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The map label for this gene is argE [H]

Identifier: 187928985

GI number: 187928985

Start: 2008929

End: 2010122

Strand: Direct

Name: argE [H]

Synonym: Rpic_1905

Alternate gene names: 187928985

Gene position: 2008929-2010122 (Clockwise)

Preceding gene: 187928984

Following gene: 187928986

Centisome position: 50.95

GC content: 65.83

Gene sequence:

>1194_bases
ATGAGCACCGCCCTCACCCCGTTCTCCACGCTTGACTGGACGAACAAGCTCGTCAGCTTCGACACCACGAGCCGCGGCTC
CAACCTGGCGCTGATCGAGACCGTGCGCGACTACCTGCGCGGCGTCGGCCTCGAGTCGCATCTGTCGCATAACGACGATG
GCAACAAGGCCAACCTGTTCGCCACCATTCCGGCAGCGGACGGCAGCGTGCAAGGCGGCATCGTACTGTCGGGCCATACC
GATGTCGTGCCGGTGGATGGCCAGAAATGGGACAGCAACCCGTTTGCGCCGGAAGTGCGCGACGGCAAGCTCTACGGACG
CGGCACGTGCGACATGAAGGGCTTCATCGCGTCCTCGCTGGCGCTGGTGCCGTCGCTGCTCCAGGCCAGACTGCGCGAGC
CTGTGCACTTTGCGCTGTCATACGACGAGGAAGTCGGCTGCGTGGGCGCGCCGCGCATGATTGAAGACCTGATCGCCCGC
GGCATCAAGCCTGCCGGCTGCATCGTCGGCGAACCCACCTCCATGCGCCCGATCGTCGCCCACAAAGGCATCAACGCGTA
CCGCTGCCGTGTGCACGGCCGCGCCGCGCATTCGTCGCTCACGCCGCAGGGTGTGAACGCCATCGAATACGCCGCGCGCA
TCATCTGCTTCGTGCGTGACCTGGCCGATGAATTCCGCGCCAAGGGCCCATTCGACGACGCGTTTGATGTGCCCTTCACC
ACGGCGTCGACCGGTCTCATCAACGGCGGTATCGCACTCAACACGATCCCGGCGTTGTGCGAGCTGGTGTTTGAATTCCG
CAACCTGCCGGGCGTGGATGCGCCGGCCATCCGCGCACGCGTCGAGCGCTACGTGCGCGAGACCATCGAGCCCGCCATGC
AGCGGGAGCATCCTGACGCCCACATCGAACTCGACGAGATTGCCGCCGCGCCGTCGCTGGACGCCTCCGAGCAAGCCGCC
ATCACGCAGCTTGTGCGTGTGCTGACCGAAGACAACGACAAGCGCAAGGTCGCCTACGGCACGGAAGCCGGCCTCTTCCA
GCGTGCCGGCATTCCAGCCGTGCTGTGCGGTCCGGGCAACATCGAACAGGCGCACAAGGCCAACGAATACGTCGAACTGG
CCCAGCTCGACGCCTGCGACCGCTTCCTCGCCAAGGTGGCGCGCAGCCTGATGGTCGAGACCGCGTCCGCCTAA

Upstream 100 bases:

>100_bases
ATTCCGGTCGAATTCGCCGCGCTGGCGCAGACCATTCGCCACGCCATGCGGCAATTGACGTGATCCAGTAGGATCAGCCC
GTCAGAACAAGGAAACCATC

Downstream 100 bases:

>100_bases
CGCTTACACAGCAATGCCTCACCTTTTGGTGGGGCGCATGCCGCCCGGGGCGTTCGCTACAATAGCGGGCTTCCCCGGCG
CCGAACCGCCCGCTCCCCGC

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MSTALTPFSTLDWTNKLVSFDTTSRGSNLALIETVRDYLRGVGLESHLSHNDDGNKANLFATIPAADGSVQGGIVLSGHT
DVVPVDGQKWDSNPFAPEVRDGKLYGRGTCDMKGFIASSLALVPSLLQARLREPVHFALSYDEEVGCVGAPRMIEDLIAR
GIKPAGCIVGEPTSMRPIVAHKGINAYRCRVHGRAAHSSLTPQGVNAIEYAARIICFVRDLADEFRAKGPFDDAFDVPFT
TASTGLINGGIALNTIPALCELVFEFRNLPGVDAPAIRARVERYVRETIEPAMQREHPDAHIELDEIAAAPSLDASEQAA
ITQLVRVLTEDNDKRKVAYGTEAGLFQRAGIPAVLCGPGNIEQAHKANEYVELAQLDACDRFLAKVARSLMVETASA

Sequences:

>Translated_397_residues
MSTALTPFSTLDWTNKLVSFDTTSRGSNLALIETVRDYLRGVGLESHLSHNDDGNKANLFATIPAADGSVQGGIVLSGHT
DVVPVDGQKWDSNPFAPEVRDGKLYGRGTCDMKGFIASSLALVPSLLQARLREPVHFALSYDEEVGCVGAPRMIEDLIAR
GIKPAGCIVGEPTSMRPIVAHKGINAYRCRVHGRAAHSSLTPQGVNAIEYAARIICFVRDLADEFRAKGPFDDAFDVPFT
TASTGLINGGIALNTIPALCELVFEFRNLPGVDAPAIRARVERYVRETIEPAMQREHPDAHIELDEIAAAPSLDASEQAA
ITQLVRVLTEDNDKRKVAYGTEAGLFQRAGIPAVLCGPGNIEQAHKANEYVELAQLDACDRFLAKVARSLMVETASA
>Mature_396_residues
STALTPFSTLDWTNKLVSFDTTSRGSNLALIETVRDYLRGVGLESHLSHNDDGNKANLFATIPAADGSVQGGIVLSGHTD
VVPVDGQKWDSNPFAPEVRDGKLYGRGTCDMKGFIASSLALVPSLLQARLREPVHFALSYDEEVGCVGAPRMIEDLIARG
IKPAGCIVGEPTSMRPIVAHKGINAYRCRVHGRAAHSSLTPQGVNAIEYAARIICFVRDLADEFRAKGPFDDAFDVPFTT
ASTGLINGGIALNTIPALCELVFEFRNLPGVDAPAIRARVERYVRETIEPAMQREHPDAHIELDEIAAAPSLDASEQAAI
TQLVRVLTEDNDKRKVAYGTEAGLFQRAGIPAVLCGPGNIEQAHKANEYVELAQLDACDRFLAKVARSLMVETASA

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily [H]

Homologues:

Organism=Homo sapiens, GI269846968, Length=278, Percent_Identity=26.978417266187, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790395, Length=363, Percent_Identity=33.6088154269972, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788816, Length=338, Percent_Identity=27.810650887574, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17551016, Length=381, Percent_Identity=24.9343832020997, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24649202, Length=308, Percent_Identity=26.9480519480519, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24649204, Length=308, Percent_Identity=26.9480519480519, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.16 [H]

Molecular weight: Translated: 42777; Mature: 42646

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTALTPFSTLDWTNKLVSFDTTSRGSNLALIETVRDYLRGVGLESHLSHNDDGNKANLF
CCCCCCCCHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEE
ATIPAADGSVQGGIVLSGHTDVVPVDGQKWDSNPFAPEVRDGKLYGRGTCDMKGFIASSL
EEECCCCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHH
ALVPSLLQARLREPVHFALSYDEEVGCVGAPRMIEDLIARGIKPAGCIVGEPTSMRPIVA
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCHHH
HKGINAYRCRVHGRAAHSSLTPQGVNAIEYAARIICFVRDLADEFRAKGPFDDAFDVPFT
HCCCCEEEEEEECCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
TASTGLINGGIALNTIPALCELVFEFRNLPGVDAPAIRARVERYVRETIEPAMQREHPDA
CCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
HIELDEIAAAPSLDASEQAAITQLVRVLTEDNDKRKVAYGTEAGLFQRAGIPAVLCGPGN
CEEHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHCCCCEEEECCCC
IEQAHKANEYVELAQLDACDRFLAKVARSLMVETASA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STALTPFSTLDWTNKLVSFDTTSRGSNLALIETVRDYLRGVGLESHLSHNDDGNKANLF
CCCCCCCHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEE
ATIPAADGSVQGGIVLSGHTDVVPVDGQKWDSNPFAPEVRDGKLYGRGTCDMKGFIASSL
EEECCCCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHH
ALVPSLLQARLREPVHFALSYDEEVGCVGAPRMIEDLIARGIKPAGCIVGEPTSMRPIVA
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCHHH
HKGINAYRCRVHGRAAHSSLTPQGVNAIEYAARIICFVRDLADEFRAKGPFDDAFDVPFT
HCCCCEEEEEEECCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
TASTGLINGGIALNTIPALCELVFEFRNLPGVDAPAIRARVERYVRETIEPAMQREHPDA
CCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
HIELDEIAAAPSLDASEQAAITQLVRVLTEDNDKRKVAYGTEAGLFQRAGIPAVLCGPGN
CEEHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHCCCCEEEECCCC
IEQAHKANEYVELAQLDACDRFLAKVARSLMVETASA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]