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The map label for this gene is alkK [H]

Identifier: 187928541

GI number: 187928541

Start: 1546442

End: 1548070

Strand: Reverse

Name: alkK [H]

Synonym: Rpic_1455

Alternate gene names: 187928541

Gene position: 1548070-1546442 (Counterclockwise)

Preceding gene: 187928555

Following gene: 187928540

Centisome position: 39.27

GC content: 61.63

Gene sequence:

>1629_bases
ATGGCCCTGATGGGACAAATGATGAGCGCTCCGTTGCTCATCTCGACCATCATCGAACATGCAGCGCGCAATTCCGGTTC
GACTGAAGTCGTGTCGCGCCGTGTCGAGGGCGATATCCATCGCACCACGTACCGGCACGTGCGAGACCGTTCCAAGCAAC
TGGCGAATGCGCTGGCCGCACTGGGCGTGCAGCCCGGCGAACGCGTCGGTACGCTGGCCTGGAACGGCTATCGCCATCTT
GAAATCTATTACGGCGTCTCCGGTTCGGGCTCGGTGTGCCACACCATCAACCCGCGGCTGTTTCCTGACCAGATCGCCTA
CATCGTCAATCACGCAGACGATCAGTACGTTTTCTTCGACCTGACGTTCGTGCCGCTCATCGAGGGCATCGCCCCGCACT
GCCCGAACGTGAAGGGCTGGGTGGCGATGACCGATCGCGCGCACATGCCCACTTCCAGCGTGCCGATGCTCTGCTACGAA
GAGCTGCTGGACGCGCAGAGCGCCGACTACACCTGGCCGCAGTTCGACGAGAACACCGCAGCAGGCCTGTGCTACACGTC
GGGCACTACGGGCAACCCGAAGGGCGCGTTGTACTCGCATCGATCCACAGTGCTGCATTCGTATGCGTCTGCATTGCCCG
ATGCGCTCGGGTGCTCGGCGCAGGACGTGATTCTGCCGGTGGTGCCGATGTTCCACGTCAACGCGTGGGGGCTGCCGTAT
TCGGTGCCGCTGGTGGGCGCCAAGCTCGTCTTCCCGGGGCCGAAACTGGATGGCGCTTCGCTGTTCGAACTGTTCGAGCA
GGAGAAGGTCACGTTCTCCGCCGGCGTGCCGACGGTATGGCTGGGCCTGCTGCAACACGTGCAGGCCAACAAGCTGAAAT
TCTCGACGTTCCGCAAGACCGTGATTGGCGGCTCGGCTGCGCCGCCGGCCATGATCCGTACGCTCAAAGAACTGGACGTC
GAAGTCATCCACGCGTGGGGCATGACGGAAATGTCCCCGCTGGGCACCACGTGCAAGCTGATGGGCAAGCATGCCGACCT
GCCGGACGAGGCCAAGCAGCATGTGCTCGAACGTCAGGGCCGCGCCATCTACGGCGTCGAGATGAAGATCGTCGATGCCG
AGGGCCACGAACTGCCGTGGGACGGCAAGGCTTTCGGCGATCTCTACGTGCGCGGGCCTTGGACCATTCAGAGCTATTAC
CGCAACGAAGTGTCGCCGCTGGTTGATGGCTGGTTCCCGACGGGGGACGTGGCCAATATCGATGCCGATGGCTACATGCA
GATCACAGATCGGAGCAAGGACGTGATCAAGTCGGGCGGTGAGTGGATTTCGTCCATCGATGTGGAAAACGTGGCCGCTG
CGCACCCCGGCGTGCACATGGCCGCATGCATCTCGTGCCACCACCCGAAGTGGGACGAGCGCCCGTTGCTGGTGGTGATG
AAGAAGCCAGGTGTGGAACTCACGCGTGAGGAGATGCTCAAGTTCTTCGAAGGCAAGGTTGCCAAATGGTGGATTCCGGA
TGACGTGGTGTTTGTCACCGAAATTCCGCTCACGGCCACCGGCAAGATGCAGAAGCTGAAGCTGCGCGAGCAGTTCAAGG
ATTATCAGTTCCCCGCTGTACAGGCTTAG

Upstream 100 bases:

>100_bases
ATGTGGCAGCGCACAACAATATCCCGTTGACGTGCTTGACGATCACGGGAACAATCGGCCAAAAAATAGAACGGTTGTTC
AGTTTTTTCTAGGAGACACC

Downstream 100 bases:

>100_bases
CTACATATAGAAACCGCCGCCCGTGCACGGGGTCACCCCGGCACGAGGACGGCGGACGTAAGACAACCGGATCAGGGCCG
GCCGCCGCGCGACGGACACG

Product: long-chain-fatty-acid--CoA ligase

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MALMGQMMSAPLLISTIIEHAARNSGSTEVVSRRVEGDIHRTTYRHVRDRSKQLANALAALGVQPGERVGTLAWNGYRHL
EIYYGVSGSGSVCHTINPRLFPDQIAYIVNHADDQYVFFDLTFVPLIEGIAPHCPNVKGWVAMTDRAHMPTSSVPMLCYE
ELLDAQSADYTWPQFDENTAAGLCYTSGTTGNPKGALYSHRSTVLHSYASALPDALGCSAQDVILPVVPMFHVNAWGLPY
SVPLVGAKLVFPGPKLDGASLFELFEQEKVTFSAGVPTVWLGLLQHVQANKLKFSTFRKTVIGGSAAPPAMIRTLKELDV
EVIHAWGMTEMSPLGTTCKLMGKHADLPDEAKQHVLERQGRAIYGVEMKIVDAEGHELPWDGKAFGDLYVRGPWTIQSYY
RNEVSPLVDGWFPTGDVANIDADGYMQITDRSKDVIKSGGEWISSIDVENVAAAHPGVHMAACISCHHPKWDERPLLVVM
KKPGVELTREEMLKFFEGKVAKWWIPDDVVFVTEIPLTATGKMQKLKLREQFKDYQFPAVQA

Sequences:

>Translated_542_residues
MALMGQMMSAPLLISTIIEHAARNSGSTEVVSRRVEGDIHRTTYRHVRDRSKQLANALAALGVQPGERVGTLAWNGYRHL
EIYYGVSGSGSVCHTINPRLFPDQIAYIVNHADDQYVFFDLTFVPLIEGIAPHCPNVKGWVAMTDRAHMPTSSVPMLCYE
ELLDAQSADYTWPQFDENTAAGLCYTSGTTGNPKGALYSHRSTVLHSYASALPDALGCSAQDVILPVVPMFHVNAWGLPY
SVPLVGAKLVFPGPKLDGASLFELFEQEKVTFSAGVPTVWLGLLQHVQANKLKFSTFRKTVIGGSAAPPAMIRTLKELDV
EVIHAWGMTEMSPLGTTCKLMGKHADLPDEAKQHVLERQGRAIYGVEMKIVDAEGHELPWDGKAFGDLYVRGPWTIQSYY
RNEVSPLVDGWFPTGDVANIDADGYMQITDRSKDVIKSGGEWISSIDVENVAAAHPGVHMAACISCHHPKWDERPLLVVM
KKPGVELTREEMLKFFEGKVAKWWIPDDVVFVTEIPLTATGKMQKLKLREQFKDYQFPAVQA
>Mature_541_residues
ALMGQMMSAPLLISTIIEHAARNSGSTEVVSRRVEGDIHRTTYRHVRDRSKQLANALAALGVQPGERVGTLAWNGYRHLE
IYYGVSGSGSVCHTINPRLFPDQIAYIVNHADDQYVFFDLTFVPLIEGIAPHCPNVKGWVAMTDRAHMPTSSVPMLCYEE
LLDAQSADYTWPQFDENTAAGLCYTSGTTGNPKGALYSHRSTVLHSYASALPDALGCSAQDVILPVVPMFHVNAWGLPYS
VPLVGAKLVFPGPKLDGASLFELFEQEKVTFSAGVPTVWLGLLQHVQANKLKFSTFRKTVIGGSAAPPAMIRTLKELDVE
VIHAWGMTEMSPLGTTCKLMGKHADLPDEAKQHVLERQGRAIYGVEMKIVDAEGHELPWDGKAFGDLYVRGPWTIQSYYR
NEVSPLVDGWFPTGDVANIDADGYMQITDRSKDVIKSGGEWISSIDVENVAAAHPGVHMAACISCHHPKWDERPLLVVMK
KPGVELTREEMLKFFEGKVAKWWIPDDVVFVTEIPLTATGKMQKLKLREQFKDYQFPAVQA

Specific function: Unknown

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=526, Percent_Identity=27.3764258555133, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI187761345, Length=530, Percent_Identity=26.7924528301887, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI187761343, Length=530, Percent_Identity=26.7924528301887, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI38505220, Length=507, Percent_Identity=25.0493096646943, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI157311624, Length=507, Percent_Identity=24.0631163708087, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI157311622, Length=507, Percent_Identity=24.0631163708087, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI58082049, Length=511, Percent_Identity=24.0704500978474, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI42544132, Length=514, Percent_Identity=22.7626459143969, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI122937307, Length=513, Percent_Identity=23.9766081871345, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI28416953, Length=570, Percent_Identity=22.6315789473684, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI13375727, Length=536, Percent_Identity=21.8283582089552, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI145693145, Length=501, Percent_Identity=27.5449101796407, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1788107, Length=525, Percent_Identity=24.1904761904762, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI221142682, Length=511, Percent_Identity=22.1135029354207, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786810, Length=385, Percent_Identity=27.2727272727273, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI1789201, Length=502, Percent_Identity=23.3067729083665, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788595, Length=454, Percent_Identity=23.568281938326, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994694, Length=572, Percent_Identity=24.8251748251748, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71994703, Length=572, Percent_Identity=24.8251748251748, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71994690, Length=572, Percent_Identity=24.8251748251748, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17558820, Length=509, Percent_Identity=26.7190569744597, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17560308, Length=532, Percent_Identity=25.9398496240602, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17531443, Length=546, Percent_Identity=22.7106227106227, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17557194, Length=534, Percent_Identity=25.6554307116105, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI32563687, Length=362, Percent_Identity=30.1104972375691, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17538037, Length=562, Percent_Identity=24.5551601423488, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17559526, Length=516, Percent_Identity=25.3875968992248, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71985884, Length=385, Percent_Identity=26.2337662337662, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319699, Length=399, Percent_Identity=27.0676691729323, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24581924, Length=565, Percent_Identity=27.9646017699115, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI21355181, Length=521, Percent_Identity=23.4165067178503, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI18859661, Length=531, Percent_Identity=25.2354048964218, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24648260, Length=501, Percent_Identity=25.3493013972056, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922652, Length=495, Percent_Identity=23.2323232323232, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24648253, Length=534, Percent_Identity=21.5355805243446, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24648255, Length=534, Percent_Identity=21.5355805243446, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24653035, Length=502, Percent_Identity=19.9203187250996, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281365686, Length=252, Percent_Identity=24.2063492063492, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356441, Length=502, Percent_Identity=21.5139442231076, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24667955, Length=401, Percent_Identity=23.9401496259352, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI62472339, Length=412, Percent_Identity=23.3009708737864, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24667959, Length=412, Percent_Identity=23.3009708737864, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648257, Length=488, Percent_Identity=23.3606557377049, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI161076582, Length=510, Percent_Identity=20.3921568627451, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI20130357, Length=367, Percent_Identity=22.3433242506812, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356947, Length=361, Percent_Identity=24.3767313019391, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 59935; Mature: 59804

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALMGQMMSAPLLISTIIEHAARNSGSTEVVSRRVEGDIHRTTYRHVRDRSKQLANALAA
CCCHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LGVQPGERVGTLAWNGYRHLEIYYGVSGSGSVCHTINPRLFPDQIAYIVNHADDQYVFFD
HCCCCCCCEEEEEECCEEEEEEEEEECCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEE
LTFVPLIEGIAPHCPNVKGWVAMTDRAHMPTSSVPMLCYEELLDAQSADYTWPQFDENTA
EEHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
AGLCYTSGTTGNPKGALYSHRSTVLHSYASALPDALGCSAQDVILPVVPMFHVNAWGLPY
CEEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCHHHCCCCCCHHHCCCHHHEEECCCCCE
SVPLVGAKLVFPGPKLDGASLFELFEQEKVTFSAGVPTVWLGLLQHVQANKLKFSTFRKT
ECCEECEEEEECCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHCCEEHHHHHHH
VIGGSAAPPAMIRTLKELDVEVIHAWGMTEMSPLGTTCKLMGKHADLPDEAKQHVLERQG
HCCCCCCCHHHHHHHHHCCHHEEEECCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHCC
RAIYGVEMKIVDAEGHELPWDGKAFGDLYVRGPWTIQSYYRNEVSPLVDGWFPTGDVANI
CEEEEEEEEEECCCCCCCCCCCCCCCCEEEECCEEHHHHHHCCCCHHHCCCCCCCCEEEC
DADGYMQITDRSKDVIKSGGEWISSIDVENVAAAHPGVHMAACISCHHPKWDERPLLVVM
CCCCEEEECCCCHHHHHCCCHHHHHCCHHHHHHCCCCCCEEHHHCCCCCCCCCCCEEEEE
KKPGVELTREEMLKFFEGKVAKWWIPDDVVFVTEIPLTATGKMQKLKLREQFKDYQFPAV
ECCCCCCCHHHHHHHHCCCCEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCC
QA
CC
>Mature Secondary Structure 
ALMGQMMSAPLLISTIIEHAARNSGSTEVVSRRVEGDIHRTTYRHVRDRSKQLANALAA
CCHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LGVQPGERVGTLAWNGYRHLEIYYGVSGSGSVCHTINPRLFPDQIAYIVNHADDQYVFFD
HCCCCCCCEEEEEECCEEEEEEEEEECCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEE
LTFVPLIEGIAPHCPNVKGWVAMTDRAHMPTSSVPMLCYEELLDAQSADYTWPQFDENTA
EEHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
AGLCYTSGTTGNPKGALYSHRSTVLHSYASALPDALGCSAQDVILPVVPMFHVNAWGLPY
CEEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCHHHCCCCCCHHHCCCHHHEEECCCCCE
SVPLVGAKLVFPGPKLDGASLFELFEQEKVTFSAGVPTVWLGLLQHVQANKLKFSTFRKT
ECCEECEEEEECCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHCCEEHHHHHHH
VIGGSAAPPAMIRTLKELDVEVIHAWGMTEMSPLGTTCKLMGKHADLPDEAKQHVLERQG
HCCCCCCCHHHHHHHHHCCHHEEEECCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHCC
RAIYGVEMKIVDAEGHELPWDGKAFGDLYVRGPWTIQSYYRNEVSPLVDGWFPTGDVANI
CEEEEEEEEEECCCCCCCCCCCCCCCCEEEECCEEHHHHHHCCCCHHHCCCCCCCCEEEC
DADGYMQITDRSKDVIKSGGEWISSIDVENVAAAHPGVHMAACISCHHPKWDERPLLVVM
CCCCEEEECCCCHHHHHCCCHHHHHCCHHHHHHCCCCCCEEHHHCCCCCCCCCCCEEEEE
KKPGVELTREEMLKFFEGKVAKWWIPDDVVFVTEIPLTATGKMQKLKLREQFKDYQFPAV
ECCCCCCCHHHHHHHHCCCCEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCC
QA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]