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The map label for this gene is fkpA [H]

Identifier: 187929068

GI number: 187929068

Start: 2097957

End: 2098370

Strand: Reverse

Name: fkpA [H]

Synonym: Rpic_1988

Alternate gene names: 187929068

Gene position: 2098370-2097957 (Counterclockwise)

Preceding gene: 187929069

Following gene: 187929067

Centisome position: 53.22

GC content: 64.73

Gene sequence:

>414_bases
ATGAAACACGTTTCCCCGCTGCTGTGTGCTTCGTTGCTTGCCCTGGCTGCCGTTAGCGCGCAAGCCGCATCGCCCGCATC
CGAGACGCTGCCTTCCGGTGTGATCGTCCAGACGCTGACCAAAGGCACCGGCCCGTCGCCCAAGGCCAGCGACACGGTCA
AGGTGCACTACCGCGGCACGCTCACCAACGGTACCGAGTTCGACAGCTCCTACAAGCGCGGCCAGCCGATCTCCTTCCCG
CTGAATCGCGTGATTCCGTGCTGGACCGAAGGCGTGCAGAAGATCCAGGTGGGCGGCAAAGCCAAGCTGACGTGCCCGGC
AGCCACTGCTTACGGCGAGCGCGGCGTGCCGGGCACGATTCCGCCCAACTCCACGCTGAACTTTGACGTCGAGCTGCTGG
GTATCGGTGGCTGA

Upstream 100 bases:

>100_bases
TCTAGCGCCTGGCGCCCCTGCGGACTTCGATACACTGCCGGTCGGCCTGCAATCGGCCTTCATGCGTTTTTTCTGACCTC
CAACTTTCCCGTTACCTGCC

Downstream 100 bases:

>100_bases
TCTGGAGGCCGGTGGATCGGCCTTACAATAGCGTTTTCCTGATGTTTCGCGCCGCGGCCGTCGCGGCGCCTTCCTGAGCA
CGATCATGTCTGGCAATACC

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MKHVSPLLCASLLALAAVSAQAASPASETLPSGVIVQTLTKGTGPSPKASDTVKVHYRGTLTNGTEFDSSYKRGQPISFP
LNRVIPCWTEGVQKIQVGGKAKLTCPAATAYGERGVPGTIPPNSTLNFDVELLGIGG

Sequences:

>Translated_137_residues
MKHVSPLLCASLLALAAVSAQAASPASETLPSGVIVQTLTKGTGPSPKASDTVKVHYRGTLTNGTEFDSSYKRGQPISFP
LNRVIPCWTEGVQKIQVGGKAKLTCPAATAYGERGVPGTIPPNSTLNFDVELLGIGG
>Mature_137_residues
MKHVSPLLCASLLALAAVSAQAASPASETLPSGVIVQTLTKGTGPSPKASDTVKVHYRGTLTNGTEFDSSYKRGQPISFP
LNRVIPCWTEGVQKIQVGGKAKLTCPAATAYGERGVPGTIPPNSTLNFDVELLGIGG

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=47.1698113207547, Blast_Score=94, Evalue=3e-20,
Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=49.0566037735849, Blast_Score=93, Evalue=5e-20,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=49.0566037735849, Blast_Score=93, Evalue=5e-20,
Organism=Homo sapiens, GI4503729, Length=108, Percent_Identity=42.5925925925926, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI206725530, Length=90, Percent_Identity=45.5555555555556, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI17149844, Length=90, Percent_Identity=45.5555555555556, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI17149842, Length=90, Percent_Identity=45.5555555555556, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI224809329, Length=94, Percent_Identity=42.5531914893617, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI224809327, Length=94, Percent_Identity=42.5531914893617, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI4758384, Length=94, Percent_Identity=42.5531914893617, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI224809331, Length=124, Percent_Identity=37.0967741935484, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI4503727, Length=126, Percent_Identity=36.5079365079365, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI8923659, Length=93, Percent_Identity=43.010752688172, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI192448443, Length=116, Percent_Identity=36.2068965517241, Blast_Score=63, Evalue=1e-10,
Organism=Escherichia coli, GI1789745, Length=108, Percent_Identity=57.4074074074074, Blast_Score=117, Evalue=4e-28,
Organism=Escherichia coli, GI87082390, Length=104, Percent_Identity=50.9615384615385, Blast_Score=108, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=48.1132075471698, Blast_Score=89, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17540882, Length=126, Percent_Identity=39.6825396825397, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17561782, Length=89, Percent_Identity=48.314606741573, Blast_Score=75, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6324194, Length=112, Percent_Identity=49.1071428571429, Blast_Score=102, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=57.9545454545455, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323566, Length=113, Percent_Identity=40.7079646017699, Blast_Score=81, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323482, Length=114, Percent_Identity=39.4736842105263, Blast_Score=78, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=51.8867924528302, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24583150, Length=108, Percent_Identity=43.5185185185185, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281363946, Length=93, Percent_Identity=46.2365591397849, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17352457, Length=93, Percent_Identity=46.2365591397849, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24647110, Length=118, Percent_Identity=43.2203389830509, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356629, Length=127, Percent_Identity=41.7322834645669, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 14133; Mature: 14133

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHVSPLLCASLLALAAVSAQAASPASETLPSGVIVQTLTKGTGPSPKASDTVKVHYRGT
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEECCCCCCCCCCCCEEEEEEEEE
LTNGTEFDSSYKRGQPISFPLNRVIPCWTEGVQKIQVGGKAKLTCPAATAYGERGVPGTI
ECCCCCCCCCCCCCCCCCCCHHHCCCHHHHCHHEEECCCCEEEECCCCCCCCCCCCCCCC
PPNSTLNFDVELLGIGG
CCCCCEEEEEEEEEECC
>Mature Secondary Structure
MKHVSPLLCASLLALAAVSAQAASPASETLPSGVIVQTLTKGTGPSPKASDTVKVHYRGT
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEECCCCCCCCCCCCEEEEEEEEE
LTNGTEFDSSYKRGQPISFPLNRVIPCWTEGVQKIQVGGKAKLTCPAATAYGERGVPGTI
ECCCCCCCCCCCCCCCCCCCHHHCCCHHHHCHHEEECCCCEEEECCCCCCCCCCCCCCCC
PPNSTLNFDVELLGIGG
CCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]