organism=Escherichia coli, GI1788716, Length=539, Percent_Identity=25.417439703154, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1787096, Length=581, Percent_Identity=22.7194492254733, Blast_Score=109, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17531299, Length=460, Percent_Identity=26.9565217391304, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17531301, Length=460, Percent_Identity=26.9565217391304, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17542570, Length=579, Percent_Identity=21.9343696027634, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323755, Length=582, Percent_Identity=27.319587628866, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320816, Length=507, Percent_Identity=24.4575936883629, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321524, Length=512, Percent_Identity=25.1953125, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320123, Length=526, Percent_Identity=21.6730038022814, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6323073, Length=515, Percent_Identity=23.3009708737864, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323163, Length=507, Percent_Identity=23.6686390532544, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320588, Length=535, Percent_Identity=21.6822429906542, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19922626, Length=480, Percent_Identity=25.4166666666667, Blast_Score=152, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 66915; Mature: 66915

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLSDYVFKFIEEKMVKHAFLLPGGGAMHLIDSIGKSKIEYICCGHEQAAAIAAESYGQ
CCCCHHHHHHHHHHHHHHHEEECCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCC
HTNNIGVVLVTSGPGATNAITGVTAGWIDSTPMLVISGQAKRSDLVGKTGVRQMGSQEVQ
CCCCEEEEEEECCCCCCCCCCCCEECCCCCCCEEEEECCCCHHCCCCCHHHHHCCCCHHH
IIEMIKPITKYAVQVLEPMKIKYYLEKAYCEATTGRMGPVWLDIPVDVQAAMIDEEKLEG
HHHHHHHHHHHHHHHHCCHHHEEEHHHHHHHHCCCCCCCEEEECCCCCEEEECCHHHHCC
YYDKSSSEYKLDISKEIGETLELLKNSKKPLILAGNGIKLARAENNFYQLINKLQIPVLT
CCCCCCCCEEEEEHHHHHHHHHHHHCCCCCEEEECCCEEEEECCCHHHHHHHHCCCCEEE
TWKAIDMLDEKDPLYAGHPGIMGDRGANFILQSSDLLLILGSRLDTSITAFNHKNFGKSA
CHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCEEEEECCCCCCCCC
QKVMVDIDKNEINKMQMNIDVKVVCNVKYFIDVLNENSSELINNLSNKEIKEKEKWLSYS
EEEEEEECCCCCCEEEEEEEEEEEEEHEEEHHHHCCCHHHHHHCCCCHHHHHHHHHHHHC
RDIRAKYPLVTKEHNEVKDYVSAYCFIDELCKQLNCDDIIVPESSGGAGEITYQAFKIKK
CCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEEECC
GQKMKNAAGLGSMGFGLPYSIGACLANDRRRTILINGDGAFQLNIQELETLKRLQLPIKI
CCCHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCEEEEEHHHHHHHHHHCCCEEE
FIWNNNGYASIRAMQRNTFNGYYVASDEGSGLTMPSISKIASAYGIKTFRVKNNDEMKYI
EEECCCCEEEEEEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHCEEEEEECCCCCHHHH
LPQVLESEGTVLCELMVLPEETVSPRIKSIKLEDGNMISKPLEDMWPFMDEAEIKCNLKI
HHHHHCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHCCCCCCCEEEEEEEC
>Mature Secondary Structure
MIKLSDYVFKFIEEKMVKHAFLLPGGGAMHLIDSIGKSKIEYICCGHEQAAAIAAESYGQ
CCCCHHHHHHHHHHHHHHHEEECCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCC
HTNNIGVVLVTSGPGATNAITGVTAGWIDSTPMLVISGQAKRSDLVGKTGVRQMGSQEVQ
CCCCEEEEEEECCCCCCCCCCCCEECCCCCCCEEEEECCCCHHCCCCCHHHHHCCCCHHH
IIEMIKPITKYAVQVLEPMKIKYYLEKAYCEATTGRMGPVWLDIPVDVQAAMIDEEKLEG
HHHHHHHHHHHHHHHHCCHHHEEEHHHHHHHHCCCCCCCEEEECCCCCEEEECCHHHHCC
YYDKSSSEYKLDISKEIGETLELLKNSKKPLILAGNGIKLARAENNFYQLINKLQIPVLT
CCCCCCCCEEEEEHHHHHHHHHHHHCCCCCEEEECCCEEEEECCCHHHHHHHHCCCCEEE
TWKAIDMLDEKDPLYAGHPGIMGDRGANFILQSSDLLLILGSRLDTSITAFNHKNFGKSA
CHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCEEEEECCCCCCCCC
QKVMVDIDKNEINKMQMNIDVKVVCNVKYFIDVLNENSSELINNLSNKEIKEKEKWLSYS
EEEEEEECCCCCCEEEEEEEEEEEEEHEEEHHHHCCCHHHHHHCCCCHHHHHHHHHHHHC
RDIRAKYPLVTKEHNEVKDYVSAYCFIDELCKQLNCDDIIVPESSGGAGEITYQAFKIKK
CCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEEECC
GQKMKNAAGLGSMGFGLPYSIGACLANDRRRTILINGDGAFQLNIQELETLKRLQLPIKI
CCCHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCEEEEEHHHHHHHHHHCCCEEE
FIWNNNGYASIRAMQRNTFNGYYVASDEGSGLTMPSISKIASAYGIKTFRVKNNDEMKYI
EEECCCCEEEEEEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHCEEEEEECCCCCHHHH
LPQVLESEGTVLCELMVLPEETVSPRIKSIKLEDGNMISKPLEDMWPFMDEAEIKCNLKI
HHHHHCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 1577690; 9298659 [H]