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The map label for this gene is fusA [H]

Identifier: 187934063

GI number: 187934063

Start: 3578652

End: 3580733

Strand: Reverse

Name: fusA [H]

Synonym: CLL_A3399

Alternate gene names: 187934063

Gene position: 3580733-3578652 (Counterclockwise)

Preceding gene: 187934111

Following gene: 187935253

Centisome position: 94.22

GC content: 30.21

Gene sequence:

>2082_bases
ATGAGAAGTTATAATATTAAAAACTTAAGAAATATAGGGTTAATGGGTCATAGCGGTACAGGAAAGACTTCATTGGTTGA
AGCTATTTTATACTATTCTAACATAATAGATAGATTAGGAAATATAGAAGATGGAACAACTACTTTAGATTATGATGAAG
AAGAGAAAAAAAGAAAACTTACAATTTCACTTTCAGTAGCACCAATTGAAGTTAATGATGTAAAAATAAACATTGTTGAT
ACTCCAGGATATTACGATTTTGAGGGTGAATATATTGAAGGTATGAGAGCTGTAGATGTTGGAATGATAGTTGTAAGTGG
AGTATCTGGAATAAAGGTGGGAACAGAAAAAGCTTGGAAATATTGTAATAAAATAAACTTGCCAAGAACATTTTTTATAA
ATAAATTAGATAGAGAAAATTCTAGTTTTGATAAGGTATTACAATCACTTAAGGATAAATTTGGTATGAGCGTGGTTCCA
ATTCAATATCCAATTGGTTCTGAAGGCAATTTTGAAGGTGTAGTTAACATTATTTCAAATGAAGCGAAGGTATATAATCT
TAAAACTAAGAAAACTGAAATAATAGATATACCAGAAAATTTAAAAGATAAAATACAAAAATGTAAAGAGATGATTATGG
AATCAGTAGCAGAAACTGATGAAGCTTTACTTGAGAAGTATTTTAGTGAAGGTACTTTAAGTGACGAAGAGATATATAAA
GGTCTTATTAATGGGTGTTCTACTGGTGAAATTGCCCCAGTAATGTGTGGTAGCTCGTTAAAAGTTATAGGTGTTGATAC
TTTACTTGATAATATAATTGCTTGCTTTCCATCACCAGAATATGCAATTCCACAAAAAGCTTTAAATATTGAAACCAATG
AAGAAGAGTTTATAAGCCTTGATGAAGACAAACCTTTTTCAGCTTTAGTATTTAAAACAATTGCAGATCCATTCGTAGGA
AAAATATCATTCTTTAGAGTTATGACAGGAACGGCAACAGAAGATAGTAATGTATTAAATTCTAATAAAAATAAATTGGA
GAAATTTTCTCATATGTATTTTATTAGAGGAAAAAATCAAATACCAACTAAGAAAGTTATAGCTGGAGATATAGGCGCTA
TATCTAAATTACAATATACAGATACAGGAGATACTCTATGTGATAGTAATTTTAAAATATTATATGATAAAATGAATTTT
CCTGTTCCAGTTATTTCAATGTCTGTGATTCCTAAGGCTAAAGGTGATGAAGAAAAGATATCTCAAGCTTTAACTAAATT
AAAAGATGAGGATTTAGTTTTTGATATAACTAGAGATAATGAAAGTTCAGAAATAATCATATCAGGTCTTGGTGAAACAC
ATATAGATATAATTGCAAGTAAGATTAAAAATAAATTTGGTGTTGATGTTATATTAAAAGCACCTAGAATTCCTTATAAG
GAAACTATAAAATCGTCGTCAGATGTAAGAGGTAAGCATAAAAAACAATCTGGCGGACATGGACAATATGGTGATGTAGT
AATAAAATTTGAACCTAGAAATGATGGGGAGACAGATTTAGAATTTGTAGATAAAATAGTTGGAGGGTCTGTACCTAGAA
ACTTTATACCAGCAGTAGAAAAGGGATTAAGAGAATGTATAGAGCATGGAGTTCTTGCAAAATGTCCAGTAATAGGTCTT
AAAGCTACATTACATGATGGATCATATCATCCTGTAGATTCATCAGAAATGGCATTTAAAGTTGCAGCATCAATGGCTTA
TAAAAAAGGTTTAGAAGAAGCTAAGCCAATATTGTTAGAACCTATAATGAAGTTACAAGTAACTGTTCCAGATGAATATA
CAGGTGATGTTATGGGTGACATTAACAAGAAGAGGGGGAGGATTATTGGGATGGAACCAAAAGATTCAGATCAAGAAATA
ACTGCAGAAATTCCCCTTTCTGAAATAAGTAGGTATGTAACAGAATTAAGATCTATTACACATGGTAGTGGAAATTTTAA
AAAGGAATTCTTAAGGTATGAAGAGGTTCCTGAAATGGAGTCAAATAAAATAATAGAGAATTTAAACTCTGAAGAGAAGT
AA

