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The map label for this gene is graR [H]

Identifier: 187933755

GI number: 187933755

Start: 3725600

End: 3726271

Strand: Reverse

Name: graR [H]

Synonym: CLL_A3518

Alternate gene names: 187933755

Gene position: 3726271-3725600 (Counterclockwise)

Preceding gene: 187934084

Following gene: 187932997

Centisome position: 98.05

GC content: 24.55

Gene sequence:

>672_bases
ATGTACAAAATAATGATAGTAGAAGATGATATTACTATAAGGGATGAACTTAAAAGTTTATTGAATAGATATGGATATAA
AGTTAGTATTGTAGAAGATTTCTTTAATGCAGTTAATAGTATTAAAGAAAGTAATTGTGATTTAATTTTGTTAGATGTGA
ACTTACCTGTATTTGATGGATATCATATTTGTAGAGAGATAAGAAAAAATTTAGATATACCAATAATTATAGTTACAAGT
AGAGATAGTGAAATAGATGAGCTTATGAGTATGAATTTAGGAGCAGATGATTTTATAACTAAGCCATATAATACTGAAAT
ATTACTAGCTAGAATATCATCAATCTTAAAAAGAACTTATAAAAAAAATGAGTCCTCTGAAATACTAAGATATAAAGATT
TAATTTTAGATTTATCTAATGGAAGCATTAGTTATAATAATAATTATTGTGAACTCACTAAAAATGAGTTAAAGATATTA
TCATATTTAATTAAAAATCAAAATAGTATAGTGTCTAGAGATATACTTATGGAAATACTATGGAATTCGGATATTTTTGT
AGATGACAATACTCTTTCTGTAAATATAACAAGGCTAAGAAGAAAGCTTGAGGATATAGGAATAAAAGATGCAATAGAGA
CTAGAAGAGGATTAGGATATATAATGCCATGA

Upstream 100 bases:

>100_bases
AACTACTTTAGATAATAAAATTTTATTTAAGGTAGTTATTTTTATAGATATAGTACGATATTAAATTTAAGAACAAAAAC
TTATATAAAAGGAGAAAATC

Downstream 100 bases:

>100_bases
GTATATTAGGGTATTTAAAAGATAGGCTACTTTATTTAATAATAAATTTCATATTATTTATAAGTATAGTTAGTGTTATG
CTTATGTTAAAAATTCCGTT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: Glycopeptide resistance-associated protein R [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MYKIMIVEDDITIRDELKSLLNRYGYKVSIVEDFFNAVNSIKESNCDLILLDVNLPVFDGYHICREIRKNLDIPIIIVTS
RDSEIDELMSMNLGADDFITKPYNTEILLARISSILKRTYKKNESSEILRYKDLILDLSNGSISYNNNYCELTKNELKIL
SYLIKNQNSIVSRDILMEILWNSDIFVDDNTLSVNITRLRRKLEDIGIKDAIETRRGLGYIMP

Sequences:

>Translated_223_residues
MYKIMIVEDDITIRDELKSLLNRYGYKVSIVEDFFNAVNSIKESNCDLILLDVNLPVFDGYHICREIRKNLDIPIIIVTS
RDSEIDELMSMNLGADDFITKPYNTEILLARISSILKRTYKKNESSEILRYKDLILDLSNGSISYNNNYCELTKNELKIL
SYLIKNQNSIVSRDILMEILWNSDIFVDDNTLSVNITRLRRKLEDIGIKDAIETRRGLGYIMP
>Mature_223_residues
MYKIMIVEDDITIRDELKSLLNRYGYKVSIVEDFFNAVNSIKESNCDLILLDVNLPVFDGYHICREIRKNLDIPIIIVTS
RDSEIDELMSMNLGADDFITKPYNTEILLARISSILKRTYKKNESSEILRYKDLILDLSNGSISYNNNYCELTKNELKIL
SYLIKNQNSIVSRDILMEILWNSDIFVDDNTLSVNITRLRRKLEDIGIKDAIETRRGLGYIMP

Specific function: Member of the two-component regulatory system graR/graS involved in resistance against cationic antimicrobial peptides (CAMPs) [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=32.1266968325792, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1788394, Length=219, Percent_Identity=33.7899543378995, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=30.1369863013699, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=31.2775330396476, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=31.2217194570136, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=30.316742081448, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=31.1926605504587, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=29.7777777777778, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=28.0542986425339, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=34.3891402714932, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=28.5067873303167, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=32.034632034632, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.9559471365639, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=30.0429184549356, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1790437, Length=118, Percent_Identity=31.3559322033898, Blast_Score=64, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25917; Mature: 25917

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKIMIVEDDITIRDELKSLLNRYGYKVSIVEDFFNAVNSIKESNCDLILLDVNLPVFDG
CEEEEEEECCCCHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
YHICREIRKNLDIPIIIVTSRDSEIDELMSMNLGADDFITKPYNTEILLARISSILKRTY
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
KKNESSEILRYKDLILDLSNGSISYNNNYCELTKNELKILSYLIKNQNSIVSRDILMEIL
CCCCHHHHHHHHHHEEECCCCEEEECCCEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHH
WNSDIFVDDNTLSVNITRLRRKLEDIGIKDAIETRRGLGYIMP
HCCCEEEECCEEEEEHHHHHHHHHHCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MYKIMIVEDDITIRDELKSLLNRYGYKVSIVEDFFNAVNSIKESNCDLILLDVNLPVFDG
CEEEEEEECCCCHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
YHICREIRKNLDIPIIIVTSRDSEIDELMSMNLGADDFITKPYNTEILLARISSILKRTY
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
KKNESSEILRYKDLILDLSNGSISYNNNYCELTKNELKILSYLIKNQNSIVSRDILMEIL
CCCCHHHHHHHHHHEEECCCCEEEECCCEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHH
WNSDIFVDDNTLSVNITRLRRKLEDIGIKDAIETRRGLGYIMP
HCCCEEEECCEEEEEHHHHHHHHHHCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA