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The map label for this gene is gltA [H]

Identifier: 187929225

GI number: 187929225

Start: 2258491

End: 2259792

Strand: Reverse

Name: gltA [H]

Synonym: Rpic_2146

Alternate gene names: 187929225

Gene position: 2259792-2258491 (Counterclockwise)

Preceding gene: 187929226

Following gene: 187929224

Centisome position: 57.32

GC content: 59.45

Gene sequence:

>1302_bases
ATGACGCCGTCCGAAGTGAAAGCCACCCTATCGTTTTCCGATGGCTCGCCCAGCGTCGAGCTGCCGATCTACAAGGGCAC
GGTTGGCCCGGACGTGATCGACATCCGCAAGCTGTACGGTCAGACGGGCAAGTTCACGTACGACCCCGGCTTCATGTCGA
CTGCGTCGTGCAATTCCAAGATCACCTACATCGATGGTGACAAAGGTGAGCTGCTGTACCGCGGCTACGCCATCGACGAT
TTGGCCAGCAAGTGCGATTTCATGGAAATCTGCTATCTGCTGCTGAAGGGCGAGCTGCCCAACGCCAAGCAGAAGGAAGA
GTTCAACCATGTGGTGACGAATCACACCATGGTCCACGAGCAGATGCAGTTCTTCCTGCGCGGTTTCCGTCGTGACGCCC
ACCCGATGGCCGTGCTGACGGGTTTGGTTGGTGCCATGAGCGCGTTCTATCCGGACGCTGCCAACATCAATGATCCGCGC
GAGCGTGAAATCTCGCAGATCCGCTTGATCGCCAAGCTGCCGACGCTGGTGGCCATGGCATACAAGTACAACATCGGCCA
GCCGCTCATCTACCCGCAGAACAACCTGTCGTACACGGGCAATTTCATGCGCATGATGTTTGCCACGCCGTGCGAGGACT
ACAAGGTGAACCCGGTGCTGGAGAAGGCACTGGACCGCATCTTCATCCTGCACGCAGACCACGAGCAGAACGCCTCGACG
TCGACGGTGCGTCTGGCGGGCTCGTCGGGCACCAACCCGATCGCAGCCATCGCTGCCGGTATCGCCTGCCTGTGGGGCCC
GGCGCACGGTGGCGCGAACGAAGCTGCGCTGAACATGCTGGAAGAAATCGGTACCGTGGACAAGGTGCCCGAGTTCATCA
AGCAGGTGAAGGACAAGAACAGCGGCGTGCGCCTGATGGGCTTTGGTCACCGCGTGTACAAGAACTACGATCCGCGCGCC
AAGCTGATGCGGGAAACCTGCCACGAAGTGCTGAATGAGCTGGGTCTGCATAACGACCCGCTGTTCAAGCTGGCGATGGA
GCTGGAAAAGATTGCCCTGGAAGACGAGTACTTCGTCAGCCGCAAGCTGTATCCGAACGTCGATTTCTACTCGGGTATCG
TGCAACGCGCGCTGGGCATCCCGACTTCGATGTTCACCTGTATCTTCGCGCTGGCCCGCTCGGTGGGCTGGATCTCGCAA
TGGGAAGAGATGATCACCGATCCGGAATACAAGATCGGCCGTCCGCGCCAGCTGTTCAACGGTGCAGCCACCCGCGAAGT
GCCGTCGATCGACAAGCGCTAA

Upstream 100 bases:

>100_bases
GCAAGACGAATCGGTCCAGCCGCCCCCGGCCGGCGACCTCGATCCGTCTGGCGGGAGTCTCCCGACTTCATTTTTATAAA
CAGCAGAGAAGGAAACCGAC

Downstream 100 bases:

>100_bases
GCCACGCTGTTCGCCTTGAAGAAACCCCGCTCGGGAAACCGGCGGGGTTTTTTGTTGCACGTCGCCGGAGGTGCCCGGAA
AGGGCCTTCGCGAAATGGCG

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MTPSEVKATLSFSDGSPSVELPIYKGTVGPDVIDIRKLYGQTGKFTYDPGFMSTASCNSKITYIDGDKGELLYRGYAIDD
LASKCDFMEICYLLLKGELPNAKQKEEFNHVVTNHTMVHEQMQFFLRGFRRDAHPMAVLTGLVGAMSAFYPDAANINDPR
EREISQIRLIAKLPTLVAMAYKYNIGQPLIYPQNNLSYTGNFMRMMFATPCEDYKVNPVLEKALDRIFILHADHEQNAST
STVRLAGSSGTNPIAAIAAGIACLWGPAHGGANEAALNMLEEIGTVDKVPEFIKQVKDKNSGVRLMGFGHRVYKNYDPRA
KLMRETCHEVLNELGLHNDPLFKLAMELEKIALEDEYFVSRKLYPNVDFYSGIVQRALGIPTSMFTCIFALARSVGWISQ
WEEMITDPEYKIGRPRQLFNGAATREVPSIDKR

Sequences:

>Translated_433_residues
MTPSEVKATLSFSDGSPSVELPIYKGTVGPDVIDIRKLYGQTGKFTYDPGFMSTASCNSKITYIDGDKGELLYRGYAIDD
LASKCDFMEICYLLLKGELPNAKQKEEFNHVVTNHTMVHEQMQFFLRGFRRDAHPMAVLTGLVGAMSAFYPDAANINDPR
EREISQIRLIAKLPTLVAMAYKYNIGQPLIYPQNNLSYTGNFMRMMFATPCEDYKVNPVLEKALDRIFILHADHEQNAST
STVRLAGSSGTNPIAAIAAGIACLWGPAHGGANEAALNMLEEIGTVDKVPEFIKQVKDKNSGVRLMGFGHRVYKNYDPRA
KLMRETCHEVLNELGLHNDPLFKLAMELEKIALEDEYFVSRKLYPNVDFYSGIVQRALGIPTSMFTCIFALARSVGWISQ
WEEMITDPEYKIGRPRQLFNGAATREVPSIDKR
>Mature_432_residues
TPSEVKATLSFSDGSPSVELPIYKGTVGPDVIDIRKLYGQTGKFTYDPGFMSTASCNSKITYIDGDKGELLYRGYAIDDL
ASKCDFMEICYLLLKGELPNAKQKEEFNHVVTNHTMVHEQMQFFLRGFRRDAHPMAVLTGLVGAMSAFYPDAANINDPRE
REISQIRLIAKLPTLVAMAYKYNIGQPLIYPQNNLSYTGNFMRMMFATPCEDYKVNPVLEKALDRIFILHADHEQNASTS
TVRLAGSSGTNPIAAIAAGIACLWGPAHGGANEAALNMLEEIGTVDKVPEFIKQVKDKNSGVRLMGFGHRVYKNYDPRAK
LMRETCHEVLNELGLHNDPLFKLAMELEKIALEDEYFVSRKLYPNVDFYSGIVQRALGIPTSMFTCIFALARSVGWISQW
EEMITDPEYKIGRPRQLFNGAATREVPSIDKR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=421, Percent_Identity=27.5534441805226, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1786939, Length=430, Percent_Identity=63.4883720930233, Blast_Score=590, Evalue=1e-170,
Organism=Escherichia coli, GI1786527, Length=379, Percent_Identity=30.3430079155673, Blast_Score=164, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17555174, Length=397, Percent_Identity=27.2040302267003, Blast_Score=111, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=339, Percent_Identity=27.1386430678466, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324328, Length=333, Percent_Identity=27.027027027027, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325257, Length=370, Percent_Identity=27.027027027027, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24640124, Length=424, Percent_Identity=26.6509433962264, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24640126, Length=424, Percent_Identity=26.6509433962264, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356863, Length=426, Percent_Identity=26.7605633802817, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48514; Mature: 48383

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSEVKATLSFSDGSPSVELPIYKGTVGPDVIDIRKLYGQTGKFTYDPGFMSTASCNSK
CCCCCEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCEECCCCCE
ITYIDGDKGELLYRGYAIDDLASKCDFMEICYLLLKGELPNAKQKEEFNHVVTNHTMVHE
EEEEECCCCCEEEECCCHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QMQFFLRGFRRDAHPMAVLTGLVGAMSAFYPDAANINDPREREISQIRLIAKLPTLVAMA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YKYNIGQPLIYPQNNLSYTGNFMRMMFATPCEDYKVNPVLEKALDRIFILHADHEQNAST
HHHCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCC
STVRLAGSSGTNPIAAIAAGIACLWGPAHGGANEAALNMLEEIGTVDKVPEFIKQVKDKN
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCC
SGVRLMGFGHRVYKNYDPRAKLMRETCHEVLNELGLHNDPLFKLAMELEKIALEDEYFVS
CCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHH
RKLYPNVDFYSGIVQRALGIPTSMFTCIFALARSVGWISQWEEMITDPEYKIGRPRQLFN
HCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHC
GAATREVPSIDKR
CCHHCCCCCCCCC
>Mature Secondary Structure 
TPSEVKATLSFSDGSPSVELPIYKGTVGPDVIDIRKLYGQTGKFTYDPGFMSTASCNSK
CCCCEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCEECCCCCE
ITYIDGDKGELLYRGYAIDDLASKCDFMEICYLLLKGELPNAKQKEEFNHVVTNHTMVHE
EEEEECCCCCEEEECCCHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QMQFFLRGFRRDAHPMAVLTGLVGAMSAFYPDAANINDPREREISQIRLIAKLPTLVAMA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YKYNIGQPLIYPQNNLSYTGNFMRMMFATPCEDYKVNPVLEKALDRIFILHADHEQNAST
HHHCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCC
STVRLAGSSGTNPIAAIAAGIACLWGPAHGGANEAALNMLEEIGTVDKVPEFIKQVKDKN
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCC
SGVRLMGFGHRVYKNYDPRAKLMRETCHEVLNELGLHNDPLFKLAMELEKIALEDEYFVS
CCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHH
RKLYPNVDFYSGIVQRALGIPTSMFTCIFALARSVGWISQWEEMITDPEYKIGRPRQLFN
HCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHC
GAATREVPSIDKR
CCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]