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The map label for this gene is penA [H]

Identifier: 187930163

GI number: 187930163

Start: 3233718

End: 3235505

Strand: Reverse

Name: penA [H]

Synonym: Rpic_3095

Alternate gene names: 187930163

Gene position: 3235505-3233718 (Counterclockwise)

Preceding gene: 187930164

Following gene: 187930162

Centisome position: 82.07

GC content: 64.82

Gene sequence:

>1788_bases
ATGAGCGGCGCACGCAAATCCAACGGCACCACGGCGCGCGCGCGCCTGGGTCAGTTTTCCGCCAGCCCGGTGCTGGGCCT
GCGCCTGCCCATGTGGCGCTCCAAGCTGGTCGTGTTCCTGATGTTCGCGGCGTTCCTGGCACTGATCGGCCGTGCGCTGT
GGATTCAAGGCCCGGGCAACCGCTTCTATGAGGCTGAAGGCAAGAAGCGCTTCCAGCGCACGCTGGAATTGCCGGCCACG
CGCGGCAAGATTCTCGATCGCAATGGTCTGGTGCTGGCCACGAGCCTGCCGGTGAAGGCCATCTGGGCCGTGCCCGAAGA
CGTGCCCAACAACGTGCCTGGCGAAGACATGATGAAGCTCGCCAAGCTGCTGGGCATGAACAACAAGGAGCTTTCGGGCA
AGCTCGGCGAAGACAAGGGCTTCGTCTACCTCAAGCGTCAAGTGCTGCCGGAGGTGGCCGACCAGATTGCAGCGCTGAAG
ATCGAAGGCATCTATCAGACGCGAGAGTACAAGCGTTTCTACCCGGAAGGCGAGGCGATGGCGCACATCGTCGGTTTCAC
CAACGTTGAGGACAAGGGCCAGGAAGGCATGGAGTTGGCGCGCGAGTCCGACCTGGCGGGTGCCGCGGGCCAGCGTCAGG
TGATCAAGGACCGGCTGGGCCGCGTGGTGGAAGACGTGGGCGTGCTCAAGGCCCCGCGTAATGGGCATGACCAGACCCTG
TCGATCGACGCCAAGATCCAGTACCTGACCTTCAACGAACTGAAAGCCGCCATCGAGCGCACCCACGCCAAGGCCGCCAG
CGCGATCGTGCTGGATGCCCAGACCGGCGAGGTGCTGGCGCTCGCGAACTATCCGACCTACAACCCGAACGACCGCAGCC
GCCTGTCGGGCGAGCAACTGCGCAACCGCGTGCTGACCGACACCTTCGAGCCCGGCTCGATGATGAAGCCGGTGACGATC
AGCCTGGCGCTGCAGCTCAAGCGCGTGACGCCCAACACGCTGGTGCAGACCAACGGCAAATACAGCTTCGAAGGCGCGAC
CATTTCGGATACCGGCAACTACGGAACGCTGACGGTCGCCCAGGTGATCCAGCACTCCAGCAACATCGGTACGACCAAGA
TCGCGATGATGCTCAAGCCGCAGGAAATGTGGGATATGTTCACCAGCGTTGGCTTGGGGCAGGCGCCGAAGATCGGCTTC
CCGGGCGCGGTGGCGGGGCGGCTGCGGCCGGCAAACAAATGGCGCCGCATCGAGCAGGCGACCATGTCTTACGGCTACGG
TCTGTCGGTGTCGCTGTTCCAGATTGCGCACGCGTACACCATCTTCGCGCACGATGGCGAGCTGATTCCGATCACCATGT
ACCGCACCGATGGCCAGCCGCCGCAGGGCGAGCGCGTAATCTCGCCGGAGGTGGCGCGCCAGGTCCGTCAGATGCTGGAG
ACGGTGACGGCCCCCGGCGGTACCGCACCGCAGGCCCAGGTAATGGGCTATCGCGTCGGCGGCAAGACCGGCACGGCCTG
GAAGCACACCGGACGCGGCTATGACCGCTCCAAGTATCGTGCCTCGTTCATTGGCCTGGCGCCGATGTCAAACCCGCGCA
TCATCGTGGCCGTGAGCGTGGACGAGCCTACGGTGGGTAACCGCTATGGCGGTGGCGCGGCCGGCCCGGTGTTCTCCCAA
ATCGTGGGCGGTACCCTGCGCGCGTTGAACGTGCCGCCGGATTCGCCGGTACGGCAGCTCGTGATGACCCCGGATGTGCC
GGAAGAACCGGTGGGAGGCCTGCAATGA

Upstream 100 bases:

