Click here to switch to the map view.

The map label for this gene is lon [H]

Identifier: 187928948

GI number: 187928948

Start: 1965578

End: 1967992

Strand: Reverse

Name: lon [H]

Synonym: Rpic_1867

Alternate gene names: 187928948

Gene position: 1967992-1965578 (Counterclockwise)

Preceding gene: 187928949

Following gene: 187928947

Centisome position: 49.92

GC content: 61.04

Gene sequence:

>2415_bases
ATGTCCGGAACCCAACTTTTACCCGCTGAGCAGATTCGCCTGCCGCTGTTGCCGCTGCGTGACGTCGTGGTGTTTCCGCA
CATGGTGATTCCGCTGTTCGTGGGGCGCCCCAAATCCATCAAGGCGCTGGAAGCTGCGATGGAGGCGGGCAAGAGCATCA
TGCTCGTGGCGCAAAAGACTGCCGCCAAGGACGAGCCGACCGATAAGGATCTGTATGAGGTCGGCTGTATCGCCAACATT
CTGCAGATGCTGAAGCTGCCGGACGGCACCGTGAAGGTGCTGGTCGAGGGCACGCAGCGCGCCAATATCCTGTCCGTCAC
CGACGACGAATCGCACTTCTTCTGCGAAGCTGTGCCCGTCGGCCCGGAACCCACTGAATCGGCTGAGACCGAGGCGCTGC
GTCGCGCCATCGTGTCGCAGTTCGATCAGTACGTGAAGCTGAACAAGAAGATCCCGCCTGAAATCCTGACTTCGTTGTCG
GGCATCGACGAGCCGGGTCGTCTGGCCGACACCATTGCTGCGCATCTGCCGATTAAGCTCGAGCAGAAGCAGAAGATTCT
CGAGATGTTCAATGTGACCGAACGTCTGGAGAGCCTGCTTTCGCAGCTGGAAGGCGAGATCGACATCCTGCAGGTGGAAA
AGCGCATCCGTGGCCGCGTCAAGCGCCAGATGGAGAAGAGCCAGCGCGAGTACTACCTGAACGAGCAGGTCAAGGCCATC
CAGAAGGAACTGGGCGAAGGCGAGGAAGGCGCCGATCTCGAAGAGCTGGACAAGAAGATCAAGGCCGCCCGCATGCCGAA
GGAGGCCAAGAAGAAGGCCGAGTCCGAGTTCAAGAAGCTCAAGCTGATGTCGCCGATGTCGGCCGAGGCGACGGTCGTGC
GCAACTACATCGACACGTTGGTTGGTCTGCCGTGGCGCAAGAAGAGCAAGGTGAACAACGATCTGTCGAACGCCGAGCAG
GTGCTGGATCAGGACCACTATGGTTTGGAGAAGGTCAAGGAACGCATCCTTGAATACCTCGCGGTGCAACAGCGCGTCGA
CAAACTGAAGGCGCCGATCCTGTGCCTCGTGGGGCCGCCGGGGGTTGGCAAGACGTCGCTCGGGCAGTCGGTGGCGCGTG
CAACGAACCGCAAGTTCGTGCGCATGGCGCTGGGTGGCGTGCGTGACGAGGCCGAGATTCGCGGTCACCGCCGTACGTAC
ATCGGGTCGATGCCGGGCAAGATCCTGCAGAGCCTGACGAAGGTCGGCGTGCGCAATCCGTTGTTCCTGCTGGACGAGAT
CGACAAGATGGGTGCGGATTTCCGCGGCGATCCGTCGTCGGCCCTGCTCGAAGTGCTGGACCCGGAACAGAACCACACGT
TCCAGGACCACTACATCGAAGTGGACTTCGACCTGTCGGATGTGATGTTCGTGGCGACGTCGAACTCGCTGAACATTCCG
GCGCCGCTGCTGGACCGGATGGAAGTGATTCGTCTGTCGGGCTACACGGAAGACGAAAAGGTCAACATCGCCCGTCGCTA
CTTGCTGCCCAAGCAGATCAAGAACAATGGTCTGAAAGAGGGCGAGATCGAGGTGACCGAAGCCGCGCTGCGCGACATCA
TCCGCTACTACACGCGGGAAGCTGGTGTGCGTTCCCTGGAACGCGAGGTCTCGAAGATCTGCCGCAAGGTCGTCAAGCAA
CTGCTGCTGAAGAAGGAAGCCAATACGTCCGTGAAGGTGGATTCGGACAACCTGGACAAATTCCTTGGCGTGCGTCGTTT
CGACTTCGGTCTGGCCGGCAAGGAAGACCAGGTGGGCCAGGTGACTGGTTTGGCATGGACCGAAGTGGGCGGCGATCTGC
TGACCATCGAGGCAGCGCTGATGCCGGGCAAGGGCAACATCACCCGCACCGGTTCGTTGGGCGACGTGATGAAGGAGTCG
GTTGAGGCTGCGCGGTCGGTGGTGCGTTCGCGTTCGGCACGGCTGGGTATCAAGGATGAGATGTTCGAGAAGCGCGACAT
TCACATCCACGTGCCCGAAGGTGCGACGCCCAAGGATGGCCCTTCGGCGGGTATTGCGATGACGACGGCGCTGGTGTCGG
TGCTGACCGGGATCCCGGTGCGCGCTGATGTGGCGATGACCGGCGAAATCACCCTGCGCGGCGAAGTGCTGCCGATCGGC
GGCTTGAAGGAAAAGCTGCTGGCTGCACACCGCGGCGGCATCAAGCTGGCGCTGATTCCGGAGGAGAACGTCAAGGACTT
GGCGGACATTCCGGACAACGTGAAGAACAGCATCGAGATTCAGCCGGTGCGCTGGATCGACAAGGTGCTGGAACTCGCGC
TGGTGCGCAAGCCGGAGCCTCTTCCGGAGGAAGAAGCCAAGCCGGCGCCCGCCCAGGGCGATGACGGCAAGTCGCAGGAA
ATGGTGCATCACTGA

