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The map label for this gene is mltA [H]

Identifier: 187930186

GI number: 187930186

Start: 3267768

End: 3268910

Strand: Reverse

Name: mltA [H]

Synonym: Rpic_3118

Alternate gene names: 187930186

Gene position: 3268910-3267768 (Counterclockwise)

Preceding gene: 187930188

Following gene: 187930182

Centisome position: 82.91

GC content: 67.28

Gene sequence:

>1143_bases
ATGACAGCAGCAACCTTGGACGCATTGACACAAGCCCGCACCGGCACCTGTCGCCGCTGGGGCGGACTGGCCGCTGTTCT
GGTCGTGGCCTTGCTTGCCGCTTGTACGAGCGGGCCCCCGCCCCGCGTCGAAACGCCGCAAGCGCCAACAGGCTCGCTCG
GCGGGCATCTGGCCCCCGCCACCTGGGCTGATGTGTCCGGCTGGACCGCCGATGACCTCGCCTCCGCCTGGCCCGCGCTG
CAATCGAACTGCCAGGCGATGAAGCGCCGCACCGATTGGTCGCGCGTGTGCTCCGCTGGCCTGATGGTCGATGCCGGTGA
TCCGATTGCCATGCGCGTGTTTTTTGAAGACAACTTCACGCCGTATCGGGTCGTGAAGGACGACGGCACCGACAGCGGCC
TCATCACCGGTTACTACGAACCGCTGCTGCGTGGCTCGCGCACCCGCCACGGCGCCTATCAGACGCCGCTGTACCGCATG
CCTGCCGCGTGGCGCGGCAAGACGCTGCCGGCGCGCGCGCAGTTGATCCGCAGTCCGGCGCTTCAGGGGCAAGAAGTTGT
CTGGGTGGACGACCCGGTCGAAGCGGCGTTCCTGCAGATCCAGGGCTCGGGACAGGTTCAGCTGGAAGAGGGGGGCATCA
TGCGCCTGGGCGTGGGGGGCACGAACAACCAGCCGTTCCGTTCGTTTGCGCGCTGGCTGCTCGACATGGGCGAAATCACG
CCGATGCAGGCCACCATGCAAGGGATCAAGGCGTGGGCCCGCGCCAATCCGAGCCGCGTGGAAGAGATGCTCAACATCAA
CCCGCGCTACGTGTTCTTTGCCGAAACGCCGGGCAACACGGGCGGCCCGATCGGCAAGCTGGGCGTGCCGCTCACGGACG
AACGCTCGATCGCCGTCGACCCGACCTACATTCCGCTGGGCTCGCCGGTGTTCCTGTCGACGACCAAGCCGCTATCGACC
GATCCGATCCAGAAGCTCGTGTTTGCGCAGGACGTGGGTTCGGCCATTCGCGGGGCTGTGCGCGCCGACTATTACTTCGG
CCATGGCGATGCCGCTGGCGACCTCGCGGGCCGCATGAAGCAGGCCGGTCGGCTGTGGGTGCTGGTGCCGAAGGGGGGCA
GCATCGGCGTTGCTGCCCGGTAA

Upstream 100 bases:

>100_bases
GGATGGTTTTCAAAGAATTGGCTCATGGTCGATGGCGGGAAGCTCGGGTGCGAGGCATTGTAGCCAAGCCCGCGGCCGCA
CCGGACAGGATGAAACACGC

Downstream 100 bases:

>100_bases
CACGCTGCAAGACGCTAGGTGCGCCGCAAGTCCACCACGCGGCGCGCCTTGCCGACCGACCGCTCGATTCCGCCGCTGGC
CAGTGTCTCGATCGCGGCGG

Product: MltA domain-containing protein

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTAATLDALTQARTGTCRRWGGLAAVLVVALLAACTSGPPPRVETPQAPTGSLGGHLAPATWADVSGWTADDLASAWPAL
QSNCQAMKRRTDWSRVCSAGLMVDAGDPIAMRVFFEDNFTPYRVVKDDGTDSGLITGYYEPLLRGSRTRHGAYQTPLYRM
PAAWRGKTLPARAQLIRSPALQGQEVVWVDDPVEAAFLQIQGSGQVQLEEGGIMRLGVGGTNNQPFRSFARWLLDMGEIT
PMQATMQGIKAWARANPSRVEEMLNINPRYVFFAETPGNTGGPIGKLGVPLTDERSIAVDPTYIPLGSPVFLSTTKPLST
DPIQKLVFAQDVGSAIRGAVRADYYFGHGDAAGDLAGRMKQAGRLWVLVPKGGSIGVAAR

Sequences:

>Translated_380_residues
MTAATLDALTQARTGTCRRWGGLAAVLVVALLAACTSGPPPRVETPQAPTGSLGGHLAPATWADVSGWTADDLASAWPAL
QSNCQAMKRRTDWSRVCSAGLMVDAGDPIAMRVFFEDNFTPYRVVKDDGTDSGLITGYYEPLLRGSRTRHGAYQTPLYRM
PAAWRGKTLPARAQLIRSPALQGQEVVWVDDPVEAAFLQIQGSGQVQLEEGGIMRLGVGGTNNQPFRSFARWLLDMGEIT
PMQATMQGIKAWARANPSRVEEMLNINPRYVFFAETPGNTGGPIGKLGVPLTDERSIAVDPTYIPLGSPVFLSTTKPLST
DPIQKLVFAQDVGSAIRGAVRADYYFGHGDAAGDLAGRMKQAGRLWVLVPKGGSIGVAAR
>Mature_379_residues
TAATLDALTQARTGTCRRWGGLAAVLVVALLAACTSGPPPRVETPQAPTGSLGGHLAPATWADVSGWTADDLASAWPALQ
SNCQAMKRRTDWSRVCSAGLMVDAGDPIAMRVFFEDNFTPYRVVKDDGTDSGLITGYYEPLLRGSRTRHGAYQTPLYRMP
AAWRGKTLPARAQLIRSPALQGQEVVWVDDPVEAAFLQIQGSGQVQLEEGGIMRLGVGGTNNQPFRSFARWLLDMGEITP
MQATMQGIKAWARANPSRVEEMLNINPRYVFFAETPGNTGGPIGKLGVPLTDERSIAVDPTYIPLGSPVFLSTTKPLSTD
PIQKLVFAQDVGSAIRGAVRADYYFGHGDAAGDLAGRMKQAGRLWVLVPKGGSIGVAAR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=359, Percent_Identity=28.9693593314763, Blast_Score=125, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40712; Mature: 40581

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAATLDALTQARTGTCRRWGGLAAVLVVALLAACTSGPPPRVETPQAPTGSLGGHLAPA
CCCHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
TWADVSGWTADDLASAWPALQSNCQAMKRRTDWSRVCSAGLMVDAGDPIAMRVFFEDNFT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEECCCCEEEEEEEECCCC
PYRVVKDDGTDSGLITGYYEPLLRGSRTRHGAYQTPLYRMPAAWRGKTLPARAQLIRSPA
EEEEEECCCCCCCEEEHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHCCC
LQGQEVVWVDDPVEAAFLQIQGSGQVQLEEGGIMRLGVGGTNNQPFRSFARWLLDMGEIT
CCCCEEEEECCCCCEEEEEEECCCEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHCCCC
PMQATMQGIKAWARANPSRVEEMLNINPRYVFFAETPGNTGGPIGKLGVPLTDERSIAVD
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEC
PTYIPLGSPVFLSTTKPLSTDPIQKLVFAQDVGSAIRGAVRADYYFGHGDAAGDLAGRMK
CEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHH
QAGRLWVLVPKGGSIGVAAR
HCCCEEEEEECCCCEECCCC
>Mature Secondary Structure 
TAATLDALTQARTGTCRRWGGLAAVLVVALLAACTSGPPPRVETPQAPTGSLGGHLAPA
CCHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
TWADVSGWTADDLASAWPALQSNCQAMKRRTDWSRVCSAGLMVDAGDPIAMRVFFEDNFT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEECCCCEEEEEEEECCCC
PYRVVKDDGTDSGLITGYYEPLLRGSRTRHGAYQTPLYRMPAAWRGKTLPARAQLIRSPA
EEEEEECCCCCCCEEEHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHCCC
LQGQEVVWVDDPVEAAFLQIQGSGQVQLEEGGIMRLGVGGTNNQPFRSFARWLLDMGEIT
CCCCEEEEECCCCCEEEEEEECCCEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHCCCC
PMQATMQGIKAWARANPSRVEEMLNINPRYVFFAETPGNTGGPIGKLGVPLTDERSIAVD
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEC
PTYIPLGSPVFLSTTKPLSTDPIQKLVFAQDVGSAIRGAVRADYYFGHGDAAGDLAGRMK
CEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHH
QAGRLWVLVPKGGSIGVAAR
HCCCEEEEEECCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]