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The map label for this gene is ytpA [H]

Identifier: 187930605

GI number: 187930605

Start: 3710092

End: 3710961

Strand: Reverse

Name: ytpA [H]

Synonym: Rpic_3541

Alternate gene names: 187930605

Gene position: 3710961-3710092 (Counterclockwise)

Preceding gene: 187930606

Following gene: 187930604

Centisome position: 94.13

GC content: 65.17

Gene sequence:

>870_bases
ATGACGCAAGCCCCCGCTCAGGTCACTGCCCATCCAGCGCTGGAAAGCCGCCAGCGCATGAAGGACGGCACTGAACTGCT
GGTCCGCACCTGGTTGCCCGCGCCCGACACCGGCGAGCCGCGCGGCACCGTCATCCTCGTCCATGGCATGGCCGAACACA
GCGGCCGCTATCCGCATGTGGCCAAGGTGCTCACCGATCTTGGCCTGCGCGTAAGGGCCTTCGACCTGCGCGGCCACGGC
AAGAGCGGCGGCCCGCGCATGGCGCTCGACGCGCAAGACAACTACCTCACCGATCTCGCAGAAATCGTCGATGCGGCGGT
CGCCGAATGGCACGAGATGCCGTTCGTGCTCGGCCACAGCATGGGCGGATTGATCGTCGCGCGCTTCACCACCGCGCGTA
TCCGCCCCGTGCGCGGCGTGCTGTTGTCATCGCCCGCACTGCGCGTGAGGTTGCCGCCCGGAACGGGCATCGTGCGGGGG
ATTCTCTCCGCCATCGCGCCGAGGTTGCCGGTGCCCAATCCCGTCGATCCAGCCAAGCTTTCGCACGATCCGAGCATCGC
CGCCGCCTATCGGGCAGACACACTGGTGCAAAGCACGATCAGCGCATCATTGCTGGAGTTCATGCTCAATGCGATCACGC
AGGCGCAGCAAGACGCGCCGCGCCTGGAAGCGCCGATGCTGCTGATGGCCGGCGGCGCGGATTCGATTGTCGATCCGTCT
GGCAGCCGCGACTTTTATGCGAATGCGCCGGAGGATTTGCGCTCGTTGGCGTGGTTTGAATCGGGGTACCACGAGATCTT
CAACGAAGCCGAACCGCTGCGTAGCGAGGTATTCGGAAAGATGACGGAGTGGTTGGCTTCGCGGATTTGA

Upstream 100 bases:

>100_bases
CGGCACCGATGCCTGCTGCCACTGACGGGCCGCACGATTAACGCAGATTGCGACAGGCGGCGTCTATGCCACAATCTGGC
AACCCAAGGAGGAGACGCCG

Downstream 100 bases:

>100_bases
TTTGAAGTGAGTTGGTTGCACCACAAAAAACAAAAACCAATAACACCAAGGAAAAGAAGCACGGAGACATGGACACCTAC
GACTACATCATCATCGGCGC

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTQAPAQVTAHPALESRQRMKDGTELLVRTWLPAPDTGEPRGTVILVHGMAEHSGRYPHVAKVLTDLGLRVRAFDLRGHG
KSGGPRMALDAQDNYLTDLAEIVDAAVAEWHEMPFVLGHSMGGLIVARFTTARIRPVRGVLLSSPALRVRLPPGTGIVRG
ILSAIAPRLPVPNPVDPAKLSHDPSIAAAYRADTLVQSTISASLLEFMLNAITQAQQDAPRLEAPMLLMAGGADSIVDPS
GSRDFYANAPEDLRSLAWFESGYHEIFNEAEPLRSEVFGKMTEWLASRI

Sequences:

>Translated_289_residues
MTQAPAQVTAHPALESRQRMKDGTELLVRTWLPAPDTGEPRGTVILVHGMAEHSGRYPHVAKVLTDLGLRVRAFDLRGHG
KSGGPRMALDAQDNYLTDLAEIVDAAVAEWHEMPFVLGHSMGGLIVARFTTARIRPVRGVLLSSPALRVRLPPGTGIVRG
ILSAIAPRLPVPNPVDPAKLSHDPSIAAAYRADTLVQSTISASLLEFMLNAITQAQQDAPRLEAPMLLMAGGADSIVDPS
GSRDFYANAPEDLRSLAWFESGYHEIFNEAEPLRSEVFGKMTEWLASRI
>Mature_288_residues
TQAPAQVTAHPALESRQRMKDGTELLVRTWLPAPDTGEPRGTVILVHGMAEHSGRYPHVAKVLTDLGLRVRAFDLRGHGK
SGGPRMALDAQDNYLTDLAEIVDAAVAEWHEMPFVLGHSMGGLIVARFTTARIRPVRGVLLSSPALRVRLPPGTGIVRGI
LSAIAPRLPVPNPVDPAKLSHDPSIAAAYRADTLVQSTISASLLEFMLNAITQAQQDAPRLEAPMLLMAGGADSIVDPSG
SRDFYANAPEDLRSLAWFESGYHEIFNEAEPLRSEVFGKMTEWLASRI

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=273, Percent_Identity=31.1355311355311, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI6005786, Length=273, Percent_Identity=31.1355311355311, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1787678, Length=269, Percent_Identity=27.8810408921933, Blast_Score=91, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6322756, Length=285, Percent_Identity=25.2631578947368, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 31332; Mature: 31201

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAPAQVTAHPALESRQRMKDGTELLVRTWLPAPDTGEPRGTVILVHGMAEHSGRYPHV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHCCCCCHH
AKVLTDLGLRVRAFDLRGHGKSGGPRMALDAQDNYLTDLAEIVDAAVAEWHEMPFVLGHS
HHHHHHCCCEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHCC
MGGLIVARFTTARIRPVRGVLLSSPALRVRLPPGTGIVRGILSAIAPRLPVPNPVDPAKL
CCCEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHC
SHDPSIAAAYRADTLVQSTISASLLEFMLNAITQAQQDAPRLEAPMLLMAGGADSIVDPS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCC
GSRDFYANAPEDLRSLAWFESGYHEIFNEAEPLRSEVFGKMTEWLASRI
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQAPAQVTAHPALESRQRMKDGTELLVRTWLPAPDTGEPRGTVILVHGMAEHSGRYPHV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHCCCCCHH
AKVLTDLGLRVRAFDLRGHGKSGGPRMALDAQDNYLTDLAEIVDAAVAEWHEMPFVLGHS
HHHHHHCCCEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHCC
MGGLIVARFTTARIRPVRGVLLSSPALRVRLPPGTGIVRGILSAIAPRLPVPNPVDPAKL
CCCEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHC
SHDPSIAAAYRADTLVQSTISASLLEFMLNAITQAQQDAPRLEAPMLLMAGGADSIVDPS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCC
GSRDFYANAPEDLRSLAWFESGYHEIFNEAEPLRSEVFGKMTEWLASRI
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]