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The map label for this gene is tcp [H]

Identifier: 187929174

GI number: 187929174

Start: 2207007

End: 2208569

Strand: Direct

Name: tcp [H]

Synonym: Rpic_2095

Alternate gene names: 187929174

Gene position: 2207007-2208569 (Clockwise)

Preceding gene: 187929173

Following gene: 187929175

Centisome position: 55.98

GC content: 64.68

Gene sequence:

>1563_bases
ATGACCATCAAAGCCAAGCTGACCACGGGTTTTGGCGTGCTGGCAGCCATTGTTGTCGTCGTGTCGGGCATGTCGCTGCG
GGCGCTGTCCGAATCGACCGAAGGATTCTCGAACTACGTGCACGGCATCAGCGCCCGCGCAGACGTCGCGAACGACGTGC
GCACGGCGGTGGATCGCCGCGCCATTGCCGCACGCAACCTGGTACTCGTGGTCACCCAAAAAGACCTGGATCTGGAGAAG
GCTGACGTCTTCCGTGCGCACGACGATGTGAAGAACAAGCTCAAGCAGCTCAACGACATGATTGCGGGCGCCAAGGACGT
AACCGACCGCGCCCGTACGCTGGTGGAAGACATCAACCGCGTGGAAGCACAGTACGGCCCTGTGGCGACCGACATCGTCG
GGCTGGCACTGGCCGGCAAACGCGACGAAGCCGTCCAGAAGATGGACAACGAGTGCCGCCCGCTGCTGGCAGCGCTCATC
AAGACCACCGACGCGTACGCCACCTACACGCACGAGCGCCAGGAACAGCTCGTGCAGGCATATGAGGCGCAGTACGTCAT
GCAGCGCAACCTGCTGGCCGGCCTGTCGATCGGCGCGGTGCTGCTGGCAGTGATCGCCGGCATGGTCATCACGCGCTCGA
TCACGCAGCCGATCCGCACCGCCGTGAACGTCGCCCAGACGGTGGCACGCGGCGATCTGAGCAGCCGCATCGAGGTGCGC
GGCAAGGATGAGACGAGCCGCCTGCTCTCCGCCCTGCGTGACATGAATGACCGCCTGACCGAGATCGTGGACAAGGTGCG
CGACAGCAGCAGCAGCGTTGCCGGTGCAGCCAAGCAGATTGCCGCCGGCAATGCCGACCTGAGCCAGCGCACGGAAGCCC
AGGCGTCGTCGCTGCAGGAAACAGCCGCCAGCATGGAAGAGCTGACGTCCACCGTGAAGCAGAACGCCGAGAACGCCCAG
CACGCCACCGCGCTCGCCTCCACCGCGTCGGAGGTGGCGCTCAAGGGCAGCACGGTCGTCAGCCAGGTCGTGTCCACCAT
GCAGGACATCAGCGACCGTTCGAGCAAGATCGCCGACATCACGGGCATCATCGAAGGCATTGCGTTTCAGACCAACATCC
TCGCGTTGAACGCCGCCGTGGAAGCCGCACGTGCAGGCGAGCAGGGCCGCGGCTTTGCGGTGGTCGCCAGCGAAGTGCGC
AGCCTGGCGCAGCGTTCGTCAACGGCCGCCAAGGAGATCAAGGAACTGATCGCCTCGTCGGTGGAGCGCATTCACGACGG
CTCCACGCTGGCCGGAGAAGCCGGCGAGACGATGACGGAGGTCACGCAAGCCGTGGCCCGCGTCACGCACATCATGGAAG
AGATTGCCGCTGCATCGGTCGAGCAGAAGCGCGGCATCGAACAGGTCAATCAGGCGATCTCGCAAATGGATGAAGTCACG
CAGCGCAATGCAGCGCTGGTGGAAGAGGCCGCCGCCGCATCGCAATCGCTGCAGGACCAGGGGCAGGAGCTGAACGCCAC
GATGTCGTTCTTCCGAGTCGATCCGCACGCCGTACACGCCTGA

Upstream 100 bases:

>100_bases
TAACAAACGTGGTCGTCGACCGTCTTTCTCAAGCCGCTCCGGTGCGCGACCACATCTCAAGTCATTCAGCAAACCGGAGA
ACGCTGTGAACCTTTCTCAG

Downstream 100 bases:

>100_bases
TCGCAGCACAGTCACCGTAGCAACCGCCATCTCCAAGCTGTCATTGCGCCCGCTGCCGAAAGGCCGCGGGCGTTTTCTCT
TTTATTTCCTGTGTCTTTCG

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: Citrate chemoreceptor protein [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MTIKAKLTTGFGVLAAIVVVVSGMSLRALSESTEGFSNYVHGISARADVANDVRTAVDRRAIAARNLVLVVTQKDLDLEK
ADVFRAHDDVKNKLKQLNDMIAGAKDVTDRARTLVEDINRVEAQYGPVATDIVGLALAGKRDEAVQKMDNECRPLLAALI
KTTDAYATYTHERQEQLVQAYEAQYVMQRNLLAGLSIGAVLLAVIAGMVITRSITQPIRTAVNVAQTVARGDLSSRIEVR
GKDETSRLLSALRDMNDRLTEIVDKVRDSSSSVAGAAKQIAAGNADLSQRTEAQASSLQETAASMEELTSTVKQNAENAQ
HATALASTASEVALKGSTVVSQVVSTMQDISDRSSKIADITGIIEGIAFQTNILALNAAVEAARAGEQGRGFAVVASEVR
SLAQRSSTAAKEIKELIASSVERIHDGSTLAGEAGETMTEVTQAVARVTHIMEEIAAASVEQKRGIEQVNQAISQMDEVT
QRNAALVEEAAAASQSLQDQGQELNATMSFFRVDPHAVHA

Sequences:

>Translated_520_residues
MTIKAKLTTGFGVLAAIVVVVSGMSLRALSESTEGFSNYVHGISARADVANDVRTAVDRRAIAARNLVLVVTQKDLDLEK
ADVFRAHDDVKNKLKQLNDMIAGAKDVTDRARTLVEDINRVEAQYGPVATDIVGLALAGKRDEAVQKMDNECRPLLAALI
KTTDAYATYTHERQEQLVQAYEAQYVMQRNLLAGLSIGAVLLAVIAGMVITRSITQPIRTAVNVAQTVARGDLSSRIEVR
GKDETSRLLSALRDMNDRLTEIVDKVRDSSSSVAGAAKQIAAGNADLSQRTEAQASSLQETAASMEELTSTVKQNAENAQ
HATALASTASEVALKGSTVVSQVVSTMQDISDRSSKIADITGIIEGIAFQTNILALNAAVEAARAGEQGRGFAVVASEVR
SLAQRSSTAAKEIKELIASSVERIHDGSTLAGEAGETMTEVTQAVARVTHIMEEIAAASVEQKRGIEQVNQAISQMDEVT
QRNAALVEEAAAASQSLQDQGQELNATMSFFRVDPHAVHA
>Mature_519_residues
TIKAKLTTGFGVLAAIVVVVSGMSLRALSESTEGFSNYVHGISARADVANDVRTAVDRRAIAARNLVLVVTQKDLDLEKA
DVFRAHDDVKNKLKQLNDMIAGAKDVTDRARTLVEDINRVEAQYGPVATDIVGLALAGKRDEAVQKMDNECRPLLAALIK
TTDAYATYTHERQEQLVQAYEAQYVMQRNLLAGLSIGAVLLAVIAGMVITRSITQPIRTAVNVAQTVARGDLSSRIEVRG
KDETSRLLSALRDMNDRLTEIVDKVRDSSSSVAGAAKQIAAGNADLSQRTEAQASSLQETAASMEELTSTVKQNAENAQH
ATALASTASEVALKGSTVVSQVVSTMQDISDRSSKIADITGIIEGIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRS
LAQRSSTAAKEIKELIASSVERIHDGSTLAGEAGETMTEVTQAVARVTHIMEEIAAASVEQKRGIEQVNQAISQMDEVTQ
RNAALVEEAAAASQSLQDQGQELNATMSFFRVDPHAVHA

Specific function: Acts as a receptor for citrate and mediates taxis away from phenol. Also mediates an attractant response to metal-citrate complexes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=390, Percent_Identity=49.4871794871795, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI2367378, Length=369, Percent_Identity=49.8644986449864, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI1788194, Length=337, Percent_Identity=50.4451038575668, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI1788195, Length=304, Percent_Identity=54.9342105263158, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1789453, Length=308, Percent_Identity=37.6623376623377, Blast_Score=199, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR003122
- InterPro:   IPR004091
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 55407; Mature: 55276

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKAKLTTGFGVLAAIVVVVSGMSLRALSESTEGFSNYVHGISARADVANDVRTAVDRR
CCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIAARNLVLVVTQKDLDLEKADVFRAHDDVKNKLKQLNDMIAGAKDVTDRARTLVEDINR
HHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VEAQYGPVATDIVGLALAGKRDEAVQKMDNECRPLLAALIKTTDAYATYTHERQEQLVQA
HHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YEAQYVMQRNLLAGLSIGAVLLAVIAGMVITRSITQPIRTAVNVAQTVARGDLSSRIEVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEC
GKDETSRLLSALRDMNDRLTEIVDKVRDSSSSVAGAAKQIAAGNADLSQRTEAQASSLQE
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
TAASMEELTSTVKQNAENAQHATALASTASEVALKGSTVVSQVVSTMQDISDRSSKIADI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
TGIIEGIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRSLAQRSSTAAKEIKELIASS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VERIHDGSTLAGEAGETMTEVTQAVARVTHIMEEIAAASVEQKRGIEQVNQAISQMDEVT
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QRNAALVEEAAAASQSLQDQGQELNATMSFFRVDPHAVHA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure 
TIKAKLTTGFGVLAAIVVVVSGMSLRALSESTEGFSNYVHGISARADVANDVRTAVDRR
CEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIAARNLVLVVTQKDLDLEKADVFRAHDDVKNKLKQLNDMIAGAKDVTDRARTLVEDINR
HHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VEAQYGPVATDIVGLALAGKRDEAVQKMDNECRPLLAALIKTTDAYATYTHERQEQLVQA
HHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YEAQYVMQRNLLAGLSIGAVLLAVIAGMVITRSITQPIRTAVNVAQTVARGDLSSRIEVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEC
GKDETSRLLSALRDMNDRLTEIVDKVRDSSSSVAGAAKQIAAGNADLSQRTEAQASSLQE
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
TAASMEELTSTVKQNAENAQHATALASTASEVALKGSTVVSQVVSTMQDISDRSSKIADI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
TGIIEGIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRSLAQRSSTAAKEIKELIASS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VERIHDGSTLAGEAGETMTEVTQAVARVTHIMEEIAAASVEQKRGIEQVNQAISQMDEVT
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QRNAALVEEAAAASQSLQDQGQELNATMSFFRVDPHAVHA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8419927; 11677609 [H]