Click here to switch to the map view.

The map label for this gene is htrA [H]

Identifier: 187930484

GI number: 187930484

Start: 3584529

End: 3585449

Strand: Reverse

Name: htrA [H]

Synonym: Rpic_3418

Alternate gene names: 187930484

Gene position: 3585449-3584529 (Counterclockwise)

Preceding gene: 187930485

Following gene: 187930483

Centisome position: 90.94

GC content: 62.87

Gene sequence:

>921_bases
ATGCATATCGTTCGACTGGTTTCACTGCTGGCTGCTGCCGTGGTCTGCGCCGGCGCTGCAGAGCGCGCGGTCGCGCTTGA
GCCCGCAGCGGTCTTTGCCAAGGTCTCGCCTAGCGTCTGGGAGGTCCGCGTTGCGGGTTCGGACGGCCGGCCGCTGTCCA
TTGGCAGCGCAGTGGTCATTGCCGATGGTGTGGCGATTACGAACTGCCATGTGCTGCGCGGCGGCAAGCAAGTCTGGCTC
AAACGCGGCAACGCAAGCTACGGTGCTCGCTTGCAGTATCCCGACGTGGAGCGCGACCTCTGTCAACTGCGGGTCGCGGA
TTTCCACGCGCCTGCAGTGACGCTTGCTCCGGGTAGCGCGCTCGTGACGGGGCAGAAGGTGTACGCAGTCGGCAATCCGC
TGGGGCTGGAGCTGACGATCAGTGAGGGTTTGATCTCGTCATTGCGTACCGATGACGAAGGACGTCTCAAGAGCATCCAG
ACGTCTGCCCCAATCTCACAAGGGTCCAGCGGGGGCGGCCTGTTCGATGCGGACGGCCGATTGATTGGCATAACAGACCA
TCAAGTCGTGCTCACCATGGGGCAGAACCTGAACTTCGCGATTCCTGCGGACTGGATTGCCGATGTCCCTGCGCGCGGGC
AGAAATCGCTGGCTCAGGCGACGGCTGCACCGGCCGCTTACGCATCGAGCGCGCAGGCGGCGCCACCAGGCCGCTCCGGC
GAACTCGGGCGAAACCAACAGGCCGGCTTCGATATGTATCTGAAGAAAACGTGGCCGAAGATTTTTGTCGCCTCCGACGG
CGATCACTACTCCTGGGCCGTAGGCCAGAACGCAGAATTTCGGGCGATGGCTTTCTGTACCGAGCGATGGGTCAATTGCC
GCGTCTACGCCCGAGACGACACCATCGTCGAGGCCAAGTGA

Upstream 100 bases:

>100_bases
GCGCACATGCGTGATCGCACCCGTTCGGAAGATGGATCGACCACGCTGAGCGACCTCAAAGATTTGCTGGTGCCCCAATG
AGGCGGCCCGCTTGACTAAC

Downstream 100 bases:

>100_bases
CCACCGTTGCTACGCCGGAATGCTATTAAGATGTCGGCCTCTGCGGCATCTTGGGGCGCTCTTGTGCTGCGAGTAATCCC
CGTCGAATAGGAACCTGCCA

Product: peptidase S1 and S6 chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MHIVRLVSLLAAAVVCAGAAERAVALEPAAVFAKVSPSVWEVRVAGSDGRPLSIGSAVVIADGVAITNCHVLRGGKQVWL
KRGNASYGARLQYPDVERDLCQLRVADFHAPAVTLAPGSALVTGQKVYAVGNPLGLELTISEGLISSLRTDDEGRLKSIQ
TSAPISQGSSGGGLFDADGRLIGITDHQVVLTMGQNLNFAIPADWIADVPARGQKSLAQATAAPAAYASSAQAAPPGRSG
ELGRNQQAGFDMYLKKTWPKIFVASDGDHYSWAVGQNAEFRAMAFCTERWVNCRVYARDDTIVEAK

Sequences:

>Translated_306_residues
MHIVRLVSLLAAAVVCAGAAERAVALEPAAVFAKVSPSVWEVRVAGSDGRPLSIGSAVVIADGVAITNCHVLRGGKQVWL
KRGNASYGARLQYPDVERDLCQLRVADFHAPAVTLAPGSALVTGQKVYAVGNPLGLELTISEGLISSLRTDDEGRLKSIQ
TSAPISQGSSGGGLFDADGRLIGITDHQVVLTMGQNLNFAIPADWIADVPARGQKSLAQATAAPAAYASSAQAAPPGRSG
ELGRNQQAGFDMYLKKTWPKIFVASDGDHYSWAVGQNAEFRAMAFCTERWVNCRVYARDDTIVEAK
>Mature_306_residues
MHIVRLVSLLAAAVVCAGAAERAVALEPAAVFAKVSPSVWEVRVAGSDGRPLSIGSAVVIADGVAITNCHVLRGGKQVWL
KRGNASYGARLQYPDVERDLCQLRVADFHAPAVTLAPGSALVTGQKVYAVGNPLGLELTISEGLISSLRTDDEGRLKSIQ
TSAPISQGSSGGGLFDADGRLIGITDHQVVLTMGQNLNFAIPADWIADVPARGQKSLAQATAAPAAYASSAQAAPPGRSG
ELGRNQQAGFDMYLKKTWPKIFVASDGDHYSWAVGQNAEFRAMAFCTERWVNCRVYARDDTIVEAK

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=194, Percent_Identity=31.4432989690722, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4506141, Length=196, Percent_Identity=30.6122448979592, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI22129776, Length=202, Percent_Identity=31.6831683168317, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI7019477, Length=202, Percent_Identity=31.6831683168317, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786356, Length=171, Percent_Identity=32.1637426900585, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789629, Length=231, Percent_Identity=29.4372294372294, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646839, Length=195, Percent_Identity=32.3076923076923, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 32286; Mature: 32286

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIVRLVSLLAAAVVCAGAAERAVALEPAAVFAKVSPSVWEVRVAGSDGRPLSIGSAVVI
CHHHHHHHHHHHHHHHCCCCCCEEEECCHHEEEECCCCEEEEEEECCCCCEEECCCEEEE
ADGVAITNCHVLRGGKQVWLKRGNASYGARLQYPDVERDLCQLRVADFHAPAVTLAPGSA
ECCEEEEEEEEEECCCEEEEECCCCCCCCEEECCCHHHHHHHEEHHCCCCCEEEECCCCE
LVTGQKVYAVGNPLGLELTISEGLISSLRTDDEGRLKSIQTSAPISQGSSGGGLFDADGR
EEECCEEEEECCCCEEEEEECHHHHHHHCCCCCCHHEEEECCCCCCCCCCCCCEEECCCC
LIGITDHQVVLTMGQNLNFAIPADWIADVPARGQKSLAQATAAPAAYASSAQAAPPGRSG
EEEECCCEEEEEECCCCCEEECCHHHHCCCCCCHHHHHHHHCCCHHHCCCCCCCCCCCCC
ELGRNQQAGFDMYLKKTWPKIFVASDGDHYSWAVGQNAEFRAMAFCTERWVNCRVYARDD
CCCCCCCCCCEEEEECCCCEEEEEECCCEEEEEECCCCCCHHHHEEHHCCCEEEEEECCC
TIVEAK
EEEECC
>Mature Secondary Structure
MHIVRLVSLLAAAVVCAGAAERAVALEPAAVFAKVSPSVWEVRVAGSDGRPLSIGSAVVI
CHHHHHHHHHHHHHHHCCCCCCEEEECCHHEEEECCCCEEEEEEECCCCCEEECCCEEEE
ADGVAITNCHVLRGGKQVWLKRGNASYGARLQYPDVERDLCQLRVADFHAPAVTLAPGSA
ECCEEEEEEEEEECCCEEEEECCCCCCCCEEECCCHHHHHHHEEHHCCCCCEEEECCCCE
LVTGQKVYAVGNPLGLELTISEGLISSLRTDDEGRLKSIQTSAPISQGSSGGGLFDADGR
EEECCEEEEECCCCEEEEEECHHHHHHHCCCCCCHHEEEECCCCCCCCCCCCCEEECCCC
LIGITDHQVVLTMGQNLNFAIPADWIADVPARGQKSLAQATAAPAAYASSAQAAPPGRSG
EEEECCCEEEEEECCCCCEEECCHHHHCCCCCCHHHHHHHHCCCHHHCCCCCCCCCCCCC
ELGRNQQAGFDMYLKKTWPKIFVASDGDHYSWAVGQNAEFRAMAFCTERWVNCRVYARDD
CCCCCCCCCCEEEEECCCCEEEEEECCCEEEEEECCCCCCHHHHEEHHCCCEEEEEECCC
TIVEAK
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]