Click here to switch to the map view.

The map label for this gene is cdr [H]

Identifier: 187934598

GI number: 187934598

Start: 2060303

End: 2062003

Strand: Reverse

Name: cdr [H]

Synonym: CLL_A1981

Alternate gene names: 187934598

Gene position: 2062003-2060303 (Counterclockwise)

Preceding gene: 187935585

Following gene: 187934812

Centisome position: 54.26

GC content: 28.69

Gene sequence:

>1701_bases
ATGAGAAAGAAGATATTAATAGTAGGTGGAGTTGCAGGAGGAGCCTCAGCAGCTGCAAGACTTAGAAGAAATAGTGAGGA
AGATGAAATAATAATGTTTGAAAAAGGACCTCATGTATCTTTTTCAAATTGTGCACTACCTTATCATTTAAGTGGAGTAA
TAGATTCTCCTAATAGATTAGTTTTAATGAGTCCAGAAAAATTTATATCACAATATAATATTAAAGCAAGAGTAAATAAT
GATGTTATTTCAATTAATAGAAAAAATAAAACTGTAGACGTAAAAGATTTAATGAGTGGAGAAGTTTACAAAGAATCTTA
TGATAAACTTATTTTATCTCCAGGAGCACATCCAATAGTGCCTAATATACCTGGTATTGAAAAAGTTAATGTTTTTACAA
TAAGAAACGTAGTTGACATAGATAAATTAAATAGATATTTAAAGGAGATAAATAGTAATGATGTAGCTGTAATTGGTGGT
GGTTACATAGGGGTAGAAGCTGCTGAAAATTTAAGAAAAGCAGAATTTAATGTATCACTTATAGAAGCTACTAAACAAAT
TTTAAAACCTTTTGATTATGATATTGTACAAATACTTCATAAGGAAATTTATGATAATGGTGTAAATTTAATCGTTGGAG
ATAAGGTTGAGCGTTTTGAAGAAGATACTATAGTTTTGTCATCAGGAAAAAAAGTTAATGCAAGTGCAGTTGTTATGGCA
ATAGGAGTTGCACCAGAAGTAACTTTAGCTAAGGATGCGGGAATAGAACTTGGAGAAACAGGCGCAATAAAAGTAGATAA
AAACTATAAAACAAATGATGATAGTATTTATGCTGTAGGTGATGTAATTGAAGTGTACAATTCCCTTACTCATTCTATGA
CTAAATTATCACTAGCTGGACCAGCTCAAAAGGCAGCAAGGAGTGTAGCAGATAATATAAACAATAAAAGTACAATAAAT
AAAGGATATATAGGATCATCAGCTATAAAGGTATTTAATTATAATGGAGCATCAACAGGATTAAATGAATCATTAATAAA
AGTTCTTAATATGAATATAAATTATGATATAGTAAATATAATACTTAATGATAAAGTTGGAATAATGCCGAAATCTTCAC
CAATATACTTTAAAATGCTTTATGAAGTACCAACTGGGAAAATATTAGGTGCTCAAGCTATAGGCAAAGGCGATGTTACT
AAAAGAATAGATATAATCGCTACAGCAATAAAATTTGGTGGAACAGTAGAAGATTTGAAAGATTTAGAATTATGTTATGC
ACCACCATTTTCAACAGCAAAAGATGTTGTTAATTATGCAGGATATGTTGGATCTAATTTACTAAATAATGATTTTAAGC
AAGTTAACATAGATAAGGTTAGAGAACTTGTAGAAAATAATGCTGTAATAATAGATGTTAGAGAAAGAGGAGAATATGAA
AATGGCCATATAAAAAATTCAAAAAATATACCATTAAGTGAACTTAGAGAAAGAGTCAATGAAATACCAAAAGATGCACT
GGTATACCTTCATTGTAGAACAGGGCAAAGAAGTTATAATGCAACTTTAGCACTTCAAAATTTAGGATATACTAATGTTT
ATAACATAACAGGAAGTTTTTTAGGATTATCTTTTTATGAATATTATAATGATAAGACTATGAATAGAAATAGTATTGTT
ACAGAATATAATTTTAAATAA

Upstream 100 bases:

>100_bases
TCAAAAAAGAAGTAACTTAAGTTAATATTTTAAAACAGTGTTGATGTTATAGTATTAAAGTTAAAAATCAAGTTACAATA
ATAATTAGGAGGATGATATT

Downstream 100 bases:

>100_bases
TAGAGTGAGCTATATCAAAATGATTAAAGTTAATTATTTTGATATAGTTTTTATCTGTGTTAATCAAAGAAAAAACGGTT
ATTGTTATTGCCCATAGAAT

Product: pyridine nucleotide-disulphide oxidoreductase family protein

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MRKKILIVGGVAGGASAAARLRRNSEEDEIIMFEKGPHVSFSNCALPYHLSGVIDSPNRLVLMSPEKFISQYNIKARVNN
DVISINRKNKTVDVKDLMSGEVYKESYDKLILSPGAHPIVPNIPGIEKVNVFTIRNVVDIDKLNRYLKEINSNDVAVIGG
GYIGVEAAENLRKAEFNVSLIEATKQILKPFDYDIVQILHKEIYDNGVNLIVGDKVERFEEDTIVLSSGKKVNASAVVMA
IGVAPEVTLAKDAGIELGETGAIKVDKNYKTNDDSIYAVGDVIEVYNSLTHSMTKLSLAGPAQKAARSVADNINNKSTIN
KGYIGSSAIKVFNYNGASTGLNESLIKVLNMNINYDIVNIILNDKVGIMPKSSPIYFKMLYEVPTGKILGAQAIGKGDVT
KRIDIIATAIKFGGTVEDLKDLELCYAPPFSTAKDVVNYAGYVGSNLLNNDFKQVNIDKVRELVENNAVIIDVRERGEYE
NGHIKNSKNIPLSELRERVNEIPKDALVYLHCRTGQRSYNATLALQNLGYTNVYNITGSFLGLSFYEYYNDKTMNRNSIV
TEYNFK

Sequences:

>Translated_566_residues
MRKKILIVGGVAGGASAAARLRRNSEEDEIIMFEKGPHVSFSNCALPYHLSGVIDSPNRLVLMSPEKFISQYNIKARVNN
DVISINRKNKTVDVKDLMSGEVYKESYDKLILSPGAHPIVPNIPGIEKVNVFTIRNVVDIDKLNRYLKEINSNDVAVIGG
GYIGVEAAENLRKAEFNVSLIEATKQILKPFDYDIVQILHKEIYDNGVNLIVGDKVERFEEDTIVLSSGKKVNASAVVMA
IGVAPEVTLAKDAGIELGETGAIKVDKNYKTNDDSIYAVGDVIEVYNSLTHSMTKLSLAGPAQKAARSVADNINNKSTIN
KGYIGSSAIKVFNYNGASTGLNESLIKVLNMNINYDIVNIILNDKVGIMPKSSPIYFKMLYEVPTGKILGAQAIGKGDVT
KRIDIIATAIKFGGTVEDLKDLELCYAPPFSTAKDVVNYAGYVGSNLLNNDFKQVNIDKVRELVENNAVIIDVRERGEYE
NGHIKNSKNIPLSELRERVNEIPKDALVYLHCRTGQRSYNATLALQNLGYTNVYNITGSFLGLSFYEYYNDKTMNRNSIV
TEYNFK
>Mature_566_residues
MRKKILIVGGVAGGASAAARLRRNSEEDEIIMFEKGPHVSFSNCALPYHLSGVIDSPNRLVLMSPEKFISQYNIKARVNN
DVISINRKNKTVDVKDLMSGEVYKESYDKLILSPGAHPIVPNIPGIEKVNVFTIRNVVDIDKLNRYLKEINSNDVAVIGG
GYIGVEAAENLRKAEFNVSLIEATKQILKPFDYDIVQILHKEIYDNGVNLIVGDKVERFEEDTIVLSSGKKVNASAVVMA
IGVAPEVTLAKDAGIELGETGAIKVDKNYKTNDDSIYAVGDVIEVYNSLTHSMTKLSLAGPAQKAARSVADNINNKSTIN
KGYIGSSAIKVFNYNGASTGLNESLIKVLNMNINYDIVNIILNDKVGIMPKSSPIYFKMLYEVPTGKILGAQAIGKGDVT
KRIDIIATAIKFGGTVEDLKDLELCYAPPFSTAKDVVNYAGYVGSNLLNNDFKQVNIDKVRELVENNAVIIDVRERGEYE
NGHIKNSKNIPLSELRERVNEIPKDALVYLHCRTGQRSYNATLALQNLGYTNVYNITGSFLGLSFYEYYNDKTMNRNSIV
TEYNFK

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=288, Percent_Identity=30.5555555555556, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI21389617, Length=288, Percent_Identity=30.5555555555556, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI65787454, Length=288, Percent_Identity=30.5555555555556, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1789065, Length=272, Percent_Identity=26.1029411764706, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788892, Length=293, Percent_Identity=25.5972696245734, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789765, Length=321, Percent_Identity=24.9221183800623, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1786307, Length=188, Percent_Identity=32.4468085106383, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1787352, Length=233, Percent_Identity=26.6094420600858, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082354, Length=194, Percent_Identity=28.8659793814433, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=228, Percent_Identity=27.1929824561404, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24585130, Length=298, Percent_Identity=21.1409395973154, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 62476; Mature: 62476

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKILIVGGVAGGASAAARLRRNSEEDEIIMFEKGPHVSFSNCALPYHLSGVIDSPNRL
CCCEEEEEEECCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEEECEECCCCEE
VLMSPEKFISQYNIKARVNNDVISINRKNKTVDVKDLMSGEVYKESYDKLILSPGAHPIV
EEECCHHHHHHCCEEEEECCCEEEEECCCCEEEHHHHHCCHHHHHCCCEEEECCCCCCCC
PNIPGIEKVNVFTIRNVVDIDKLNRYLKEINSNDVAVIGGGYIGVEAAENLRKAEFNVSL
CCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCEEEHHHHHHHHHHHCCHHH
IEATKQILKPFDYDIVQILHKEIYDNGVNLIVGDKVERFEEDTIVLSSGKKVNASAVVMA
HHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCHHHHCCCCEEEEECCCEECCCEEEEE
IGVAPEVTLAKDAGIELGETGAIKVDKNYKTNDDSIYAVGDVIEVYNSLTHSMTKLSLAG
ECCCCCEEEECCCCCEECCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHEECCC
PAQKAARSVADNINNKSTINKGYIGSSAIKVFNYNGASTGLNESLIKVLNMNINYDIVNI
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEE
ILNDKVGIMPKSSPIYFKMLYEVPTGKILGAQAIGKGDVTKRIDIIATAIKFGGTVEDLK
EECCCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
DLELCYAPPFSTAKDVVNYAGYVGSNLLNNDFKQVNIDKVRELVENNAVIIDVRERGEYE
CCCEEECCCCCHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHCCCEEEEEHHCCCCC
NGHIKNSKNIPLSELRERVNEIPKDALVYLHCRTGQRSYNATLALQNLGYTNVYNITGSF
CCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEEECCCCCEEEECCHHH
LGLSFYEYYNDKTMNRNSIVTEYNFK
HHHHHHHHHCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MRKKILIVGGVAGGASAAARLRRNSEEDEIIMFEKGPHVSFSNCALPYHLSGVIDSPNRL
CCCEEEEEEECCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEEECEECCCCEE
VLMSPEKFISQYNIKARVNNDVISINRKNKTVDVKDLMSGEVYKESYDKLILSPGAHPIV
EEECCHHHHHHCCEEEEECCCEEEEECCCCEEEHHHHHCCHHHHHCCCEEEECCCCCCCC
PNIPGIEKVNVFTIRNVVDIDKLNRYLKEINSNDVAVIGGGYIGVEAAENLRKAEFNVSL
CCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCEEEHHHHHHHHHHHCCHHH
IEATKQILKPFDYDIVQILHKEIYDNGVNLIVGDKVERFEEDTIVLSSGKKVNASAVVMA
HHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCHHHHCCCCEEEEECCCEECCCEEEEE
IGVAPEVTLAKDAGIELGETGAIKVDKNYKTNDDSIYAVGDVIEVYNSLTHSMTKLSLAG
ECCCCCEEEECCCCCEECCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHEECCC
PAQKAARSVADNINNKSTINKGYIGSSAIKVFNYNGASTGLNESLIKVLNMNINYDIVNI
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEE
ILNDKVGIMPKSSPIYFKMLYEVPTGKILGAQAIGKGDVTKRIDIIATAIKFGGTVEDLK
EECCCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
DLELCYAPPFSTAKDVVNYAGYVGSNLLNNDFKQVNIDKVRELVENNAVIIDVRERGEYE
CCCEEECCCCCHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHCCCEEEEEHHCCCCC
NGHIKNSKNIPLSELRERVNEIPKDALVYLHCRTGQRSYNATLALQNLGYTNVYNITGSF
CCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEEECCCCCEEEECCHHH
LGLSFYEYYNDKTMNRNSIVTEYNFK
HHHHHHHHHCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA