Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 187933947

GI number: 187933947

Start: 3636088

End: 3636996

Strand: Reverse

Name: serA [H]

Synonym: CLL_A3438

Alternate gene names: 187933947

Gene position: 3636996-3636088 (Counterclockwise)

Preceding gene: 187935440

Following gene: 187932928

Centisome position: 95.7

GC content: 30.03

Gene sequence:

>909_bases
ATGATTAAGGTATTAACAAACGATGGTTTGCAACCTAAAGCTATAGAAAGTTTAAAAAGTTTGGGTATTGAAGTTATAAA
TGAACATTTTGATCAAGATATTTTAGGTGAAAAATTAAAAGAATTTGATGCATTAGTTATAAGATCAGCTACTAAAGTTA
CAGCTGATGTTATTGATAAAGAAATAGGTGGTAATTTAAAGTTAATTATTAGAGCAGGGGTAGGGATAGACAATATAGAT
ATACCATATGCTGTTAAAAATAATTTAAGTGTTACAAATACTCCATCAGCAAGCTCTGATTCGGTTGCAGAACTAGCATT
AGCGCATATGTTTGCAGTTTCAAGATTTGTTGGAATAGCTAATGTAACTATGAGAAATGGTGAATGGAATAAGAAAAAAT
ATCAAGGCTTTGAATTGGCAGGAAAGACACTTGGAATTATTGGAATGGGAAGAATAGGACAATCTTTAGCTAAAAAGGCA
ACAGCATTAGGCATGAATGTTATATATAATACAATAGAAGGAAAGCATGAAGAGTTAAGCTATCCATTTGTATCATTTGA
AGAAGCTTTAAAAGAATCTGATTTTATATCATTACATGTTCCATATGATAAAGAAAATGGATCATTAATAGGAAAAGATG
AATTAAATTTAATGAAAAAAAGTGCATATTTAATTAATTGTGCTAGAGGAAAAGTTGTTGATGAAGCAGCATTATTAGAA
GCACTTAACAATGAAGTTATTGCAGGTGCTGGAATTGATGTATTTGAAGAAGAACCAACAAAAAATGAAACTTTAATTAA
TCATCCTAAAGTTAGCGTAACTCCTCATATTGGAGCAGCGACTAAAGAAGCTCAAACCAGAATTGGGGATGAGGTAGTTT
CAATTATTAAGGATTTTTTTAAATTATAG

Upstream 100 bases:

>100_bases
ATATGGCAGATTGCACAGTAGAAGATGTAAAGGAATTGCTTAAAAATATAGAAGAAATTTTAGAGTTGATGTGATGGCTT
AAAAAATTGGGGGGATTTTT

Downstream 100 bases:

>100_bases
AATTCTTAAAGTTTAAAAGCTTGATGAAATCTAAGATTTTAAAAATAATAGTTAAAAATTGATGGTGGAGAGGTTTTAAA
GTCTCCACTATCAACTAAAA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MIKVLTNDGLQPKAIESLKSLGIEVINEHFDQDILGEKLKEFDALVIRSATKVTADVIDKEIGGNLKLIIRAGVGIDNID
IPYAVKNNLSVTNTPSASSDSVAELALAHMFAVSRFVGIANVTMRNGEWNKKKYQGFELAGKTLGIIGMGRIGQSLAKKA
TALGMNVIYNTIEGKHEELSYPFVSFEEALKESDFISLHVPYDKENGSLIGKDELNLMKKSAYLINCARGKVVDEAALLE
ALNNEVIAGAGIDVFEEEPTKNETLINHPKVSVTPHIGAATKEAQTRIGDEVVSIIKDFFKL

Sequences:

>Translated_302_residues
MIKVLTNDGLQPKAIESLKSLGIEVINEHFDQDILGEKLKEFDALVIRSATKVTADVIDKEIGGNLKLIIRAGVGIDNID
IPYAVKNNLSVTNTPSASSDSVAELALAHMFAVSRFVGIANVTMRNGEWNKKKYQGFELAGKTLGIIGMGRIGQSLAKKA
TALGMNVIYNTIEGKHEELSYPFVSFEEALKESDFISLHVPYDKENGSLIGKDELNLMKKSAYLINCARGKVVDEAALLE
ALNNEVIAGAGIDVFEEEPTKNETLINHPKVSVTPHIGAATKEAQTRIGDEVVSIIKDFFKL
>Mature_302_residues
MIKVLTNDGLQPKAIESLKSLGIEVINEHFDQDILGEKLKEFDALVIRSATKVTADVIDKEIGGNLKLIIRAGVGIDNID
IPYAVKNNLSVTNTPSASSDSVAELALAHMFAVSRFVGIANVTMRNGEWNKKKYQGFELAGKTLGIIGMGRIGQSLAKKA
TALGMNVIYNTIEGKHEELSYPFVSFEEALKESDFISLHVPYDKENGSLIGKDELNLMKKSAYLINCARGKVVDEAALLE
ALNNEVIAGAGIDVFEEEPTKNETLINHPKVSVTPHIGAATKEAQTRIGDEVVSIIKDFFKL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=305, Percent_Identity=39.344262295082, Blast_Score=224, Evalue=5e-59,
Organism=Homo sapiens, GI61743967, Length=245, Percent_Identity=34.2857142857143, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4557497, Length=245, Percent_Identity=34.2857142857143, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI6912396, Length=243, Percent_Identity=34.5679012345679, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI145580575, Length=245, Percent_Identity=32.6530612244898, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI145580578, Length=245, Percent_Identity=32.6530612244898, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4557499, Length=245, Percent_Identity=32.6530612244898, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789279, Length=300, Percent_Identity=38.6666666666667, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI87082289, Length=224, Percent_Identity=36.1607142857143, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1787645, Length=197, Percent_Identity=31.4720812182741, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87081824, Length=237, Percent_Identity=26.5822784810127, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788660, Length=267, Percent_Identity=27.3408239700375, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=303, Percent_Identity=40.5940594059406, Blast_Score=220, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI25147481, Length=241, Percent_Identity=27.3858921161826, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320925, Length=318, Percent_Identity=34.2767295597484, Blast_Score=183, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6322116, Length=318, Percent_Identity=33.9622641509434, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324055, Length=238, Percent_Identity=32.3529411764706, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=265, Percent_Identity=27.9245283018868, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324980, Length=196, Percent_Identity=26.530612244898, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921140, Length=297, Percent_Identity=39.0572390572391, Blast_Score=207, Evalue=6e-54,
Organism=Drosophila melanogaster, GI24585514, Length=260, Percent_Identity=32.3076923076923, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI28574282, Length=260, Percent_Identity=32.3076923076923, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI45552429, Length=260, Percent_Identity=32.3076923076923, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI28574284, Length=260, Percent_Identity=32.3076923076923, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24585516, Length=296, Percent_Identity=29.0540540540541, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI45551003, Length=260, Percent_Identity=32.3076923076923, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI28574286, Length=292, Percent_Identity=31.5068493150685, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28571528, Length=257, Percent_Identity=34.2412451361868, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24646446, Length=249, Percent_Identity=30.5220883534137, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24646448, Length=249, Percent_Identity=30.5220883534137, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24646452, Length=249, Percent_Identity=30.5220883534137, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24646450, Length=249, Percent_Identity=30.5220883534137, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI62472511, Length=262, Percent_Identity=32.0610687022901, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 32855; Mature: 32855

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVLTNDGLQPKAIESLKSLGIEVINEHFDQDILGEKLKEFDALVIRSATKVTADVIDK
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIGGNLKLIIRAGVGIDNIDIPYAVKNNLSVTNTPSASSDSVAELALAHMFAVSRFVGIA
HHCCCEEEEEEECCCCCCCCCCEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
NVTMRNGEWNKKKYQGFELAGKTLGIIGMGRIGQSLAKKATALGMNVIYNTIEGKHEELS
EEEEECCCCCHHHHCCHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
YPFVSFEEALKESDFISLHVPYDKENGSLIGKDELNLMKKSAYLINCARGKVVDEAALLE
CCHHHHHHHHCCCCEEEEECCCCCCCCCEECHHHHHHHHHHHHEEECCCCCHHHHHHHHH
ALNNEVIAGAGIDVFEEEPTKNETLINHPKVSVTPHIGAATKEAQTRIGDEVVSIIKDFF
HHCCCEEECCCCCCCCCCCCCCCCEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
KL
CC
>Mature Secondary Structure
MIKVLTNDGLQPKAIESLKSLGIEVINEHFDQDILGEKLKEFDALVIRSATKVTADVIDK
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIGGNLKLIIRAGVGIDNIDIPYAVKNNLSVTNTPSASSDSVAELALAHMFAVSRFVGIA
HHCCCEEEEEEECCCCCCCCCCEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
NVTMRNGEWNKKKYQGFELAGKTLGIIGMGRIGQSLAKKATALGMNVIYNTIEGKHEELS
EEEEECCCCCHHHHCCHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
YPFVSFEEALKESDFISLHVPYDKENGSLIGKDELNLMKKSAYLINCARGKVVDEAALLE
CCHHHHHHHHCCCCEEEEECCCCCCCCCEECHHHHHHHHHHHHEEECCCCCHHHHHHHHH
ALNNEVIAGAGIDVFEEEPTKNETLINHPKVSVTPHIGAATKEAQTRIGDEVVSIIKDFF
HHCCCEEECCCCCCCCCCCCCCCCEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
KL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]