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The map label for this gene is cdd [H]

Identifier: 187934737

GI number: 187934737

Start: 3054849

End: 3055256

Strand: Reverse

Name: cdd [H]

Synonym: CLL_A2970

Alternate gene names: 187934737

Gene position: 3055256-3054849 (Counterclockwise)

Preceding gene: 187933300

Following gene: 187935222

Centisome position: 80.39

GC content: 30.64

Gene sequence:

>408_bases
ATGGAAAATAAAGAACTTATTAAAATAGCACTAAAGTATAGAGAAAAGGCATATTCACCATATTCTAATTTTAAAGTTGG
TGCAGCTGTATTATTTGATAGTGGAAAAGTGTATGGCGGATGCAATATTGAAAATGCTTCTTTTGGTGCAACTAACTGTG
CTGAAAGAACAGCAATTTTTACTGGTGTAGCAGAAGGTGAAACTAAGATTAATGCAATTGCAATAGTAGGAAGCTTAGAA
GAAAATACTTATCCTTGTGGAATATGTCGACAAGTTATAAGTGAATTTGGTGGTCCAGAAGTAAAAGTAATACTTGCAAA
AAGTGAAGAAGACTATATTGAAACAGATATGGCAGAAATTTTACCAGGTACATTTACAAAAGTAGATTTAGATAAAAATA
ATAAATAA

Upstream 100 bases:

>100_bases
TAACATATTTACTTTAATATATTAGTATAAAAAAATATATTAAAGTCAAATGTTTGGAATCCTATAGTTATATAAATTTA
GAATAAAGGGGACATGAAAA

Downstream 100 bases:

>100_bases
AGATGTATTTTAGTATATAAAAATTAGATTGTATGGAGGTAACAAAATGAGTATTCATATTAATGCACCAGAAGGTGCAA
TTGCAGAAAGCATATTATTA

Product: cytidine deaminase

Products: NA

Alternate protein names: CDA; Cytidine aminohydrolase [H]

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MENKELIKIALKYREKAYSPYSNFKVGAAVLFDSGKVYGGCNIENASFGATNCAERTAIFTGVAEGETKINAIAIVGSLE
ENTYPCGICRQVISEFGGPEVKVILAKSEEDYIETDMAEILPGTFTKVDLDKNNK

Sequences:

>Translated_135_residues
MENKELIKIALKYREKAYSPYSNFKVGAAVLFDSGKVYGGCNIENASFGATNCAERTAIFTGVAEGETKINAIAIVGSLE
ENTYPCGICRQVISEFGGPEVKVILAKSEEDYIETDMAEILPGTFTKVDLDKNNK
>Mature_135_residues
MENKELIKIALKYREKAYSPYSNFKVGAAVLFDSGKVYGGCNIENASFGATNCAERTAIFTGVAEGETKINAIAIVGSLE
ENTYPCGICRQVISEFGGPEVKVILAKSEEDYIETDMAEILPGTFTKVDLDKNNK

Specific function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis [H]

COG id: COG0295

COG function: function code F; Cytidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI11386157, Length=132, Percent_Identity=41.6666666666667, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17540514, Length=131, Percent_Identity=45.8015267175573, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17551074, Length=133, Percent_Identity=48.1203007518797, Blast_Score=115, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6323274, Length=129, Percent_Identity=34.8837209302326, Blast_Score=80, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24582744, Length=127, Percent_Identity=44.8818897637795, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19920920, Length=139, Percent_Identity=38.8489208633094, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24582741, Length=128, Percent_Identity=39.84375, Blast_Score=96, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR006262
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.5 [H]

Molecular weight: Translated: 14687; Mature: 14687

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKELIKIALKYREKAYSPYSNFKVGAAVLFDSGKVYGGCNIENASFGATNCAERTAIF
CCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCCHHHEEE
TGVAEGETKINAIAIVGSLEENTYPCGICRQVISEFGGPEVKVILAKSEEDYIETDMAEI
EECCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHH
LPGTFTKVDLDKNNK
CCCCCEEEECCCCCC
>Mature Secondary Structure
MENKELIKIALKYREKAYSPYSNFKVGAAVLFDSGKVYGGCNIENASFGATNCAERTAIF
CCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCCHHHEEE
TGVAEGETKINAIAIVGSLEENTYPCGICRQVISEFGGPEVKVILAKSEEDYIETDMAEI
EECCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHH
LPGTFTKVDLDKNNK
CCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2526291; 8969508; 9384377 [H]