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The map label for this gene is moeA [H]

Identifier: 187928294

GI number: 187928294

Start: 1292897

End: 1294156

Strand: Direct

Name: moeA [H]

Synonym: Rpic_1205

Alternate gene names: 187928294

Gene position: 1292897-1294156 (Clockwise)

Preceding gene: 187928293

Following gene: 187928295

Centisome position: 32.79

GC content: 67.86

Gene sequence:

>1260_bases
ATGTCCGCCAACGATGCTCCCGCCGTCAAACCGTCCTTGTTGACGCTCGATGCGGCGCTGTCGCAACTGCTTGCCGCAGT
GCGCGCTTTGCACGAGACCGAAACCGTGTCGACGTTGCACGCCAACGGGCGCGTGCTCGCGCAGGCCGTGCGCAGCAGCT
TGAACGTGCCGCCCGCCGACAACACGCAGATGGACGGTTACGCCGTGCGCGCCGCCGACATCACCGCGCCGGGTGCCCGC
CTGAAGGTGGCGCAGCGCATTCCCGCGGGCCACGTCGGCCAACGGCTGAATCCGGGCGAGGCGGCGCGTATCTTTACCGG
CGCGCTGATCCCGCCAGGCGCCGACGCGGTGGTCATGCAGGAGCAATGCAAGGCTGACCCGGACACGGGCACCGTCACCA
TTGACCACGTACCCGAATCCGGCGAATGGATCCGCCGCGCCGGCGAGGACATCGCCGACGGCGCCGAGATCCTGCCGCGC
GGCACGCGCCTTGGCCCGCAGCAACTCGGCCTGGCGGCTTCGGTCGGCTGCGCCAACCTGCACGTGGTGCGTCGTCCGCG
CGTGGCCGTGTTCTTCACCGGCGACGAGCTTGCCATGCCCGGCGAGCCGCTCAAGCCCGGCGCCATCTACAACTCCAATC
GCTTTACGCTGCGCGCGCTGCTGGAAAACCTCGGCTGCGACATCACCGATTTCGGCATCGTGCCCGACACGCTGCAGGCC
ACGCGCGACACGCTGCGCGAAGCGGCCGAGGAGCACGACCTCATCATCACCTCCGGGGGCGTGTCGGTGGGCGAAGAAGA
CCACATCAAGCCCGCCGTGGAAGCTGAAGGGCGCCTGAACCTATGGCAGATCGCCATCAAGCCGGGCAAGCCGCTGGCCT
TTGGCGAGGTTCGCCGCCCCGAAGGCATGGTGGGCGGCCCCACCGCATTTTTCATTGGGCTGCCGGGCAACCCGGTGTCG
AGCTTCGTCACCTTCCTGCTGTTCGTGCGGCCGTTCATCCTGCGCCTGCAGGGCGTGGCCGATGTGGCCACGAAACGCAT
CCCGATGCGCGCCGACTTTGCGCTGCCCAAGGGCGATCGCCGCAACGAGTTCCTGCGTGCGCGCATCAACGCCAACGGTG
GGCTGGACCTGTTCCCGAATCAAAGCTCGGGCGTGCTGACCTCCACCGTGTGGGGTGATGGCCTGATCGACAACCCGCCC
AACCAGCCGATCGCGCAGGGCGATGTTGTCAGCTTCCTGCCGTTTGCAGGCCTGGTGTAA

Upstream 100 bases:

>100_bases
GGCCGACGCATTCGCTTGATACGCCTGGGCTGATGCATGGCATTGGCCTGGAACCGATACAATCGAAATCTCCTTTTCGA
TTTCGCTTTCCCATTCCCGC

Downstream 100 bases:

>100_bases
GGAGCGATGGCCATGCAGATCGAGCTTCGTTTCTTTGCCAGCGTGCGTGAACAGCTGGGAACCTCGCAGGAGCGGGTGGT
TGTGCCGGAAGCGGTGCGCA

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSANDAPAVKPSLLTLDAALSQLLAAVRALHETETVSTLHANGRVLAQAVRSSLNVPPADNTQMDGYAVRAADITAPGAR
LKVAQRIPAGHVGQRLNPGEAARIFTGALIPPGADAVVMQEQCKADPDTGTVTIDHVPESGEWIRRAGEDIADGAEILPR
GTRLGPQQLGLAASVGCANLHVVRRPRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRALLENLGCDITDFGIVPDTLQA
TRDTLREAAEEHDLIITSGGVSVGEEDHIKPAVEAEGRLNLWQIAIKPGKPLAFGEVRRPEGMVGGPTAFFIGLPGNPVS
SFVTFLLFVRPFILRLQGVADVATKRIPMRADFALPKGDRRNEFLRARINANGGLDLFPNQSSGVLTSTVWGDGLIDNPP
NQPIAQGDVVSFLPFAGLV

Sequences:

>Translated_419_residues
MSANDAPAVKPSLLTLDAALSQLLAAVRALHETETVSTLHANGRVLAQAVRSSLNVPPADNTQMDGYAVRAADITAPGAR
LKVAQRIPAGHVGQRLNPGEAARIFTGALIPPGADAVVMQEQCKADPDTGTVTIDHVPESGEWIRRAGEDIADGAEILPR
GTRLGPQQLGLAASVGCANLHVVRRPRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRALLENLGCDITDFGIVPDTLQA
TRDTLREAAEEHDLIITSGGVSVGEEDHIKPAVEAEGRLNLWQIAIKPGKPLAFGEVRRPEGMVGGPTAFFIGLPGNPVS
SFVTFLLFVRPFILRLQGVADVATKRIPMRADFALPKGDRRNEFLRARINANGGLDLFPNQSSGVLTSTVWGDGLIDNPP
NQPIAQGDVVSFLPFAGLV
>Mature_418_residues
SANDAPAVKPSLLTLDAALSQLLAAVRALHETETVSTLHANGRVLAQAVRSSLNVPPADNTQMDGYAVRAADITAPGARL
KVAQRIPAGHVGQRLNPGEAARIFTGALIPPGADAVVMQEQCKADPDTGTVTIDHVPESGEWIRRAGEDIADGAEILPRG
TRLGPQQLGLAASVGCANLHVVRRPRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRALLENLGCDITDFGIVPDTLQAT
RDTLREAAEEHDLIITSGGVSVGEEDHIKPAVEAEGRLNLWQIAIKPGKPLAFGEVRRPEGMVGGPTAFFIGLPGNPVSS
FVTFLLFVRPFILRLQGVADVATKRIPMRADFALPKGDRRNEFLRARINANGGLDLFPNQSSGVLTSTVWGDGLIDNPPN
QPIAQGDVVSFLPFAGLV

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=418, Percent_Identity=35.6459330143541, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI10880983, Length=418, Percent_Identity=35.6459330143541, Blast_Score=194, Evalue=9e-50,
Organism=Escherichia coli, GI1787049, Length=390, Percent_Identity=42.8205128205128, Blast_Score=264, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI25147659, Length=345, Percent_Identity=33.3333333333333, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=421, Percent_Identity=24.2280285035629, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136978, Length=389, Percent_Identity=32.9048843187661, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24638841, Length=389, Percent_Identity=32.9048843187661, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44452; Mature: 44321

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANDAPAVKPSLLTLDAALSQLLAAVRALHETETVSTLHANGRVLAQAVRSSLNVPPAD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCCC
NTQMDGYAVRAADITAPGARLKVAQRIPAGHVGQRLNPGEAARIFTGALIPPGADAVVMQ
CCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHEEEECCCCCCCCCCEEEH
EQCKADPDTGTVTIDHVPESGEWIRRAGEDIADGAEILPRGTRLGPQQLGLAASVGCANL
HHHCCCCCCCEEEEECCCCCCHHHHHCCCCHHCCHHHCCCCCCCCHHHHCHHHCCCCCEE
HVVRRPRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRALLENLGCDITDFGIVPDTLQA
EEEECCCEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCEEECCCCCHHHHH
TRDTLREAAEEHDLIITSGGVSVGEEDHIKPAVEAEGRLNLWQIAIKPGKPLAFGEVRRP
HHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCC
EGMVGGPTAFFIGLPGNPVSSFVTFLLFVRPFILRLQGVADVATKRIPMRADFALPKGDR
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
RNEFLRARINANGGLDLFPNQSSGVLTSTVWGDGLIDNPPNQPIAQGDVVSFLPFAGLV
CCCEEEEEECCCCCEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SANDAPAVKPSLLTLDAALSQLLAAVRALHETETVSTLHANGRVLAQAVRSSLNVPPAD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCCC
NTQMDGYAVRAADITAPGARLKVAQRIPAGHVGQRLNPGEAARIFTGALIPPGADAVVMQ
CCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHEEEECCCCCCCCCCEEEH
EQCKADPDTGTVTIDHVPESGEWIRRAGEDIADGAEILPRGTRLGPQQLGLAASVGCANL
HHHCCCCCCCEEEEECCCCCCHHHHHCCCCHHCCHHHCCCCCCCCHHHHCHHHCCCCCEE
HVVRRPRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRALLENLGCDITDFGIVPDTLQA
EEEECCCEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCEEECCCCCHHHHH
TRDTLREAAEEHDLIITSGGVSVGEEDHIKPAVEAEGRLNLWQIAIKPGKPLAFGEVRRP
HHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCC
EGMVGGPTAFFIGLPGNPVSSFVTFLLFVRPFILRLQGVADVATKRIPMRADFALPKGDR
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
RNEFLRARINANGGLDLFPNQSSGVLTSTVWGDGLIDNPPNQPIAQGDVVSFLPFAGLV
CCCEEEEEECCCCCEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]