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The map label for this gene is clpB [H]

Identifier: 187928299

GI number: 187928299

Start: 1297855

End: 1300443

Strand: Direct

Name: clpB [H]

Synonym: Rpic_1210

Alternate gene names: 187928299

Gene position: 1297855-1300443 (Clockwise)

Preceding gene: 187928298

Following gene: 187928300

Centisome position: 32.92

GC content: 64.08

Gene sequence:

>2589_bases
ATGCGTTTGGACAAATTGACCACCCGCTTCCAGGAAGCGCTGGCCGACGCGCAGAGCCTGGCGCTGGGCAACGACAATCC
GTACATCGAACCCGTCCACCTGTTGCTGGCCATGCTGCGCCAGCCGGATGGGGCCACCAAGAACCTGCTGGCCCGTGCGG
GCGTCAATACCGGCGCCCTCGACACGGCGCTGGACCGTGCCATCAAGCATCTGCCGCAGGTGCAGGGTGGCGAACAGGTG
CAGGTCGGCCGTGATCTGGGCAACCTGCTGCAGCAAACCGAGAAGGAAGGCATCAAGCGCGGCGACCAGTTCATCGCCAG
CGAGCTGTTCCTGCTGGCCGCGGCTGACGACAAGGGTGAGGCCGGGCGCATTGCGCGCGAGCACGGCCTGTCGCGCAAGC
CGCTCGAAGCCGCCATCGACGCCGTGCGCGGCGGCCAGACCGTCGGCAGCGCCGAGGCCGAAAGCCAGCGCGAAGCGCTC
AAGAAGTACACCATCGACCTGACCGAAATGGCCCGGATCGGCAAGCTGGACCCCGTCATCGGCCGCGATGATGAGATCCG
CCGTGCCATCCAGATCCTGCAGCGCCGCACCAAGAACAACCCGGTGCTGATCGGCGAGCCGGGCGTGGGCAAGACGGCCA
TCGTCGAAGGCCTGGCGCAGCGCATCATCAACGGCGAGGTGCCTGAAAGCCTGAAGAACAAGCGCGTGCTGGTGCTTGAC
ATGGCAGGCCTGCTGGCCGGTGCCAAGTACCGCGGCGAGTTCGAGGAACGCCTGAAGGCGGTGCTCAACGACATCGCCAA
GGAAGAGGGCCAGACCATTCTCTTCATCGACGAAATCCACACCATGGTGGGCGCGGGCAAGGCCGAAGGCGCGATGGATG
CCGGCAACATGCTCAAGCCGGCGCTTGCGCGCGGCGAGCTGCATTGCATCGGCGCGACCACGCTGGATGAATACCGCAAG
TACATCGAGAAAGACGCCGCGCTGGAGCGCCGCTTCCAGAAGGTGCTCGTGGGCGAGCCGAGCGTGGAGGCCACCATCGC
CATCCTGCGCGGCCTGCAGGAGAAGTACGAACTGCACCACGGCGTGGAGATCACCGACCCGGCGATCGTGGCCGCGGCTG
AACTCAGCCACCGCTACATCACCGACCGCTTCCTGCCGGACAAGGCCATCGACCTGATCGACGAAGCTGCGGCGCGCATC
AAGATGGAAATCGACTCGAAACCCGAGGCGATGGACAAGCTCGACCGCCGACTGATCCAGCTCAAGATCGAGCGCGAAGC
CGTCAAGAAGGAAACCGACGAGGCATCGCAGAAGCGCCTGGAGCTGATCGAGCAGGAAATCGAGCGTCTGCAGAAGGAGT
ACGCCGATCTGGATGAAATCTGGAAGGCCGAGAAGGGCGCCGCGCAAGGTGCGGCTGCGCTCAAGGAAGAGATCGACAAG
ATCAAGCTGGAGATCACCAAGCTGCAGCGCGAAGGCAAGCTCGAGAAAGTGGCCGAACTGCAATACGGCAAGCTGCCCGA
GCTGGAAGGCAAGCTGAAGGCCGCCACCGCCGCCGAGTCTGCCGGCCAGAAGCAGCCGAACAAGCTGCTGCGCACGCAGG
TGGGTGCCGAAGAGATTGCCGAAGTCGTCAGCCGCGCCACGGGCATCCCCGTGGCAAAGATGATGACCGGCGAGCGCGAG
AAGCTGCTGAAGATGGAAGACCGCCTGCACGAGCGCGTGGTCGGCCAGGACGAGGCCGTGCGTTTGGTGTCGGATGCCAT
CCGCCGTTCACGCGCCGGCATTGCGGACGAGAACAAGCCCTATGGCTCGTTCCTGTTCCTGGGTCCGACGGGCGTCGGCA
AGACCGAGCTGTGCAAGGCGCTGGCCGGCTTCCTGTTCGATTCGGAAGAGCACCTCATCCGCATCGACATGAGCGAGTTC
ATGGAGAAGCATTCCGTGAGCCGCCTGATTGGCGCGCCGCCGGGCTATGTCGGCTACGAGGAAGGTGGTTACCTGACCGA
AGCCGTGCGTCGCAAGCCGTACAGCGTGGTGCTGCTCGATGAAGTGGAGAAGGCGCACCCGGACGTCTTCAACGTGCTGC
TGCAAGTGCTGGACGATGGTCGCCTGACCGACGGCCAGGGCCGCACGGTGGACTTCAAGAACACGGTGATCGTGATGACG
TCGAACCTCGGCTCGCAGCTCATCCAGCAGATGGCGACCGAACCGGCGGACGTGATCAAGGGTGCCGTGTGGCAGGAAGT
GAAGACGCATTTCCGCCCCGAGTTCCTGAACCGGATCGACGAGGTGGTGGTGTTCCACGCGCTGGACCAACGCAACATCG
AATCGATCGCGCGGATCCAGCTCAAGCGCTTGTCGGCACGCCTGGCGCACATGGACCTGGCGCTGGAAATCAGCGACGAA
GCGGTGGCCAAGCTGGCCTCTGCGGGTTACGACCCGGTGTTTGGGGCACGGCCGTTGAAGCGGGCGATCCAGCAGCAGAT
TGAGAATCCGGTGGCGCGGATGATCCTGGAGGGCAAGTTCGCGCCTAAGGATGTGGTGCCGGTGGATTATCGGGACGGGC
AGTTCTCGTTTGAGAGGATTGTGCACTAA

Upstream 100 bases:

>100_bases
TGGCGCAAATCTGCGTCAAAACTCGCGTTTCCATGCTTGAAATGCCACCGAAGCTCCCTATCTTTCGGAGCAGTGAAACA
TTTTCCGCAAGGGGTTTTTA

Downstream 100 bases:

>100_bases
GGCTGTTGCTGGGCTTCAAAGAACCGCTCTGGTTTTTCCAGAGCGGTTTTTTTTTGTTCTGTTTTTTTGTTGGTGGTGCA
TCTCTTGTTTCACCCCCTGC

Product: ATP-dependent chaperone ClpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 862; Mature: 862

Protein sequence:

>862_residues
MRLDKLTTRFQEALADAQSLALGNDNPYIEPVHLLLAMLRQPDGATKNLLARAGVNTGALDTALDRAIKHLPQVQGGEQV
QVGRDLGNLLQQTEKEGIKRGDQFIASELFLLAAADDKGEAGRIAREHGLSRKPLEAAIDAVRGGQTVGSAEAESQREAL
KKYTIDLTEMARIGKLDPVIGRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPESLKNKRVLVLD
MAGLLAGAKYRGEFEERLKAVLNDIAKEEGQTILFIDEIHTMVGAGKAEGAMDAGNMLKPALARGELHCIGATTLDEYRK
YIEKDAALERRFQKVLVGEPSVEATIAILRGLQEKYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARI
KMEIDSKPEAMDKLDRRLIQLKIEREAVKKETDEASQKRLELIEQEIERLQKEYADLDEIWKAEKGAAQGAAALKEEIDK
IKLEITKLQREGKLEKVAELQYGKLPELEGKLKAATAAESAGQKQPNKLLRTQVGAEEIAEVVSRATGIPVAKMMTGERE
KLLKMEDRLHERVVGQDEAVRLVSDAIRRSRAGIADENKPYGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDMSEF
MEKHSVSRLIGAPPGYVGYEEGGYLTEAVRRKPYSVVLLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVMT
SNLGSQLIQQMATEPADVIKGAVWQEVKTHFRPEFLNRIDEVVVFHALDQRNIESIARIQLKRLSARLAHMDLALEISDE
AVAKLASAGYDPVFGARPLKRAIQQQIENPVARMILEGKFAPKDVVPVDYRDGQFSFERIVH

Sequences:

>Translated_862_residues
MRLDKLTTRFQEALADAQSLALGNDNPYIEPVHLLLAMLRQPDGATKNLLARAGVNTGALDTALDRAIKHLPQVQGGEQV
QVGRDLGNLLQQTEKEGIKRGDQFIASELFLLAAADDKGEAGRIAREHGLSRKPLEAAIDAVRGGQTVGSAEAESQREAL
KKYTIDLTEMARIGKLDPVIGRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPESLKNKRVLVLD
MAGLLAGAKYRGEFEERLKAVLNDIAKEEGQTILFIDEIHTMVGAGKAEGAMDAGNMLKPALARGELHCIGATTLDEYRK
YIEKDAALERRFQKVLVGEPSVEATIAILRGLQEKYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARI
KMEIDSKPEAMDKLDRRLIQLKIEREAVKKETDEASQKRLELIEQEIERLQKEYADLDEIWKAEKGAAQGAAALKEEIDK
IKLEITKLQREGKLEKVAELQYGKLPELEGKLKAATAAESAGQKQPNKLLRTQVGAEEIAEVVSRATGIPVAKMMTGERE
KLLKMEDRLHERVVGQDEAVRLVSDAIRRSRAGIADENKPYGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDMSEF
MEKHSVSRLIGAPPGYVGYEEGGYLTEAVRRKPYSVVLLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVMT
SNLGSQLIQQMATEPADVIKGAVWQEVKTHFRPEFLNRIDEVVVFHALDQRNIESIARIQLKRLSARLAHMDLALEISDE
AVAKLASAGYDPVFGARPLKRAIQQQIENPVARMILEGKFAPKDVVPVDYRDGQFSFERIVH
>Mature_862_residues
MRLDKLTTRFQEALADAQSLALGNDNPYIEPVHLLLAMLRQPDGATKNLLARAGVNTGALDTALDRAIKHLPQVQGGEQV
QVGRDLGNLLQQTEKEGIKRGDQFIASELFLLAAADDKGEAGRIAREHGLSRKPLEAAIDAVRGGQTVGSAEAESQREAL
KKYTIDLTEMARIGKLDPVIGRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPESLKNKRVLVLD
MAGLLAGAKYRGEFEERLKAVLNDIAKEEGQTILFIDEIHTMVGAGKAEGAMDAGNMLKPALARGELHCIGATTLDEYRK
YIEKDAALERRFQKVLVGEPSVEATIAILRGLQEKYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARI
KMEIDSKPEAMDKLDRRLIQLKIEREAVKKETDEASQKRLELIEQEIERLQKEYADLDEIWKAEKGAAQGAAALKEEIDK
IKLEITKLQREGKLEKVAELQYGKLPELEGKLKAATAAESAGQKQPNKLLRTQVGAEEIAEVVSRATGIPVAKMMTGERE
KLLKMEDRLHERVVGQDEAVRLVSDAIRRSRAGIADENKPYGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDMSEF
MEKHSVSRLIGAPPGYVGYEEGGYLTEAVRRKPYSVVLLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVMT
SNLGSQLIQQMATEPADVIKGAVWQEVKTHFRPEFLNRIDEVVVFHALDQRNIESIARIQLKRLSARLAHMDLALEISDE
AVAKLASAGYDPVFGARPLKRAIQQQIENPVARMILEGKFAPKDVVPVDYRDGQFSFERIVH

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=300, Percent_Identity=38, Blast_Score=207, Evalue=3e-53,
Organism=Escherichia coli, GI1788943, Length=848, Percent_Identity=67.3349056603774, Blast_Score=1146, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=391, Percent_Identity=41.6879795396419, Blast_Score=283, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=707, Percent_Identity=53.4653465346535, Blast_Score=750, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=870, Percent_Identity=42.8735632183908, Blast_Score=673, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 95509; Mature: 95509

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLDKLTTRFQEALADAQSLALGNDNPYIEPVHLLLAMLRQPDGATKNLLARAGVNTGAL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCHH
DTALDRAIKHLPQVQGGEQVQVGRDLGNLLQQTEKEGIKRGDQFIASELFLLAAADDKGE
HHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
AGRIAREHGLSRKPLEAAIDAVRGGQTVGSAEAESQREALKKYTIDLTEMARIGKLDPVI
CCHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCC
GRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPESLKNKRVLVLD
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEEEEE
MAGLLAGAKYRGEFEERLKAVLNDIAKEEGQTILFIDEIHTMVGAGKAEGAMDAGNMLKP
HHHHHHCCHHCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHHH
ALARGELHCIGATTLDEYRKYIEKDAALERRFQKVLVGEPSVEATIAILRGLQEKYELHH
HHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
GVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARIKMEIDSKPEAMDKLDRRLIQ
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHH
LKIEREAVKKETDEASQKRLELIEQEIERLQKEYADLDEIWKAEKGAAQGAAALKEEIDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHH
IKLEITKLQREGKLEKVAELQYGKLPELEGKLKAATAAESAGQKQPNKLLRTQVGAEEIA
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCHHHHH
EVVSRATGIPVAKMMTGEREKLLKMEDRLHERVVGQDEAVRLVSDAIRRSRAGIADENKP
HHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
YGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDMSEFMEKHSVSRLIGAPPGYVGYE
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCC
EGGYLTEAVRRKPYSVVLLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVMT
CCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEE
SNLGSQLIQQMATEPADVIKGAVWQEVKTHFRPEFLNRIDEVVVFHALDQRNIESIARIQ
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LKRLSARLAHMDLALEISDEAVAKLASAGYDPVFGARPLKRAIQQQIENPVARMILEGKF
HHHHHHHHHHHHHEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
APKDVVPVDYRDGQFSFERIVH
CCCCCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MRLDKLTTRFQEALADAQSLALGNDNPYIEPVHLLLAMLRQPDGATKNLLARAGVNTGAL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCHH
DTALDRAIKHLPQVQGGEQVQVGRDLGNLLQQTEKEGIKRGDQFIASELFLLAAADDKGE
HHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
AGRIAREHGLSRKPLEAAIDAVRGGQTVGSAEAESQREALKKYTIDLTEMARIGKLDPVI
CCHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCC
GRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPESLKNKRVLVLD
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEEEEE
MAGLLAGAKYRGEFEERLKAVLNDIAKEEGQTILFIDEIHTMVGAGKAEGAMDAGNMLKP
HHHHHHCCHHCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHHH
ALARGELHCIGATTLDEYRKYIEKDAALERRFQKVLVGEPSVEATIAILRGLQEKYELHH
HHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
GVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARIKMEIDSKPEAMDKLDRRLIQ
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHH
LKIEREAVKKETDEASQKRLELIEQEIERLQKEYADLDEIWKAEKGAAQGAAALKEEIDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHH
IKLEITKLQREGKLEKVAELQYGKLPELEGKLKAATAAESAGQKQPNKLLRTQVGAEEIA
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCHHHHH
EVVSRATGIPVAKMMTGEREKLLKMEDRLHERVVGQDEAVRLVSDAIRRSRAGIADENKP
HHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
YGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDMSEFMEKHSVSRLIGAPPGYVGYE
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCC
EGGYLTEAVRRKPYSVVLLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVMT
CCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEE
SNLGSQLIQQMATEPADVIKGAVWQEVKTHFRPEFLNRIDEVVVFHALDQRNIESIARIQ
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LKRLSARLAHMDLALEISDEAVAKLASAGYDPVFGARPLKRAIQQQIENPVARMILEGKF
HHHHHHHHHHHHHEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
APKDVVPVDYRDGQFSFERIVH
CCCCCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]