Upstream 100 bases:

>100_bases
TTGCTTCGGGAAACCGGGTCGGCATGCGACTTGCAGCAGCGGTCTTGTAAAACCGCCGCTGTGCCCAATTTAGCCCTTAC
ATGACTTTCTGGGGAAAATA

Downstream 100 bases:

>100_bases
CACCGTAGCCTGCCGAGGTTGAAGAAGGGCCCGACATGTTCGGGCCCTTTTTCTTTGCGCTGGCTGCGACATGTGGCACA
CAGTTCTTCGCCTTGACACG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 804; Mature: 803

Protein sequence:

>804_residues
MSGTQLLPAEQIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEAGKSIMLVAQKTAAKDEPTDKDLYEVGCIANI
LQMLKLPDGTVKVLVEGTQRANILSVTDDESHFFCEAVPVGPEPTESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEPGRLADTIAAHLPIKLEQKQKILEMFNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELDKKIKAARMPKEAKKKAESEFKKLKLMSPMSAEATVVRNYIDTLVGLPWRKKSKVNNDLSNAEQ
VLDQDHYGLEKVKERILEYLAVQQRVDKLKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLTKVGVRNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
APLLDRMEVIRLSGYTEDEKVNIARRYLLPKQIKNNGLKEGEIEVTEAALRDIIRYYTREAGVRSLEREVSKICRKVVKQ
LLLKKEANTSVKVDSDNLDKFLGVRRFDFGLAGKEDQVGQVTGLAWTEVGGDLLTIEAALMPGKGNITRTGSLGDVMKES
VEAARSVVRSRSARLGIKDEMFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIG
GLKEKLLAAHRGGIKLALIPEENVKDLADIPDNVKNSIEIQPVRWIDKVLELALVRKPEPLPEEEAKPAPAQGDDGKSQE
MVHH

Sequences:

>Translated_804_residues
MSGTQLLPAEQIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEAGKSIMLVAQKTAAKDEPTDKDLYEVGCIANI
LQMLKLPDGTVKVLVEGTQRANILSVTDDESHFFCEAVPVGPEPTESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEPGRLADTIAAHLPIKLEQKQKILEMFNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELDKKIKAARMPKEAKKKAESEFKKLKLMSPMSAEATVVRNYIDTLVGLPWRKKSKVNNDLSNAEQ
VLDQDHYGLEKVKERILEYLAVQQRVDKLKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLTKVGVRNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
APLLDRMEVIRLSGYTEDEKVNIARRYLLPKQIKNNGLKEGEIEVTEAALRDIIRYYTREAGVRSLEREVSKICRKVVKQ
LLLKKEANTSVKVDSDNLDKFLGVRRFDFGLAGKEDQVGQVTGLAWTEVGGDLLTIEAALMPGKGNITRTGSLGDVMKES
VEAARSVVRSRSARLGIKDEMFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIG
GLKEKLLAAHRGGIKLALIPEENVKDLADIPDNVKNSIEIQPVRWIDKVLELALVRKPEPLPEEEAKPAPAQGDDGKSQE
MVHH
>Mature_803_residues
SGTQLLPAEQIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEAGKSIMLVAQKTAAKDEPTDKDLYEVGCIANIL
QMLKLPDGTVKVLVEGTQRANILSVTDDESHFFCEAVPVGPEPTESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSG
IDEPGRLADTIAAHLPIKLEQKQKILEMFNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEGEEGADLEELDKKIKAARMPKEAKKKAESEFKKLKLMSPMSAEATVVRNYIDTLVGLPWRKKSKVNNDLSNAEQV
LDQDHYGLEKVKERILEYLAVQQRVDKLKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYI
GSMPGKILQSLTKVGVRNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIPA
PLLDRMEVIRLSGYTEDEKVNIARRYLLPKQIKNNGLKEGEIEVTEAALRDIIRYYTREAGVRSLEREVSKICRKVVKQL
LLKKEANTSVKVDSDNLDKFLGVRRFDFGLAGKEDQVGQVTGLAWTEVGGDLLTIEAALMPGKGNITRTGSLGDVMKESV
EAARSVVRSRSARLGIKDEMFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLALIPEENVKDLADIPDNVKNSIEIQPVRWIDKVLELALVRKPEPLPEEEAKPAPAQGDDGKSQEM
VHH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=828, Percent_Identity=38.4057971014493, Blast_Score=529, Evalue=1e-150,
Organism=Homo sapiens, GI21396489, Length=677, Percent_Identity=41.2112259970458, Blast_Score=508, Evalue=1e-143,
Organism=Escherichia coli, GI1786643, Length=771, Percent_Identity=70.6874189364462, Blast_Score=1100, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=708, Percent_Identity=40.5367231638418, Blast_Score=495, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17556486, Length=542, Percent_Identity=39.4833948339483, Blast_Score=421, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=709, Percent_Identity=41.0437235543018, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24666867, Length=631, Percent_Identity=44.3740095087163, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221513036, Length=631, Percent_Identity=44.3740095087163, Blast_Score=518, Evalue=1e-147,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89173; Mature: 89042

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTQLLPAEQIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEAGKSIMLVAQKT
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEEHH
AAKDEPTDKDLYEVGCIANILQMLKLPDGTVKVLVEGTQRANILSVTDDESHFFCEAVPV
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCEEEEEECC
GPEPTESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEPGRLADTIAAHLPIKL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCH
EQKQKILEMFNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELDKKIKAARMPKEAKKKAESEFKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VGLPWRKKSKVNNDLSNAEQVLDQDHYGLEKVKERILEYLAVQQRVDKLKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLTKVGVRNP
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
HHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCC
APLLDRMEVIRLSGYTEDEKVNIARRYLLPKQIKNNGLKEGEIEVTEAALRDIIRYYTRE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKQLLLKKEANTSVKVDSDNLDKFLGVRRFDFGLAGKEDQVGQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCHHHCCCCCCCCCCCCC
VTGLAWTEVGGDLLTIEAALMPGKGNITRTGSLGDVMKESVEAARSVVRSRSARLGIKDE
EECEEHHHCCCCEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHH
MFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIG
HHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECC
GLKEKLLAAHRGGIKLALIPEENVKDLADIPDNVKNSIEIQPVRWIDKVLELALVRKPEP
CHHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHCCEEECHHHHHHHHHHHHHHCCCCC
LPEEEAKPAPAQGDDGKSQEMVHH
CCCCCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
SGTQLLPAEQIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEAGKSIMLVAQKT
CCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEEHH
AAKDEPTDKDLYEVGCIANILQMLKLPDGTVKVLVEGTQRANILSVTDDESHFFCEAVPV
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCEEEEEECC
GPEPTESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEPGRLADTIAAHLPIKL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCH
EQKQKILEMFNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELDKKIKAARMPKEAKKKAESEFKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VGLPWRKKSKVNNDLSNAEQVLDQDHYGLEKVKERILEYLAVQQRVDKLKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLTKVGVRNP
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
HHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCC
APLLDRMEVIRLSGYTEDEKVNIARRYLLPKQIKNNGLKEGEIEVTEAALRDIIRYYTRE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKQLLLKKEANTSVKVDSDNLDKFLGVRRFDFGLAGKEDQVGQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCHHHCCCCCCCCCCCCC
VTGLAWTEVGGDLLTIEAALMPGKGNITRTGSLGDVMKESVEAARSVVRSRSARLGIKDE
EECEEHHHCCCCEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHH
MFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIG
HHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECC
GLKEKLLAAHRGGIKLALIPEENVKDLADIPDNVKNSIEIQPVRWIDKVLELALVRKPEP
CHHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHCCEEECHHHHHHHHHHHHHHCCCCC
LPEEEAKPAPAQGDDGKSQEMVHH
CCCCCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]