Click here to switch to the map view.

The map label for this gene is fadA [H]

Identifier: 187928531

GI number: 187928531

Start: 1533473

End: 1534651

Strand: Reverse

Name: fadA [H]

Synonym: Rpic_1445

Alternate gene names: 187928531

Gene position: 1534651-1533473 (Counterclockwise)

Preceding gene: 187928532

Following gene: 187928530

Centisome position: 38.93

GC content: 65.65

Gene sequence:

>1179_bases
ATGACCGAAGCAGTCATCGTTTCCACCGCACGTACCGGCCTGGCCAAGAGCTGGAAGGGCGCCTTCAACATGACGCACGG
CGCCACGCTGGGCGGCCATGCGGTTCAGCACGCCATCGAGCGCGCCAAGATCGAGCCGGGCGAAGTGGAAGACATCCTGA
TGGGCTGTGCGAACCCGGAAGGCGCAACGGGCGCCAACATCGCTCGCCAGATCGCCCTGCGTGCCGGCTGCCCCGTGACC
GTGCCGGGCGCGACCGTCAACCGCTTCTGCTCGTCGGGCCTGCAGACCATCGCCATGGCGGCGCAGCGTGTGATTGCCGA
TGAAGGCGACATCTTCGTGGCGGGCGGCGTGGAATCCATCTCGTGCGTGCAGCAGGAAATGAACCGCCACATGATGACCG
AAGGCTGGCTCAACAAGCACAAGCCGGAAATCTACTGGAGCATGCTGCAGACCGCCGAGAACGTCGCCAAGCGCTACAAC
ATCGCCAAGGAGCGCATGGACGAGTACGGCGTGCAAAGCCAGCAGCGCGCCGCTGCCGCCGCTGCCGCCGGCAAGTTCGA
CGACGAAATCGTCCCGATGACCACGGTGATGGGCGTGGCCGATGCCAAGACCGGCCAGCTCATGACGCGCGAAGTCACGA
TCTCAGCCGACGAAGGCATTCGCGCTGACACCACGCTCGAAGGCGTGTCGAAGATTCGCACGGCCATGCCGGGCGGCGTG
ATCACGGCCGGCAACGCCAGCCAATTCTCCGACGGCGCATCCGCTGCTGTGGTCATGAATGGCAAGGTGGCAGCCGCAAA
GGGCCTGCAGCCGCTCGGCGTGTTCCGCGGCTTCGCCGTGGCCGGCTGCGAGCCGGACGAAATGGGCATCGGCCCCGTCT
TTGCCGTGCCCAAGCTGCTGAAGAAGGCGGGTCTCAAGGTTGAAGACATTGGCCTGTGGGAACTGAACGAAGCGTTTGCT
GTGCAGGTGCTGTACTGCGCAGACAAGCTGGGCATCCCGATGGACCGCCTGAACGTCAACGGCGGCGCCATCGCCGTGGG
CCATCCGTACGGCGTGTCGGGCGCACGCCTGGTCGGCCACGCGCTGATCGAAGGCAAGCGCCGCGGCGTCAAGTACGTGG
TCGTGACCATGTGCATTGGCGGCGGCCAAGGCGCAGCCGGCCTGTTCGAGGTGCTCTAA

Upstream 100 bases:

>100_bases
GGCATCGCGCGGTTGCAGTCGCACACAGTCTTGAACGGATAACGGAACACATCGGGCGCTGCCGGAGCCGCGCCCGCCAC
CAGATACGAGGAGCAACACC

Downstream 100 bases:

>100_bases
AGCCAAGCAGGCTCCCCCTCAAAACGGGAGCCTGATTTGTTTCCGCTGGAACTGGCTTGATCGCCAGAGCATGCACCCAG
ATGGTTGGGCCGCTCTCGCC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTEAVIVSTARTGLAKSWKGAFNMTHGATLGGHAVQHAIERAKIEPGEVEDILMGCANPEGATGANIARQIALRAGCPVT
VPGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESISCVQQEMNRHMMTEGWLNKHKPEIYWSMLQTAENVAKRYN
IAKERMDEYGVQSQQRAAAAAAAGKFDDEIVPMTTVMGVADAKTGQLMTREVTISADEGIRADTTLEGVSKIRTAMPGGV
ITAGNASQFSDGASAAVVMNGKVAAAKGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLKKAGLKVEDIGLWELNEAFA
VQVLYCADKLGIPMDRLNVNGGAIAVGHPYGVSGARLVGHALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL

Sequences:

