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The map label for this gene is yaaO [H]

Identifier: 187933413

GI number: 187933413

Start: 3069278

End: 3070693

Strand: Reverse

Name: yaaO [H]

Synonym: CLL_A2982

Alternate gene names: 187933413

Gene position: 3070693-3069278 (Counterclockwise)

Preceding gene: 187932459

Following gene: 187934959

Centisome position: 80.8

GC content: 26.2

Gene sequence:

>1416_bases
ATGAAAGAACGTATTCCATTATTAGATGAATTGATGAAATACCATAAAGAAAAGAATTTATTGCTTTCTATGCCTGGCAA
TAAAGCTGGGATAGGCTTTCTAAGAGATGATATTGGAAAGGAATTTGCAGAAAAATTAGGATTTCTTGATATTACAGAAG
TAGACCCTTTGGATAATCTTCATTGTCCAGAAGGAGTTATAAAGGAAGCACAAGAGCTACTTAGTAAAACTTATAATTCA
AAAAAAGCATATTTCTTAGTGAATGGGAGTTCTTGTGGAAATTTAGCTTCAATATTTGATGCATTTGATGAAGGTGATGA
TGTTATAGTAGAAAGAAATTGTCACAAATCTATATACAATGCATTAATATTGAGAAAACTAAAGGTTAGATATATTGAAC
CAATAATAAATCTTGAAAAAGATATATTTTTACCTCCTAATAAAGAGAATATATATCAGGCGGTAGATAACTGCAATAAT
CCTAAAGGAATAATTTTAACTTATCCAAATTATTTTGGAATAACTTATGATATTGAAGAGATTATAAAAGATTTAAAGAA
AAGAAATTTAAATATTATTATAGATGCGGCTCATGGAGCACATTTTGGACAAAGTGATAAGTTACCTAAAGATATATATT
ATCTAGCTGATTATGTTGTTTTAAGTGCACATAAAACTTTGCCAGCATTAACGCAAGGGGCTTATCTATTGGTTAATAAT
GATAGTGAAAGCATAGAGTTTTATTTAAAAACTTTTATGAGCACATCACCATCATATTTAATTATGGCTTCTTTAGATTA
TTCAAGACATTATTTAGATGAATATGGAGTGAATGATTACAAAGAATTAATATGTAAATGCGAAATATGGAAAGAAAAAA
TTAATTCTTTAAATAAAATTAATATATTTTCTAAAGAAGATTTAGAATTTGGATATGATATAGATATAACAAGATATGTA
ATGTTATTACCAAGTGGGTATAGTGGACATAAATTTTTGGATTATTTAAGAGATAATAAAATACAAGCTGAAATGAGTTT
TTCAAGAGGGGTAGTTCTAATATTATCTCCGTTTAATACTGAAGGTGATTTTGAATATATTTTTAAGGTCATAGAAAATT
TAGATATAGAATTATTAAAAAATAATAGCCATGTTAATGCTAAATATTATAATCTTGTTCCAGATAAAAAATTAGAACCT
CATGAGGTATTTAAATTAAAGGGAACTTATTGTAAGGTGAAAGAGAGTGAAGGAAAAATATCTAAAAATATGATTATACC
TTATCCACCAGGAATACCTTTAGTTTGCCCAGGCGAATTAATAAGTAAAGAGGTAATTAATATAATAGAAGATTATAATT
TAAATAAAAAAAGTATCATAGGTGTAAAAAATAATATAATAGAAGTTGTAGATTAG

Upstream 100 bases:

>100_bases
TATATTCATTATTAGTGTTCTTAAAGTAAATTTCACAGTCCACGAGCTTTATATTACACTATTAACTACTAGTTAAAATA
TATAAAGGAAAGGGAACAAT

Downstream 100 bases:

>100_bases
CTAATAAGTTCAATTACAATGTTACTTCACCTATTGCATATATCAACACATATTTAAAACCGAGATTAATAAAAATAATC
CTATATTTAGTAGAAAATAA

Product: arginine/lysine decarboxylase

Products: Agmatine; CO2 [C]

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MKERIPLLDELMKYHKEKNLLLSMPGNKAGIGFLRDDIGKEFAEKLGFLDITEVDPLDNLHCPEGVIKEAQELLSKTYNS
KKAYFLVNGSSCGNLASIFDAFDEGDDVIVERNCHKSIYNALILRKLKVRYIEPIINLEKDIFLPPNKENIYQAVDNCNN
PKGIILTYPNYFGITYDIEEIIKDLKKRNLNIIIDAAHGAHFGQSDKLPKDIYYLADYVVLSAHKTLPALTQGAYLLVNN
DSESIEFYLKTFMSTSPSYLIMASLDYSRHYLDEYGVNDYKELICKCEIWKEKINSLNKINIFSKEDLEFGYDIDITRYV
MLLPSGYSGHKFLDYLRDNKIQAEMSFSRGVVLILSPFNTEGDFEYIFKVIENLDIELLKNNSHVNAKYYNLVPDKKLEP
HEVFKLKGTYCKVKESEGKISKNMIIPYPPGIPLVCPGELISKEVINIIEDYNLNKKSIIGVKNNIIEVVD

Sequences:

>Translated_471_residues
MKERIPLLDELMKYHKEKNLLLSMPGNKAGIGFLRDDIGKEFAEKLGFLDITEVDPLDNLHCPEGVIKEAQELLSKTYNS
KKAYFLVNGSSCGNLASIFDAFDEGDDVIVERNCHKSIYNALILRKLKVRYIEPIINLEKDIFLPPNKENIYQAVDNCNN
PKGIILTYPNYFGITYDIEEIIKDLKKRNLNIIIDAAHGAHFGQSDKLPKDIYYLADYVVLSAHKTLPALTQGAYLLVNN
DSESIEFYLKTFMSTSPSYLIMASLDYSRHYLDEYGVNDYKELICKCEIWKEKINSLNKINIFSKEDLEFGYDIDITRYV
MLLPSGYSGHKFLDYLRDNKIQAEMSFSRGVVLILSPFNTEGDFEYIFKVIENLDIELLKNNSHVNAKYYNLVPDKKLEP
HEVFKLKGTYCKVKESEGKISKNMIIPYPPGIPLVCPGELISKEVINIIEDYNLNKKSIIGVKNNIIEVVD
>Mature_471_residues
MKERIPLLDELMKYHKEKNLLLSMPGNKAGIGFLRDDIGKEFAEKLGFLDITEVDPLDNLHCPEGVIKEAQELLSKTYNS
KKAYFLVNGSSCGNLASIFDAFDEGDDVIVERNCHKSIYNALILRKLKVRYIEPIINLEKDIFLPPNKENIYQAVDNCNN
PKGIILTYPNYFGITYDIEEIIKDLKKRNLNIIIDAAHGAHFGQSDKLPKDIYYLADYVVLSAHKTLPALTQGAYLLVNN
DSESIEFYLKTFMSTSPSYLIMASLDYSRHYLDEYGVNDYKELICKCEIWKEKINSLNKINIFSKEDLEFGYDIDITRYV
MLLPSGYSGHKFLDYLRDNKIQAEMSFSRGVVLILSPFNTEGDFEYIFKVIENLDIELLKNNSHVNAKYYNLVPDKKLEP
HEVFKLKGTYCKVKESEGKISKNMIIPYPPGIPLVCPGELISKEVINIIEDYNLNKKSIIGVKNNIIEVVD

Specific function: Adc Can Be Found In Two Forms: Biodegradative And Biosynthetic. The Biodegradative Form May Play A Role In Regulating pH By Consuming Proteins. [C]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI221142684, Length=333, Percent_Identity=25.5255255255255, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1786384, Length=289, Percent_Identity=23.1833910034602, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790573, Length=280, Percent_Identity=24.6428571428571, Blast_Score=82, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C [H]

EC number: 4.1.1.19 [C]

Molecular weight: Translated: 53991; Mature: 53991

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKERIPLLDELMKYHKEKNLLLSMPGNKAGIGFLRDDIGKEFAEKLGFLDITEVDPLDNL
CCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCC
HCPEGVIKEAQELLSKTYNSKKAYFLVNGSSCGNLASIFDAFDEGDDVIVERNCHKSIYN
CCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEECCHHHHHHH
ALILRKLKVRYIEPIINLEKDIFLPPNKENIYQAVDNCNNPKGIILTYPNYFGITYDIEE
HHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEECHHH
IIKDLKKRNLNIIIDAAHGAHFGQSDKLPKDIYYLADYVVLSAHKTLPALTQGAYLLVNN
HHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCEEEEEC
DSESIEFYLKTFMSTSPSYLIMASLDYSRHYLDEYGVNDYKELICKCEIWKEKINSLNKI
CCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEE
NIFSKEDLEFGYDIDITRYVMLLPSGYSGHKFLDYLRDNKIQAEMSFSRGVVLILSPFNT
EEECCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCEEEEEECCCC
EGDFEYIFKVIENLDIELLKNNSHVNAKYYNLVPDKKLEPHEVFKLKGTYCKVKESEGKI
CCCHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCCCCCEEEECCCEEEEECCCCCC
SKNMIIPYPPGIPLVCPGELISKEVINIIEDYNLNKKSIIGVKNNIIEVVD
CCCEEEECCCCCCEECCHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECC
>Mature Secondary Structure
MKERIPLLDELMKYHKEKNLLLSMPGNKAGIGFLRDDIGKEFAEKLGFLDITEVDPLDNL
CCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCC
HCPEGVIKEAQELLSKTYNSKKAYFLVNGSSCGNLASIFDAFDEGDDVIVERNCHKSIYN
CCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEECCHHHHHHH
ALILRKLKVRYIEPIINLEKDIFLPPNKENIYQAVDNCNNPKGIILTYPNYFGITYDIEE
HHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEECHHH
IIKDLKKRNLNIIIDAAHGAHFGQSDKLPKDIYYLADYVVLSAHKTLPALTQGAYLLVNN
HHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCEEEEEC
DSESIEFYLKTFMSTSPSYLIMASLDYSRHYLDEYGVNDYKELICKCEIWKEKINSLNKI
CCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEE
NIFSKEDLEFGYDIDITRYVMLLPSGYSGHKFLDYLRDNKIQAEMSFSRGVVLILSPFNT
EEECCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCEEEEEECCCC
EGDFEYIFKVIENLDIELLKNNSHVNAKYYNLVPDKKLEPHEVFKLKGTYCKVKESEGKI
CCCHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCCCCCEEEECCCEEEEECCCCCC
SKNMIIPYPPGIPLVCPGELISKEVINIIEDYNLNKKSIIGVKNNIIEVVD
CCCEEEECCCCCCEECCHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 2-Norpyridoxal phosphate; 6-Methylpyridoxal phosphate; Pyridoxal 5'-phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.65 {L-Arg}} 1.2 {L-canavanine}} [C]

Substrates: L-Arginine; H+ [C]

Specific reaction: L-Arginine + H+ --> Agmatine + CO2 [C]

General reaction: Decarboxylation [C]

Inhibitor: 2-Nor-2-butyl pyridoxalphosphate; 5-Deoxypyridoxal; Ag+; Agmatine; Citrulline; Guanidine; Guanidinoacetic acid; L-2-Amino-3-guanidinopropanoate; L-2-Amino-4-guanidinobutyrate; L-2-Amino-5-guanidinopentanoate; L-2-Amino-6-guanidinohexanoate; L-2-Chloro-5-g

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]