Upstream 100 bases:

>100_bases
AAATGTATTATTGAATAATATATTTAATATAATAAGTATTTAAAGGAAAGGCAGGTGAAAGCCAACTCCTAAGGAAACTT
ATAGGTTTGGCTATGAATTT

Downstream 100 bases:

>100_bases
AAATTATATATTAAAAACTCAATTAAAAGAGAGATAAGCGTTAGGAAATAATGGGACTTATCTCTCTTTTTACATATTAA
TGTTTAGAATAATATTAACT

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: EF-G [H]

Number of amino acids: Translated: 693; Mature: 693

Protein sequence:

>693_residues
MRSYNIKNLRNIGLMGHSGTGKTSLVEAILYYSNIIDRLGNIEDGTTTLDYDEEEKKRKLTISLSVAPIEVNDVKINIVD
TPGYYDFEGEYIEGMRAVDVGMIVVSGVSGIKVGTEKAWKYCNKINLPRTFFINKLDRENSSFDKVLQSLKDKFGMSVVP
IQYPIGSEGNFEGVVNIISNEAKVYNLKTKKTEIIDIPENLKDKIQKCKEMIMESVAETDEALLEKYFSEGTLSDEEIYK
GLINGCSTGEIAPVMCGSSLKVIGVDTLLDNIIACFPSPEYAIPQKALNIETNEEEFISLDEDKPFSALVFKTIADPFVG
KISFFRVMTGTATEDSNVLNSNKNKLEKFSHMYFIRGKNQIPTKKVIAGDIGAISKLQYTDTGDTLCDSNFKILYDKMNF
PVPVISMSVIPKAKGDEEKISQALTKLKDEDLVFDITRDNESSEIIISGLGETHIDIIASKIKNKFGVDVILKAPRIPYK
ETIKSSSDVRGKHKKQSGGHGQYGDVVIKFEPRNDGETDLEFVDKIVGGSVPRNFIPAVEKGLRECIEHGVLAKCPVIGL
KATLHDGSYHPVDSSEMAFKVAASMAYKKGLEEAKPILLEPIMKLQVTVPDEYTGDVMGDINKKRGRIIGMEPKDSDQEI
TAEIPLSEISRYVTELRSITHGSGNFKKEFLRYEEVPEMESNKIIENLNSEEK

Sequences:

>Translated_693_residues
MRSYNIKNLRNIGLMGHSGTGKTSLVEAILYYSNIIDRLGNIEDGTTTLDYDEEEKKRKLTISLSVAPIEVNDVKINIVD
TPGYYDFEGEYIEGMRAVDVGMIVVSGVSGIKVGTEKAWKYCNKINLPRTFFINKLDRENSSFDKVLQSLKDKFGMSVVP
IQYPIGSEGNFEGVVNIISNEAKVYNLKTKKTEIIDIPENLKDKIQKCKEMIMESVAETDEALLEKYFSEGTLSDEEIYK
GLINGCSTGEIAPVMCGSSLKVIGVDTLLDNIIACFPSPEYAIPQKALNIETNEEEFISLDEDKPFSALVFKTIADPFVG
KISFFRVMTGTATEDSNVLNSNKNKLEKFSHMYFIRGKNQIPTKKVIAGDIGAISKLQYTDTGDTLCDSNFKILYDKMNF
PVPVISMSVIPKAKGDEEKISQALTKLKDEDLVFDITRDNESSEIIISGLGETHIDIIASKIKNKFGVDVILKAPRIPYK
ETIKSSSDVRGKHKKQSGGHGQYGDVVIKFEPRNDGETDLEFVDKIVGGSVPRNFIPAVEKGLRECIEHGVLAKCPVIGL
KATLHDGSYHPVDSSEMAFKVAASMAYKKGLEEAKPILLEPIMKLQVTVPDEYTGDVMGDINKKRGRIIGMEPKDSDQEI
TAEIPLSEISRYVTELRSITHGSGNFKKEFLRYEEVPEMESNKIIENLNSEEK
>Mature_693_residues
MRSYNIKNLRNIGLMGHSGTGKTSLVEAILYYSNIIDRLGNIEDGTTTLDYDEEEKKRKLTISLSVAPIEVNDVKINIVD
TPGYYDFEGEYIEGMRAVDVGMIVVSGVSGIKVGTEKAWKYCNKINLPRTFFINKLDRENSSFDKVLQSLKDKFGMSVVP
IQYPIGSEGNFEGVVNIISNEAKVYNLKTKKTEIIDIPENLKDKIQKCKEMIMESVAETDEALLEKYFSEGTLSDEEIYK
GLINGCSTGEIAPVMCGSSLKVIGVDTLLDNIIACFPSPEYAIPQKALNIETNEEEFISLDEDKPFSALVFKTIADPFVG
KISFFRVMTGTATEDSNVLNSNKNKLEKFSHMYFIRGKNQIPTKKVIAGDIGAISKLQYTDTGDTLCDSNFKILYDKMNF
PVPVISMSVIPKAKGDEEKISQALTKLKDEDLVFDITRDNESSEIIISGLGETHIDIIASKIKNKFGVDVILKAPRIPYK
ETIKSSSDVRGKHKKQSGGHGQYGDVVIKFEPRNDGETDLEFVDKIVGGSVPRNFIPAVEKGLRECIEHGVLAKCPVIGL
KATLHDGSYHPVDSSEMAFKVAASMAYKKGLEEAKPILLEPIMKLQVTVPDEYTGDVMGDINKKRGRIIGMEPKDSDQEI
TAEIPLSEISRYVTELRSITHGSGNFKKEFLRYEEVPEMESNKIIENLNSEEK

Specific function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=678, Percent_Identity=33.1858407079646, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI19923640, Length=721, Percent_Identity=27.877947295423, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI25306287, Length=721, Percent_Identity=26.7683772538141, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI25306283, Length=394, Percent_Identity=30.4568527918782, Blast_Score=184, Evalue=3e-46,
Organism=Escherichia coli, GI1789738, Length=703, Percent_Identity=40.9672830725462, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1790835, Length=490, Percent_Identity=23.265306122449, Blast_Score=134, Evalue=3e-32,
Organism=Escherichia coli, GI48994988, Length=153, Percent_Identity=35.9477124183007, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17533571, Length=682, Percent_Identity=31.6715542521994, Blast_Score=377, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17556745, Length=729, Percent_Identity=22.0850480109739, Blast_Score=175, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6323098, Length=676, Percent_Identity=31.6568047337278, Blast_Score=354, Evalue=3e-98,
Organism=Saccharomyces cerevisiae, GI6322359, Length=794, Percent_Identity=26.0705289672544, Blast_Score=256, Evalue=7e-69,
Organism=Drosophila melanogaster, GI24582462, Length=678, Percent_Identity=33.0383480825959, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI221458488, Length=725, Percent_Identity=27.1724137931035, Blast_Score=239, Evalue=4e-63,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR004540
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 77155; Mature: 77155

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00214 FABP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSYNIKNLRNIGLMGHSGTGKTSLVEAILYYSNIIDRLGNIEDGTTTLDYDEEEKKRKL
CCCCCCCCHHHCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHCCEEE
TISLSVAPIEVNDVKINIVDTPGYYDFEGEYIEGMRAVDVGMIVVSGVSGIKVGTEKAWK
EEEEEEEEEEEEEEEEEEEECCCCCCCCCHHHCCCHHHHHEEEEEECCCCCEECHHHHHH
YCNKINLPRTFFINKLDRENSSFDKVLQSLKDKFGMSVVPIQYPIGSEGNFEGVVNIISN
HHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHCC
EAKVYNLKTKKTEIIDIPENLKDKIQKCKEMIMESVAETDEALLEKYFSEGTLSDEEIYK
CCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
GLINGCSTGEIAPVMCGSSLKVIGVDTLLDNIIACFPSPEYAIPQKALNIETNEEEFISL
HHHCCCCCCCCCEEEECCCEEEEEHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHEEEC
DEDKPFSALVFKTIADPFVGKISFFRVMTGTATEDSNVLNSNKNKLEKFSHMYFIRGKNQ
CCCCCHHHHHHHHHHCHHHHHHEEEEEEECCCCCCCHHHCCCHHHHHHHHCEEEEECCCC
IPTKKVIAGDIGAISKLQYTDTGDTLCDSNFKILYDKMNFPVPVISMSVIPKAKGDEEKI
CCCHHHHCCCCCCCCEEEECCCCCCEECCCCEEEEECCCCCCCEEEEEECCCCCCCHHHH
SQALTKLKDEDLVFDITRDNESSEIIISGLGETHIDIIASKIKNKFGVDVILKAPRIPYK
HHHHHHCCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCHH
ETIKSSSDVRGKHKKQSGGHGQYGDVVIKFEPRNDGETDLEFVDKIVGGSVPRNFIPAVE
HHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHH
KGLRECIEHGVLAKCPVIGLKATLHDGSYHPVDSSEMAFKVAASMAYKKGLEEAKPILLE
HHHHHHHHCCCEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCHHHCCCHHHC
PIMKLQVTVPDEYTGDVMGDINKKRGRIIGMEPKDSDQEITAEIPLSEISRYVTELRSIT
CCEEEEEECCCCCCCCHHHCCCCCCCCEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHC
HGSGNFKKEFLRYEEVPEMESNKIIENLNSEEK
CCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MRSYNIKNLRNIGLMGHSGTGKTSLVEAILYYSNIIDRLGNIEDGTTTLDYDEEEKKRKL
CCCCCCCCHHHCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHCCEEE
TISLSVAPIEVNDVKINIVDTPGYYDFEGEYIEGMRAVDVGMIVVSGVSGIKVGTEKAWK
EEEEEEEEEEEEEEEEEEEECCCCCCCCCHHHCCCHHHHHEEEEEECCCCCEECHHHHHH
YCNKINLPRTFFINKLDRENSSFDKVLQSLKDKFGMSVVPIQYPIGSEGNFEGVVNIISN
HHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHCC
EAKVYNLKTKKTEIIDIPENLKDKIQKCKEMIMESVAETDEALLEKYFSEGTLSDEEIYK
CCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
GLINGCSTGEIAPVMCGSSLKVIGVDTLLDNIIACFPSPEYAIPQKALNIETNEEEFISL
HHHCCCCCCCCCEEEECCCEEEEEHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHEEEC
DEDKPFSALVFKTIADPFVGKISFFRVMTGTATEDSNVLNSNKNKLEKFSHMYFIRGKNQ
CCCCCHHHHHHHHHHCHHHHHHEEEEEEECCCCCCCHHHCCCHHHHHHHHCEEEEECCCC
IPTKKVIAGDIGAISKLQYTDTGDTLCDSNFKILYDKMNFPVPVISMSVIPKAKGDEEKI
CCCHHHHCCCCCCCCEEEECCCCCCEECCCCEEEEECCCCCCCEEEEEECCCCCCCHHHH
SQALTKLKDEDLVFDITRDNESSEIIISGLGETHIDIIASKIKNKFGVDVILKAPRIPYK
HHHHHHCCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCHH
ETIKSSSDVRGKHKKQSGGHGQYGDVVIKFEPRNDGETDLEFVDKIVGGSVPRNFIPAVE
HHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHH
KGLRECIEHGVLAKCPVIGLKATLHDGSYHPVDSSEMAFKVAASMAYKKGLEEAKPILLE
HHHHHHHHCCCEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCHHHCCCHHHC
PIMKLQVTVPDEYTGDVMGDINKKRGRIIGMEPKDSDQEITAEIPLSEISRYVTELRSIT
CCEEEEEECCCCCCCCHHHCCCCCCCCEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHC
HGSGNFKKEFLRYEEVPEMESNKIIENLNSEEK
CCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA