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The map label for this gene is clpP [H]

Identifier: 187928950

GI number: 187928950

Start: 1969634

End: 1970281

Strand: Reverse

Name: clpP [H]

Synonym: Rpic_1869

Alternate gene names: 187928950

Gene position: 1970281-1969634 (Counterclockwise)

Preceding gene: 187928951

Following gene: 187928949

Centisome position: 49.97

GC content: 62.04

Gene sequence:

>648_bases
ATGATCCGCAATGAACTGATCGACCAACTTGCCCGCACCCAGGCTTCCGCGCTCGAAACGCAGGGGCTCGGTCTGGTGCC
GATGGTGGTCGAGCAGTCGGGCCGCGGCGAGCGCGCCTACGATATCTACTCGCGCCTGCTCAAGGAACGAGTGATCTTCA
TGGTGGGCGAGGTCAACGACCAGACTGCCAACCTCGTGGTGGCACAGTTGCTGTTTTTGGAAAGCGAGAATCCGGACAAG
GACATCTCGCTGTACATCAATTCCCCGGGTGGTTCGGTTTCGTCCGGCCTGGCGATGTACGACACGATGCAGTTCATCAA
GCCCGACGTGTCGACGCTGTGCATGGGCATGGCGGCCAGCATGGGCGCGTTCCTGCTCGCGGCCGGTGCCAAGGGCAAGC
GTCTGGCGCTGCCGAACTCGCGCATCATGATTCACCAGCCGCTGGGCGGTGCTCGGGGCCAGGCCTCGGATATCGAGATC
CAGGCGCGCGAGATTCTGTATCTGCGCGAGCGCCTGAACACGGTGCTTTCGGAGGTAACGGGTCAGCCCGTCGACAAGAT
CGCCCGCGATACGGATCGCGACAACTTCATGAGTAGCGAGCAGGCCAAGGAGTACGGCCTGATCGACCAGGTCATCGCCA
AGCGTTGA

Upstream 100 bases:

>100_bases
AAGTCACTGACAAGGCCGTGTCGTTCGAAGAGCTGACTGCCACGCCGGCGCAAGGCTGATTCGATCGATATAGCTCCCGA
AATAAGCACCGGAGAACCGC

Downstream 100 bases:

>100_bases
AGTGTCGAAGTCGTGCGCCGATGTGCGCGGTAGGCGAGGTTGCCGGTGCATTCTACGGCACCCCGGTTAACCGCACGAAA
CATGTCAAGCGGTGTCAAAA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MIRNELIDQLARTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFMVGEVNDQTANLVVAQLLFLESENPDK
DISLYINSPGGSVSSGLAMYDTMQFIKPDVSTLCMGMAASMGAFLLAAGAKGKRLALPNSRIMIHQPLGGARGQASDIEI
QAREILYLRERLNTVLSEVTGQPVDKIARDTDRDNFMSSEQAKEYGLIDQVIAKR

Sequences:

>Translated_215_residues
MIRNELIDQLARTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFMVGEVNDQTANLVVAQLLFLESENPDK
DISLYINSPGGSVSSGLAMYDTMQFIKPDVSTLCMGMAASMGAFLLAAGAKGKRLALPNSRIMIHQPLGGARGQASDIEI
QAREILYLRERLNTVLSEVTGQPVDKIARDTDRDNFMSSEQAKEYGLIDQVIAKR
>Mature_215_residues
MIRNELIDQLARTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFMVGEVNDQTANLVVAQLLFLESENPDK
DISLYINSPGGSVSSGLAMYDTMQFIKPDVSTLCMGMAASMGAFLLAAGAKGKRLALPNSRIMIHQPLGGARGQASDIEI
QAREILYLRERLNTVLSEVTGQPVDKIARDTDRDNFMSSEQAKEYGLIDQVIAKR

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=196, Percent_Identity=56.6326530612245, Blast_Score=238, Evalue=4e-63,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=66.839378238342, Blast_Score=291, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=54.3010752688172, Blast_Score=216, Evalue=5e-57,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=56.3157894736842, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23611; Mature: 23611

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRNELIDQLARTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFMVGEVND
CCHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCCCHHHHHHHHHHHHHHHHEECCCCC
QTANLVVAQLLFLESENPDKDISLYINSPGGSVSSGLAMYDTMQFIKPDVSTLCMGMAAS
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHCCHHHHHHHHHHCCCHHHHHHHHHHH
MGAFLLAAGAKGKRLALPNSRIMIHQPLGGARGQASDIEIQAREILYLRERLNTVLSEVT
HHHHHHHCCCCCCEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GQPVDKIARDTDRDNFMSSEQAKEYGLIDQVIAKR
CCCHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIRNELIDQLARTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFMVGEVND
CCHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCCCHHHHHHHHHHHHHHHHEECCCCC
QTANLVVAQLLFLESENPDKDISLYINSPGGSVSSGLAMYDTMQFIKPDVSTLCMGMAAS
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHCCHHHHHHHHHHCCCHHHHHHHHHHH
MGAFLLAAGAKGKRLALPNSRIMIHQPLGGARGQASDIEIQAREILYLRERLNTVLSEVT
HHHHHHHCCCCCCEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GQPVDKIARDTDRDNFMSSEQAKEYGLIDQVIAKR
CCCHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]