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The map label for this gene is add

Identifier: 187929328

GI number: 187929328

Start: 2360950

End: 2361987

Strand: Direct

Name: add

Synonym: Rpic_2249

Alternate gene names: 187929328

Gene position: 2360950-2361987 (Clockwise)

Preceding gene: 187929327

Following gene: 187929329

Centisome position: 59.88

GC content: 63.2

Gene sequence:

>1038_bases
ATGCCGATTTCCTCCGCGCTTGCAGAACGCATCGCCACCAGCCCCAAAGCTGAACTGCACATCCACATCGAAGGCTCGCT
CGAACCTGAACTGATGTTCGCGCTGGCCGAGCGCAACGGCGTGAAGCTGCCGTATGCGTCCGTGGAAGAAGTGCGAGCAG
CCTACGCCTTTGACGATCTGCAATCGTTCCTCGACCTGTACTACGCCGGCGCCAGCGTGCTGCTCACCGAGCAGGATTTC
TACGACATGACCGCCGCATACGTGGCACGTGCGCTGGCCGACAACGTCCACCACGCCGAAATCTTCTTCGACCCGCAGAC
GCACACCGCGCGCAACGTGCCCATGCATGTGGTCATTCACGGTATCGTCCGCGCGTTGGATGACGCCGAGCGCGAGCATG
GTTTTTCGAGCGCGCTGATCCTCTGCTTCCTGCGCCATCTGAGCGAGGAAGACGCTTTCGACACGCTCGAAGCGGCCCTG
CCCTATATCCAGGATCCGGCCAACCGCATCATCGGCGTGGGGCTGGATTCGTCCGAGCGCGGCAACCCGCCGGAGAAGTT
CGCACGCGTATTCGCACGCTGCAAGGAACTCGGCCTGCGCCTGGTCGCCCACGCTGGTGAAGAAGGCCCGGCGCAATACG
TGATCGACGCCCTCGACATCCTCAAGGTGGAGCGCATCGATCACGGCGTACGCGCCATCGACGATGCCGCGCTCGTCAAG
CGCCTCGCGGCCGAACGCATCGCGCTGACGGTCTGCCCGCTGTCGAACGAAAAACTGAAGGTCTACCCCGACCTGCGCGA
CCACTCGCTCAAGCAACTGCTGGACGCCGGCTGCGCTGTGACGCTGCATTCCGACGATCCGGCCTACTTTGGCGGCTACA
TGAACACCAACTGGCTCGCCACGTTCAACGCCCTCGACCTGTCTGCAGCCGATGCCCACGCGCTCGCGCGCAACAGCTTC
GAGGCGTCATTCCTGCCCGAACAGGACAAAGCCCTGTGGCTCGCCAAGGTCGACGACCACTGGAAAGCCGCACACTAA

Upstream 100 bases:

>100_bases
TCGCGCAACTGCTGCAGGTGCGAGAGCTGCAACAGCATGCGCTCACCAGCGCGAGCAGCGGCGCGGCGGTCCCTTACCGA
GTCCCCACGCCTGTCTGATC

Downstream 100 bases:

>100_bases
AAATCCACGAGACGATATGACCACGATGCCTCCGACTTCCAACACCGTTCACGCCTACCGCGGCCGCGTGCTGCATTTCC
TGCACGATCCGCAGTATCGC

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MPISSALAERIATSPKAELHIHIEGSLEPELMFALAERNGVKLPYASVEEVRAAYAFDDLQSFLDLYYAGASVLLTEQDF
YDMTAAYVARALADNVHHAEIFFDPQTHTARNVPMHVVIHGIVRALDDAEREHGFSSALILCFLRHLSEEDAFDTLEAAL
PYIQDPANRIIGVGLDSSERGNPPEKFARVFARCKELGLRLVAHAGEEGPAQYVIDALDILKVERIDHGVRAIDDAALVK
RLAAERIALTVCPLSNEKLKVYPDLRDHSLKQLLDAGCAVTLHSDDPAYFGGYMNTNWLATFNALDLSAADAHALARNSF
EASFLPEQDKALWLAKVDDHWKAAH

Sequences:

>Translated_345_residues
MPISSALAERIATSPKAELHIHIEGSLEPELMFALAERNGVKLPYASVEEVRAAYAFDDLQSFLDLYYAGASVLLTEQDF
YDMTAAYVARALADNVHHAEIFFDPQTHTARNVPMHVVIHGIVRALDDAEREHGFSSALILCFLRHLSEEDAFDTLEAAL
PYIQDPANRIIGVGLDSSERGNPPEKFARVFARCKELGLRLVAHAGEEGPAQYVIDALDILKVERIDHGVRAIDDAALVK
RLAAERIALTVCPLSNEKLKVYPDLRDHSLKQLLDAGCAVTLHSDDPAYFGGYMNTNWLATFNALDLSAADAHALARNSF
EASFLPEQDKALWLAKVDDHWKAAH
>Mature_344_residues
PISSALAERIATSPKAELHIHIEGSLEPELMFALAERNGVKLPYASVEEVRAAYAFDDLQSFLDLYYAGASVLLTEQDFY
DMTAAYVARALADNVHHAEIFFDPQTHTARNVPMHVVIHGIVRALDDAEREHGFSSALILCFLRHLSEEDAFDTLEAALP
YIQDPANRIIGVGLDSSERGNPPEKFARVFARCKELGLRLVAHAGEEGPAQYVIDALDILKVERIDHGVRAIDDAALVKR
LAAERIALTVCPLSNEKLKVYPDLRDHSLKQLLDAGCAVTLHSDDPAYFGGYMNTNWLATFNALDLSAADAHALARNSFE
ASFLPEQDKALWLAKVDDHWKAAH

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=333, Percent_Identity=24.9249249249249, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1787910, Length=330, Percent_Identity=27.2727272727273, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17538512, Length=352, Percent_Identity=23.2954545454545, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32565969, Length=340, Percent_Identity=23.5294117647059, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324188, Length=341, Percent_Identity=43.108504398827, Blast_Score=276, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24645260, Length=338, Percent_Identity=23.6686390532544, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_RALPJ (B2U7U6)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001899815.1
- ProteinModelPortal:   B2U7U6
- SMR:   B2U7U6
- GeneID:   6287743
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_2249
- HOGENOM:   HBG630382
- OMA:   YFGGYLN
- ProtClustDB:   PRK09358
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 38139; Mature: 38008

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 207-207 BINDING 22-22 BINDING 24-24 BINDING 286-286

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISSALAERIATSPKAELHIHIEGSLEPELMFALAERNGVKLPYASVEEVRAAYAFDDL
CCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
QSFLDLYYAGASVLLTEQDFYDMTAAYVARALADNVHHAEIFFDPQTHTARNVPMHVVIH
HHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHH
GIVRALDDAEREHGFSSALILCFLRHLSEEDAFDTLEAALPYIQDPANRIIGVGLDSSER
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHEEEECCCCCCC
GNPPEKFARVFARCKELGLRLVAHAGEEGPAQYVIDALDILKVERIDHGVRAIDDAALVK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAAERIALTVCPLSNEKLKVYPDLRDHSLKQLLDAGCAVTLHSDDPAYFGGYMNTNWLA
HHHHHHEEEEEECCCCCCEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEE
TFNALDLSAADAHALARNSFEASFLPEQDKALWLAKVDDHWKAAH
EECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
PISSALAERIATSPKAELHIHIEGSLEPELMFALAERNGVKLPYASVEEVRAAYAFDDL
CCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
QSFLDLYYAGASVLLTEQDFYDMTAAYVARALADNVHHAEIFFDPQTHTARNVPMHVVIH
HHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHH
GIVRALDDAEREHGFSSALILCFLRHLSEEDAFDTLEAALPYIQDPANRIIGVGLDSSER
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHEEEECCCCCCC
GNPPEKFARVFARCKELGLRLVAHAGEEGPAQYVIDALDILKVERIDHGVRAIDDAALVK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAAERIALTVCPLSNEKLKVYPDLRDHSLKQLLDAGCAVTLHSDDPAYFGGYMNTNWLA
HHHHHHEEEEEECCCCCCEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEE
TFNALDLSAADAHALARNSFEASFLPEQDKALWLAKVDDHWKAAH
EECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA