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The map label for this gene is guaA [H]

Identifier: 187928397

GI number: 187928397

Start: 1403803

End: 1405422

Strand: Direct

Name: guaA [H]

Synonym: Rpic_1308

Alternate gene names: 187928397

Gene position: 1403803-1405422 (Clockwise)

Preceding gene: 187928396

Following gene: 187928399

Centisome position: 35.61

GC content: 65.0

Gene sequence:

>1620_bases
ATGCACGACAAAGTCCTCATCCTTGATTTCGGCTCGCAGGTCACGCAACTGATTGCGCGGCGCGTGCGTGAAGCACACGT
CTACTGCGAAATCCATCCGAACGACGTGTCCGACGCCTTCGTGCGCGAATTCGCGCCCAAGGCGATCATCCTGTCCGGCA
GCCACGCCAGCACGTACGAAGATCATCAACTGCGCGCCCCGCAGGCCGTGTGGGACCTGGGCGTGCCGGTGCTGGGCATC
TGCTACGGCATGCAGACCATGGCCGTGCAGCTTGGCGGCAAGGTGGAGTGGAGCGACCACCGCGAATTCGGTTACGCCGA
AGTGCGCGCGCATGGCCACACCCGCCTGCTCAAGGACATCCAGGACTTCGCTACGCCCGAAGGCCACGGCATGCTCAAGG
TGTGGATGAGCCACGGCGACAAGGTCACAGAGCTGCCACCGGGCTTCAAGCTGCTGGCCTCGACGCCGAGCTGCCCCGTC
GCGGGCATGGCCGACGAGGCGCGTGGCTACTACGCGGTGCAGTTCCACCCGGAAGTCACGCACACCGTGCAGGGCCGCGC
GCTGCTCGAGCGCTTTGTGCTGGAGATCGCTGGCGCCAAGCCCGACTGGGTCATGCGCGATCACATCGACGAGGCCGTCA
AGGCGATCCGCGAGCAGGTGGGCGATGAAGAGGTGATCCTCGGCCTGTCGGGTGGCGTCGATTCTTCGGTGGCGGCGGCG
CTGATCCACCGCGCCATTGGCGACCAGCTGACCTGCGTGTTTGTCGACCATGGCCTGCTGCGCCTGGACGAAGGCAAGAT
GGTGATGGACATGTTCGCCGGCCGCCTGCATGCCAAGGTTGTGCATGTGGATGCGTCCGAGCAGTTCCTCGGCCATCTGG
CTGGCGTGACTGACCCCGAAGCCAAGCGCAAGATCATCGGCCGCGAGTTCGTTGAAGTGTTCCAGGCCGAAGCCAAGAAA
CTCAGCAACGCCAAGTGGCTGGCGCAGGGCACGATCTACCCGGATGTGGTGGAATCGGGCGGCACCAAGACCAAGAAGGC
GACGACGATCAAGAGCCACCACAACGTGGGCGGCCTGCCGGAGACGCTGGGCCTGAAGCTGCTCGAGCCGCTGCGCGACC
TGTTCAAGGATGAAGTCCGCGAGCTGGGTGTGGCGCTGGGCCTGCCGCACGAGATGGTGTATCGCCACCCGTTCCCGGGG
CCTGGCCTGGGCGTGCGCATTCTGGGTGAGGTCAAGCGTGAATATGCAGACCTGCTGCGCCGTGCCGATGCGATCTTCAT
CGAAGAGCTGCGCGGCACGAAGGCCACGGCGCAGGATGCGGCCGCCGGCCTGTGCGGCGAAGGCGATGTTGGCAAGAGCT
GGTACGACCTGACCAGCCAGGCGTTTGCGGTGTTCCTGCCGATCAAGTCCGTCGGCGTGATGGGCGATGGCCGCACATAC
GACTACGTGACGGCGCTGCGTGCAGTGCAGACCACCGACTTCATGACCGCACATTGGGCGCATCTGCCGTACGCCCTGCT
GGGCCGCGTGTCGAACCGCATCATCAACGAGGTGCGTGGTTTGAGCCGGGTCGTGTATGACGTGTCGGGCAAGCCGCCTG
CGACGATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
GCAGAAAAGGCGCAACGCAAAGAACCTGGCTACATGCCGCCTCCGGGCTACGGCCCCGGCACTGAAGTCGACACGATTGC
CGATTCCATTCCTCCACAAC

Downstream 100 bases:

>100_bases
GGTTCACCTGCCAAGTCGGAAGAAGCCCGCGTTATGCGGGCTTTTTTTCGTCCTTGTAGTTGGCTATCCAGTGTCTGCCA
AAAAGCTACCCCGAACGGCG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MHDKVLILDFGSQVTQLIARRVREAHVYCEIHPNDVSDAFVREFAPKAIILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLKDIQDFATPEGHGMLKVWMSHGDKVTELPPGFKLLASTPSCPV
AGMADEARGYYAVQFHPEVTHTVQGRALLERFVLEIAGAKPDWVMRDHIDEAVKAIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHVDASEQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKK
LSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPHEMVYRHPFPG
PGLGVRILGEVKREYADLLRRADAIFIEELRGTKATAQDAAAGLCGEGDVGKSWYDLTSQAFAVFLPIKSVGVMGDGRTY
DYVTALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGLSRVVYDVSGKPPATIEWE

Sequences:

>Translated_539_residues
MHDKVLILDFGSQVTQLIARRVREAHVYCEIHPNDVSDAFVREFAPKAIILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLKDIQDFATPEGHGMLKVWMSHGDKVTELPPGFKLLASTPSCPV
AGMADEARGYYAVQFHPEVTHTVQGRALLERFVLEIAGAKPDWVMRDHIDEAVKAIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHVDASEQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKK
LSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPHEMVYRHPFPG
PGLGVRILGEVKREYADLLRRADAIFIEELRGTKATAQDAAAGLCGEGDVGKSWYDLTSQAFAVFLPIKSVGVMGDGRTY
DYVTALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGLSRVVYDVSGKPPATIEWE
>Mature_539_residues
MHDKVLILDFGSQVTQLIARRVREAHVYCEIHPNDVSDAFVREFAPKAIILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLKDIQDFATPEGHGMLKVWMSHGDKVTELPPGFKLLASTPSCPV
AGMADEARGYYAVQFHPEVTHTVQGRALLERFVLEIAGAKPDWVMRDHIDEAVKAIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHVDASEQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKK
LSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPHEMVYRHPFPG
PGLGVRILGEVKREYADLLRRADAIFIEELRGTKATAQDAAAGLCGEGDVGKSWYDLTSQAFAVFLPIKSVGVMGDGRTY
DYVTALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGLSRVVYDVSGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=563, Percent_Identity=34.6358792184725, Blast_Score=278, Evalue=9e-75,
Organism=Escherichia coli, GI1788854, Length=536, Percent_Identity=63.6194029850746, Blast_Score=691, Evalue=0.0,
Organism=Caenorhabditis elegans, GI133901714, Length=578, Percent_Identity=34.4290657439446, Blast_Score=275, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI71992710, Length=578, Percent_Identity=34.4290657439446, Blast_Score=275, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI71992717, Length=578, Percent_Identity=34.4290657439446, Blast_Score=275, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6323873, Length=548, Percent_Identity=47.8102189781022, Blast_Score=501, Evalue=1e-143,
Organism=Drosophila melanogaster, GI281365319, Length=560, Percent_Identity=34.4642857142857, Blast_Score=279, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 59309; Mature: 59309

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDKVLILDFGSQVTQLIARRVREAHVYCEIHPNDVSDAFVREFAPKAIILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHCCCCEEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLKDI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHCCHHHHHHHH
QDFATPEGHGMLKVWMSHGDKVTELPPGFKLLASTPSCPVAGMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCEECCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCHH
HTVQGRALLERFVLEIAGAKPDWVMRDHIDEAVKAIREQVGDEEVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHVDASEQFLGHLAGVTDPE
HHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHCCCEEEEEEECCHHHHHHHHCCCCCHH
AKRKIIGREFVEVFQAEAKKLSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHCCCCCCCCEEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPHEMVYRHPFPGPGLGVRILGEVKREYADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRGTKATAQDAAAGLCGEGDVGKSWYDLTSQAFAVFLPIKSVGVMGDGRTY
HHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHEEEEEEHHHHCCCCCCCCH
DYVTALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGLSRVVYDVSGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECC
>Mature Secondary Structure
MHDKVLILDFGSQVTQLIARRVREAHVYCEIHPNDVSDAFVREFAPKAIILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHCCCCEEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLKDI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHCCHHHHHHHH
QDFATPEGHGMLKVWMSHGDKVTELPPGFKLLASTPSCPVAGMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCEECCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCHH
HTVQGRALLERFVLEIAGAKPDWVMRDHIDEAVKAIREQVGDEEVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHVDASEQFLGHLAGVTDPE
HHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHCCCEEEEEEECCHHHHHHHHCCCCCHH
AKRKIIGREFVEVFQAEAKKLSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHCCCCCCCCEEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPHEMVYRHPFPGPGLGVRILGEVKREYADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRGTKATAQDAAAGLCGEGDVGKSWYDLTSQAFAVFLPIKSVGVMGDGRTY
HHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHEEEEEEHHHHCCCCCCCCH
DYVTALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGLSRVVYDVSGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA