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The map label for this gene is iscS [H]

Identifier: 187929082

GI number: 187929082

Start: 2109715

End: 2111193

Strand: Direct

Name: iscS [H]

Synonym: Rpic_2002

Alternate gene names: 187929082

Gene position: 2109715-2111193 (Clockwise)

Preceding gene: 187929079

Following gene: 187929084

Centisome position: 53.51

GC content: 66.19

Gene sequence:

>1479_bases
ATGAGCGACAGCAACACCCTCCACTACCTCGACTACGCAGCCACCACGCCGGCCGACCCACGCGTGATTGCGGCCATGAC
CGCCTGCCTTGGCATGGAAGGCGCCTTCGGCAACCCTGCGTCGAGTTCACATGCGACCGGCCGCGTCGCGCGGAACAAGG
TCGAGCAAGCGCGCGAGCAAGTCGCCGCGCTCATTGGCGCTGATGCCGACGAGATCATCTGGACGTCGGGCGCCACCGAA
TCCAACAACCTCGCGCTGAAGGGCTATGCAGACGCCGCCACAGGCAAGCGCCACCTCATCACCAGCCGCATCGAACACAA
GGCCATTCTCGACACGATGGCGAACCTGTCGGCGCGCGGCCGTTCGGTGACGTATCTCACGCCAACACGCGACGGCGAAA
TTACGCCTGAAGCCGTGGCCGTTGCGATGACGCCCGACACCGGTCTCGTATCGCTGATGCTGGTGAACAACGAGCTGGGC
ACGCTGACCGACGTTGGCGCGATCGCGCAGATCGTGCATGCCGCCGGCGCGCTGTTCCACGTCGACGCCGCACAGGCACT
CGGCAAGACGCCGATCGATGTGCGAGCGCTCGGCATCGACATGCTCTCGATGTCCGCCCACAAGGTGTATGGCCCCAAGG
GGATCGGCGCACTGTATGTCCGCCGCGACATTGCCTCGCGCATTGCACCGCAAATCCACGGCGGCGGCCACGAGCGCGGC
CTGCGCTCGGGCACGCTGGCGACGCATCAGATCGTCGGTATGGGCGTGGCGTGTGAATTGGCCGCTGAAGAGCTGGAGCA
CGAGACCGCCCGCATTGCTGCGCTGAGCCAGCGGCTGAAGGCAGCGGTGCTGGCCCTCGGCGACGTGGTGCAGAACGCCG
ATGTGGCACGCCGCATTCCCCACACCCTCAGCCTCACGGTCAACGCGCCCGGCTTCTTGCCGATGATGCTCGGCGACGAC
CTTGCCGTGTCGTCCACATCGGCGTGCAACTCCGCTGCGGGCACGCCCTCGCACGTGCTGACGGCCATCGGCCTGGATGC
CGATGCCGCAGGCCGCACCGTGCGGATCAGCCTGGGCCGCTTTGCGACCGAGCACGACGTCGATTTTGCCGCTGTCTGTT
TCCAGCGCGCGATCGAGCAATGCCGCGCCACGGCATCGAGCGGGTTGACCGCTTCGCGACAGATCATGCCGGCGGATCTC
AAGGCCATCCGCAATGCAGGTTTCCGCTCGGTGATCTGCAACCGCCCAGATGGCGAGAGCAGCGACCAGCCCTCCTTTGA
AGTCATTGCCGCTGCCGCCCGCGAACTCGGCCTGGAAGCGCGCTACCTGCCTGTCGAGCCAAACGGCATTGGCGATGCAG
ACGTCGCGGCATTCGGCGTATTGGTCGATACGCTGCCCAAGCCCATCCTCGCGTATTGCAGGAGCGGCAACCGGGCCGGC
ATGCTCTGGAACCGCCTGATGGACCAGCGCAAGGGCTGA

Upstream 100 bases:

>100_bases
ATTTTCTGCCACATCGAGCAACTCACAGGAAACTTTGAATTATTTTTCTGGGCTGTCCGCCGTATCATTTTCCCTGCCTC
CACCGCAGCACAGAAACGAA

Downstream 100 bases:

>100_bases
ACCTCCGCCCCGCCCGGCCAAGCGACGCTACGCCACTGGCAGCTCCGTCGTCGACAGCACCTGCTTGAGCACCATGAACG
TCCGGATCTGCCGCACGCCC

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MSDSNTLHYLDYAATTPADPRVIAAMTACLGMEGAFGNPASSSHATGRVARNKVEQAREQVAALIGADADEIIWTSGATE
SNNLALKGYADAATGKRHLITSRIEHKAILDTMANLSARGRSVTYLTPTRDGEITPEAVAVAMTPDTGLVSLMLVNNELG
TLTDVGAIAQIVHAAGALFHVDAAQALGKTPIDVRALGIDMLSMSAHKVYGPKGIGALYVRRDIASRIAPQIHGGGHERG
LRSGTLATHQIVGMGVACELAAEELEHETARIAALSQRLKAAVLALGDVVQNADVARRIPHTLSLTVNAPGFLPMMLGDD
LAVSSTSACNSAAGTPSHVLTAIGLDADAAGRTVRISLGRFATEHDVDFAAVCFQRAIEQCRATASSGLTASRQIMPADL
KAIRNAGFRSVICNRPDGESSDQPSFEVIAAAARELGLEARYLPVEPNGIGDADVAAFGVLVDTLPKPILAYCRSGNRAG
MLWNRLMDQRKG

Sequences:

>Translated_492_residues
MSDSNTLHYLDYAATTPADPRVIAAMTACLGMEGAFGNPASSSHATGRVARNKVEQAREQVAALIGADADEIIWTSGATE
SNNLALKGYADAATGKRHLITSRIEHKAILDTMANLSARGRSVTYLTPTRDGEITPEAVAVAMTPDTGLVSLMLVNNELG
TLTDVGAIAQIVHAAGALFHVDAAQALGKTPIDVRALGIDMLSMSAHKVYGPKGIGALYVRRDIASRIAPQIHGGGHERG
LRSGTLATHQIVGMGVACELAAEELEHETARIAALSQRLKAAVLALGDVVQNADVARRIPHTLSLTVNAPGFLPMMLGDD
LAVSSTSACNSAAGTPSHVLTAIGLDADAAGRTVRISLGRFATEHDVDFAAVCFQRAIEQCRATASSGLTASRQIMPADL
KAIRNAGFRSVICNRPDGESSDQPSFEVIAAAARELGLEARYLPVEPNGIGDADVAAFGVLVDTLPKPILAYCRSGNRAG
MLWNRLMDQRKG
>Mature_491_residues
SDSNTLHYLDYAATTPADPRVIAAMTACLGMEGAFGNPASSSHATGRVARNKVEQAREQVAALIGADADEIIWTSGATES
NNLALKGYADAATGKRHLITSRIEHKAILDTMANLSARGRSVTYLTPTRDGEITPEAVAVAMTPDTGLVSLMLVNNELGT
LTDVGAIAQIVHAAGALFHVDAAQALGKTPIDVRALGIDMLSMSAHKVYGPKGIGALYVRRDIASRIAPQIHGGGHERGL
RSGTLATHQIVGMGVACELAAEELEHETARIAALSQRLKAAVLALGDVVQNADVARRIPHTLSLTVNAPGFLPMMLGDDL
AVSSTSACNSAAGTPSHVLTAIGLDADAAGRTVRISLGRFATEHDVDFAAVCFQRAIEQCRATASSGLTASRQIMPADLK
AIRNAGFRSVICNRPDGESSDQPSFEVIAAAARELGLEARYLPVEPNGIGDADVAAFGVLVDTLPKPILAYCRSGNRAGM
LWNRLMDQRKG

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=371, Percent_Identity=47.1698113207547, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI156713448, Length=418, Percent_Identity=34.9282296650718, Blast_Score=200, Evalue=3e-51,
Organism=Escherichia coli, GI48994898, Length=376, Percent_Identity=50, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1789175, Length=397, Percent_Identity=28.7153652392947, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1787970, Length=274, Percent_Identity=28.8321167883212, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25143064, Length=363, Percent_Identity=46.2809917355372, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17533177, Length=314, Percent_Identity=32.484076433121, Blast_Score=138, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6319831, Length=407, Percent_Identity=41.2776412776413, Blast_Score=286, Evalue=4e-78,
Organism=Drosophila melanogaster, GI20129463, Length=377, Percent_Identity=46.4190981432361, Blast_Score=308, Evalue=7e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 51551; Mature: 51420

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSNTLHYLDYAATTPADPRVIAAMTACLGMEGAFGNPASSSHATGRVARNKVEQAREQ
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VAALIGADADEIIWTSGATESNNLALKGYADAATGKRHLITSRIEHKAILDTMANLSARG
HHHHHCCCHHHEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
RSVTYLTPTRDGEITPEAVAVAMTPDTGLVSLMLVNNELGTLTDVGAIAQIVHAAGALFH
CEEEEECCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCEEE
VDAAQALGKTPIDVRALGIDMLSMSAHKVYGPKGIGALYVRRDIASRIAPQIHGGGHERG
ECHHHHHCCCCCEEEEECHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHCC
LRSGTLATHQIVGMGVACELAAEELEHETARIAALSQRLKAAVLALGDVVQNADVARRIP
CCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC
HTLSLTVNAPGFLPMMLGDDLAVSSTSACNSAAGTPSHVLTAIGLDADAAGRTVRISLGR
CEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHEEECCCCCCCCCEEEEECCC
FATEHDVDFAAVCFQRAIEQCRATASSGLTASRQIMPADLKAIRNAGFRSVICNRPDGES
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCCC
SDQPSFEVIAAAARELGLEARYLPVEPNGIGDADVAAFGVLVDTLPKPILAYCRSGNRAG
CCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCH
MLWNRLMDQRKG
HHHHHHHHHCCC
>Mature Secondary Structure 
SDSNTLHYLDYAATTPADPRVIAAMTACLGMEGAFGNPASSSHATGRVARNKVEQAREQ
CCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VAALIGADADEIIWTSGATESNNLALKGYADAATGKRHLITSRIEHKAILDTMANLSARG
HHHHHCCCHHHEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
RSVTYLTPTRDGEITPEAVAVAMTPDTGLVSLMLVNNELGTLTDVGAIAQIVHAAGALFH
CEEEEECCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCEEE
VDAAQALGKTPIDVRALGIDMLSMSAHKVYGPKGIGALYVRRDIASRIAPQIHGGGHERG
ECHHHHHCCCCCEEEEECHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHCC
LRSGTLATHQIVGMGVACELAAEELEHETARIAALSQRLKAAVLALGDVVQNADVARRIP
CCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC
HTLSLTVNAPGFLPMMLGDDLAVSSTSACNSAAGTPSHVLTAIGLDADAAGRTVRISLGR
CEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHEEECCCCCCCCCEEEEECCC
FATEHDVDFAAVCFQRAIEQCRATASSGLTASRQIMPADLKAIRNAGFRSVICNRPDGES
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCCC
SDQPSFEVIAAAARELGLEARYLPVEPNGIGDADVAAFGVLVDTLPKPILAYCRSGNRAG
CCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCH
MLWNRLMDQRKG
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA