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The map label for this gene is dhaT [H]

Identifier: 187934841

GI number: 187934841

Start: 2194226

End: 2195383

Strand: Reverse

Name: dhaT [H]

Synonym: CLL_A2098

Alternate gene names: 187934841

Gene position: 2195383-2194226 (Counterclockwise)

Preceding gene: 187933018

Following gene: 187935597

Centisome position: 57.77

GC content: 34.72

Gene sequence:

>1158_bases
ATGAGAATGTACGATTATTTAGTACCAAGTGTTAACTTTATGGGCGCTGGATGTGTAAAATTAGTAGGAGAAAGATGTCA
AATATTAGGCGGAAAAAAAGCTTTAATAGTAACAGATAAATTTTTAAGAAGCATGGAAGGTGGAGCAGTAGAATTAACTG
TTAAATCATTACAAGAAGCTGGAATAGAAGTTGCATACTATGATGCAGTTGAACCAAATCCAAAAGATACAAACGTTGCT
GATGGATTAAAAATATTCCAAGACGAAAAATGCGATATGATAGTTACAGTTGGAGGCGGAAGTGCTCATGACTGTGGTAA
AGGTATTGGTATAGTTGCTACTCATGAAGGAGATCTTTATGAATATGCTGGAATAGAAACTTTAACTAAAGCTCTTCCAC
CAATCGTTGCAGTTAATACTACAGCTGGAACAGCAAGTGAAGTTACAAGACATTGTGTTATAACTAACACTAAAACTAAA
GTTAAATATGTTATAGTTAGCTGGAGAAACTTACCATTAGCTTCATTCAACGATCCAGAATTAATGGTTAAAAAACCTGC
TGGTTTAACAGCTGCTACAGGAATGGATGCATTAACTCATGCTATCGAAGCTTATGTATCAAAAGATGCAAACCCTGTAA
CTGATGCTGCTGCTATACAAGCAATAAAATTAATATCAAACAATTTAAGACAGGCGGTTGCTTTAGGTGAAAACTTAGTA
GCAAGAGAAAACATGGCATACGGTTCATTATTAGCTGGTATGGCATTCAACAACGCTAACTTAGGATATGTTCATGCTAT
GGCTCACCAATTAGGTGGATTATACGATATGCCACATGGAGTAGCTAATGCTATGCTTCTTCCACATGTTGAAAAATACA
ACTTAATCTCAAACCCACAAAAATTTGCTGATATAGCAGAATTCATGGGAGAAAACATACAAGGATTATCAGTTATGGAA
GCAGCAGAAAAAGCTATAGATGCTATGTTCAGACTTTCAACTGATATCGGAATTCCTACAAGCTTAAAAGAAATGGGAAT
AAAAGAAGAAGATTTCCAATATATGGCTGAAATGGCATTAAAAGATGGAAATGCATTCAGTAACCCAAGAAAAGGAAATG
AAAAAGATATAGTTGCAATATTTAAAGCTGCATTTTAA

Upstream 100 bases:

>100_bases
TATTTTAAATTTAAATATTTATATTATTAATAATGTAGATATATTTTAAATTAATATATTAAAGATTAAATATATGATTA
ACCAATAGGAGGAATTTACA

Downstream 100 bases:

>100_bases
GATAATTAAAAAGTAGATTAATACATAACTATTATTAGAACCCCTTTACATTTAAAGGGGTTCTTTAAATGAAATTATAT
AAATTCATAAGATAAATTAA

Product: 1,3-propanediol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MRMYDYLVPSVNFMGAGCVKLVGERCQILGGKKALIVTDKFLRSMEGGAVELTVKSLQEAGIEVAYYDAVEPNPKDTNVA
DGLKIFQDEKCDMIVTVGGGSAHDCGKGIGIVATHEGDLYEYAGIETLTKALPPIVAVNTTAGTASEVTRHCVITNTKTK
VKYVIVSWRNLPLASFNDPELMVKKPAGLTAATGMDALTHAIEAYVSKDANPVTDAAAIQAIKLISNNLRQAVALGENLV
ARENMAYGSLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAMLLPHVEKYNLISNPQKFADIAEFMGENIQGLSVME
AAEKAIDAMFRLSTDIGIPTSLKEMGIKEEDFQYMAEMALKDGNAFSNPRKGNEKDIVAIFKAAF

Sequences:

>Translated_385_residues
MRMYDYLVPSVNFMGAGCVKLVGERCQILGGKKALIVTDKFLRSMEGGAVELTVKSLQEAGIEVAYYDAVEPNPKDTNVA
DGLKIFQDEKCDMIVTVGGGSAHDCGKGIGIVATHEGDLYEYAGIETLTKALPPIVAVNTTAGTASEVTRHCVITNTKTK
VKYVIVSWRNLPLASFNDPELMVKKPAGLTAATGMDALTHAIEAYVSKDANPVTDAAAIQAIKLISNNLRQAVALGENLV
ARENMAYGSLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAMLLPHVEKYNLISNPQKFADIAEFMGENIQGLSVME
AAEKAIDAMFRLSTDIGIPTSLKEMGIKEEDFQYMAEMALKDGNAFSNPRKGNEKDIVAIFKAAF
>Mature_385_residues
MRMYDYLVPSVNFMGAGCVKLVGERCQILGGKKALIVTDKFLRSMEGGAVELTVKSLQEAGIEVAYYDAVEPNPKDTNVA
DGLKIFQDEKCDMIVTVGGGSAHDCGKGIGIVATHEGDLYEYAGIETLTKALPPIVAVNTTAGTASEVTRHCVITNTKTK
VKYVIVSWRNLPLASFNDPELMVKKPAGLTAATGMDALTHAIEAYVSKDANPVTDAAAIQAIKLISNNLRQAVALGENLV
ARENMAYGSLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAMLLPHVEKYNLISNPQKFADIAEFMGENIQGLSVME
AAEKAIDAMFRLSTDIGIPTSLKEMGIKEEDFQYMAEMALKDGNAFSNPRKGNEKDIVAIFKAAF

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=409, Percent_Identity=26.6503667481663, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI48994951, Length=385, Percent_Identity=47.7922077922078, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1789163, Length=375, Percent_Identity=42.4, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI87082107, Length=385, Percent_Identity=35.3246753246753, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1787493, Length=399, Percent_Identity=32.8320802005013, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1789386, Length=358, Percent_Identity=24.5810055865922, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17537053, Length=392, Percent_Identity=23.469387755102, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321181, Length=382, Percent_Identity=43.1937172774869, Blast_Score=313, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24657991, Length=408, Percent_Identity=24.2647058823529, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 41362; Mature: 41362

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMYDYLVPSVNFMGAGCVKLVGERCQILGGKKALIVTDKFLRSMEGGAVELTVKSLQEA
CCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCEEEEEHHHHHHC
GIEVAYYDAVEPNPKDTNVADGLKIFQDEKCDMIVTVGGGSAHDCGKGIGIVATHEGDLY
CCEEEEECCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCH
EYAGIETLTKALPPIVAVNTTAGTASEVTRHCVITNTKTKVKYVIVSWRNLPLASFNDPE
HHHHHHHHHHHCCCEEEEECCCCCHHHHHCEEEEECCCCEEEEEEEEECCCCCCCCCCCC
LMVKKPAGLTAATGMDALTHAIEAYVSKDANPVTDAAAIQAIKLISNNLRQAVALGENLV
EEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
ARENMAYGSLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAMLLPHVEKYNLISNPQ
HHCCCHHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHCCCCCHH
KFADIAEFMGENIQGLSVMEAAEKAIDAMFRLSTDIGIPTSLKEMGIKEEDFQYMAEMAL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHH
KDGNAFSNPRKGNEKDIVAIFKAAF
CCCCCCCCCCCCCCCCEEHEEECCC
>Mature Secondary Structure
MRMYDYLVPSVNFMGAGCVKLVGERCQILGGKKALIVTDKFLRSMEGGAVELTVKSLQEA
CCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCEEEEEHHHHHHC
GIEVAYYDAVEPNPKDTNVADGLKIFQDEKCDMIVTVGGGSAHDCGKGIGIVATHEGDLY
CCEEEEECCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCH
EYAGIETLTKALPPIVAVNTTAGTASEVTRHCVITNTKTKVKYVIVSWRNLPLASFNDPE
HHHHHHHHHHHCCCEEEEECCCCCHHHHHCEEEEECCCCEEEEEEEEECCCCCCCCCCCC
LMVKKPAGLTAATGMDALTHAIEAYVSKDANPVTDAAAIQAIKLISNNLRQAVALGENLV
EEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
ARENMAYGSLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAMLLPHVEKYNLISNPQ
HHCCCHHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHCCCCCHH
KFADIAEFMGENIQGLSVMEAAEKAIDAMFRLSTDIGIPTSLKEMGIKEEDFQYMAEMAL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHH
KDGNAFSNPRKGNEKDIVAIFKAAF
CCCCCCCCCCCCCCCCEEHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]