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The map label for this gene is bioA [H]

Identifier: 187928458

GI number: 187928458

Start: 1469199

End: 1470614

Strand: Direct

Name: bioA [H]

Synonym: Rpic_1371

Alternate gene names: 187928458

Gene position: 1469199-1470614 (Clockwise)

Preceding gene: 187928456

Following gene: 187928459

Centisome position: 37.27

GC content: 66.45

Gene sequence:

>1416_bases
ATGGCGTATCCCCCCATTCCTGTGCCGGCTGCCGGCGCGCAAGGTGCCTGCTCGGCCAACACGGCGTGGCAGGCGCGCAG
CCGCGCGGCCGTCTGGCATCCGTGCACGCAGAACGCACGGCTCGATGCCATGCCGCCGCTGCCGATCGCGCGCGGCCAGG
GCCCGTGGCTGATCGACTTTGACGGCAAGCGCTACCTGGACGGCACCAGCTCGTGGTGGGTCAACCTGTTCGGCCACGCC
AATCCGCATATCAACGCTGCGCTCAAGACGCAGCTCGATTCGCTGGAGCACGTCATGCTGGCGGGCGCCACACATCGCCC
GGCTGTGGAGTTGGCCGAGCGCCTGATCGATCTGACGGGCGGCGTGCTGGGCCACAGCTTCTTCGGCTCAGACGGCGCCT
CTGCCGTGGAAATTGCGCTCAAGATGAGCTTCCACGCGCATCGGAATGCAGGGCGGGGCGCCCGCAATCGCTTTATCTGC
CTGGAACACGGCTACCACGGTGAAACGCTCGGCGCGCTGGGCGTGACCGATGTTGCGGTCTTCCGCGATGCGTATGACCC
GCTGATCCTGCAGTCGCACCGCGTGCCATCGCCCGACGCACGCCTGGCCGGCCCCGGCGAAACCGCCGCTGATGTGGCCG
ACCGCGCCTTGGCCGCACTGCGCGATTGCCTCGTCGCCAACGCGGGCACCATCGCCGCCGTCATCATCGAGCCGCTGGTG
CAGTGCGCGGCCGGCATGGCCATGCACGACGTGAGCTATCTGCGCGGCGTGCGTGCGCTGTGCGACGAGTTTGGCGTGCA
TTGGATTGCAGACGAAATTGCCGTTGGCTGCGGCCGCACCGGTACATTCTTCGCATGCGAGCAGGCTGGCGTGTGGCCGG
ACCTGCTTTGCCTGTCCAAGGGCATCAGCGGGGGGTATCTGCCGCTGTCGATCGTGCTCTCGCGCGATGTCATCTACAAC
GCGTTCAACGACGATGCGCCGGTACGCAGCTTCCTGCATTCGCATTCGTATACCGGCAACCCGCTGGCGTGCCGCGCGGC
ACTGGCCACGCTCGATCTGTTTGCTGAAGAAGACGTCTTTGCGCGCAATCGCGTAACCGCGGCACGCATCGCTCAGGGCC
TGGCGCCACTGTCGCACGATGCGCGTTTTGCCCATCTGCGCCAGACCGGGATGATCACCGCGTTCGACGTGCACCCGGAC
GTGGCCGGTGCACGCTTTGCCGAGCGCTTTGCGCTCACGGCGCGCACGCACGGGCTGCTGCTGCGCCCGATCGGCAACAC
CGTCTATCTGCTGCCGCCATATGTGCTGAGCGATGAAGAGACCGACACGCTGGTCGAACGCACGCTGCAGACGCTTGAAG
ACACGCTGGCCCAAGCCACGGGCGAAACAGAGGGACACACCTATGCGATTGCTTGA

Upstream 100 bases:

>100_bases
CCGCTTGTCGTTTGATCCGCAAGGCACCTACCATACGCCGCCATGTGCCGGTTCCGCTTTGCAGCATGATGCGGGCCGGT
GTTGTTGACTGGAGGTTCGT

Downstream 100 bases:

>100_bases
CGACCTGCAGGCGGGCCTAGCTGCTATCGACGCCGCGCACCTGCGCCGCGTGCGCCGCACCGCGTACAGCCCGACCGACC
GCAGCCAGCGCATCAGCGTG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MAYPPIPVPAAGAQGACSANTAWQARSRAAVWHPCTQNARLDAMPPLPIARGQGPWLIDFDGKRYLDGTSSWWVNLFGHA
NPHINAALKTQLDSLEHVMLAGATHRPAVELAERLIDLTGGVLGHSFFGSDGASAVEIALKMSFHAHRNAGRGARNRFIC
LEHGYHGETLGALGVTDVAVFRDAYDPLILQSHRVPSPDARLAGPGETAADVADRALAALRDCLVANAGTIAAVIIEPLV
QCAAGMAMHDVSYLRGVRALCDEFGVHWIADEIAVGCGRTGTFFACEQAGVWPDLLCLSKGISGGYLPLSIVLSRDVIYN
AFNDDAPVRSFLHSHSYTGNPLACRAALATLDLFAEEDVFARNRVTAARIAQGLAPLSHDARFAHLRQTGMITAFDVHPD
VAGARFAERFALTARTHGLLLRPIGNTVYLLPPYVLSDEETDTLVERTLQTLEDTLAQATGETEGHTYAIA

Sequences:

>Translated_471_residues
MAYPPIPVPAAGAQGACSANTAWQARSRAAVWHPCTQNARLDAMPPLPIARGQGPWLIDFDGKRYLDGTSSWWVNLFGHA
NPHINAALKTQLDSLEHVMLAGATHRPAVELAERLIDLTGGVLGHSFFGSDGASAVEIALKMSFHAHRNAGRGARNRFIC
LEHGYHGETLGALGVTDVAVFRDAYDPLILQSHRVPSPDARLAGPGETAADVADRALAALRDCLVANAGTIAAVIIEPLV
QCAAGMAMHDVSYLRGVRALCDEFGVHWIADEIAVGCGRTGTFFACEQAGVWPDLLCLSKGISGGYLPLSIVLSRDVIYN
AFNDDAPVRSFLHSHSYTGNPLACRAALATLDLFAEEDVFARNRVTAARIAQGLAPLSHDARFAHLRQTGMITAFDVHPD
VAGARFAERFALTARTHGLLLRPIGNTVYLLPPYVLSDEETDTLVERTLQTLEDTLAQATGETEGHTYAIA
>Mature_470_residues
AYPPIPVPAAGAQGACSANTAWQARSRAAVWHPCTQNARLDAMPPLPIARGQGPWLIDFDGKRYLDGTSSWWVNLFGHAN
PHINAALKTQLDSLEHVMLAGATHRPAVELAERLIDLTGGVLGHSFFGSDGASAVEIALKMSFHAHRNAGRGARNRFICL
EHGYHGETLGALGVTDVAVFRDAYDPLILQSHRVPSPDARLAGPGETAADVADRALAALRDCLVANAGTIAAVIIEPLVQ
CAAGMAMHDVSYLRGVRALCDEFGVHWIADEIAVGCGRTGTFFACEQAGVWPDLLCLSKGISGGYLPLSIVLSRDVIYNA
FNDDAPVRSFLHSHSYTGNPLACRAALATLDLFAEEDVFARNRVTAARIAQGLAPLSHDARFAHLRQTGMITAFDVHPDV
AGARFAERFALTARTHGLLLRPIGNTVYLLPPYVLSDEETDTLVERTLQTLEDTLAQATGETEGHTYAIA

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=413, Percent_Identity=29.0556900726392, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI37574042, Length=443, Percent_Identity=26.410835214447, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI284507298, Length=224, Percent_Identity=33.0357142857143, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI13994255, Length=429, Percent_Identity=25.6410256410256, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI226442705, Length=443, Percent_Identity=26.6365688487585, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI226442709, Length=409, Percent_Identity=25.9168704156479, Blast_Score=96, Evalue=1e-19,
Organism=Escherichia coli, GI1786991, Length=426, Percent_Identity=35.4460093896714, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI145693181, Length=394, Percent_Identity=31.4720812182741, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789016, Length=420, Percent_Identity=28.5714285714286, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789759, Length=403, Percent_Identity=27.2952853598015, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=28.8177339901478, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1787560, Length=415, Percent_Identity=30.1204819277108, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786349, Length=340, Percent_Identity=28.5294117647059, Blast_Score=101, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=421, Percent_Identity=25.6532066508314, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32564660, Length=438, Percent_Identity=27.1689497716895, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI25144274, Length=244, Percent_Identity=29.9180327868852, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324386, Length=463, Percent_Identity=27.2138228941685, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6323470, Length=446, Percent_Identity=27.8026905829596, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324432, Length=426, Percent_Identity=26.2910798122066, Blast_Score=116, Evalue=8e-27,
Organism=Drosophila melanogaster, GI21357415, Length=450, Percent_Identity=27.1111111111111, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI161085790, Length=449, Percent_Identity=26.7260579064588, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21356575, Length=421, Percent_Identity=25.8907363420428, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574759, Length=356, Percent_Identity=27.247191011236, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 50477; Mature: 50346

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYPPIPVPAAGAQGACSANTAWQARSRAAVWHPCTQNARLDAMPPLPIARGQGPWLIDF
CCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEE
DGKRYLDGTSSWWVNLFGHANPHINAALKTQLDSLEHVMLAGATHRPAVELAERLIDLTG
CCCEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GVLGHSFFGSDGASAVEIALKMSFHAHRNAGRGARNRFICLEHGYHGETLGALGVTDVAV
HHHHHHCCCCCCCCCEEEEEHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHH
FRDAYDPLILQSHRVPSPDARLAGPGETAADVADRALAALRDCLVANAGTIAAVIIEPLV
HHHCCCCHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
QCAAGMAMHDVSYLRGVRALCDEFGVHWIADEIAVGCGRTGTFFACEQAGVWPDLLCLSK
HHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHC
GISGGYLPLSIVLSRDVIYNAFNDDAPVRSFLHSHSYTGNPLACRAALATLDLFAEEDVF
CCCCCCCHHHEEEHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHH
ARNRVTAARIAQGLAPLSHDARFAHLRQTGMITAFDVHPDVAGARFAERFALTARTHGLL
HHCCHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEE
LRPIGNTVYLLPPYVLSDEETDTLVERTLQTLEDTLAQATGETEGHTYAIA
EEECCCEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
>Mature Secondary Structure 
AYPPIPVPAAGAQGACSANTAWQARSRAAVWHPCTQNARLDAMPPLPIARGQGPWLIDF
CCCCCCCCCCCCCCCCCCCCHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEE
DGKRYLDGTSSWWVNLFGHANPHINAALKTQLDSLEHVMLAGATHRPAVELAERLIDLTG
CCCEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GVLGHSFFGSDGASAVEIALKMSFHAHRNAGRGARNRFICLEHGYHGETLGALGVTDVAV
HHHHHHCCCCCCCCCEEEEEHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHH
FRDAYDPLILQSHRVPSPDARLAGPGETAADVADRALAALRDCLVANAGTIAAVIIEPLV
HHHCCCCHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
QCAAGMAMHDVSYLRGVRALCDEFGVHWIADEIAVGCGRTGTFFACEQAGVWPDLLCLSK
HHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHC
GISGGYLPLSIVLSRDVIYNAFNDDAPVRSFLHSHSYTGNPLACRAALATLDLFAEEDVF
CCCCCCCHHHEEEHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHH
ARNRVTAARIAQGLAPLSHDARFAHLRQTGMITAFDVHPDVAGARFAERFALTARTHGLL
HHCCHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEE
LRPIGNTVYLLPPYVLSDEETDTLVERTLQTLEDTLAQATGETEGHTYAIA
EEECCCEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]