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The map label for this gene is ldh3 [H]

Identifier: 187934099

GI number: 187934099

Start: 3717614

End: 3718561

Strand: Reverse

Name: ldh3 [H]

Synonym: CLL_A3511

Alternate gene names: 187934099

Gene position: 3718561-3717614 (Counterclockwise)

Preceding gene: 187932997

Following gene: 187932852

Centisome position: 97.85

GC content: 29.64

Gene sequence:

>948_bases
ATGGCTTTAAATAAAAGTAAAATAGCAATAATAGGAGCAGGACTTGTTGGTTCTACAACTGCATTTAACTTAATAACACA
AGGTGTATGTGATGAAATATTAATGATTGATATTAATACAGAAAAAGCATATGGAGAAGTTATGGATTTAAATCACTGTA
TTGAATATTTAAATAGAAATACAAAGGTTGTAACTGGTGAATATAAAGACTGTAAGGATGTTGATATAGTAGTTATAACA
GCAGGACCACCACCTAAACCAGGACAATCAAGATTAGATACACTAGAATTATCAGCTAAAATAACAGAATCAATTGTTAA
TCCAATTATGGAAAGCGGTTTTAAGGGATATTTTATTATTGTCTCTAACCCTGTTGATATAATTGCTCATTATGTATATA
AAATATCACAACTTCCTAAAAATCATATAATTGGAACTGGTACTTCAGTAGATTCGGCTAGATTAAAGAATTTTATAGGA
GAATTATTAAATGTAGATCCTAGAAGTGTTCAGGGTTATTCAATGGGGGAACATGGAGATTCTCAAATGGTACCATGGTC
TCATGTTACAGTTGGAGGAAAATCATTTTATGCTATATTAGAAGATAATAAAGATTTAATGGGAGAAGTTGATTTAGACA
AATTAGTATTAGATACATCTAGAGCTGGATGGGAAGTTTATGAGAGAAAAGGAACTACTTATTATGCAATAGCAGCAGCA
ACAGTAGCAATAATAAAAGCTATAATGCATAATGAAAATAAAATTATTCCTGTATCAACATTATTAGAAGGCGAATATGG
GGAAAAAGATGTCTTTTGTGGAGTACCAGCAATATTAAATCGTGATGGTGTTAAAGATGTAGTTGAAATTCATATGACTG
ATGATGAGATGATTAAATTTAAAAATTCACTGAATGTAATTAGAAAATATACTGATAAAATAATCTAG

Upstream 100 bases:

>100_bases
ACAAATTATTATGGATTATGTTGATAAGTAGTTAATAATTTATAAATTATGTGTAAAAGTGACTAAACTAAGATTATAAA
TACTTTAGGGAGGGATTTTT

Downstream 100 bases:

>100_bases
TTTGTTAAAATATTGTAAATAAATATTAAAAATGTTAAAAGTCTGTAAAGAATTTATATATTTAGATTCTTTATGGACTT
TTTTTAGTAATATTAGTCTA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH 3 [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MALNKSKIAIIGAGLVGSTTAFNLITQGVCDEILMIDINTEKAYGEVMDLNHCIEYLNRNTKVVTGEYKDCKDVDIVVIT
AGPPPKPGQSRLDTLELSAKITESIVNPIMESGFKGYFIIVSNPVDIIAHYVYKISQLPKNHIIGTGTSVDSARLKNFIG
ELLNVDPRSVQGYSMGEHGDSQMVPWSHVTVGGKSFYAILEDNKDLMGEVDLDKLVLDTSRAGWEVYERKGTTYYAIAAA
TVAIIKAIMHNENKIIPVSTLLEGEYGEKDVFCGVPAILNRDGVKDVVEIHMTDDEMIKFKNSLNVIRKYTDKII

Sequences:

>Translated_315_residues
MALNKSKIAIIGAGLVGSTTAFNLITQGVCDEILMIDINTEKAYGEVMDLNHCIEYLNRNTKVVTGEYKDCKDVDIVVIT
AGPPPKPGQSRLDTLELSAKITESIVNPIMESGFKGYFIIVSNPVDIIAHYVYKISQLPKNHIIGTGTSVDSARLKNFIG
ELLNVDPRSVQGYSMGEHGDSQMVPWSHVTVGGKSFYAILEDNKDLMGEVDLDKLVLDTSRAGWEVYERKGTTYYAIAAA
TVAIIKAIMHNENKIIPVSTLLEGEYGEKDVFCGVPAILNRDGVKDVVEIHMTDDEMIKFKNSLNVIRKYTDKII
>Mature_314_residues
ALNKSKIAIIGAGLVGSTTAFNLITQGVCDEILMIDINTEKAYGEVMDLNHCIEYLNRNTKVVTGEYKDCKDVDIVVITA
GPPPKPGQSRLDTLELSAKITESIVNPIMESGFKGYFIIVSNPVDIIAHYVYKISQLPKNHIIGTGTSVDSARLKNFIGE
LLNVDPRSVQGYSMGEHGDSQMVPWSHVTVGGKSFYAILEDNKDLMGEVDLDKLVLDTSRAGWEVYERKGTTYYAIAAAT
VAIIKAIMHNENKIIPVSTLLEGEYGEKDVFCGVPAILNRDGVKDVVEIHMTDDEMIKFKNSLNVIRKYTDKII

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI5031857, Length=308, Percent_Identity=35.7142857142857, Blast_Score=198, Evalue=4e-51,
Organism=Homo sapiens, GI260099723, Length=308, Percent_Identity=35.7142857142857, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI9257228, Length=305, Percent_Identity=34.7540983606557, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI4504973, Length=305, Percent_Identity=34.7540983606557, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI291575128, Length=306, Percent_Identity=33.6601307189542, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4557032, Length=306, Percent_Identity=33.6601307189542, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI15082234, Length=320, Percent_Identity=31.5625, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI47059044, Length=306, Percent_Identity=33.0065359477124, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI221136809, Length=306, Percent_Identity=33.0065359477124, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI260099727, Length=199, Percent_Identity=37.1859296482412, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI260099725, Length=199, Percent_Identity=37.1859296482412, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI207028494, Length=223, Percent_Identity=35.8744394618834, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI103472011, Length=311, Percent_Identity=23.1511254019293, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI103472015, Length=182, Percent_Identity=24.1758241758242, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1789632, Length=295, Percent_Identity=26.7796610169492, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17535107, Length=300, Percent_Identity=29.3333333333333, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322765, Length=314, Percent_Identity=25.4777070063694, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136226, Length=305, Percent_Identity=34.7540983606557, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI45550422, Length=304, Percent_Identity=31.5789473684211, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24647881, Length=313, Percent_Identity=25.8785942492013, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24663599, Length=326, Percent_Identity=26.3803680981595, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 34721; Mature: 34590

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALNKSKIAIIGAGLVGSTTAFNLITQGVCDEILMIDINTEKAYGEVMDLNHCIEYLNRN
CCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCC
TKVVTGEYKDCKDVDIVVITAGPPPKPGQSRLDTLELSAKITESIVNPIMESGFKGYFII
CEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VSNPVDIIAHYVYKISQLPKNHIIGTGTSVDSARLKNFIGELLNVDPRSVQGYSMGEHGD
ECCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SQMVPWSHVTVGGKSFYAILEDNKDLMGEVDLDKLVLDTSRAGWEVYERKGTTYYAIAAA
CCCCCCCEEEECCCEEEEEEECCCHHCCCCCHHHHEEECCCCCCHHHHCCCCEEEHHHHH
TVAIIKAIMHNENKIIPVSTLLEGEYGEKDVFCGVPAILNRDGVKDVVEIHMTDDEMIKF
HHHHHHHHHCCCCCEEEHHHEECCCCCCCCEEECCHHHHCCCCCCEEEEEEECCHHHHHH
KNSLNVIRKYTDKII
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALNKSKIAIIGAGLVGSTTAFNLITQGVCDEILMIDINTEKAYGEVMDLNHCIEYLNRN
CCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCC
TKVVTGEYKDCKDVDIVVITAGPPPKPGQSRLDTLELSAKITESIVNPIMESGFKGYFII
CEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VSNPVDIIAHYVYKISQLPKNHIIGTGTSVDSARLKNFIGELLNVDPRSVQGYSMGEHGD
ECCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SQMVPWSHVTVGGKSFYAILEDNKDLMGEVDLDKLVLDTSRAGWEVYERKGTTYYAIAAA
CCCCCCCEEEECCCEEEEEEECCCHHCCCCCHHHHEEECCCCCCHHHHCCCCEEEHHHHH
TVAIIKAIMHNENKIIPVSTLLEGEYGEKDVFCGVPAILNRDGVKDVVEIHMTDDEMIKF
HHHHHHHHHCCCCCEEEHHHEECCCCCCCCEEECCHHHHCCCCCCEEEEEEECCHHHHHH
KNSLNVIRKYTDKII
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]