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The map label for this gene is lon2 [H]

Identifier: 187928656

GI number: 187928656

Start: 1661109

End: 1662299

Strand: Direct

Name: lon2 [H]

Synonym: Rpic_1572

Alternate gene names: 187928656

Gene position: 1661109-1662299 (Clockwise)

Preceding gene: 187928655

Following gene: 187928657

Centisome position: 42.13

GC content: 61.04

Gene sequence:

>1191_bases
ATGTCTGCTTCCGAGCGCTCCTCGGATCACCCCCCTGGGTTTCTGCCCTTGGGCGATCTCACAGCGTGGCCCAGTGCCGC
GGCATGGCGGTTACTTATCCCCTCTGACACTCGCACAGCTCTTGCCGCGGCCCGACAAAGCAAGGAGTCCCAGGAGGAAA
TCCCCGGATTCTCAATTGAGGAGCCCCCCGCGGCCGCGCCGGTGGCTGTACCTGCACCACCTCGTCGAAATCGGCGCGGG
CATGTTCAAATTTTTCGGCCTGAGACGCTGGCGCTCGCCGCCGAGAACCTTCAAGGTGCCGACCGGCACCAGGAGCGATA
TGCACAACCATTGCTAGCGCAAGCCGGCATTGATGACGGCTACAGAGCCCTGCCTCGCACCCGCTCCACGCTGAAGAGGC
TCGAAACGACCCAGGACTTGTTTGACAACCTGCGCGAGCCAATTCAGAAGCTGAAGATCGACCTCACGCTCATGAGTGCG
ATGCGGACGAAGGACTTTCGCGTTCGGCCGATCCTGTTGACGGGACAGCCTGGTGTCGGAAAAACGCACTTCGCGCTGAA
GCTGGCCGAAATCTTGGGTGTGCCGATGCGGAAATGGTCTGCGGGAAGCGCACAAGCAGGTTTCCAACTGACGGGCGGTG
ATAGCGCATGGCGCGACGCTCGGCCAGGGATGATCTTTGAGGTGCTCGCTCGCGGCGATTCAGCGACGCCCGTGTTGGTC
CTGGATGAGGTGGACAAGCTTGGAGAAGGCGGCCGCTATCCGGTAACTCCAGTACTGCTGGACCTCCTTGAGTCCGGAAC
AGCACGCATGTTCGAGGACACATTTCTGCGTATCGCATTTGACGCCAGTCGGATCATCTATGTCCTCACTGCGAACGATC
TCGCCGCGGTGCCTGCGCCGCTATTGAGCCGCGTGGAAGTATTCGACATCCCTGCACCCGAGCCCGAGCAACGGTTGCGG
CTCGTCTTGGCAGAAGTTCGTCGGCTGCAGCGGGCCACCGGCAGATGCATTGAACTAGACGCCAATGCGGCAGACGCCTT
GTCCGAGCGAAGCGACATCGACCTGCGCGCAACCCATCGCTTAGTGCAGGATGCGTTCGCGACCGCGATGGCGTCTGGCA
AGAACATCGCCGTGCCGAAGGTACCGCGGCATGTTACGCAGATGTCGATTGGTTTCGTACCCAACACATAG

Upstream 100 bases:

>100_bases
TACGCGAATAGTCAGCTGACTCCCAGCCCTATAGGTCCCGGGCATTGCCCGATTGGACAGCTGCGGTTGCATGCCGCAAG
TTCGCGTATGGAGAAAGATC

Downstream 100 bases:

>100_bases
ATTTTGGTGGCGGTGGCTGCGATTGCAGGATGGCGTTATTCCCCAAATAAACGCTTAACCACCGTTGCCGCACTGGTTCC
ACGGTATAGAACTCGGAGCG

Product: AAA ATPase central domain-containing protein

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSASERSSDHPPGFLPLGDLTAWPSAAAWRLLIPSDTRTALAAARQSKESQEEIPGFSIEEPPAAAPVAVPAPPRRNRRG
HVQIFRPETLALAAENLQGADRHQERYAQPLLAQAGIDDGYRALPRTRSTLKRLETTQDLFDNLREPIQKLKIDLTLMSA
MRTKDFRVRPILLTGQPGVGKTHFALKLAEILGVPMRKWSAGSAQAGFQLTGGDSAWRDARPGMIFEVLARGDSATPVLV
LDEVDKLGEGGRYPVTPVLLDLLESGTARMFEDTFLRIAFDASRIIYVLTANDLAAVPAPLLSRVEVFDIPAPEPEQRLR
LVLAEVRRLQRATGRCIELDANAADALSERSDIDLRATHRLVQDAFATAMASGKNIAVPKVPRHVTQMSIGFVPNT

Sequences:

>Translated_396_residues
MSASERSSDHPPGFLPLGDLTAWPSAAAWRLLIPSDTRTALAAARQSKESQEEIPGFSIEEPPAAAPVAVPAPPRRNRRG
HVQIFRPETLALAAENLQGADRHQERYAQPLLAQAGIDDGYRALPRTRSTLKRLETTQDLFDNLREPIQKLKIDLTLMSA
MRTKDFRVRPILLTGQPGVGKTHFALKLAEILGVPMRKWSAGSAQAGFQLTGGDSAWRDARPGMIFEVLARGDSATPVLV
LDEVDKLGEGGRYPVTPVLLDLLESGTARMFEDTFLRIAFDASRIIYVLTANDLAAVPAPLLSRVEVFDIPAPEPEQRLR
LVLAEVRRLQRATGRCIELDANAADALSERSDIDLRATHRLVQDAFATAMASGKNIAVPKVPRHVTQMSIGFVPNT
>Mature_395_residues
SASERSSDHPPGFLPLGDLTAWPSAAAWRLLIPSDTRTALAAARQSKESQEEIPGFSIEEPPAAAPVAVPAPPRRNRRGH
VQIFRPETLALAAENLQGADRHQERYAQPLLAQAGIDDGYRALPRTRSTLKRLETTQDLFDNLREPIQKLKIDLTLMSAM
RTKDFRVRPILLTGQPGVGKTHFALKLAEILGVPMRKWSAGSAQAGFQLTGGDSAWRDARPGMIFEVLARGDSATPVLVL
DEVDKLGEGGRYPVTPVLLDLLESGTARMFEDTFLRIAFDASRIIYVLTANDLAAVPAPLLSRVEVFDIPAPEPEQRLRL
VLAEVRRLQRATGRCIELDANAADALSERSDIDLRATHRLVQDAFATAMASGKNIAVPKVPRHVTQMSIGFVPNT

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=202, Percent_Identity=32.1782178217822, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI21396489, Length=174, Percent_Identity=27.5862068965517, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786643, Length=224, Percent_Identity=26.3392857142857, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17556486, Length=171, Percent_Identity=32.7485380116959, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17505831, Length=153, Percent_Identity=30.0653594771242, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319449, Length=152, Percent_Identity=30.9210526315789, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221513036, Length=174, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24666867, Length=174, Percent_Identity=27.5862068965517, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 43332; Mature: 43201

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASERSSDHPPGFLPLGDLTAWPSAAAWRLLIPSDTRTALAAARQSKESQEEIPGFSIE
CCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCC
EPPAAAPVAVPAPPRRNRRGHVQIFRPETLALAAENLQGADRHQERYAQPLLAQAGIDDG
CCCCCCCEECCCCCCCCCCCCEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
YRALPRTRSTLKRLETTQDLFDNLREPIQKLKIDLTLMSAMRTKDFRVRPILLTGQPGVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCC
KTHFALKLAEILGVPMRKWSAGSAQAGFQLTGGDSAWRDARPGMIFEVLARGDSATPVLV
CHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHCCCCCCCEEE
LDEVDKLGEGGRYPVTPVLLDLLESGTARMFEDTFLRIAFDASRIIYVLTANDLAAVPAP
ECCHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHEEEEEECCEEEEEEECCCHHHCCHH
LLSRVEVFDIPAPEPEQRLRLVLAEVRRLQRATGRCIELDANAADALSERSDIDLRATHR
HHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCCHHHHHH
LVQDAFATAMASGKNIAVPKVPRHVTQMSIGFVPNT
HHHHHHHHHHHCCCCCCCCCCCHHHHHHEECCCCCC
>Mature Secondary Structure 
SASERSSDHPPGFLPLGDLTAWPSAAAWRLLIPSDTRTALAAARQSKESQEEIPGFSIE
CCCCCCCCCCCCEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCC
EPPAAAPVAVPAPPRRNRRGHVQIFRPETLALAAENLQGADRHQERYAQPLLAQAGIDDG
CCCCCCCEECCCCCCCCCCCCEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
YRALPRTRSTLKRLETTQDLFDNLREPIQKLKIDLTLMSAMRTKDFRVRPILLTGQPGVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCC
KTHFALKLAEILGVPMRKWSAGSAQAGFQLTGGDSAWRDARPGMIFEVLARGDSATPVLV
CHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHCCCCCCCEEE
LDEVDKLGEGGRYPVTPVLLDLLESGTARMFEDTFLRIAFDASRIIYVLTANDLAAVPAP
ECCHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHEEEEEECCEEEEEEECCCHHHCCHH
LLSRVEVFDIPAPEPEQRLRLVLAEVRRLQRATGRCIELDANAADALSERSDIDLRATHR
HHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCCHHHHHH
LVQDAFATAMASGKNIAVPKVPRHVTQMSIGFVPNT
HHHHHHHHHHHCCCCCCCCCCCHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA