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The map label for this gene is holA [H]

Identifier: 187930049

GI number: 187930049

Start: 3106294

End: 3107370

Strand: Reverse

Name: holA [H]

Synonym: Rpic_2981

Alternate gene names: 187930049

Gene position: 3107370-3106294 (Counterclockwise)

Preceding gene: 187930050

Following gene: 187930048

Centisome position: 78.82

GC content: 66.76

Gene sequence:

>1077_bases
ATGCAATTGCGGCTCGACGCGCTCGAAGGTCATCTGAAGCAGGCCACTGCCAAGGGGCTCGCGCCGCTGTACGTGGTGCA
CGGCGACGAGCACCTGCTCGCACTTGAGACTGTCGATGCGCTGCGCCAAGCTGCGCGCGCGCAGGGCTTTAGCGAGCGCG
AGGTGATGAGCGTCGAACGCGGCTTCTCGTGGTCGCGCGTGACCGAGGCGCAGCAGTCGATGTCGCTGTTCGGAGATCGC
AAGATCGTCGAGCTGCGCATTCCGTCCGGCAAGCCTGGCAAGGATGGCGGCGAAGCATTGCGCGCATTGGCGGCCGGCAC
ACCGTCCGGCCCCGCCACCGACACCCTCACGCTGATCACGCTGCCGCGCCTGGATTTTGCGACCGCCAAGTCGGCGTGGT
TCGCGGCGCTGGAAGGCGCTGGCGTGTCGATCAAGGTCGATTCGGTGGACCGCACCAAGCTGCCCGGCTGGATTGGCGAG
CGCTTGGCGCGCCAGCAGCAACGTGTGGAGCCCGGTGAGCCTGGCCGCCGCGCCCTGCAGTTCATTGCCGACCGTGTGGA
AGGCAATCTGCTGGCCGCGCATCAGGAAATCCAGAAACTCGGCTTGCTGCATCCGCCCGGTGTACTGACGTTCGACGATG
TGCACGATGCGGTGCTCAACGTGGCGCGTTACGACGTGTTCAAGCTGTCCGAAGCCATGCTGGCTGGAGACGTGCCGCGC
CTGGTACGCATGCTCGAAGGGCTGCGGGGCGAGGGCGAAGCGACGGTCCTGGTCCTCTGGACGTTGACCGAAGAAATTCG
CGTATTATCAAAAATCGCCTCGGGCGCGGCCCAAGGCAAGCCGGTGGCGTCCATGCTGCGGGAACTTCGGGTGTGGGGCC
CGCGCGAGCGGCTGGTGCCGCAGGCGGCGCAGCGGTTGTCGCAGCGCGAGCTGGAGGGAGCGCTCTCCATGGCGGCCAAG
CTGGATCGGCAGGTCAAGGGGTTGCGTGAACCATCGCTACCCGCTGAACCTTGGGATGGCTTGCTGCAACTGGCGATGCG
TATCGCGCGGCCGGGCAGCCTCCCGGTGCCGGCCTGA

Upstream 100 bases:

>100_bases
CTCTACCGGGACATGCAGGGCGATACGATCAACCAGCTCGTACGGCGCCTGGGCGCCGTGAAACTGCCGTCGTAAGCGGC
AGATCAGGGCAAGGTTTCCC

Downstream 100 bases:

>100_bases
TCCGCGCCATCGGCGCAAGCCTTCGAATTGTCCTCACACTGAATTGCCGGCAGCTTGCCGGTCGCGATCATCATGAAGCA
GCTCGACGTCAACGAATACA

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MQLRLDALEGHLKQATAKGLAPLYVVHGDEHLLALETVDALRQAARAQGFSEREVMSVERGFSWSRVTEAQQSMSLFGDR
KIVELRIPSGKPGKDGGEALRALAAGTPSGPATDTLTLITLPRLDFATAKSAWFAALEGAGVSIKVDSVDRTKLPGWIGE
RLARQQQRVEPGEPGRRALQFIADRVEGNLLAAHQEIQKLGLLHPPGVLTFDDVHDAVLNVARYDVFKLSEAMLAGDVPR
LVRMLEGLRGEGEATVLVLWTLTEEIRVLSKIASGAAQGKPVASMLRELRVWGPRERLVPQAAQRLSQRELEGALSMAAK
LDRQVKGLREPSLPAEPWDGLLQLAMRIARPGSLPVPA

Sequences:

>Translated_358_residues
MQLRLDALEGHLKQATAKGLAPLYVVHGDEHLLALETVDALRQAARAQGFSEREVMSVERGFSWSRVTEAQQSMSLFGDR
KIVELRIPSGKPGKDGGEALRALAAGTPSGPATDTLTLITLPRLDFATAKSAWFAALEGAGVSIKVDSVDRTKLPGWIGE
RLARQQQRVEPGEPGRRALQFIADRVEGNLLAAHQEIQKLGLLHPPGVLTFDDVHDAVLNVARYDVFKLSEAMLAGDVPR
LVRMLEGLRGEGEATVLVLWTLTEEIRVLSKIASGAAQGKPVASMLRELRVWGPRERLVPQAAQRLSQRELEGALSMAAK
LDRQVKGLREPSLPAEPWDGLLQLAMRIARPGSLPVPA
>Mature_358_residues
MQLRLDALEGHLKQATAKGLAPLYVVHGDEHLLALETVDALRQAARAQGFSEREVMSVERGFSWSRVTEAQQSMSLFGDR
KIVELRIPSGKPGKDGGEALRALAAGTPSGPATDTLTLITLPRLDFATAKSAWFAALEGAGVSIKVDSVDRTKLPGWIGE
RLARQQQRVEPGEPGRRALQFIADRVEGNLLAAHQEIQKLGLLHPPGVLTFDDVHDAVLNVARYDVFKLSEAMLAGDVPR
LVRMLEGLRGEGEATVLVLWTLTEEIRVLSKIASGAAQGKPVASMLRELRVWGPRERLVPQAAQRLSQRELEGALSMAAK
LDRQVKGLREPSLPAEPWDGLLQLAMRIARPGSLPVPA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=292, Percent_Identity=31.8493150684932, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 38923; Mature: 38923

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRLDALEGHLKQATAKGLAPLYVVHGDEHLLALETVDALRQAARAQGFSEREVMSVER
CCEEHHHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHC
GFSWSRVTEAQQSMSLFGDRKIVELRIPSGKPGKDGGEALRALAAGTPSGPATDTLTLIT
CCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEE
LPRLDFATAKSAWFAALEGAGVSIKVDSVDRTKLPGWIGERLARQQQRVEPGEPGRRALQ
ECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
FIADRVEGNLLAAHQEIQKLGLLHPPGVLTFDDVHDAVLNVARYDVFKLSEAMLAGDVPR
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LVRMLEGLRGEGEATVLVLWTLTEEIRVLSKIASGAAQGKPVASMLRELRVWGPRERLVP
HHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHH
QAAQRLSQRELEGALSMAAKLDRQVKGLREPSLPAEPWDGLLQLAMRIARPGSLPVPA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQLRLDALEGHLKQATAKGLAPLYVVHGDEHLLALETVDALRQAARAQGFSEREVMSVER
CCEEHHHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHC
GFSWSRVTEAQQSMSLFGDRKIVELRIPSGKPGKDGGEALRALAAGTPSGPATDTLTLIT
CCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEE
LPRLDFATAKSAWFAALEGAGVSIKVDSVDRTKLPGWIGERLARQQQRVEPGEPGRRALQ
ECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
FIADRVEGNLLAAHQEIQKLGLLHPPGVLTFDDVHDAVLNVARYDVFKLSEAMLAGDVPR
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LVRMLEGLRGEGEATVLVLWTLTEEIRVLSKIASGAAQGKPVASMLRELRVWGPRERLVP
HHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHH
QAAQRLSQRELEGALSMAAKLDRQVKGLREPSLPAEPWDGLLQLAMRIARPGSLPVPA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]