>Translated_392_residues
MTEAVIVSTARTGLAKSWKGAFNMTHGATLGGHAVQHAIERAKIEPGEVEDILMGCANPEGATGANIARQIALRAGCPVT
VPGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESISCVQQEMNRHMMTEGWLNKHKPEIYWSMLQTAENVAKRYN
IAKERMDEYGVQSQQRAAAAAAAGKFDDEIVPMTTVMGVADAKTGQLMTREVTISADEGIRADTTLEGVSKIRTAMPGGV
ITAGNASQFSDGASAAVVMNGKVAAAKGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLKKAGLKVEDIGLWELNEAFA
VQVLYCADKLGIPMDRLNVNGGAIAVGHPYGVSGARLVGHALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL
>Mature_391_residues
TEAVIVSTARTGLAKSWKGAFNMTHGATLGGHAVQHAIERAKIEPGEVEDILMGCANPEGATGANIARQIALRAGCPVTV
PGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESISCVQQEMNRHMMTEGWLNKHKPEIYWSMLQTAENVAKRYNI
AKERMDEYGVQSQQRAAAAAAAGKFDDEIVPMTTVMGVADAKTGQLMTREVTISADEGIRADTTLEGVSKIRTAMPGGVI
TAGNASQFSDGASAAVVMNGKVAAAKGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLKKAGLKVEDIGLWELNEAFAV
QVLYCADKLGIPMDRLNVNGGAIAVGHPYGVSGARLVGHALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=42.9667519181586, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=36.5239294710327, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=38.1188118811881, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=34.5088161209068, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI4504327, Length=393, Percent_Identity=31.0432569974555, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI194353979, Length=394, Percent_Identity=31.2182741116751, Blast_Score=152, Evalue=6e-37,
Organism=Escherichia coli, GI1787663, Length=409, Percent_Identity=39.119804400978, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1788554, Length=409, Percent_Identity=40.3422982885086, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=38.3838383838384, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI87082165, Length=409, Percent_Identity=35.6968215158924, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=29.3144208037825, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI133906874, Length=397, Percent_Identity=37.7833753148615, Blast_Score=233, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=37.2839506172839, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17551802, Length=437, Percent_Identity=30.2059496567506, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=398, Percent_Identity=31.4070351758794, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=388, Percent_Identity=27.8350515463918, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=37.1212121212121, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=31.358024691358, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24655093, Length=405, Percent_Identity=40.4938271604938, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24640423, Length=403, Percent_Identity=35.7320099255583, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI17648125, Length=358, Percent_Identity=37.7094972067039, Blast_Score=225, Evalue=5e-59,
Organism=Drosophila melanogaster, GI17137578, Length=408, Percent_Identity=30.6372549019608, Blast_Score=170, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40971; Mature: 40840

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAVIVSTARTGLAKSWKGAFNMTHGATLGGHAVQHAIERAKIEPGEVEDILMGCANPE
CCCEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
GATGANIARQIALRAGCPVTVPGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESI
CCCHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQQEMNRHMMTEGWLNKHKPEIYWSMLQTAENVAKRYNIAKERMDEYGVQSQQRAAAA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AAAGKFDDEIVPMTTVMGVADAKTGQLMTREVTISADEGIRADTTLEGVSKIRTAMPGGV
HHCCCCCCCCCCHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCE
ITAGNASQFSDGASAAVVMNGKVAAAKGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCCCEEEEECCCCHHHCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHH
KKAGLKVEDIGLWELNEAFAVQVLYCADKLGIPMDRLNVNGGAIAVGHPYGVSGARLVGH
HHCCCCEEECCCEECCHHHHEEHEEEHHHHCCCHHHEECCCCEEEECCCCCCCHHHHHHH
ALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL
HHHHHCCCCCEEEEEEEEECCCCCCCHHHHCC
>Mature Secondary Structure 
TEAVIVSTARTGLAKSWKGAFNMTHGATLGGHAVQHAIERAKIEPGEVEDILMGCANPE
CCEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
GATGANIARQIALRAGCPVTVPGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESI
CCCHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQQEMNRHMMTEGWLNKHKPEIYWSMLQTAENVAKRYNIAKERMDEYGVQSQQRAAAA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AAAGKFDDEIVPMTTVMGVADAKTGQLMTREVTISADEGIRADTTLEGVSKIRTAMPGGV
HHCCCCCCCCCCHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCE
ITAGNASQFSDGASAAVVMNGKVAAAKGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCCCEEEEECCCCHHHCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHH
KKAGLKVEDIGLWELNEAFAVQVLYCADKLGIPMDRLNVNGGAIAVGHPYGVSGARLVGH
HHCCCCEEECCCEECCHHHHEEHEEEHHHHCCCHHHEECCCCEEEECCCCCCCHHHHHHH
ALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL
HHHHHCCCCCEEEEEEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]