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The map label for this gene is ydgK [H]

Identifier: 187929454

GI number: 187929454

Start: 2468755

End: 2469939

Strand: Reverse

Name: ydgK [H]

Synonym: Rpic_2375

Alternate gene names: 187929454

Gene position: 2469939-2468755 (Counterclockwise)

Preceding gene: 187929460

Following gene: 187929453

Centisome position: 62.65

GC content: 68.52

Gene sequence:

>1185_bases
ATGCCCGGCCCGATCCCCGGCTGGCTCCTGCTGCTTGGCGCGCTCACGGCCATCGGCCCGCTGTCGGTGGACATGTACCT
GCCGAGCCTGCCGACCATCGCGCGCGATCTGAATACGTCGTCGGCCGCGGCGGGGCTCACGCTGACTGTGTTCCTGATCA
GCCTGGCGATCGGCCAGCTCATCTACGGCCCAGCCAGCGATCGGTTTGGCCGCAAGCCGCCGCTCTATATCGGTCTGGCG
ATGTACGTGGCGGCGTCCATCGGTTGCGCGTTCGCCAAAGACGCCACGATGCTGGCCGTGCTGCGCGGCGTGCAGGGGTT
TGGCGGCTGCGCGGGCATGGTCATCGCACGCGCTGCCGTGCGTGATCGCATGGACCCGGCCGGCGCCGCGCAGGCGTATT
CGACGCTGATGCTGGTGATGGGTGTAGCGCCCATCCTCGCGCCGATGATTGGCGGCGCAGTGCTGCAGTTCACAACGTGG
CGGGTCATCTTTGCTCTGCTGACGGCATTTGGCGTGCTGTCGCTGGTCGCGGTGCATTACCTGATGCGCGAGTCGCTGGC
GCCCGAGCAGGCGCGCAGGCTGGCAGTCCGCCACGTGCTGCGCGACTACTGGGAACTCCTGCGCGATCACCACTACGCTG
CCTATATGTGGTGCGGCGCCGTGTTTCTGTCGGGCATGTTCGCGTACATCACCGTGTCGTCGTTCGTGCTGATCGACGGT
TATGGGCTGACGCCGTCGCAGTACGCCTGGGTGTTCGGCAGCAACGCCGCCGGGATGATCGCGGCCTCGCGCGTGAATGT
GCGGCTGGTGCGCAAGTATTCGCCGGCGCGCGTGCTGCGACGGGCGCTGTGGGTGCCGGCCATCACCAGCGTGCTGGCTG
CCGCTGCCGCCGCGGCCGGTTTTACGCCGCTGCCGCTCGTGCTGGCGGCGCTGTTCTGCTACATCGCCTCGATCGGCTGC
ATCTCTCCCAACACCGGCGCGCTGGCAATGGCGGGGCAGGGTGCGCGTGCGGGTACGGGCTCGGCGCTCATGGGCGCCAT
GCAATTTGGCCTCGGCATGGTGACCGGTACGGTGGTTGCCGCCGTCGGCCAGACGGCGCTGCCGCTGCTGGGCATGATGG
CTGTCTGCGCCGTCGCCGCACTCGTTCTGGGTCTGCGCATCACGCGCGAAGAGCCCGCCGCCTGA

Upstream 100 bases:

>100_bases
CTTTGCGCTACAGTTCCCGGTTTACTCCGGCGCGGGCCTCCCGTCTGCCGCCGCGTCAAGTTCTCCCTTCATGACTGCTC
CCGCTCCTGCACGATCCCGC

Downstream 100 bases:

>100_bases
CCCTCAGTTCCGGTCTCGATCTACGCCTCTTGTTCTGGGGGCGTCTTCCTCCTTTCATATGACTTTGGCATAACATGCCT
GTCACGCTAACCGCGTCCGG

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MPGPIPGWLLLLGALTAIGPLSVDMYLPSLPTIARDLNTSSAAAGLTLTVFLISLAIGQLIYGPASDRFGRKPPLYIGLA
MYVAASIGCAFAKDATMLAVLRGVQGFGGCAGMVIARAAVRDRMDPAGAAQAYSTLMLVMGVAPILAPMIGGAVLQFTTW
RVIFALLTAFGVLSLVAVHYLMRESLAPEQARRLAVRHVLRDYWELLRDHHYAAYMWCGAVFLSGMFAYITVSSFVLIDG
YGLTPSQYAWVFGSNAAGMIAASRVNVRLVRKYSPARVLRRALWVPAITSVLAAAAAAAGFTPLPLVLAALFCYIASIGC
ISPNTGALAMAGQGARAGTGSALMGAMQFGLGMVTGTVVAAVGQTALPLLGMMAVCAVAALVLGLRITREEPAA

Sequences:

>Translated_394_residues
MPGPIPGWLLLLGALTAIGPLSVDMYLPSLPTIARDLNTSSAAAGLTLTVFLISLAIGQLIYGPASDRFGRKPPLYIGLA
MYVAASIGCAFAKDATMLAVLRGVQGFGGCAGMVIARAAVRDRMDPAGAAQAYSTLMLVMGVAPILAPMIGGAVLQFTTW
RVIFALLTAFGVLSLVAVHYLMRESLAPEQARRLAVRHVLRDYWELLRDHHYAAYMWCGAVFLSGMFAYITVSSFVLIDG
YGLTPSQYAWVFGSNAAGMIAASRVNVRLVRKYSPARVLRRALWVPAITSVLAAAAAAAGFTPLPLVLAALFCYIASIGC
ISPNTGALAMAGQGARAGTGSALMGAMQFGLGMVTGTVVAAVGQTALPLLGMMAVCAVAALVLGLRITREEPAA
>Mature_393_residues
PGPIPGWLLLLGALTAIGPLSVDMYLPSLPTIARDLNTSSAAAGLTLTVFLISLAIGQLIYGPASDRFGRKPPLYIGLAM
YVAASIGCAFAKDATMLAVLRGVQGFGGCAGMVIARAAVRDRMDPAGAAQAYSTLMLVMGVAPILAPMIGGAVLQFTTWR
VIFALLTAFGVLSLVAVHYLMRESLAPEQARRLAVRHVLRDYWELLRDHHYAAYMWCGAVFLSGMFAYITVSSFVLIDGY
GLTPSQYAWVFGSNAAGMIAASRVNVRLVRKYSPARVLRRALWVPAITSVLAAAAAAAGFTPLPLVLAALFCYIASIGCI
SPNTGALAMAGQGARAGTGSALMGAMQFGLGMVTGTVVAAVGQTALPLLGMMAVCAVAALVLGLRITREEPAA

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=386, Percent_Identity=30.0518134715026, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI48994889, Length=399, Percent_Identity=30.8270676691729, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790794, Length=281, Percent_Identity=28.1138790035587, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1790146, Length=245, Percent_Identity=28.1632653061224, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787065, Length=329, Percent_Identity=24.0121580547112, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082312, Length=198, Percent_Identity=28.7878787878788, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081983, Length=148, Percent_Identity=27.027027027027, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790195, Length=149, Percent_Identity=29.5302013422819, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319657, Length=169, Percent_Identity=27.2189349112426, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319480, Length=209, Percent_Identity=23.444976076555, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41074; Mature: 40943

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PGPIPGWLLLLGALTAIGPLSVDMYLPSLPTIARDLNTSSAAAGLTLTVFLISLAIGQL
CCCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IYGPASDRFGRKPPLYIGLAMYVAASIGCAFAKDATMLAVLRGVQGFGGCAGMVIARAAV
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RDRMDPAGAAQAYSTLMLVMGVAPILAPMIGGAVLQFTTWRVIFALLTAFGVLSLVAVHY
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMRESLAPEQARRLAVRHVLRDYWELLRDHHYAAYMWCGAVFLSGMFAYITVSSFVLIDG
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
YGLTPSQYAWVFGSNAAGMIAASRVNVRLVRKYSPARVLRRALWVPAITSVLAAAAAAAG
CCCCCCCEEEEEECCCCCHHEEHHCCEEHECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
FTPLPLVLAALFCYIASIGCISPNTGALAMAGQGARAGTGSALMGAMQFGLGMVTGTVVA
CCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AVGQTALPLLGMMAVCAVAALVLGLRITREEPAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]