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The map label for this gene is 187934391

Identifier: 187934391

GI number: 187934391

Start: 534145

End: 534588

Strand: Reverse

Name: 187934391

Synonym: CLL_A0539

Alternate gene names: NA

Gene position: 534588-534145 (Counterclockwise)

Preceding gene: 187932413

Following gene: 187935564

Centisome position: 14.07

GC content: 28.83

Gene sequence:

>444_bases
ATGACTAATTTAATAAATTATATGAATGTATCACAAGCACAAATTAATGATTCCTATTTTGGAAGAATTCATTTAAAACC
ATTTGGGCAAGCAGGAGGAACCATGCAGTTGCCAGGAGGCTATACATCACCAGAACGATTTGTAAGAACAGCATATCAAA
AAACACATATTAAAAACCCCAAAAATAGTTCAGATGCAATAAATTCATGCTTTCACATCATGGAAAGTGTTACTATTCCT
AAGGGAATAGTAATAACAAATAGAAATGCTTATGATTATACAAAATATACTGCTTTTATAAATACAAATCCTTGTGAATA
TTTCTTTAAAACTTATGACAATACTCAAGTTATAAAAGCAAGTCTTTGGGATAATTGTAAAGATAGTAGTAATCCGATTT
CATTAGGAAAATTAGAACGTGCAGTTAAATTTGAAGAAATATAA

Upstream 100 bases:

>100_bases
GGATTATTCAATAATATAATATTAATGCCTTGTAAACTTATATACTTAGATATCTTACGTTTTTAACTTTAGTTTTAGAA
AAATAGAATTTAATATATAT

Downstream 100 bases:

>100_bases
AAATATTTAGAGATATATTTTTTAGTTTTAATTAGATTATCTTCTATTTCAAGTTTTCATTATGTTTTTTCATAAGTAGA
AAACCCTCGACAAATTTGTC

Product: penicillin acylase

Products: NA

Alternate protein names: Penicillin V amidase; PVA [H]

Number of amino acids: Translated: 147; Mature: 146

Protein sequence:

>147_residues
MTNLINYMNVSQAQINDSYFGRIHLKPFGQAGGTMQLPGGYTSPERFVRTAYQKTHIKNPKNSSDAINSCFHIMESVTIP
KGIVITNRNAYDYTKYTAFINTNPCEYFFKTYDNTQVIKASLWDNCKDSSNPISLGKLERAVKFEEI

Sequences:

>Translated_147_residues
MTNLINYMNVSQAQINDSYFGRIHLKPFGQAGGTMQLPGGYTSPERFVRTAYQKTHIKNPKNSSDAINSCFHIMESVTIP
KGIVITNRNAYDYTKYTAFINTNPCEYFFKTYDNTQVIKASLWDNCKDSSNPISLGKLERAVKFEEI
>Mature_146_residues
TNLINYMNVSQAQINDSYFGRIHLKPFGQAGGTMQLPGGYTSPERFVRTAYQKTHIKNPKNSSDAINSCFHIMESVTIPK
GIVITNRNAYDYTKYTAFINTNPCEYFFKTYDNTQVIKASLWDNCKDSSNPISLGKLERAVKFEEI

Specific function: The enzyme catalyzes the conversion of penicillin to 6- aminopenicillanate The precursor, furthermore, acts as a self- processing peptidase that cleaves off the propeptide. All peptidase activity is lost on conversion to the mature peptidase [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.11 [H]

Molecular weight: Translated: 16739; Mature: 16608

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLINYMNVSQAQINDSYFGRIHLKPFGQAGGTMQLPGGYTSPERFVRTAYQKTHIKNP
CCCCCCCCCCCHHCCCCCEEEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCC
KNSSDAINSCFHIMESVTIPKGIVITNRNAYDYTKYTAFINTNPCEYFFKTYDNTQVIKA
CCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEEEECCCHHHHEECCCCCEEEEE
SLWDNCKDSSNPISLGKLERAVKFEEI
CCCCCCCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TNLINYMNVSQAQINDSYFGRIHLKPFGQAGGTMQLPGGYTSPERFVRTAYQKTHIKNP
CCCCCCCCCCHHCCCCCEEEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCC
KNSSDAINSCFHIMESVTIPKGIVITNRNAYDYTKYTAFINTNPCEYFFKTYDNTQVIKA
CCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEEEECCCHHHHEECCCCCEEEEE
SLWDNCKDSSNPISLGKLERAVKFEEI
CCCCCCCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3026906 [H]