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The map label for this gene is hisA [H]

Identifier: 187930291

GI number: 187930291

Start: 3371455

End: 3372198

Strand: Reverse

Name: hisA [H]

Synonym: Rpic_3224

Alternate gene names: 187930291

Gene position: 3372198-3371455 (Counterclockwise)

Preceding gene: 187930292

Following gene: 187930290

Centisome position: 85.53

GC content: 63.44

Gene sequence:

>744_bases
ATGCTGCTCATCCCGGCCATCGACCTGAAGGACGGTCAGTGTGTGCGCCTCAAACAAGGCGATATGGATCAAGCCACCGT
ATTCTCGGAAGACCCCGCGGCCATGGCGCGGCATTGGGTCGAGCAGGGTGCGCGCCGCTTGCATCTTGTCGATCTGAATG
GCGCTTTCGCGGGCAAGCCGCGTAACGAGGCGGCCGTCAAGGCCATCCTCGCCGAGGTGGGCGACGAGATCCCCGTGCAA
CTCGGCGGCGGCATCCGCGATCTGGGCACCATCGAGCGCTGGCTCGACGACGGCTTGTCGTACGTGATCATCGGCACGGC
GGCGGTCAAGGACCCGGGCTTTCTGCGGGACGCATGCACGGCATTCGGCGGCCATATCATCGTCGGGCTCGATGCCAAGG
ACGGCAAGGTCGCGACCGACGGCTGGAGCAAGCTCTCCGGCCACGAAGTCGTGGACCTCGCCAAGAAGTACGAAGACTAC
GGCGTCGAAGGCATCATCTACACCGACATCGGCCGCGACGGCATGCTGCAGGGCATCAACATCGATGCCACCGTCAAGTT
GGCACAGTCGGTGAAAATTCCGGTCATTGCCAGCGGCGGCTTGTCGAACCTCAAGGACATCGACCACCTGTGCGCGGTCG
AAGAGCATGGCGTGGAAGGCGTGATCTGCGGTCGCGCCATCTATTCGGGCGACCTGAACTTCAAGGAAGCACAAGCCCTC
GCGGACAAACTCGGCGCGGCCTGA

Upstream 100 bases:

>100_bases
CGGAACTTCGTGCACTGGAACCCGTGAAATCGGGCTCACAGTCGCGACCGAATCCCTTTTGCCCGTTTAACCTCACCCCC
TCAACTTTGTCGTTACGACT

Downstream 100 bases:

>100_bases
TCGTTGATCCAGCCGTGCACAACGGGCGCTCCGGCGCCCGACTCATCATGCTAGCCAAACGAATCATCCCCTGCCTGGAC
GTGACCAACGGCCGGGTGGT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MLLIPAIDLKDGQCVRLKQGDMDQATVFSEDPAAMARHWVEQGARRLHLVDLNGAFAGKPRNEAAVKAILAEVGDEIPVQ
LGGGIRDLGTIERWLDDGLSYVIIGTAAVKDPGFLRDACTAFGGHIIVGLDAKDGKVATDGWSKLSGHEVVDLAKKYEDY
GVEGIIYTDIGRDGMLQGINIDATVKLAQSVKIPVIASGGLSNLKDIDHLCAVEEHGVEGVICGRAIYSGDLNFKEAQAL
ADKLGAA

Sequences:

>Translated_247_residues
MLLIPAIDLKDGQCVRLKQGDMDQATVFSEDPAAMARHWVEQGARRLHLVDLNGAFAGKPRNEAAVKAILAEVGDEIPVQ
LGGGIRDLGTIERWLDDGLSYVIIGTAAVKDPGFLRDACTAFGGHIIVGLDAKDGKVATDGWSKLSGHEVVDLAKKYEDY
GVEGIIYTDIGRDGMLQGINIDATVKLAQSVKIPVIASGGLSNLKDIDHLCAVEEHGVEGVICGRAIYSGDLNFKEAQAL
ADKLGAA
>Mature_247_residues
MLLIPAIDLKDGQCVRLKQGDMDQATVFSEDPAAMARHWVEQGARRLHLVDLNGAFAGKPRNEAAVKAILAEVGDEIPVQ
LGGGIRDLGTIERWLDDGLSYVIIGTAAVKDPGFLRDACTAFGGHIIVGLDAKDGKVATDGWSKLSGHEVVDLAKKYEDY
GVEGIIYTDIGRDGMLQGINIDATVKLAQSVKIPVIASGGLSNLKDIDHLCAVEEHGVEGVICGRAIYSGDLNFKEAQAL
ADKLGAA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=245, Percent_Identity=35.5102040816327, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI1788336, Length=248, Percent_Identity=25.4032258064516, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26188; Mature: 26188

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATVFSEDPAAMARHWVEQGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEECCCCCCCCEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCCC
RNEAAVKAILAEVGDEIPVQLGGGIRDLGTIERWLDDGLSYVIIGTAAVKDPGFLRDACT
CHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHH
AFGGHIIVGLDAKDGKVATDGWSKLSGHEVVDLAKKYEDYGVEGIIYTDIGRDGMLQGIN
HCCCEEEEEEECCCCEEECCCCHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCC
IDATVKLAQSVKIPVIASGGLSNLKDIDHLCAVEEHGVEGVICGRAIYSGDLNFKEAQAL
CCCEEEEHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCEEECCCCCHHHHHHH
ADKLGAA
HHHHCCC
>Mature Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATVFSEDPAAMARHWVEQGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEECCCCCCCCEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCCC
RNEAAVKAILAEVGDEIPVQLGGGIRDLGTIERWLDDGLSYVIIGTAAVKDPGFLRDACT
CHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHH
AFGGHIIVGLDAKDGKVATDGWSKLSGHEVVDLAKKYEDYGVEGIIYTDIGRDGMLQGIN
HCCCEEEEEEECCCCEEECCCCHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCC
IDATVKLAQSVKIPVIASGGLSNLKDIDHLCAVEEHGVEGVICGRAIYSGDLNFKEAQAL
CCCEEEEHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCEEECCCCCHHHHHHH
ADKLGAA
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA