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The map label for this gene is uraA [H]

Identifier: 187934758

GI number: 187934758

Start: 3028821

End: 3030083

Strand: Reverse

Name: uraA [H]

Synonym: CLL_A2948

Alternate gene names: 187934758

Gene position: 3030083-3028821 (Counterclockwise)

Preceding gene: 187934460

Following gene: 187934738

Centisome position: 79.73

GC content: 30.25

Gene sequence:

>1263_bases
ATGTCAGAAATCATAAGTAATACAAAAGAGCAATTCGGAGAAATTTCTTTAAGGAAAACTGGGAAGAAGATAGTTCTAGC
ATTACAACATTTAATAGCAATGTTTGGATCTACAGTTTTAGTTCCTATCTTAACAGGTCTTGATATCTCTGTAGCATTAT
TTTGTGCAGGTATTGGAACATTAATATTTCATATTTGTACTAAAATGAAAGTTCCAGTCTTTTTAGGTTCATCATTCGCA
TTTATTCCAGTAATATGTGCTGTTAAAGTATCATATGGTGATTTAAGATATGCACAAGGTGGAATAATGATAGCTGGACT
AATCTATGTGTTAATGTCTTTTATTATCAAAAAAATTGGTACTGAAAAAATAAAAGTTGTATTACCAGCACAGGTTGTTG
GTCCTATGATTATGGTAATAGGATTAAACTTAATTCCTACAGCCTTTAATATGGCAAAAGAAAATATAATTATTGCAGTT
ATAACATTAGGCGTGACTTTAGGAATAAAGTATTTTAGTAAGGGGTTTATATCACAAATAGCAATATTATGTGGTGTTGC
TTGTGGATATTTAATATCATACTTTACTGGGTATGTAGATACTCAAGCAATTGCTGAAGCAGGTTTCATAACAATTCCAA
ACTTTACATTACCTAAATTTGATTTAGGAGCTATAGTGATTATTGCACCAGTAGTACTAGCTACATTTATGGAACATATT
GGTGATATAACAACTAATGGTCAAGTTGTTGGTGAAAACTTTATTGAAGAACCAGGATTAAATAGAACATTATTAGGCGA
TGGACTAGCTACTATGACAGCGGCATTCTTTGGGGGACCAGCGAATACTACATATGGAGAAAATACTGGTGTTTTAGCAA
TGACTAAAAATTATGATCCATCAATATTAAGATTAGCAGCTATATTTGCAATTTTATTAAGTTTTGTAGGTAAGTTTGGA
ACAGCAATAAGCACTATTCCTCAAGCAGTAATGGGAGGAATAAGTTTAATGTTGTTTACTATGATTGCACTAGTTGGATT
TAAAACTTTAAAGTATGAAAAAGTAAAAATGAATTGGAAAAATGCAATTATAGTTGTAACAATATTAGTAATAGGATTCT
TAGGCACTTTTATAGAAAAGAAATTTGGAATTTTAGTGGGAATAAGAATAAATGATGCAGTATCTATATCAGGATTAAGT
TTTGCGGCAATTGTAGGAGTGTTGCTTAATTTAGTATTAAATAAAATAAAGCTTAAAAGATAG

Upstream 100 bases:

>100_bases
AATAAAGATTTGACAAGAACTTTTAATTTAGTCCAGAGAGGCTAAAAAGGGGAAATAAATAATAGTAATTTCCTCTTATT
TTTAAGGAGGTATTTTTTTT

Downstream 100 bases:

>100_bases
TATTTATTTTAAAAGAATAAAAAATAGTATAATAAAAAACTATATCATTTTTATAATTGTTAGTTATAAAATGATATAGT
TTTTTGTTATTATATAGGAG

Product: uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSEIISNTKEQFGEISLRKTGKKIVLALQHLIAMFGSTVLVPILTGLDISVALFCAGIGTLIFHICTKMKVPVFLGSSFA
FIPVICAVKVSYGDLRYAQGGIMIAGLIYVLMSFIIKKIGTEKIKVVLPAQVVGPMIMVIGLNLIPTAFNMAKENIIIAV
ITLGVTLGIKYFSKGFISQIAILCGVACGYLISYFTGYVDTQAIAEAGFITIPNFTLPKFDLGAIVIIAPVVLATFMEHI
GDITTNGQVVGENFIEEPGLNRTLLGDGLATMTAAFFGGPANTTYGENTGVLAMTKNYDPSILRLAAIFAILLSFVGKFG
TAISTIPQAVMGGISLMLFTMIALVGFKTLKYEKVKMNWKNAIIVVTILVIGFLGTFIEKKFGILVGIRINDAVSISGLS
FAAIVGVLLNLVLNKIKLKR

Sequences:

>Translated_420_residues
MSEIISNTKEQFGEISLRKTGKKIVLALQHLIAMFGSTVLVPILTGLDISVALFCAGIGTLIFHICTKMKVPVFLGSSFA
FIPVICAVKVSYGDLRYAQGGIMIAGLIYVLMSFIIKKIGTEKIKVVLPAQVVGPMIMVIGLNLIPTAFNMAKENIIIAV
ITLGVTLGIKYFSKGFISQIAILCGVACGYLISYFTGYVDTQAIAEAGFITIPNFTLPKFDLGAIVIIAPVVLATFMEHI
GDITTNGQVVGENFIEEPGLNRTLLGDGLATMTAAFFGGPANTTYGENTGVLAMTKNYDPSILRLAAIFAILLSFVGKFG
TAISTIPQAVMGGISLMLFTMIALVGFKTLKYEKVKMNWKNAIIVVTILVIGFLGTFIEKKFGILVGIRINDAVSISGLS
FAAIVGVLLNLVLNKIKLKR
>Mature_419_residues
SEIISNTKEQFGEISLRKTGKKIVLALQHLIAMFGSTVLVPILTGLDISVALFCAGIGTLIFHICTKMKVPVFLGSSFAF
IPVICAVKVSYGDLRYAQGGIMIAGLIYVLMSFIIKKIGTEKIKVVLPAQVVGPMIMVIGLNLIPTAFNMAKENIIIAVI
TLGVTLGIKYFSKGFISQIAILCGVACGYLISYFTGYVDTQAIAEAGFITIPNFTLPKFDLGAIVIIAPVVLATFMEHIG
DITTNGQVVGENFIEEPGLNRTLLGDGLATMTAAFFGGPANTTYGENTGVLAMTKNYDPSILRLAAIFAILLSFVGKFGT
AISTIPQAVMGGISLMLFTMIALVGFKTLKYEKVKMNWKNAIIVVTILVIGFLGTFIEKKFGILVGIRINDAVSISGLSF
AAIVGVLLNLVLNKIKLKR

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=480, Percent_Identity=23.125, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI44680143, Length=484, Percent_Identity=23.3471074380165, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788843, Length=427, Percent_Identity=38.6416861826698, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI87081818, Length=411, Percent_Identity=35.5231143552311, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI87082181, Length=424, Percent_Identity=27.3584905660377, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI87082178, Length=468, Percent_Identity=24.3589743589744, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790087, Length=441, Percent_Identity=24.9433106575964, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17542262, Length=417, Percent_Identity=23.5011990407674, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17558856, Length=159, Percent_Identity=27.0440251572327, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356175, Length=470, Percent_Identity=24.6808510638298, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44915; Mature: 44784

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIISNTKEQFGEISLRKTGKKIVLALQHLIAMFGSTVLVPILTGLDISVALFCAGIGT
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHH
LIFHICTKMKVPVFLGSSFAFIPVICAVKVSYGDLRYAQGGIMIAGLIYVLMSFIIKKIG
HHHHHHHHCCCCEEECCCHHHHHHHHHHEECCCCCEECCCCHHHHHHHHHHHHHHHHHHC
TEKIKVVLPAQVVGPMIMVIGLNLIPTAFNMAKENIIIAVITLGVTLGIKYFSKGFISQI
CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHH
AILCGVACGYLISYFTGYVDTQAIAEAGFITIPNFTLPKFDLGAIVIIAPVVLATFMEHI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GDITTNGQVVGENFIEEPGLNRTLLGDGLATMTAAFFGGPANTTYGENTGVLAMTKNYDP
CCCCCCCEEECCHHHCCCCCCCCHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCH
SILRLAAIFAILLSFVGKFGTAISTIPQAVMGGISLMLFTMIALVGFKTLKYEKVKMNWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
NAIIVVTILVIGFLGTFIEKKFGILVGIRINDAVSISGLSFAAIVGVLLNLVLNKIKLKR
HHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEIISNTKEQFGEISLRKTGKKIVLALQHLIAMFGSTVLVPILTGLDISVALFCAGIGT
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHH
LIFHICTKMKVPVFLGSSFAFIPVICAVKVSYGDLRYAQGGIMIAGLIYVLMSFIIKKIG
HHHHHHHHCCCCEEECCCHHHHHHHHHHEECCCCCEECCCCHHHHHHHHHHHHHHHHHHC
TEKIKVVLPAQVVGPMIMVIGLNLIPTAFNMAKENIIIAVITLGVTLGIKYFSKGFISQI
CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHH
AILCGVACGYLISYFTGYVDTQAIAEAGFITIPNFTLPKFDLGAIVIIAPVVLATFMEHI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GDITTNGQVVGENFIEEPGLNRTLLGDGLATMTAAFFGGPANTTYGENTGVLAMTKNYDP
CCCCCCCEEECCHHHCCCCCCCCHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCH
SILRLAAIFAILLSFVGKFGTAISTIPQAVMGGISLMLFTMIALVGFKTLKYEKVKMNWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
NAIIVVTILVIGFLGTFIEKKFGILVGIRINDAVSISGLSFAAIVGVLLNLVLNKIKLKR
HHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]