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The map label for this gene is copA [H]

Identifier: 187928802

GI number: 187928802

Start: 1813007

End: 1814902

Strand: Direct

Name: copA [H]

Synonym: Rpic_1719

Alternate gene names: 187928802

Gene position: 1813007-1814902 (Clockwise)

Preceding gene: 187928799

Following gene: 187928803

Centisome position: 45.99

GC content: 63.34

Gene sequence:

>1896_bases
ATGCGCAGCAATCGTGCATCCGGCCTCGTGCTACCGAACCTGCCGCGGCGGCGGTTTGTGCAAGGTTTGGCTGCCGGCGG
TGTCATCGCCGGTTTGGGCCTGGGTGGTTTCACTTCGGCGGCATCCGCTGCGTCCACCGCGCTGGGGACCGCACCAGTGC
TGCGCGGCACCGAATTCGACTTGGTGATCGACGAGACGCCGGTCAACTTCACGGGCAAGCCGGCTATGGCCACGACCATC
AATGGCATGCTCCCGGGGCCCACGCTGCGCTGGCGCGAGGGTGACACCGTCACCTTGCGCGTGACCAATCGCCTGCGCGA
GCCGACGTCAATCCACTGGCACGGCATTGTCCTGCCGTTCGAGATGGATGGCGTACCGGGCATCAGCTTCCACGGCATTC
CGCCCGGCGAGACCTTTACCTACCGCTTCAAGGTGCGACAAAGCGGCAGCTACTGGTACCACTCGCATTCGGGCTTCCAG
GAGATGACCGGGGTCTATGGCGCCCTCATCATCGATGCCGCCGGCGGTGACGCGATCCGGGCCGACCGCGATTACAGCGT
GCTGCTGTCGGACTGGACCGACGAAGATCCGATGCGCGTCCTCTCCAAGCTCAAGACGCAGGGCGACTACTACAACTACC
ACCAGCCTACGGTGGTGGACTTCTTCCGCGACGTTTCCAACGATGGCTGGAAGGCGGCCATGGAAAAGCGGGCCATGTGG
AACCAGATGCGCATGAACCCGACCGATCTGGCCGATCTCTCCAGTGCAACGCTCACCTATCTGACCAACGGCGTCACGCC
GGCCGGCAATTGGACGGGCCTGTTTACGCCGGGCGAGACTGTGCGGTTGCGCTTCATTAACGGCTCCGGCAACACGTTCT
ACGACGTGCGCATCCCGGGGCTGAAACTCAAGGTGGTTCAGGTCGATGGGCAGAACATCGAGCCGGTCACGGTGGACGAA
TTCCGCTTCGGCCCCGGCGAGACTTGCGATGTGCTGGTCGCGCCCAAGGACGACGCCTACACCATCTTCTCGCAGTCGAT
GGACCGTACTGGTTATGCACGTGGCACGCTGGCTGTCTGCCGGGGCTTGCAGGCTGCAGTGCCTGCGCTCGACAAGGTGG
AATGGCTGTCCATGGCTGACATGATGGGTGACATGGGCGGTATGGGTGGCATGAGCCACGGTGGCATGTCGGGCATGGAC
CATGGTGCGATGTCCGGTATGAACCACGGCGGCATGCCCGGTATGGATCACGGCGACATGCAGATGATGGACGACACTGG
CATGACCATGATGGACTCCGGCGGCATGCAGATGATGGACCACAGCCAGCATGCGGAATCCGGCGGAGCGGCTAACAGCT
TGAAGGTGCCGAGCAAGACAGCACGGCACGCGCGCACGGAATACGGTCCGAGCACCGATATGCACGTCGACATGGCGCGC
ACCAACCTGGACGATCCCGGCGTCGGTCTGCGCAACAACGGGCGCCGCGTTCTGGTGCTCGCCGACATGCATACCATCGG
CGGTCCGATGGATAAGCGCGGTCCGGAGCGCGAGGTGGAACTGCACCTCACCGGCAACATGGAGCGCTACACGTGGTCGT
TCGACGGCGTGGAGTTCGGCAAATCGACACCTGTGCACTTCCGTTATGGCGAACGGCTGCGCGTCATCCTCCACAACGAC
ACGATGATGACGCACCCCATGCACCTGCATGGTATGTGGAGCGAACTGGAAGCGCCGGACGGTACGTTCCTCGCGCGCCG
GCATACCATCCCCGTCCAGCCCGCCCAACGGATCAGCTTTCTCGTCACAGCGGACGCGCTGGGTCGCTGGGCCTGGCATT
GCCACCTGATGTTGCACATGGATGCGGGTATGTTCCGCGAAGTGGTGGTGGTCTGA

Upstream 100 bases:

>100_bases
TGACGGATTTGTAATGTTTCAGTCAGGTCGGGGTAGCCTGGCGCTGGGTAGCCTGCACCCACCTTTCAGAGTCGGACATT
TTGTTAAGGAAATCTCGATC

Downstream 100 bases:

>100_bases
TGCTCGACTTTCACAGCGGATTGATCATGCACAAGCACGTAAGAACACTGTTGACTGTGGCGCTGGCTGCCGCCGGCATC
GGCGTTGCCTCGGCCCAGGA

Product: copper-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MRSNRASGLVLPNLPRRRFVQGLAAGGVIAGLGLGGFTSAASAASTALGTAPVLRGTEFDLVIDETPVNFTGKPAMATTI
NGMLPGPTLRWREGDTVTLRVTNRLREPTSIHWHGIVLPFEMDGVPGISFHGIPPGETFTYRFKVRQSGSYWYHSHSGFQ
EMTGVYGALIIDAAGGDAIRADRDYSVLLSDWTDEDPMRVLSKLKTQGDYYNYHQPTVVDFFRDVSNDGWKAAMEKRAMW
NQMRMNPTDLADLSSATLTYLTNGVTPAGNWTGLFTPGETVRLRFINGSGNTFYDVRIPGLKLKVVQVDGQNIEPVTVDE
FRFGPGETCDVLVAPKDDAYTIFSQSMDRTGYARGTLAVCRGLQAAVPALDKVEWLSMADMMGDMGGMGGMSHGGMSGMD
HGAMSGMNHGGMPGMDHGDMQMMDDTGMTMMDSGGMQMMDHSQHAESGGAANSLKVPSKTARHARTEYGPSTDMHVDMAR
TNLDDPGVGLRNNGRRVLVLADMHTIGGPMDKRGPEREVELHLTGNMERYTWSFDGVEFGKSTPVHFRYGERLRVILHND
TMMTHPMHLHGMWSELEAPDGTFLARRHTIPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVVVV

Sequences:

>Translated_631_residues
MRSNRASGLVLPNLPRRRFVQGLAAGGVIAGLGLGGFTSAASAASTALGTAPVLRGTEFDLVIDETPVNFTGKPAMATTI
NGMLPGPTLRWREGDTVTLRVTNRLREPTSIHWHGIVLPFEMDGVPGISFHGIPPGETFTYRFKVRQSGSYWYHSHSGFQ
EMTGVYGALIIDAAGGDAIRADRDYSVLLSDWTDEDPMRVLSKLKTQGDYYNYHQPTVVDFFRDVSNDGWKAAMEKRAMW
NQMRMNPTDLADLSSATLTYLTNGVTPAGNWTGLFTPGETVRLRFINGSGNTFYDVRIPGLKLKVVQVDGQNIEPVTVDE
FRFGPGETCDVLVAPKDDAYTIFSQSMDRTGYARGTLAVCRGLQAAVPALDKVEWLSMADMMGDMGGMGGMSHGGMSGMD
HGAMSGMNHGGMPGMDHGDMQMMDDTGMTMMDSGGMQMMDHSQHAESGGAANSLKVPSKTARHARTEYGPSTDMHVDMAR
TNLDDPGVGLRNNGRRVLVLADMHTIGGPMDKRGPEREVELHLTGNMERYTWSFDGVEFGKSTPVHFRYGERLRVILHND
TMMTHPMHLHGMWSELEAPDGTFLARRHTIPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVVVV
>Mature_631_residues
MRSNRASGLVLPNLPRRRFVQGLAAGGVIAGLGLGGFTSAASAASTALGTAPVLRGTEFDLVIDETPVNFTGKPAMATTI
NGMLPGPTLRWREGDTVTLRVTNRLREPTSIHWHGIVLPFEMDGVPGISFHGIPPGETFTYRFKVRQSGSYWYHSHSGFQ
EMTGVYGALIIDAAGGDAIRADRDYSVLLSDWTDEDPMRVLSKLKTQGDYYNYHQPTVVDFFRDVSNDGWKAAMEKRAMW
NQMRMNPTDLADLSSATLTYLTNGVTPAGNWTGLFTPGETVRLRFINGSGNTFYDVRIPGLKLKVVQVDGQNIEPVTVDE
FRFGPGETCDVLVAPKDDAYTIFSQSMDRTGYARGTLAVCRGLQAAVPALDKVEWLSMADMMGDMGGMGGMSHGGMSGMD
HGAMSGMNHGGMPGMDHGDMQMMDDTGMTMMDSGGMQMMDHSQHAESGGAANSLKVPSKTARHARTEYGPSTDMHVDMAR
TNLDDPGVGLRNNGRRVLVLADMHTIGGPMDKRGPEREVELHLTGNMERYTWSFDGVEFGKSTPVHFRYGERLRVILHND
TMMTHPMHLHGMWSELEAPDGTFLARRHTIPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVVVV

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=445, Percent_Identity=28.0898876404494, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320714, Length=301, Percent_Identity=26.578073089701, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321067, Length=284, Percent_Identity=27.8169014084507, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323703, Length=280, Percent_Identity=27.8571428571429, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650186, Length=270, Percent_Identity=29.2592592592593, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI18859919, Length=266, Percent_Identity=28.1954887218045, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28574104, Length=98, Percent_Identity=47.9591836734694, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24585842, Length=296, Percent_Identity=25.3378378378378, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI281360167, Length=296, Percent_Identity=25.3378378378378, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI221330000, Length=296, Percent_Identity=25.3378378378378, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI221329998, Length=296, Percent_Identity=25.3378378378378, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 69272; Mature: 69272

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
7.0 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
7.0 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSNRASGLVLPNLPRRRFVQGLAAGGVIAGLGLGGFTSAASAASTALGTAPVLRGTEFD
CCCCCCCEEECCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCEECCCEEE
LVIDETPVNFTGKPAMATTINGMLPGPTLRWREGDTVTLRVTNRLREPTSIHWHGIVLPF
EEEECCCCCCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCEEEEEEEEEE
EMDGVPGISFHGIPPGETFTYRFKVRQSGSYWYHSHSGFQEMTGVYGALIIDAAGGDAIR
ECCCCCCCEECCCCCCCEEEEEEEEEECCCEEEECCCCHHHHHCCEEEEEEECCCCCCEE
ADRDYSVLLSDWTDEDPMRVLSKLKTQGDYYNYHQPTVVDFFRDVSNDGWKAAMEKRAMW
CCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
NQMRMNPTDLADLSSATLTYLTNGVTPAGNWTGLFTPGETVRLRFINGSGNTFYDVRIPG
HHHCCCCCHHHHCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEEEECCCCEEEEEEECC
LKLKVVQVDGQNIEPVTVDEFRFGPGETCDVLVAPKDDAYTIFSQSMDRTGYARGTLAVC
EEEEEEEECCCCCCCEEHHCEECCCCCCEEEEEECCCCCEEEEHHCCCCCCCCCCHHHHH
RGLQAAVPALDKVEWLSMADMMGDMGGMGGMSHGGMSGMDHGAMSGMNHGGMPGMDHGDM
CCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCE
QMMDDTGMTMMDSGGMQMMDHSQHAESGGAANSLKVPSKTARHARTEYGPSTDMHVDMAR
EEECCCCCEEECCCCCEECCCCHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEHH
TNLDDPGVGLRNNGRRVLVLADMHTIGGPMDKRGPEREVELHLTGNMERYTWSFDGVEFG
CCCCCCCCCCCCCCCEEEEEEECHHHCCCCCCCCCCCEEEEEEECCCEEEEEEECCEECC
KSTPVHFRYGERLRVILHNDTMMTHPMHLHGMWSELEAPDGTFLARRHTIPVQPAQRISF
CCCCEEEEECCEEEEEEECCEEEECCEEEECCHHHCCCCCCCEEEEECCCCCCHHHHEEE
LVTADALGRWAWHCHLMLHMDAGMFREVVVV
EEEHHHHCCEEEEEEEEEEECCCCCEEEEEC
>Mature Secondary Structure
MRSNRASGLVLPNLPRRRFVQGLAAGGVIAGLGLGGFTSAASAASTALGTAPVLRGTEFD
CCCCCCCEEECCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCEECCCEEE
LVIDETPVNFTGKPAMATTINGMLPGPTLRWREGDTVTLRVTNRLREPTSIHWHGIVLPF
EEEECCCCCCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCEEEEEEEEEE
EMDGVPGISFHGIPPGETFTYRFKVRQSGSYWYHSHSGFQEMTGVYGALIIDAAGGDAIR
ECCCCCCCEECCCCCCCEEEEEEEEEECCCEEEECCCCHHHHHCCEEEEEEECCCCCCEE
ADRDYSVLLSDWTDEDPMRVLSKLKTQGDYYNYHQPTVVDFFRDVSNDGWKAAMEKRAMW
CCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
NQMRMNPTDLADLSSATLTYLTNGVTPAGNWTGLFTPGETVRLRFINGSGNTFYDVRIPG
HHHCCCCCHHHHCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEEEECCCCEEEEEEECC
LKLKVVQVDGQNIEPVTVDEFRFGPGETCDVLVAPKDDAYTIFSQSMDRTGYARGTLAVC
EEEEEEEECCCCCCCEEHHCEECCCCCCEEEEEECCCCCEEEEHHCCCCCCCCCCHHHHH
RGLQAAVPALDKVEWLSMADMMGDMGGMGGMSHGGMSGMDHGAMSGMNHGGMPGMDHGDM
CCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCE
QMMDDTGMTMMDSGGMQMMDHSQHAESGGAANSLKVPSKTARHARTEYGPSTDMHVDMAR
EEECCCCCEEECCCCCEECCCCHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEHH
TNLDDPGVGLRNNGRRVLVLADMHTIGGPMDKRGPEREVELHLTGNMERYTWSFDGVEFG
CCCCCCCCCCCCCCCEEEEEEECHHHCCCCCCCCCCCEEEEEEECCCEEEEEEECCEECC
KSTPVHFRYGERLRVILHNDTMMTHPMHLHGMWSELEAPDGTFLARRHTIPVQPAQRISF
CCCCEEEEECCEEEEEEECCEEEECCEEEECCHHHCCCCCCCEEEEECCCCCCHHHHEEE
LVTADALGRWAWHCHLMLHMDAGMFREVVVV
EEEHHHHCCEEEEEEEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]