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The map label for this gene is ilvG [H]

Identifier: 187928317

GI number: 187928317

Start: 1316080

End: 1317807

Strand: Direct

Name: ilvG [H]

Synonym: Rpic_1228

Alternate gene names: 187928317

Gene position: 1316080-1317807 (Clockwise)

Preceding gene: 187928316

Following gene: 187928318

Centisome position: 33.38

GC content: 66.2

Gene sequence:

>1728_bases
ATGGAGACACCAGCCGCACGCCCCGCCAGCCTTGTCGTTGAGCCCCGCCACGGCGGCCAGATTCTTGTTGATGCACTGCT
GGCCCATGGCGTCGACATGGCCTTCGGCGTGCCCGGCGAGAGCTACCTGTCTGTGCTCGAAGGCTTTTATCAGCGCCGCG
ACCGCGCACGCTTCATCGTCTGCCGGCAAGAGGGCGGTGCGGCCAACATGGCGGATGCGTACGGCAAGCTCACCGGCCGC
CCCGGCATCGTCTTCTGCACGCGCGGGCCGGGCGCCACCAACGCCAGCATTGGCGTACACACTGCGTTTCAGGACTCCAC
GCCGCTGATCCTGTTCATCGGCCAGGTCGGCCGCGATTTCGTCGACCGGGAAGCGTTTCAGGAAATCGACTACCGCCGCA
TGTTCGGCCAGATGGCCAAGTGGGTCGCGCAGATCGATAGCGTCGAACGCATCCCCGAATACATCGCACGCGCCTTCCAG
ACTGCCACCGCCGGCCGCCCCGGCCCGGTTGTGCTGGCGCTGCCCGAAGACATGCTGACCGACGTCGCCACCGTGGCTGA
TGTGCCGCCCGAGGTGGCAACGAAAGCCCGCGCGATGGCGTGGCCCAGCCCGCATGATCTTGCCCGGCTGAAGACGCTGC
TGCAGGACGCCGAGCGCCCGATGCTGCTGCTGGGCGGTTCCGGCTGGACGCCGCAAGCCGCCGCCCGCATGCAGGCCTTT
GCCGAGCGCTGGAATCTGCCCGCAGGCTGCGTGTTCCGTCGGCAAGACCTGTTCGACAACCGCCACCCCAATTACGCCGG
TGATGTCGGTATCGCCATCAACCCGAAGCTCGCGGCGCGCGTGAAAGACGCCGACGTCGTGCTTGCCATCGGCACACGCC
TGGGCGAAATGACGACCTCGGGCTACACGCTCTTCGATGTGCCGCGCCCGAAGCAGACGCTCGTCCACGTGCACGCCGGT
GCGGAAGAGTTGGGACGCGTCTACCAGGCTGATCTGATGATCCACGCGTCGATGCCCGCGATTGCCGAAGCGCTGGATGG
CGTGTCGCCTGATGCGCCGCCGCGTTGGTCCGCCTGGACAGAAGCCGCCAATGCCGATTACCGCGCCAACATCGTGCCAC
CGCCGTTTGGCGGCAAGGGCATCGACATGGCCCGCGCCATGCAATGGCTGCGCGAGCGCCTGCCTCGCCACAGCATCTTG
ACCAACGGCGCAGGCAACTACGCCACGTGGCTGCATCGCTTCTATCAATACGGTGCGCTGGCGGCAGGCTCGCGAACGCA
ACTCGCCCCCACGAGCGGGGCGATGGGCTATGGCGCCCCCGCTGCGGTGGCCGCCAAGATCGTCAGCCCCGACACGCCCG
TCATCTGCATGGCCGGTGACGGTTGCTTCCTGATGAACGGCCAGGAACTGGCGACCGCCATGCAGTACAACGCGCCGGTG
ATCTTCATCGTGGTCAACAACGGCATGTACGGCACCATCCGCATGCACCAGGAACGCGAGTACCCCGAGCACGTGAGCGG
TACCGAGCTGCGCAACCCGGACTTCGCCGCATTGGCCAGAGCCTACGGCGCCGAAGGGCATACGGTGCGCTCGCTTGAAG
GCTTCCAGTCTGCGGTGGAGACGGCACTTGCCGCGCTTGTGGCGAGCATCATCGAAGTGCAGACCGATCCGAACATCATC
AGCCCACGCGCGACGATCGATTCGTTGCATGCACAGTCACGCAGTTGA

Upstream 100 bases:

>100_bases
GGCAATACGCACATTTGTTCCGCCAGATGTAGTCGCCACGGCGGCGCGTTCCGCTATGATCCATCGTGTCGTCAACGGAT
CGAGAGCGCGAGCACCCGCC

Downstream 100 bases:

>100_bases
TTCCGCTTTCATTTCTTGTTTTCGCCAACGCCCATCCACCATTGCCATGACGATGATTCCCGTAACTGACTTGTGCGACA
TGCACGAAGACAAGCTGGTG

Product: thiamine pyrophosphate protein

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
METPAARPASLVVEPRHGGQILVDALLAHGVDMAFGVPGESYLSVLEGFYQRRDRARFIVCRQEGGAANMADAYGKLTGR
PGIVFCTRGPGATNASIGVHTAFQDSTPLILFIGQVGRDFVDREAFQEIDYRRMFGQMAKWVAQIDSVERIPEYIARAFQ
TATAGRPGPVVLALPEDMLTDVATVADVPPEVATKARAMAWPSPHDLARLKTLLQDAERPMLLLGGSGWTPQAAARMQAF
AERWNLPAGCVFRRQDLFDNRHPNYAGDVGIAINPKLAARVKDADVVLAIGTRLGEMTTSGYTLFDVPRPKQTLVHVHAG
AEELGRVYQADLMIHASMPAIAEALDGVSPDAPPRWSAWTEAANADYRANIVPPPFGGKGIDMARAMQWLRERLPRHSIL
TNGAGNYATWLHRFYQYGALAAGSRTQLAPTSGAMGYGAPAAVAAKIVSPDTPVICMAGDGCFLMNGQELATAMQYNAPV
IFIVVNNGMYGTIRMHQEREYPEHVSGTELRNPDFAALARAYGAEGHTVRSLEGFQSAVETALAALVASIIEVQTDPNII
SPRATIDSLHAQSRS

Sequences:

>Translated_575_residues
METPAARPASLVVEPRHGGQILVDALLAHGVDMAFGVPGESYLSVLEGFYQRRDRARFIVCRQEGGAANMADAYGKLTGR
PGIVFCTRGPGATNASIGVHTAFQDSTPLILFIGQVGRDFVDREAFQEIDYRRMFGQMAKWVAQIDSVERIPEYIARAFQ
TATAGRPGPVVLALPEDMLTDVATVADVPPEVATKARAMAWPSPHDLARLKTLLQDAERPMLLLGGSGWTPQAAARMQAF
AERWNLPAGCVFRRQDLFDNRHPNYAGDVGIAINPKLAARVKDADVVLAIGTRLGEMTTSGYTLFDVPRPKQTLVHVHAG
AEELGRVYQADLMIHASMPAIAEALDGVSPDAPPRWSAWTEAANADYRANIVPPPFGGKGIDMARAMQWLRERLPRHSIL
TNGAGNYATWLHRFYQYGALAAGSRTQLAPTSGAMGYGAPAAVAAKIVSPDTPVICMAGDGCFLMNGQELATAMQYNAPV
IFIVVNNGMYGTIRMHQEREYPEHVSGTELRNPDFAALARAYGAEGHTVRSLEGFQSAVETALAALVASIIEVQTDPNII
SPRATIDSLHAQSRS
>Mature_575_residues
METPAARPASLVVEPRHGGQILVDALLAHGVDMAFGVPGESYLSVLEGFYQRRDRARFIVCRQEGGAANMADAYGKLTGR
PGIVFCTRGPGATNASIGVHTAFQDSTPLILFIGQVGRDFVDREAFQEIDYRRMFGQMAKWVAQIDSVERIPEYIARAFQ
TATAGRPGPVVLALPEDMLTDVATVADVPPEVATKARAMAWPSPHDLARLKTLLQDAERPMLLLGGSGWTPQAAARMQAF
AERWNLPAGCVFRRQDLFDNRHPNYAGDVGIAINPKLAARVKDADVVLAIGTRLGEMTTSGYTLFDVPRPKQTLVHVHAG
AEELGRVYQADLMIHASMPAIAEALDGVSPDAPPRWSAWTEAANADYRANIVPPPFGGKGIDMARAMQWLRERLPRHSIL
TNGAGNYATWLHRFYQYGALAAGSRTQLAPTSGAMGYGAPAAVAAKIVSPDTPVICMAGDGCFLMNGQELATAMQYNAPV
IFIVVNNGMYGTIRMHQEREYPEHVSGTELRNPDFAALARAYGAEGHTVRSLEGFQSAVETALAALVASIIEVQTDPNII
SPRATIDSLHAQSRS

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=579, Percent_Identity=25.2158894645941, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI21361361, Length=553, Percent_Identity=25.3164556962025, Blast_Score=127, Evalue=4e-29,
Organism=Escherichia coli, GI87081685, Length=543, Percent_Identity=27.9926335174954, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1790104, Length=543, Percent_Identity=26.8876611418048, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1786717, Length=556, Percent_Identity=25.7194244604317, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1787096, Length=537, Percent_Identity=23.463687150838, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1788716, Length=291, Percent_Identity=27.1477663230241, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17531301, Length=581, Percent_Identity=25.9896729776248, Blast_Score=136, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17531299, Length=581, Percent_Identity=25.473321858864, Blast_Score=136, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17542570, Length=563, Percent_Identity=24.1563055062167, Blast_Score=112, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6323755, Length=569, Percent_Identity=26.5377855887522, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6320816, Length=562, Percent_Identity=21.8861209964413, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323163, Length=533, Percent_Identity=22.7016885553471, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323073, Length=533, Percent_Identity=22.3264540337711, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI19922626, Length=548, Percent_Identity=26.6423357664234, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 62128; Mature: 62128

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METPAARPASLVVEPRHGGQILVDALLAHGVDMAFGVPGESYLSVLEGFYQRRDRARFIV
CCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEE
CRQEGGAANMADAYGKLTGRPGIVFCTRGPGATNASIGVHTAFQDSTPLILFIGQVGRDF
EECCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEECHHCHHH
VDREAFQEIDYRRMFGQMAKWVAQIDSVERIPEYIARAFQTATAGRPGPVVLALPEDMLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHH
DVATVADVPPEVATKARAMAWPSPHDLARLKTLLQDAERPMLLLGGSGWTPQAAARMQAF
HHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHH
AERWNLPAGCVFRRQDLFDNRHPNYAGDVGIAINPKLAARVKDADVVLAIGTRLGEMTTS
HHHHCCCHHHEEEHHHHHCCCCCCCCCCEEEEECCHHHEEECCCCEEEEECCHHCCCCCC
GYTLFDVPRPKQTLVHVHAGAEELGRVYQADLMIHASMPAIAEALDGVSPDAPPRWSAWT
CEEEEECCCCHHEEEEEECCHHHHHHHHHHHEEEECCCHHHHHHHCCCCCCCCCCCCHHH
EAANADYRANIVPPPFGGKGIDMARAMQWLRERLPRHSILTNGAGNYATWLHRFYQYGAL
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCC
AAGSRTQLAPTSGAMGYGAPAAVAAKIVSPDTPVICMAGDGCFLMNGQELATAMQYNAPV
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCEEEECCHHHHHHHHCCCCE
IFIVVNNGMYGTIRMHQEREYPEHVSGTELRNPDFAALARAYGAEGHTVRSLEGFQSAVE
EEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEHHHHHHHHHHH
TALAALVASIIEVQTDPNIISPRATIDSLHAQSRS
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
METPAARPASLVVEPRHGGQILVDALLAHGVDMAFGVPGESYLSVLEGFYQRRDRARFIV
CCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEE
CRQEGGAANMADAYGKLTGRPGIVFCTRGPGATNASIGVHTAFQDSTPLILFIGQVGRDF
EECCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEECHHCHHH
VDREAFQEIDYRRMFGQMAKWVAQIDSVERIPEYIARAFQTATAGRPGPVVLALPEDMLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHH
DVATVADVPPEVATKARAMAWPSPHDLARLKTLLQDAERPMLLLGGSGWTPQAAARMQAF
HHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHH
AERWNLPAGCVFRRQDLFDNRHPNYAGDVGIAINPKLAARVKDADVVLAIGTRLGEMTTS
HHHHCCCHHHEEEHHHHHCCCCCCCCCCEEEEECCHHHEEECCCCEEEEECCHHCCCCCC
GYTLFDVPRPKQTLVHVHAGAEELGRVYQADLMIHASMPAIAEALDGVSPDAPPRWSAWT
CEEEEECCCCHHEEEEEECCHHHHHHHHHHHEEEECCCHHHHHHHCCCCCCCCCCCCHHH
EAANADYRANIVPPPFGGKGIDMARAMQWLRERLPRHSILTNGAGNYATWLHRFYQYGAL
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCC
AAGSRTQLAPTSGAMGYGAPAAVAAKIVSPDTPVICMAGDGCFLMNGQELATAMQYNAPV
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCEEEECCHHHHHHHHCCCCE
IFIVVNNGMYGTIRMHQEREYPEHVSGTELRNPDFAALARAYGAEGHTVRSLEGFQSAVE
EEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEHHHHHHHHHHH
TALAALVASIIEVQTDPNIISPRATIDSLHAQSRS
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]