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The map label for this gene is hemE

Identifier: 187930563

GI number: 187930563

Start: 3668413

End: 3669516

Strand: Reverse

Name: hemE

Synonym: Rpic_3498

Alternate gene names: 187930563

Gene position: 3669516-3668413 (Counterclockwise)

Preceding gene: 187930564

Following gene: 187930562

Centisome position: 93.07

GC content: 67.48

Gene sequence:

>1104_bases
ATGTCCGCACCGCTCGCCAACGACACCTTCCTGCGCGCCCTGCGCCGCCAGCCCACCGACTACACGCCGCTGTGGCTGAT
GCGCCAGGCGGGCCGCTATCTGCCCGAGTACAACGCCACGCGCGCACGGGCTGGCAGCTTCCTCGGCCTGGCCAAGTCGC
CGGCGTATGCGACCGAGGTGACGCTGCAGCCGCTGGATCGCTATGCGCTGGACGCGGCAATCCTGTTCTCCGACATCCTG
ACCGTGCCCGACGCCATGGGCCTGGGGCTGTCGTTTGCACAGGGCGAGGGCCCGCGCTTTGCCAAGCCGGTGCGCACGGA
AGCCGATGTGGCTGCGCTGTCGGTGCCTGACATGTCGTCTCTGCAATACGTGTTCGACGCCGTGGCGGAAATCCGCCGTG
CGCTCGTGCAGGACGGCCGCCAGCGTGTGCCGCTCATCGGCTTCTCGGGCAGCCCGTGGACGCTCGCCTGTTACATGGTC
GAAGGCGGCGGCTCGGACGACTTCCGCACCGTCAAGTCGATGCTCTATGCGCGCCCGGACCTGATGCACCGCATCCTGGA
GATCAACGCGCAAGCCGTGATCGACTATCTCAACGCGCAGATCGATGCCGGTGCCCAAGCTGTGCAGGTGTTTGATACCT
GGGGCGGTGCCTTGGCCGATGGCATCTATCAGCAGTTCTCGCTGGCCTACATGGCGCGCGTGGTGGAAGGCATCCGCGCC
GGGGCAGACGGCCAGCGCGTGCCGGTCATCCTCTTCACCAAGGGCGGTGGCCTGTGGCTCGAAGCCATGGCCGAGACCGG
TGCCGACGCGCTGGGTGTGGACTGGACCGTCAACCTGCAGCTTGCGCGCCAGCGAACGGCAGGGCGCGTTGCCCTGCAGG
GCAACCTGGACCCGACGGTGCTGTTTGCTGAACCCGACGCGATTCGTGCCCAAGTGCGTCGCGTGCTGGAAGACTACGCA
GCCGGCGGCGGCAGCGACGGCCACATCTTCAACCTCGGCCACGGCATCTCGCAGTTCACACCGCCCGAAGCGGTGTCGGT
GCTGGTGGACGAGGTGCACAGCTTCAGCCGCGCGCTGCGCACGAAAGCGAGGTCACACGGTTGA

Upstream 100 bases:

>100_bases
CCGTGATATCTGCGCCCTGATCTTCGGCATGTTGGCCTGGGTCAGGTCGGAATAAAAACACCATCCCTTACAATGGCGCC
CTCCTAAAGAGTCCATCGCC

Downstream 100 bases:

>100_bases
GATCAATGCTGCGGTGCGATAGCGTTTGAATCGTGCCGCAGTCGTGCGTGAAGCCAGGGGCACGAGTTGAATCTTCGCCG
CTTTGGTGCATTAGGGGTGA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MSAPLANDTFLRALRRQPTDYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKSPAYATEVTLQPLDRYALDAAILFSDIL
TVPDAMGLGLSFAQGEGPRFAKPVRTEADVAALSVPDMSSLQYVFDAVAEIRRALVQDGRQRVPLIGFSGSPWTLACYMV
EGGGSDDFRTVKSMLYARPDLMHRILEINAQAVIDYLNAQIDAGAQAVQVFDTWGGALADGIYQQFSLAYMARVVEGIRA
GADGQRVPVILFTKGGGLWLEAMAETGADALGVDWTVNLQLARQRTAGRVALQGNLDPTVLFAEPDAIRAQVRRVLEDYA
AGGGSDGHIFNLGHGISQFTPPEAVSVLVDEVHSFSRALRTKARSHG

Sequences:

>Translated_367_residues
MSAPLANDTFLRALRRQPTDYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKSPAYATEVTLQPLDRYALDAAILFSDIL
TVPDAMGLGLSFAQGEGPRFAKPVRTEADVAALSVPDMSSLQYVFDAVAEIRRALVQDGRQRVPLIGFSGSPWTLACYMV
EGGGSDDFRTVKSMLYARPDLMHRILEINAQAVIDYLNAQIDAGAQAVQVFDTWGGALADGIYQQFSLAYMARVVEGIRA
GADGQRVPVILFTKGGGLWLEAMAETGADALGVDWTVNLQLARQRTAGRVALQGNLDPTVLFAEPDAIRAQVRRVLEDYA
AGGGSDGHIFNLGHGISQFTPPEAVSVLVDEVHSFSRALRTKARSHG
>Mature_366_residues
SAPLANDTFLRALRRQPTDYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKSPAYATEVTLQPLDRYALDAAILFSDILT
VPDAMGLGLSFAQGEGPRFAKPVRTEADVAALSVPDMSSLQYVFDAVAEIRRALVQDGRQRVPLIGFSGSPWTLACYMVE
GGGSDDFRTVKSMLYARPDLMHRILEINAQAVIDYLNAQIDAGAQAVQVFDTWGGALADGIYQQFSLAYMARVVEGIRAG
ADGQRVPVILFTKGGGLWLEAMAETGADALGVDWTVNLQLARQRTAGRVALQGNLDPTVLFAEPDAIRAQVRRVLEDYAA
GGGSDGHIFNLGHGISQFTPPEAVSVLVDEVHSFSRALRTKARSHG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=361, Percent_Identity=45.983379501385, Blast_Score=304, Evalue=8e-83,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=60.4519774011299, Blast_Score=425, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6320252, Length=356, Percent_Identity=37.9213483146067, Blast_Score=259, Evalue=4e-70,
Organism=Drosophila melanogaster, GI221330099, Length=355, Percent_Identity=40, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI19921920, Length=355, Percent_Identity=40, Blast_Score=263, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_RALPJ (B2UGT5)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001901050.1
- ProteinModelPortal:   B2UGT5
- SMR:   B2UGT5
- GeneID:   6288653
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_3498
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39734; Mature: 39602

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 78-78 BINDING 158-158 BINDING 213-213 BINDING 334-334

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPLANDTFLRALRRQPTDYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKSPAYATEV
CCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCHHCCCCCCCCEEEE
TLQPLDRYALDAAILFSDILTVPDAMGLGLSFAQGEGPRFAKPVRTEADVAALSVPDMSS
EHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEECCCCCCCCCCCCCCCCCEEEECCCCHHH
LQYVFDAVAEIRRALVQDGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMLYARPD
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHCHH
LMHRILEINAQAVIDYLNAQIDAGAQAVQVFDTWGGALADGIYQQFSLAYMARVVEGIRA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHC
GADGQRVPVILFTKGGGLWLEAMAETGADALGVDWTVNLQLARQRTAGRVALQGNLDPTV
CCCCCEEEEEEEECCCCEEHHHHHHCCCCCCCCCEEEEEHHHHCCCCCEEEEECCCCCEE
LFAEPDAIRAQVRRVLEDYAAGGGSDGHIFNLGHGISQFTPPEAVSVLVDEVHSFSRALR
EEECCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TKARSHG
HHHHCCC
>Mature Secondary Structure 
SAPLANDTFLRALRRQPTDYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKSPAYATEV
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCHHCCCCCCCCEEEE
TLQPLDRYALDAAILFSDILTVPDAMGLGLSFAQGEGPRFAKPVRTEADVAALSVPDMSS
EHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEECCCCCCCCCCCCCCCCCEEEECCCCHHH
LQYVFDAVAEIRRALVQDGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMLYARPD
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHCHH
LMHRILEINAQAVIDYLNAQIDAGAQAVQVFDTWGGALADGIYQQFSLAYMARVVEGIRA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHC
GADGQRVPVILFTKGGGLWLEAMAETGADALGVDWTVNLQLARQRTAGRVALQGNLDPTV
CCCCCEEEEEEEECCCCEEHHHHHHCCCCCCCCCEEEEEHHHHCCCCCEEEEECCCCCEE
LFAEPDAIRAQVRRVLEDYAAGGGSDGHIFNLGHGISQFTPPEAVSVLVDEVHSFSRALR
EEECCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TKARSHG
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA