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The map label for this gene is tpiA [H]

Identifier: 187929295

GI number: 187929295

Start: 2325425

End: 2326171

Strand: Reverse

Name: tpiA [H]

Synonym: Rpic_2216

Alternate gene names: 187929295

Gene position: 2326171-2325425 (Counterclockwise)

Preceding gene: 187929296

Following gene: 187929294

Centisome position: 59.0

GC content: 63.59

Gene sequence:

>747_bases
GTGAACGCAAGACCGAAGCTGGTGGTGGGCAACTGGAAGCTGCATGGCAGTCTGAGCACGAACGCCGCGCTGCTTGAACA
GATCAAAGCGGCAGGCAAAACCAACGCCACGCTGGCCGTGTGTGTGCCGTTCCCGTACCTGGCCCAGTGCCAGTCCTTGC
TCGCCGGTTCTGCAGTCGGCTGGGGCGCGCAGGATGTGTCGGCTGAAACGCGGGGCGCCTTTACCGGCGAAGTGGCGGCG
TCGATGCTGTCGGAGTTTGGCTGCGGCTACGCGATCGTCGGTCACTCCGAGCGTCGCTCGTACCATGGCGAAACCGATGC
GCAAGTGGCGACCAAGGCGCTGCGTGCACTGGAACATGGCATTACCCCGATCGTCTGTGTGGGCGAAACGCTCGCGCAAC
GTGAAGCAGGTGAGACCGAGCAGGTGGTCGCCCGCCAACTCGATGCAGTTCTCGAAGCGCTGTCGGTCGAGCAACTTGGT
CGTATCGTCGTGGCGTATGAGCCGGTTTGGGCCATTGGCACGGGCAAGACCGCGACGAGCGAGCAGGCGCAGGCTGTGCA
CGCGTTTCTGCGCGCACGTGTTGCTGCCCGCGACGCTGGCGTGGCGCAGCGTCTGTCAATTCTGTACGGTGGCAGCGTCA
AGCCCGACAATGCCGGCGAATTGTTTGCAATGGCGGACATCGATGGCGGCCTGATCGGCGGCGCATCGTTGAAGGCAGAA
GATTTCCTGGCGATCGGGCGCGCATAA

Upstream 100 bases:

>100_bases
ATCATGTTGGTTTGGGATTGACGCCAGGACGCCAAAATTGACCCCGTTTTTGACGCCGCGGTAGAATGCTGGGTTTATTT
GACAGTCGACCGGGCAAAAC

Downstream 100 bases:

>100_bases
ACAACCGATCGAGTCGCGATGTCACCCATGTGCGGCTGCAACATATTATTGAGAGAAACGAAATGGCAATTCTGAAGACT
CTGCTGCTGGTGGCGCAAAT

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MNARPKLVVGNWKLHGSLSTNAALLEQIKAAGKTNATLAVCVPFPYLAQCQSLLAGSAVGWGAQDVSAETRGAFTGEVAA
SMLSEFGCGYAIVGHSERRSYHGETDAQVATKALRALEHGITPIVCVGETLAQREAGETEQVVARQLDAVLEALSVEQLG
RIVVAYEPVWAIGTGKTATSEQAQAVHAFLRARVAARDAGVAQRLSILYGGSVKPDNAGELFAMADIDGGLIGGASLKAE
DFLAIGRA

Sequences:

>Translated_248_residues
MNARPKLVVGNWKLHGSLSTNAALLEQIKAAGKTNATLAVCVPFPYLAQCQSLLAGSAVGWGAQDVSAETRGAFTGEVAA
SMLSEFGCGYAIVGHSERRSYHGETDAQVATKALRALEHGITPIVCVGETLAQREAGETEQVVARQLDAVLEALSVEQLG
RIVVAYEPVWAIGTGKTATSEQAQAVHAFLRARVAARDAGVAQRLSILYGGSVKPDNAGELFAMADIDGGLIGGASLKAE
DFLAIGRA
>Mature_248_residues
MNARPKLVVGNWKLHGSLSTNAALLEQIKAAGKTNATLAVCVPFPYLAQCQSLLAGSAVGWGAQDVSAETRGAFTGEVAA
SMLSEFGCGYAIVGHSERRSYHGETDAQVATKALRALEHGITPIVCVGETLAQREAGETEQVVARQLDAVLEALSVEQLG
RIVVAYEPVWAIGTGKTATSEQAQAVHAFLRARVAARDAGVAQRLSILYGGSVKPDNAGELFAMADIDGGLIGGASLKAE
DFLAIGRA

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=239, Percent_Identity=41.4225941422594, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI226529917, Length=239, Percent_Identity=41.4225941422594, Blast_Score=169, Evalue=2e-42,
Organism=Escherichia coli, GI1790353, Length=247, Percent_Identity=49.3927125506073, Blast_Score=234, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17536593, Length=246, Percent_Identity=46.7479674796748, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6320255, Length=240, Percent_Identity=45, Blast_Score=185, Evalue=5e-48,
Organism=Drosophila melanogaster, GI28572004, Length=240, Percent_Identity=45.8333333333333, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI28572008, Length=240, Percent_Identity=45.8333333333333, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI28572006, Length=240, Percent_Identity=45.8333333333333, Blast_Score=191, Evalue=5e-49,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 25789; Mature: 25789

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNARPKLVVGNWKLHGSLSTNAALLEQIKAAGKTNATLAVCVPFPYLAQCQSLLAGSAVG
CCCCCCEEEECEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCC
WGAQDVSAETRGAFTGEVAASMLSEFGCGYAIVGHSERRSYHGETDAQVATKALRALEHG
CCCHHCCCHHCCCCHHHHHHHHHHHHCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHC
ITPIVCVGETLAQREAGETEQVVARQLDAVLEALSVEQLGRIVVAYEPVWAIGTGKTATS
CCEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHCCEEEEECCEEEEECCCCCCH
EQAQAVHAFLRARVAARDAGVAQRLSILYGGSVKPDNAGELFAMADIDGGLIGGASLKAE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEECCCCCCHH
DFLAIGRA
HHHEECCC
>Mature Secondary Structure
MNARPKLVVGNWKLHGSLSTNAALLEQIKAAGKTNATLAVCVPFPYLAQCQSLLAGSAVG
CCCCCCEEEECEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCC
WGAQDVSAETRGAFTGEVAASMLSEFGCGYAIVGHSERRSYHGETDAQVATKALRALEHG
CCCHHCCCHHCCCCHHHHHHHHHHHHCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHC
ITPIVCVGETLAQREAGETEQVVARQLDAVLEALSVEQLGRIVVAYEPVWAIGTGKTATS
CCEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHCCEEEEECCEEEEECCCCCCH
EQAQAVHAFLRARVAARDAGVAQRLSILYGGSVKPDNAGELFAMADIDGGLIGGASLKAE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEECCCCCCHH
DFLAIGRA
HHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]