>100_bases
CGCAGTATCTGCAGGGGTTTGCCGATTTGCCGGCTGCGGGGATGTCCTCCGGGGCTTCCTCGGCGGCGGCGAGCGCGCCC
ACGGCTTCCGGAGTCCAGCC

Downstream 100 bases:

>100_bases
CAGCCAAGCCCACTTCCGATCGTCCGACGATCGATGCCCGCCTCACGCCGGTGGTGGATTGGTTGCGCGCTCAGGCACCC
GCGCGTGCCGACCTCACCAG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MSGARKSNGTTARARLGQFSASPVLGLRLPMWRSKLVVFLMFAAFLALIGRALWIQGPGNRFYEAEGKKRFQRTLELPAT
RGKILDRNGLVLATSLPVKAIWAVPEDVPNNVPGEDMMKLAKLLGMNNKELSGKLGEDKGFVYLKRQVLPEVADQIAALK
IEGIYQTREYKRFYPEGEAMAHIVGFTNVEDKGQEGMELARESDLAGAAGQRQVIKDRLGRVVEDVGVLKAPRNGHDQTL
SIDAKIQYLTFNELKAAIERTHAKAASAIVLDAQTGEVLALANYPTYNPNDRSRLSGEQLRNRVLTDTFEPGSMMKPVTI
SLALQLKRVTPNTLVQTNGKYSFEGATISDTGNYGTLTVAQVIQHSSNIGTTKIAMMLKPQEMWDMFTSVGLGQAPKIGF
PGAVAGRLRPANKWRRIEQATMSYGYGLSVSLFQIAHAYTIFAHDGELIPITMYRTDGQPPQGERVISPEVARQVRQMLE
TVTAPGGTAPQAQVMGYRVGGKTGTAWKHTGRGYDRSKYRASFIGLAPMSNPRIIVAVSVDEPTVGNRYGGGAAGPVFSQ
IVGGTLRALNVPPDSPVRQLVMTPDVPEEPVGGLQ

Sequences:

>Translated_595_residues
MSGARKSNGTTARARLGQFSASPVLGLRLPMWRSKLVVFLMFAAFLALIGRALWIQGPGNRFYEAEGKKRFQRTLELPAT
RGKILDRNGLVLATSLPVKAIWAVPEDVPNNVPGEDMMKLAKLLGMNNKELSGKLGEDKGFVYLKRQVLPEVADQIAALK
IEGIYQTREYKRFYPEGEAMAHIVGFTNVEDKGQEGMELARESDLAGAAGQRQVIKDRLGRVVEDVGVLKAPRNGHDQTL
SIDAKIQYLTFNELKAAIERTHAKAASAIVLDAQTGEVLALANYPTYNPNDRSRLSGEQLRNRVLTDTFEPGSMMKPVTI
SLALQLKRVTPNTLVQTNGKYSFEGATISDTGNYGTLTVAQVIQHSSNIGTTKIAMMLKPQEMWDMFTSVGLGQAPKIGF
PGAVAGRLRPANKWRRIEQATMSYGYGLSVSLFQIAHAYTIFAHDGELIPITMYRTDGQPPQGERVISPEVARQVRQMLE
TVTAPGGTAPQAQVMGYRVGGKTGTAWKHTGRGYDRSKYRASFIGLAPMSNPRIIVAVSVDEPTVGNRYGGGAAGPVFSQ
IVGGTLRALNVPPDSPVRQLVMTPDVPEEPVGGLQ
>Mature_594_residues
SGARKSNGTTARARLGQFSASPVLGLRLPMWRSKLVVFLMFAAFLALIGRALWIQGPGNRFYEAEGKKRFQRTLELPATR
GKILDRNGLVLATSLPVKAIWAVPEDVPNNVPGEDMMKLAKLLGMNNKELSGKLGEDKGFVYLKRQVLPEVADQIAALKI
EGIYQTREYKRFYPEGEAMAHIVGFTNVEDKGQEGMELARESDLAGAAGQRQVIKDRLGRVVEDVGVLKAPRNGHDQTLS
IDAKIQYLTFNELKAAIERTHAKAASAIVLDAQTGEVLALANYPTYNPNDRSRLSGEQLRNRVLTDTFEPGSMMKPVTIS
LALQLKRVTPNTLVQTNGKYSFEGATISDTGNYGTLTVAQVIQHSSNIGTTKIAMMLKPQEMWDMFTSVGLGQAPKIGFP
GAVAGRLRPANKWRRIEQATMSYGYGLSVSLFQIAHAYTIFAHDGELIPITMYRTDGQPPQGERVISPEVARQVRQMLET
VTAPGGTAPQAQVMGYRVGGKTGTAWKHTGRGYDRSKYRASFIGLAPMSNPRIIVAVSVDEPTVGNRYGGGAAGPVFSQI
VGGTLRALNVPPDSPVRQLVMTPDVPEEPVGGLQ

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=549, Percent_Identity=40.0728597449909, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1786854, Length=600, Percent_Identity=23.6666666666667, Blast_Score=93, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 64807; Mature: 64676

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGARKSNGTTARARLGQFSASPVLGLRLPMWRSKLVVFLMFAAFLALIGRALWIQGPGN
CCCCCCCCCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
RFYEAEGKKRFQRTLELPATRGKILDRNGLVLATSLPVKAIWAVPEDVPNNVPGEDMMKL
CEEECHHHHHHHHHHCCCCCCCCEECCCCEEEEECCCEEEEEECCCCCCCCCCHHHHHHH
AKLLGMNNKELSGKLGEDKGFVYLKRQVLPEVADQIAALKIEGIYQTREYKRFYPEGEAM
HHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHEEEECHHHHHHHHHHCCCCCCE
AHIVGFTNVEDKGQEGMELARESDLAGAAGQRQVIKDRLGRVVEDVGVLKAPRNGHDQTL
EEEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCEE
SIDAKIQYLTFNELKAAIERTHAKAASAIVLDAQTGEVLALANYPTYNPNDRSRLSGEQL
EEEEEEEEEEHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEECCCCCCCCCHHHCCHHHH
RNRVLTDTFEPGSMMKPVTISLALQLKRVTPNTLVQTNGKYSFEGATISDTGNYGTLTVA
HHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCCEEECCCEEEECCCEEECCCCCCHHHHH
QVIQHSSNIGTTKIAMMLKPQEMWDMFTSVGLGQAPKIGFPGAVAGRLRPANKWRRIEQA
HHHHHCCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHH
TMSYGYGLSVSLFQIAHAYTIFAHDGELIPITMYRTDGQPPQGERVISPEVARQVRQMLE
HHHCCCCCCHHHHHHHEEEEEEEECCCEEEEEEEECCCCCCCCCEEECHHHHHHHHHHHH
TVTAPGGTAPQAQVMGYRVGGKTGTAWKHTGRGYDRSKYRASFIGLAPMSNPRIIVAVSV
HHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHEEEEEEECCCCCCEEEEEEEC
DEPTVGNRYGGGAAGPVFSQIVGGTLRALNVPPDSPVRQLVMTPDVPEEPVGGLQ
CCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCHHHHEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SGARKSNGTTARARLGQFSASPVLGLRLPMWRSKLVVFLMFAAFLALIGRALWIQGPGN
CCCCCCCCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
RFYEAEGKKRFQRTLELPATRGKILDRNGLVLATSLPVKAIWAVPEDVPNNVPGEDMMKL
CEEECHHHHHHHHHHCCCCCCCCEECCCCEEEEECCCEEEEEECCCCCCCCCCHHHHHHH
AKLLGMNNKELSGKLGEDKGFVYLKRQVLPEVADQIAALKIEGIYQTREYKRFYPEGEAM
HHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHEEEECHHHHHHHHHHCCCCCCE
AHIVGFTNVEDKGQEGMELARESDLAGAAGQRQVIKDRLGRVVEDVGVLKAPRNGHDQTL
EEEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCEE
SIDAKIQYLTFNELKAAIERTHAKAASAIVLDAQTGEVLALANYPTYNPNDRSRLSGEQL
EEEEEEEEEEHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEECCCCCCCCCHHHCCHHHH
RNRVLTDTFEPGSMMKPVTISLALQLKRVTPNTLVQTNGKYSFEGATISDTGNYGTLTVA
HHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCCEEECCCEEEECCCEEECCCCCCHHHHH
QVIQHSSNIGTTKIAMMLKPQEMWDMFTSVGLGQAPKIGFPGAVAGRLRPANKWRRIEQA
HHHHHCCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHH
TMSYGYGLSVSLFQIAHAYTIFAHDGELIPITMYRTDGQPPQGERVISPEVARQVRQMLE
HHHCCCCCCHHHHHHHEEEEEEEECCCEEEEEEEECCCCCCCCCEEECHHHHHHHHHHHH
TVTAPGGTAPQAQVMGYRVGGKTGTAWKHTGRGYDRSKYRASFIGLAPMSNPRIIVAVSV
HHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHEEEEEEECCCCCCEEEEEEEC
DEPTVGNRYGGGAAGPVFSQIVGGTLRALNVPPDSPVRQLVMTPDVPEEPVGGLQ
CCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCHHHHEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]